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  1. Article: Ankle arthrodesis in patients with haemophilia-associated ankle arthropathy - does the technique influence the outcome?

    Sandiford, Nemandra A / Wong, Fabian / Back, Diane L / Chan, Oliver

    Acta orthopaedica Belgica

    2022  Volume 88, Issue 1, Page(s) 121–125

    Abstract: Management of symptomatic osteoarthritis (OA) of the ankle in patients with haemophilia can be challenging. Arthroscopic ankle arthrodesis has been shown in non-haemophiliac patients to provide similar or superior rates of fusion to open ankle fusion. ... ...

    Abstract Management of symptomatic osteoarthritis (OA) of the ankle in patients with haemophilia can be challenging. Arthroscopic ankle arthrodesis has been shown in non-haemophiliac patients to provide similar or superior rates of fusion to open ankle fusion. However, the literature regarding ankle arthrodesis in patients with haemophilia is limited. Our aim was to compare the rate of successful fusion between open and arthroscopic assisted ankle arthrodesis in patients with haemophilia. A retrospective study was performed. All patients with haemophilia who underwent ankle arthrodesis at our centre were included. Outcomes including peri- and post-operative complications, and lengths of stay were extracted from patients' records. Radiographs were reviewed for signs of successful arthrodesis. Seventeen arthrodesis procedures were performed in 13 patients between 1980 and 2017. Nine procedures were performed arthroscopically and eight were open. Ten patients were diagnosed with haemophilia A and three with haemophilia B. The success rates of arthroscopic and open tibiotalar arthrodesis were 100% and 87.5% respectively. Four complications occurred. In the open technique group, there was one non-union. The same patient also developed subsequent haematoma after revision surgery. One patient developed a superficial wound infection which resolved with antibiotics. In the arthroscopic group, one patient developed a pseudoarthrosis of the distal tibiofibular joint which required a revision procedure. The results of this study suggest that arthroscopic ankle fusion for haemophilia- associated arthropathy is a viable option, with the rate of successful fusion being comparable to open procedures.
    MeSH term(s) Ankle ; Ankle Joint/diagnostic imaging ; Ankle Joint/surgery ; Arthrodesis/methods ; Arthroscopy ; Hemophilia A/complications ; Hemophilia A/surgery ; Humans ; Osteoarthritis/complications ; Osteoarthritis/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-05-05
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 210367-9
    ISSN 0001-6462 ; 1784-407X
    ISSN 0001-6462 ; 1784-407X
    DOI 10.52628/88.1.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 37: Show issues Location:
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  2. Article ; Online: Axial view radiograph of the shoulder.

    Chan, Oliver

    BMJ (Clinical research ed.)

    2012  Volume 345, Page(s) e6861

    MeSH term(s) Clavicle/anatomy & histology ; Clavicle/diagnostic imaging ; Humans ; Radiography ; Scapula/anatomy & histology ; Scapula/diagnostic imaging ; Shoulder Joint/anatomy & histology ; Shoulder Joint/diagnostic imaging
    Language English
    Publishing date 2012-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.e6861
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  3. Article ; Online: Patient reported outcomes following non-operatively managed Weber Type A distal fibula fractures.

    Chan, Oliver / Lee, Conrad / Titheradge, Rachel / Auld, Felicity / Iliopoulos, Efthymios

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

    2021  Volume 28, Issue 1, Page(s) 62–65

    Abstract: Introduction: The outcomes of "Weber A" type fibula fractures treated non-operatively are not well studied. The aims of this study were to investigate patient reported outcomes (PROMs) from such injuries and investigate if different radiological ... ...

    Abstract Introduction: The outcomes of "Weber A" type fibula fractures treated non-operatively are not well studied. The aims of this study were to investigate patient reported outcomes (PROMs) from such injuries and investigate if different radiological features of the fracture affects such outcomes.
    Methods: Patients with conservatively managed Weber A fractures were contacted retrospectively (minimum 11 months) to measure PROMs. PROMs included the use of the Chertsey Outcome Score for Trauma (COST) as well as the time to return to work, physical activity and time to become symptom free. The effect of fracture features such as fracture height and intra-articular extension were analysed for their effect on PROMs.
    Results: Data was collected from 72 patients from a total of 211 patients presenting with Weber A fractures. The mean COST scores were 83 (range 30-100). Patients reported on average 3.1 weeks (desk based) and 5.7 weeks (labour intensive) to return to work, 10.8 weeks to return to physical activity and 14.8 weeks to become symptom free with 21% of patients still symptomatic at follow-up. Fracture height and fractures with comminution, displacement, intra-articular extension did not appear to be associated with poorer PROMs.
    Conclusion: The outcomes are generally excellent; however, most patients do not return to their baseline before the injury, with a significant proportion of patients remaining symptomatic at follow-up. The reported times to return to work, physical activity and symptom-free are useful to manage patient expectations. Our results dispel any assumption that Weber A type distal fibula fractures are always associated with excellent outcomes.
    MeSH term(s) Ankle Fractures/diagnostic imaging ; Ankle Fractures/surgery ; Fibula/diagnostic imaging ; Fracture Fixation, Internal ; Humans ; Patient Reported Outcome Measures ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-02-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 1424533-4
    ISSN 1460-9584 ; 1268-7731
    ISSN (online) 1460-9584
    ISSN 1268-7731
    DOI 10.1016/j.fas.2021.01.013
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    Zs.A 4246: Show issues Location:
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  4. Article ; Online: Predictors of metalwork failure and nonunion after hindfoot Charcot reconstruction.

    Najefi, Ali-Asgar / Zaidi, Razi / Chan, Oliver / Hester, Thomas / Kavarthapu, Venu

    The bone & joint journal

    2022  Volume 104-B, Issue 6, Page(s) 703–708

    Abstract: Aims: Surgical reconstruction of deformed Charcot feet carries a high risk of nonunion, metalwork failure, and deformity recurrence. The primary aim of this study was to identify the factors contributing to these complications following hindfoot Charcot ...

    Abstract Aims: Surgical reconstruction of deformed Charcot feet carries a high risk of nonunion, metalwork failure, and deformity recurrence. The primary aim of this study was to identify the factors contributing to these complications following hindfoot Charcot reconstructions.
    Methods: We retrospectively analyzed patients who underwent hindfoot Charcot reconstruction with an intramedullary nail between January 2007 and December 2019 in our unit. Patient demographic details, comorbidities, weightbearing status, and postoperative complications were noted. Metalwork breakage, nonunion, deformity recurrence, concurrent midfoot reconstruction, and the measurements related to intramedullary nail were also recorded.
    Results: There were 70 patients with mean follow-up of 54 months (SD 26). Overall, 51 patients (72%) and 52 patients (74%) were fully weightbearing at one year postoperatively and at final follow-up, respectively. The overall hindfoot union rate was 83% (58/70 patients). Age, BMI, glycated haemoglobin, and prior revascularization did not affect union. The ratio of nail diameter and isthmus was greater in the united compared to the nonunited group (0.90 (SD 0.06) and 0.86 (SD 0.09), respectively; p = 0.034). In those with a supplementary hindfoot compression screw, there was a 95% union rate (19/20 patients), compared to 78% in those without screws (39/50 patients; p = 0.038). All patients with a miss-a-nail hindfoot compression screw went on to union. Hindfoot metalwork failure was seen in 13 patients (19%). An intact medial malleolus was found more frequently in those with intact metalwork ((77% (44/57 patients) vs 54% (7/13 patients); p = 0.022) and in those with union ((76% (44/58 patients) vs 50% (6/12 patients); p = 0.018). Broken metalwork occurred more frequently in patients with nonunions (69% (9/13 patients) vs 9% (5/57 patients); p < 0.001) and midfoot deformity recurrence (69% (9/13 patients) vs 9% (5/57 patients); p < 0.001).
    Conclusion: Rates of hindfoot union and intact metalwork were noted in over 80% of patients. Union after hindfoot reconstruction occurs more frequently with an isthmic fit of the intramedullary nail and supplementary hindfoot screws. An intact medial malleolus is protective against nonunion and hindfoot metalwork failure. Cite this article:
    MeSH term(s) Ankle Joint/surgery ; Arthrodesis ; Bone Screws ; Foot/surgery ; Humans ; Retrospective Studies
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.104B6.BJJ-2022-0127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6989: Show issues Location:
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  5. Article ; Online: The Bologna-Oxford ankle replacement: a case series of clinical and radiological outcomes.

    Najefi, Ali / Malhotra, Karan / Chan, Oliver / Cullen, Nicholas / Goldberg, Andy

    International orthopaedics

    2019  Volume 43, Issue 10, Page(s) 2333–2339

    Abstract: Purpose: The Bologna-Oxford (BOX®) total ankle arthroplasty (TAA) is a three-component mobile-bearing implant gaining popularity in Europe. We aimed to analyse the outcomes of this TAA.: Methods: We retrospectively analysed data on 34 consecutive BOX® ...

    Abstract Purpose: The Bologna-Oxford (BOX®) total ankle arthroplasty (TAA) is a three-component mobile-bearing implant gaining popularity in Europe. We aimed to analyse the outcomes of this TAA.
    Methods: We retrospectively analysed data on 34 consecutive BOX® TAAs performed at a single centre with a mean follow-up of 58 months. Radiographic outcomes, such as periprosthetic lucency and alignment, were measured and recorded. Prospectively captured clinical scores and range of movement (ROM) were also recorded.
    Results: There were significant improvements in patient-reported outcome scores recorded in the Manchester-Oxford Foot Questionnaire (MOxFQ) for pain (43.8 ± 20.2, p < 0.001), standing and walking (55.6 ± 19.8, p < 0.001), social activities (45.0 ± 26.9, p < 0.02) and visual analogue score (VAS) (3.1 ± 2.5, p < 0.001). Mean improvement in ROM postoperatively was 18.7° (p < 0.001), with post-operative dorsiflexion 8.8° (10°-25°) and plantar flexion 32.6° (20°-40°). There was evidence of asymptomatic lucency on five radiographs (15%), which was present in 10% at three years. Nine patients had complications (26%): six (18%) requiring secondary surgery and one requiring revision (3%) for infection.
    Conclusions: We have demonstrated 97% survivorship at a mean of 58 months. There are maintained improvements in clinical and radiological outcomes and reoperation that are consistent with the literature.
    MeSH term(s) Adult ; Aged ; Ankle Joint/diagnostic imaging ; Ankle Joint/surgery ; Arthroplasty, Replacement, Ankle ; Female ; Humans ; Joint Prosthesis ; Male ; Middle Aged ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/etiology ; Osteoarthritis/surgery ; Patient Reported Outcome Measures ; Range of Motion, Articular ; Reoperation ; Retrospective Studies ; Surveys and Questionnaires ; Treatment Outcome
    Language English
    Publishing date 2019-06-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-019-04362-6
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    Zs.A 1324: Show issues Location:
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  6. Article ; Online: Assessment and determinants of aggression in a forensic psychiatric institution in Hong Kong, China.

    Chan, Oliver / Chow, Kavin Kit-wan

    Psychiatry research

    2014  Volume 220, Issue 1-2, Page(s) 623–630

    Abstract: Institutional aggression in forensic psychiatric setting is an under-researched subject, despite the magnitude of the problem. No studies have been conducted on the assessment of risk and the examination of predictors of aggression among the Chinese ... ...

    Abstract Institutional aggression in forensic psychiatric setting is an under-researched subject, despite the magnitude of the problem. No studies have been conducted on the assessment of risk and the examination of predictors of aggression among the Chinese forensic psychiatric population. Our study aimed to examine the determinants of aggression in the only forensic psychiatric institution in Hong Kong, and to test the psychometric properties of a risk-assessment instrument, the Dynamic Appraisal of Situational Aggression (DASA). We recruited a representative sample of 530 consecutively admitted detainees. Qualified nurses completed two risk-assessment instruments, the DASA and the Brøset Violence Checklist (BVC), once daily during the participants׳ first 14 days of admission. Aggressive incidents were recorded using the revised Staff Observation Aggression Scale (SOAS-R), and participants׳ data were collected for multivariate analyses. We showed that female gender, diagnoses of personality disorder and substance-related disorder, and admission at other correctional institutions were associated with institutional aggression. Aggression was perpetrated by 17.7% of the participants, and the DASA was demonstrated to have good psychometric properties in assessing and predicting aggressive incidents. Our findings preliminarily support the use of daily in-patient risk-assessment and affirm the role of dynamic factors in institutional aggression.
    MeSH term(s) Adult ; Aggression/psychology ; Checklist ; Female ; Forensic Psychiatry ; Hong Kong ; Hospitalization ; Hospitals, Psychiatric ; Humans ; Male ; Middle Aged ; Personality Disorders/psychology ; Psychometrics ; Reproducibility of Results ; Risk Assessment/methods ; Sex Factors ; Substance-Related Disorders/psychology ; Violence/psychology
    Language English
    Publishing date 2014-12-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2014.08.008
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  7. Book: Transgenic plants

    Chan, Oliver T

    new research

    2009  

    Author's details Oliver T. Chan, editor
    Keywords Transgenic plants. ; Crops/Genetic engineering.
    Language English
    Size xxvi, 213 p. :, ill. (some col.) ;, 27 cm.
    Publisher Nova Science Publishers
    Publishing place New York
    Document type Book
    ISBN 9781606920176 ; 1606920170
    Database NAL-Catalogue (AGRICOLA)

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  8. Book: Transgenic plants

    Chan, Oliver T

    new research

    2009  

    Author's details Oliver T. Chan ed
    Keywords Crops/Genetic engineering ; Transgenic plants
    Language English
    Size XXVI, 213 S., Ill., graph. Darst
    Publisher Nova Science Publ
    Publishing place New York, N.Y
    Document type Book
    ISBN 9781606920176 ; 1606920170
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article ; Online: Dosimetric comparison of intensity modulated radiotherapy and intensity modulated proton therapy in the treatment of recurrent nasopharyngeal carcinoma.

    Hung, Hing Ming / Chan, Oliver Cheuk Ming / Mak, Chi Hang / Hung, Wai Man / Ng, Wai Tong / Lee, Michael Chi Hang

    Medical dosimetry : official journal of the American Association of Medical Dosimetrists

    2021  Volume 47, Issue 1, Page(s) 14–19

    Abstract: Background and purpose: To compare the dosimetric performance of Intensity Modulated Proton Therapy (IMPT) and Intensity Modulated Radiotherapy (IMRT) in terms of target volume coverage and sparing of neurological organs-at-risk (OARs) in salvaging ... ...

    Abstract Background and purpose: To compare the dosimetric performance of Intensity Modulated Proton Therapy (IMPT) and Intensity Modulated Radiotherapy (IMRT) in terms of target volume coverage and sparing of neurological organs-at-risk (OARs) in salvaging recurrent nasopharyngeal carcinoma (rNPC). The maximum dose to the internal carotid artery (ICA) and nasopharyngeal (NP) mucosa, which are associated with potential carotid blowout and massive epistaxis, were also evaluated.
    Materials and methods: IMRT and IMPT treatment plans were created for twenty patients with locally advanced rNPC. Planning Target Volume (PTV) was used to account for the setup and spatial error/uncertainty in the IMRT planning. Robust optimization on Clinical Target Volume (CTV) coverage with consideration of range and setup uncertainty was employed to produce two IMPT plans with 3-field and 4-field arrangements. The planning objective was to deliver 60 Gy to the PTV (IMRT) and CTV (IMPT) without exceeding the maximum lifetime cumulative Biologically Effective Dose (BED) of the neurological OARs (applied to the Planning organs-at-risk volume). The target dose coverage as well as the maximum dose to the neurological OARs, ICA, and NP mucosa were compared.
    Results: Compared with IMRT, 3-field IMPT achieved better coverage to GTV V100% (83.3% vs. 73.2%, P <0.01) and CTV V100% (80.5% vs. 72.4%, P <0.01), and lower maximum dose to the critical OARs including the spinal cord (19.2 Gy vs. 22.3 Gy, P <0.01), brainstem (30.0 Gy vs. 32.3 Gy, P <0.01) and optic chiasm (6.6 Gy vs. 9.8 Gy, P <0.01). The additional beam with the 4-fields IMPT plans further improved the target coverage from the 3-field IMPT (CTV V98%: 85.3% vs. 82.4%, P <0.01) with similar OAR sparing. However, the target dose was highly non-uniform with both IMPT plans, leading to a significantly higher maximum dose to the ICA (∼68 Gy vs. 62.6 Gy, P <0.01) and NP mucosa (∼72 Gy vs. 62.8 Gy, P <0.01) than IMRT.
    Conclusion: IMPT demonstrated some dosimetric advantage over IMRT in treating rNPC. However, IMPT could also result in very high dose hot spots in the target volume. Careful consideration of the ICA and NP mucosal complications is recommended when applying IMPT on rNPC patients.
    MeSH term(s) Humans ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/radiotherapy ; Organs at Risk ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2021-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645065-9
    ISSN 1873-4022 ; 0958-3947 ; 0739-0211
    ISSN (online) 1873-4022
    ISSN 0958-3947 ; 0739-0211
    DOI 10.1016/j.meddos.2021.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2448: Show issues Location:
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  10. Article ; Online: Elective foot and ankle surgery following the peak of the COVID-19 pandemic is safe: A report of 30-day morbidity and mortality.

    Groom, William D / Garner, Madeleine / Chan, Oliver / Latif, Ahmed / Francis, Randhir / Singh, Samrendu / Abbasian, Ali

    Foot (Edinburgh, Scotland)

    2021  Volume 48, Page(s) 101850

    Abstract: Introduction: The safety of resuming elective surgical services remains unclear following several surges of the COVID-19 pandemic worldwide. Multiple studies have reported high rates of post-operative mortality and pulmonary complications. 30-day ... ...

    Abstract Introduction: The safety of resuming elective surgical services remains unclear following several surges of the COVID-19 pandemic worldwide. Multiple studies have reported high rates of post-operative mortality and pulmonary complications. 30-day outcomes on an initial cohort of patients undergoing elective foot and ankle surgery at 3 central London hospitals are presented.
    Materials and methods: This study is a retrospective review of the first 63 patients undergoing surgery following the first UK surge via a modified treatment pathway, based on published national guidelines, designed to minimise the risks to patients and staff associated with COVID-19.
    Results: 90% of patients were ASA 1 or 2, with an average age of 46. All tested negative for COVID-19 pre-operatively and all but one underwent a general anaesthetic. 10 patients required one night hospital stays and 1 was admitted for four nights. 52 were day case procedures. 2 complications were identified, not relating to COVID-19 infection. No 30-day mortalities or pulmonary complications were recorded.
    Conclusions: With a community prevalence of COVID-19 of between 1 in 1500 and 1 in 1700, elective foot and ankle surgery was safe following the first surge of the pandemic in the UK. This data can guide elective service planning in countries with pandemic curves behind the UK's or in the event of further surges in national cases.
    MeSH term(s) Adolescent ; Adult ; Aged ; Ankle/surgery ; COVID-19/epidemiology ; Elective Surgical Procedures ; Female ; Foot/surgery ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Safety ; Postoperative Complications/epidemiology ; Prevalence ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-07-09
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1070358-5
    ISSN 1532-2963 ; 0958-2592
    ISSN (online) 1532-2963
    ISSN 0958-2592
    DOI 10.1016/j.foot.2021.101850
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