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  1. Book ; Online ; E-Book: Promoting pollination and pollinators in farming

    Kevan, Peter / Willis Chan, Susan

    (Burleigh Dodds series in agricultural science ; number 126)

    2023  

    Abstract: Intro -- Promoting pollination and pollinators in farming -- Part 1 Understanding pollinators and pollination -- Chapter 1 What is pollination and what are pollinators in agriculture? -- 1 Introduction -- 2 The basics of pollination -- 3 Pollinators and ... ...

    Author's details edited by Peter Kevan and Susan Willis Chan
    Series title Burleigh Dodds series in agricultural science ; number 126
    Collection
    Abstract Intro -- Promoting pollination and pollinators in farming -- Part 1 Understanding pollinators and pollination -- Chapter 1 What is pollination and what are pollinators in agriculture? -- 1 Introduction -- 2 The basics of pollination -- 3 Pollinators and their diversity -- 4 The ecology and evolution of floral traits -- 5 Domestication and its impact on plant-pollinator relationships -- 6 How do pollinators impact agriculture? -- 7 Modern agriculture and pollinators -- 8 Conclusion -- 9 Where to look for further information -- 10 References -- Chapter 2 The role and application of olfaction in crop plant-pollinator interactions -- 1 Introduction -- 2 Key challenges -- 3 Case studies -- 4 Summary -- 5 Future trends -- 6 Conclusion -- 7 Where to look for further information -- 8 References -- Chapter 3 The role of wind pollination in crop plants -- 1 Introduction -- 2 Fundamental mechanisms of wind pollination -- 3 Wind pollination and transgenic risks in grass crop species -- 4 Promoting wind pollination in open-pollinated crop species -- 5 Conclusion and future trends -- 6 References -- Part 2 Threats to pollinators -- Chapter 4 Assessing climate change impacts on pollinators -- 1 Introduction -- 2 Challenges anthropogenic climate change poses to pollinators -- 3 Advancing our understanding of climate change impacts on pollinators -- 4 Conserving pollinators under climate change -- 5 Conclusion -- 6 Where to look for further information -- 7 References -- Chapter 5 Assessing the impact of disease on pollinators -- 1 Introduction -- 2 A bestiary of honey bee diseases -- 3 The poorly known wild bee diseases -- 4 Disease transmission, spillover and spillback -- 5 Defence mechanisms of bees -- 6 Synergies with other risk factors -- 7 Prevention of diseases -- 8 Future trends -- 9 Where to look for further information -- 10 References.
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (415 Seiten)
    Publisher Burleigh Dodds Science Publishing Limited
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021725113
    ISBN 978-1-80146-101-6 ; 978-1-80146-100-9 ; 9781801460989 ; 1-80146-101-5 ; 1-80146-100-7 ; 1801460981
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Biologics in atopic dermatitis.

    Chan, Susan

    Current opinion in allergy and clinical immunology

    2021  Volume 21, Issue 3, Page(s) 297–302

    Abstract: Purpose of review: Until recently there have been limited options for systemic therapy in atopic dermatitis, which is unresponsive to topical treatments. However, the last few years have seen a rapid progression in this field. The purpose of this review ...

    Abstract Purpose of review: Until recently there have been limited options for systemic therapy in atopic dermatitis, which is unresponsive to topical treatments. However, the last few years have seen a rapid progression in this field. The purpose of this review is to summarise some of the recent literature and ongoing studies in the field of biologicals in atopic dermatitis.
    Recent findings: Dupilumab has been shown to be effective in moderate to severe atopic dermatitis and is now licensed in the USA and Europe. Tralokinumab is currently under review by the Food and Drug Administration and the European Medicines agency. Phase 2 and 3 studies are taking place with other biological therapies. There is increasing evidence for the use of biologicals in children and for their role in multisystem disease.
    Summary: The recent breakthroughs in treatment represent an opportunity to resolve an unmet need; the management of atopic dermatitis which is unresponsive to topical therapy.
    MeSH term(s) Biological Products/therapeutic use ; Biological Therapy ; Dermatitis, Atopic/drug therapy ; Eczema/drug therapy ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Promoting Pollination and Pollinators in Farming

    Kevan Peter / Chan Susan Willis

    Journal of Apicultural Science, Vol 67, Iss 2, Pp 147-

    2023  Volume 147

    Keywords Zoology ; QL1-991
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Evolution of the Ikaros family transcription factors: From a deuterostome ancestor to humans.

    Kastner, Philippe / Aukenova, Adina / Chan, Susan

    Biochemical and biophysical research communications

    2023  Volume 694, Page(s) 149399

    Abstract: Ikaros family proteins (Ikaros, Helios, Aiolos, Eos) are zinc finger transcription factors essential for the development and function of the adaptive immune system. They also control developmental events in neurons and other cell types, suggesting that ... ...

    Abstract Ikaros family proteins (Ikaros, Helios, Aiolos, Eos) are zinc finger transcription factors essential for the development and function of the adaptive immune system. They also control developmental events in neurons and other cell types, suggesting that they possess crucial functions across disparate cell types. These functions are likely shared among the organisms in which these factors exist, and it is thus important to obtain a view of their distribution and conservation across organisms. How this family evolved remains poorly understood. Here we mined protein, mRNA and DNA databases to identify proteins with DNA-binding domains homologous to that of Ikaros. We show that Ikaros-related proteins exist in organisms from all four deuterostome phyla (chordates, echinoderms, hemichordates, xenacoelomorpha), but not in more distant groups. While most non-vertebrates have a single family member, this family grew to six members in the acoel worm Hofstenia miamia, three in jawless and four in jawed vertebrates. Most residues involved in DNA contact from zinc fingers 2 to 4 were identical across the Ikaros family, suggesting conserved mechanisms for target sequence recognition. Further, we identified a novel KRKxxxPxK/R motif that inhibits DNA binding in vitro which was conserved across the deuterostome phyla. We also identified a EψψxxxψM(D/E)QAIxxAIxYLGA(D/E)xL motif conserved among human Ikaros, Aiolos, Helios and subsets of chordate proteins, and motifs that are specific to subsets of vertebrate family members. Some of these motifs are targets of mutations in human patients. Finally we show that the atypical family member Pegasus emerged only in vertebrates, which is consistent with its function in bone. Our data provide a novel evolutionary perspective for Ikaros family proteins and suggest that they have conserved regulatory functions across deuterostomes.
    MeSH term(s) Animals ; Humans ; DNA ; Ikaros Transcription Factor/genetics ; Ikaros Transcription Factor/metabolism ; RNA, Messenger ; Zinc Fingers/genetics
    Chemical Substances DNA (9007-49-2) ; Ikaros Transcription Factor (148971-36-2) ; RNA, Messenger
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.149399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparing the Roles of Omalizumab and UV Therapy in Treating Severe Pediatric Atopic Dermatitis-Reply.

    Chan, Susan / Lack, Gideon

    JAMA pediatrics

    2020  Volume 175, Issue 2, Page(s) 206

    MeSH term(s) Anti-Allergic Agents/therapeutic use ; Asthma/drug therapy ; Child ; Dermatitis, Atopic/drug therapy ; Humans ; Omalizumab/therapeutic use
    Chemical Substances Anti-Allergic Agents ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.0969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CD4

    Polak, Katarzyna / Marchal, Patricia / Taroni, Chiara / Ebel, Claudine / Kirstetter, Peggy / Kastner, Philippe / Chan, Susan

    Biochemical and biophysical research communications

    2023  Volume 674, Page(s) 83–89

    Abstract: The transcriptional regulators that drive regulatory T (Treg) cell development and function remain partially understood. Helios (Ikzf2) and Eos (Ikzf4) are closely-related members of the Ikaros family of transcription factors. They are highly expressed ... ...

    Abstract The transcriptional regulators that drive regulatory T (Treg) cell development and function remain partially understood. Helios (Ikzf2) and Eos (Ikzf4) are closely-related members of the Ikaros family of transcription factors. They are highly expressed in CD4
    MeSH term(s) Animals ; Mice ; Autoimmune Diseases/genetics ; Disease Susceptibility/metabolism ; Forkhead Transcription Factors/metabolism ; Ikaros Transcription Factor/genetics ; Ikaros Transcription Factor/metabolism ; T-Lymphocytes, Regulatory ; Transcription Factors/metabolism
    Chemical Substances Forkhead Transcription Factors ; Ikaros Transcription Factor (148971-36-2) ; Transcription Factors ; IKZF2 protein, human ; EOS serine protease, human (EC 3.4.21.-)
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.06.087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Atopic Dermatitis and Food Allergy: A Paediatric Approach.

    Cartledge, Natalia / Chan, Susan

    Current pediatric reviews

    2018  Volume 14, Issue 3, Page(s) 171–179

    Abstract: Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, ...

    Abstract Atopic dermatitis and food allergy are common conditions of childhood that are closely linked. 30% of children with moderate to severe eczema suffer from food allergy and can present with different types of reactions: immediate or IgE-mediated reactions, delayed or non-IgEmediated eczematous flares, or a combination of the two. A detailed history is very important when approaching such patients. The presence of IgE-mediated symptoms warrants investigation and management requires avoidance of the culprit allergen, an emergency care plan and appropriate follow up. Non-IgE-mediated reactions can be more difficult to diagnose, and investigations are more difficult to interpret. Topical treatment is paramount in all patients with atopic dermatitis, while food elimination diets remain the mainstay of the management of food allergy, and should be done under specialist supervision. In this review, we discuss the current understanding of atopic dermatitis and food allergy, the role of investigations and management of paediatric patients with both conditions. We propose an algorithm that can be used by paediatricians when dealing with children with food allergy and atopic dermatitis.
    MeSH term(s) Algorithms ; Allergens/immunology ; Child ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/therapy ; Diagnosis, Differential ; Food Hypersensitivity/complications ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/therapy ; Humans ; Immunoglobulin E ; Pediatricians ; Skin Tests
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-07-09
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1875-6336
    ISSN (online) 1875-6336
    DOI 10.2174/1573396314666180613083616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Topical steroid withdrawal and atopic dermatitis.

    Marshall, Hannah F / Leung, Donald Y M / Lack, Gideon / Sindher, Sayantani / Ciaccio, Christina E / Chan, Susan / Nadeau, Kari C / Brough, Helen A

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 132, Issue 4, Page(s) 423–425

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Steroids/adverse effects ; Administration, Topical
    Chemical Substances Steroids
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An evaluation of inverse probability weighting using the propensity score for baseline covariate adjustment in smaller population randomised controlled trials with a continuous outcome.

    Raad, Hanaya / Cornelius, Victoria / Chan, Susan / Williamson, Elizabeth / Cro, Suzie

    BMC medical research methodology

    2020  Volume 20, Issue 1, Page(s) 70

    Abstract: Background: It is important to estimate the treatment effect of interest accurately and precisely within the analysis of randomised controlled trials. One way to increase precision in the estimate and thus improve the power for randomised trials with ... ...

    Abstract Background: It is important to estimate the treatment effect of interest accurately and precisely within the analysis of randomised controlled trials. One way to increase precision in the estimate and thus improve the power for randomised trials with continuous outcomes is through adjustment for pre-specified prognostic baseline covariates. Typically covariate adjustment is conducted using regression analysis, however recently, Inverse Probability of Treatment Weighting (IPTW) using the propensity score has been proposed as an alternative method. For a continuous outcome it has been shown that the IPTW estimator has the same large sample statistical properties as that obtained via analysis of covariance. However the performance of IPTW has not been explored for smaller population trials (< 100 participants), where precise estimation of the treatment effect has potential for greater impact than in larger samples.
    Methods: In this paper we explore the performance of the baseline adjusted treatment effect estimated using IPTW in smaller population trial settings. To do so we present a simulation study including a number of different trial scenarios with sample sizes ranging from 40 to 200 and adjustment for up to 6 covariates. We also re-analyse a paediatric eczema trial that includes 60 children.
    Results: In the simulation study the performance of the IPTW variance estimator was sub-optimal with smaller sample sizes. The coverage of 95% CI's was marginally below 95% for sample sizes < 150 and ≥ 100. For sample sizes < 100 the coverage of 95% CI's was always significantly below 95% for all covariate settings. The minimum coverage obtained with IPTW was 89% with n = 40. In comparison, regression adjustment always resulted in 95% coverage. The analysis of the eczema trial confirmed discrepancies between the IPTW and regression estimators in a real life small population setting.
    Conclusions: The IPTW variance estimator does not perform so well with small samples. Thus we caution against the use of IPTW in small sample settings when the sample size is less than 150 and particularly when sample size < 100.
    MeSH term(s) Child ; Computer Simulation ; Humans ; Monte Carlo Method ; Probability ; Propensity Score ; Randomized Controlled Trials as Topic ; Regression Analysis ; Sample Size
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041362-2
    ISSN 1471-2288 ; 1471-2288
    ISSN (online) 1471-2288
    ISSN 1471-2288
    DOI 10.1186/s12874-020-00947-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction: Ikaros antagonizes DNA binding by STAT5 in pre-B cells.

    Heizmann, Beate / Le Gras, Stéphanie / Simand, Célestine / Marchal, Patricia / Chan, Susan / Kastner, Philippe

    PloS one

    2021  Volume 16, Issue 1, Page(s) e0246570

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0242211.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0242211.].
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0246570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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