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Book ; Online: A Privacy-preserving Central Bank Ledger for Central Bank Digital Currency

Chan, Wang Mong Tikvah

2023

Abstract: Retail central bank digital currency (rCBDC) is seen as a key upgrade of the monetary system in the 21st century. However, privacy concerns are the main impediment to rCBDC's development and roll-out. On the one hand, the rights of people to keep their ... ...

Abstract	Retail central bank digital currency (rCBDC) is seen as a key upgrade of the monetary system in the 21st century. However, privacy concerns are the main impediment to rCBDC's development and roll-out. On the one hand, the rights of people to keep their transactions private should be protected, including against central bank surveillance. On the other hand, the central bank needs to ensure that no over-issuance of money or other frauds occur, demanding a certain form of knowledge of rCBDC transactions to safeguard against malicious users. This work focuses on rCBDC architectures based on the unspent transaction output (UTXO) data model and tackles the research problem of preserving a sufficient degree of privacy for UTXO transaction records while allowing the central bank to verify their correctness. User privacy is not adequately addressed in the UTXO-based rCBDC architectures. Using evolving public keys as pseudonyms to hide the real identities of users only solves the privacy issue partially. Some information could still be leaked out. This work investigates techniques to address the shortcomings of the pseudonym approach. First, a Pedersen commitment scheme is applied to hide the transaction values of a UTXO transaction while allowing the central bank to verify that no over-issuance of rCBDC has occurred in the transaction.This work uses a Schnorr signature to prove no over-issuance of money, which reduces overheads and enables a non-interactive proof. Then, Coinjoin is applied to aggregate UTXO transactions from different users into one larger UTXO transaction to obfuscate the payer-payee relationship while preserving the correctness of the amount of money flow. This work applies k-anonymity to analyse the privacy guarantee of Coinjoin. By modelling the transaction traffic by a Poisson process, the trade-off between anonymity and transaction confirmation time of Coinjoin is analysed. Comment: 37 pages, 9 figures
Keywords	Computer Science - Cryptography and Security ; E.3 ; G.3 ; K.4.1 ; K.4.4
Subject code	330
Publishing date	2023-08-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Disulfiram on the Reproductive Capacity of Female Mice

Mingming Teng / Yuan Luo / Chan Wang / Anmin Lei

International Journal of Molecular Sciences, Vol 24, Iss 2371, p

2023 Volume 2371

Abstract: In the process of assisted reproduction, the high-oxygen in vitro environment can easily cause oxidative damage to oocytes. Disulfiram (DSF) can play an anti-oxidant or pro-oxidant role in different cells, and the effect of DSF on oocytes remains unclear. ...

Abstract	In the process of assisted reproduction, the high-oxygen in vitro environment can easily cause oxidative damage to oocytes. Disulfiram (DSF) can play an anti-oxidant or pro-oxidant role in different cells, and the effect of DSF on oocytes remains unclear. Moreover, it remains unclear whether the use of DSF in the early stages of pregnancy has a negative impact on the fetus. In this study, we found that DSF increased serum FSH levels and increased the ovulation rate in mice. Moreover, DSF enhanced the antioxidant capacity of oocytes and contributed to the success rate of in vitro fertilization. Moreover, the use of DSF in early pregnancy in mice increased the uterine horn volume and the degree of vascularization, which contributed to a successful pregnancy. In addition, it was found that DSF regulated the mRNA expression of angiogenesis-related genes ( VEGF ), follicular development-related genes ( C1QTNF3 , mTOR and PI3K ), ovulation-related genes ( MAPK1 , MAPK3 and p38 MAPK ) and antioxidant-related genes ( GPX4 and CAT ). These results indicate that DSF is helpful for increasing the antioxidant capacity of oocytes and the ovulation rate. In early pregnancy in mice, DSF promotes pregnancy by increasing the degree and volume of uterine vascularization.
Keywords	disulfiram ; female mice ; reproductive capacity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: R & D competition and patent values

Pu-yan NIE / Hong-xing WEN / Chan WANG

Journal of Innovation & Knowledge, Vol 8, Iss 1, Pp 100308- (2023)

2023

Abstract: Research and development (R & D) competition is standard, and it heavily affects patent values. This study captures R&D competition's effects on patent values using game-theory approaches. Cost-reduction patent values increase with technology level and ... ...

Abstract	Research and development (R & D) competition is standard, and it heavily affects patent values. This study captures R&D competition's effects on patent values using game-theory approaches. Cost-reduction patent values increase with technology level and decrease with the competition. Technology spillover's impact on innovation depends on R & D's properties. This study elucidates cooperative R & D and the allocation mechanism, and also develops the theory of cooperative innovation.
Keywords	Patent values ; R & ; D competition ; Patent industrialization ; History of scholarship and learning. The humanities ; AZ20-999 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advanced Implantable Biomedical Devices Enabled by Triboelectric Nanogenerators

Chan Wang / Qiongfeng Shi / Chengkuo Lee

Nanomaterials, Vol 12, Iss 8, p

2022 Volume 1366

Abstract: Implantable biomedical devices (IMDs) play essential roles in healthcare. Subject to the limited battery life, IMDs cannot achieve long-term in situ monitoring, diagnosis, and treatment. The proposal and rapid development of triboelectric nanogenerators ... ...

Abstract	Implantable biomedical devices (IMDs) play essential roles in healthcare. Subject to the limited battery life, IMDs cannot achieve long-term in situ monitoring, diagnosis, and treatment. The proposal and rapid development of triboelectric nanogenerators free IMDs from the shackles of batteries and spawn a self-powered healthcare system. This review aims to overview the development of IMDs based on triboelectric nanogenerators, divided into self-powered biosensors, in vivo energy harvesting devices, and direct electrical stimulation therapy devices. Meanwhile, future challenges and opportunities are discussed according to the development requirements of current-level self-powered IMDs to enhance output performance, develop advanced triboelectric nanogenerators with multifunctional materials, and self-driven close-looped diagnosis and treatment systems.
Keywords	implantable biomedical devices ; triboelectric nanogenerator ; energy harvester ; self-powered biosensor ; nerve stimulation ; muscle stimulation ; Chemistry ; QD1-999
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CEMIG: prediction of the cis-regulatory motif using the de Bruijn graph from ATAC-seq.

Wang, Yizhong / Li, Yang / Wang, Cankun / Lio, Chan-Wang Jerry / Ma, Qin / Liu, Bingqiang

Briefings in bioinformatics

2024 Volume 25, Issue 1

Abstract: Sequence motif discovery algorithms enhance the identification of novel deoxyribonucleic acid sequences with pivotal biological significance, especially transcription factor (TF)-binding motifs. The advent of assay for transposase-accessible chromatin ... ...

Abstract	Sequence motif discovery algorithms enhance the identification of novel deoxyribonucleic acid sequences with pivotal biological significance, especially transcription factor (TF)-binding motifs. The advent of assay for transposase-accessible chromatin using sequencing (ATAC-seq) has broadened the toolkit for motif characterization. Nonetheless, prevailing computational approaches have focused on delineating TF-binding footprints, with motif discovery receiving less attention. Herein, we present Cis rEgulatory Motif Influence using de Bruijn Graph (CEMIG), an algorithm leveraging de Bruijn and Hamming distance graph paradigms to predict and map motif sites. Assessment on 129 ATAC-seq datasets from the Cistrome Data Browser demonstrates CEMIG's exceptional performance, surpassing three established methodologies on four evaluative metrics. CEMIG accurately identifies both cell-type-specific and common TF motifs within GM12878 and K562 cell lines, demonstrating its comparative genomic capabilities in the identification of evolutionary conservation and cell-type specificity. In-depth transcriptional and functional genomic studies have validated the functional relevance of CEMIG-identified motifs across various cell types. CEMIG is available at https://github.com/OSU-BMBL/CEMIG, developed in C++ to ensure cross-platform compatibility with Linux, macOS and Windows operating systems.
MeSH term(s)	Chromatin Immunoprecipitation Sequencing ; Algorithms ; Benchmarking ; Biological Evolution ; Cell Line
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbad505
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Article ; Online: Speech Outcomes of Frenectomy for Tongue-Tie Release: A Systematic Review and Meta-Analysis.

Carnino, Jonathan M / Rodriguez Lara, Frances / Chan, Wang Pong / Kennedy, Dean G / Levi, Jessica R

The Annals of otology, rhinology, and laryngology

2024 Volume 133, Issue 6, Page(s) 566–574

Abstract: Objective: Tongue-tie, which is also known as ankyloglossia, is a common condition where the lingual frenulum is unusually tight or short. While most literature investigates the impact of tongue-tie on breastfeeding, recent articles have examined its ... ...

Abstract	Objective: Tongue-tie, which is also known as ankyloglossia, is a common condition where the lingual frenulum is unusually tight or short. While most literature investigates the impact of tongue-tie on breastfeeding, recent articles have examined its role in speech production in children. However, these have not previously been reviewed systematically. This study aims to determine the impact of tongue-tie on speech outcomes and assess whether frenectomy can improve speech function. Methods: In this systematic review, we conducted a comprehensive search of PubMed/MEDLINE, Cochrane Library, Embase, and speechBITE to analyze primary studies investigating the impact of frenectomy for tongue-tie on speech outcomes. We extracted data regarding patient age, male to female ratio, procedure type, follow-up time, and speech outcomes and ran statistical analyses to determine if frenectomy for tongue-tie leads to improvement in speech issues in pediatric patients. Speech outcomes extracted were subjectively measured based on the interpretation of a speech and language pathologist or parent. Results: Our analysis included 10 studies with an average patient age of 4.10 years, and average cohort size of 22.17 patients. Overall, frenectomy for tongue-tie was associated with an improvement in speech articulation (0.78; 95% CI: 0.64-0.87; Conclusion: Overall, we conclude that frenectomy is a suitable treatment to correct speech issues in select patients with tongue-tie if caught early in childhood. Despite the limited investigations around speech outcomes post-frenectomy, these results are informative to providers treating tongue-tie.
MeSH term(s)	Humans ; Ankyloglossia/surgery ; Lingual Frenum/surgery ; Speech Disorders/etiology ; Speech Disorders/physiopathology ; Treatment Outcome ; Child
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Meta-Analysis
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894241236234
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Article ; Online: Nitrogen- and Halogen-Free Multifunctional Polymer-Directed Fabrication of Aluminum-Rich Hierarchical MFI Zeolites

Yuan Hu / Chan Wang / Tiesen Li / Xiaojun Bao / Yuanyuan Yue

Nanomaterials, Vol 12, Iss 1633, p

2022 Volume 1633

Abstract: Aluminum-rich hierarchical MFI-type zeolites with high acidic-site density exhibit excellent activity and selectivity in bulky molecule-involved reactions. However, it is challenging to develop a facile and environmentally benign method for fabricating ... ...

Abstract	Aluminum-rich hierarchical MFI-type zeolites with high acidic-site density exhibit excellent activity and selectivity in bulky molecule-involved reactions. However, it is challenging to develop a facile and environmentally benign method for fabricating them. Herein, we employ a polymer that does not contain nitrogen and halogen elements to successfully synthesize aluminum-rich hierarchical ZSM-5 zeolite with a Si/Al ratio of 8 and a significant number of mesopores comprised of oriented-assembled nanocrystals. It is demonstrated that the nitrogen- and halogen-free polymer is instrumental in the formation of the ZSM-5 zeolite by serving as a template for constructing the hierarchical micro/mesoporous structure. Moreover, this polymer also acts as a crystal growth modifier to form a single-crystalline zeolite. Notably, the resultant zeolite shows a better catalytic performance in converting waste plastic into hydrocarbons than a commercial one. Our work enables the synthesis of high-quality hierarchical zeolites without requiring quaternary ammonium templates.
Keywords	hierarchical ZSM-5 zeolites ; aluminum-rich ; nitrogen- and halogen-free polymer ; waste plastics cracking ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of customer satisfaction on floral product purchase behavior, evidence from Shanghai, China

Shanshan Wang / Tinggui Chen / Chan Wang / Zengjin Liu / Lei Jia / Xintong Zhao

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract China's flower industry is developing rapidly, and the size of the retail market is increasing year by year. Studying the factors influencing residents' flower purchasing behavior and understanding their flower needs can help promote the ... ...

Abstract	Abstract China's flower industry is developing rapidly, and the size of the retail market is increasing year by year. Studying the factors influencing residents' flower purchasing behavior and understanding their flower needs can help promote the sustainable development of the flower industry. Based on customer satisfaction theory, this paper uses 838 consumer research questionnaires from 15 districts in Shanghai to analyze the influence of customer satisfaction on residents' flower purchasing behavior by conducting a binary logit model and to investigate the moderating effect of flower purchasing purpose on the influence of satisfaction. The results show that price satisfaction and satisfaction with promotional methods have a significant negative effect on flower purchasing behavior, service satisfaction has a significant positive effect on purchasing behavior, and different customer purchase purposes lead to different intensities of the effect of satisfaction on purchasing behavior. According to the conclusion of the study, three countermeasures are proposed: to popularize the knowledge of flower culture, guide the concept of flower consumption, and promote the transformation of flower consumption to daily consumption; to conduct regular research on consumers by flower merchants to clarify consumers' needs and improve their satisfaction; to clarify consumers' purchase intention, increase the investment in the research and development and cultivation of flower products, and improve the supply level of flowers.
Keywords	Medicine ; R ; Science ; Q
Subject code	650 ; 330
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Shanshan Wang / Tinggui Chen / Chan Wang / Zengjin Liu / Lei Jia / Xintong Zhao

Scientific Reports, Vol 13, Iss 1, Pp 1-

The effect of customer satisfaction on floral product purchase behavior, evidence from Shanghai, China

2023 Volume 1

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Success of Big Infectious Disease Reimbursement Policy in China

Kun-xi Nie / Chan Wang / Xin-wu Li

Inquiry: The Journal of Health Care Organization, Provision, and Financing, Vol

2020 Volume 57

Abstract: Big infectious diseases do harm to the whole society, and it is highly crucial to control them on time. The major purpose of this article is to theoretically demonstrate that the Chinese government’s intervention in large-scale infectious diseases is ... ...

Abstract	Big infectious diseases do harm to the whole society, and it is highly crucial to control them on time. The major purpose of this article is to theoretically demonstrate that the Chinese government’s intervention in large-scale infectious diseases is successful and efficient. Two potential strategies were considered: strategy 1 was infectious disease without government intervention, and strategy 2 was infectious disease with government intervention. By evolution model, this article illustrates the efficiency of big infectious disease reimbursement policy in China. Without government reimbursement, this article finds that high expenditures accelerate the disease infection. The number of infected persons decreases under big infectious disease reimbursement policy in China. The higher the treatment costs, the more important the government intervention. Big infectious disease reimbursement policy in China can serve as an efficient example to cope with big infectious diseases.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	950 ; 630
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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