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Article ; Online: Molecular assessment of proteins encoded by the mitochondrial genome of

Chand, Gyanendra Bahadur / Kumar, Sushant / Azad, Gajendra Kumar

2021 Volume 26, Page(s) 100985

Abstract: The population of catfish, ...

Abstract	The population of catfish,
Language	English
Publishing date	2021-03-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808 ; 2405-5808
ISSN (online)	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2021.100985
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure.

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

PeerJ

2020 Volume 8, Page(s) e9492

Abstract: The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate. These ... ...

Abstract	The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate. These mutations drive viral evolution and genome variability, thereby facilitating viruses to have rapid antigenic shifting to evade host immunity and to develop drug resistance. Viral RNA-dependent RNA polymerases (RdRp) perform viral genome duplication and RNA synthesis. Therefore, we compared the available RdRp sequences of SARS-CoV-2 from Indian isolates and the 'Wuhan wet sea food market virus' sequence to identify, if any, variation between them. Our data revealed the occurrence of seven mutations in Indian isolates of SARS-CoV-2. The secondary structure prediction analysis of these seven mutations shows that three of them cause alteration in the structure of RdRp. Furthermore, we did protein modelling studies to show that these mutations can potentially alter the stability of the RdRp protein. Therefore, we propose that RdRp mutations in Indian SARS-CoV-2 isolates might have functional consequences that can interfere with RdRp targeting pharmacological agents.
Keywords	covid19
Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.9492
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Article: Identification of twenty-five mutations in surface glycoprotein (Spike) of SARS-CoV-2 among Indian isolates and their impact on protein dynamics.

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

Gene reports

2020 Volume 21, Page(s) 100891

Abstract: SARS-CoV-2, the causative agent of the COVID-19 pandemic, is an RNA virus that has inherent high rate of mutation. Due to the mutations, the virus evolves at a rapid pace that helps them to survive better inside the host. One of the hotspots of ... ...

Abstract	SARS-CoV-2, the causative agent of the COVID-19 pandemic, is an RNA virus that has inherent high rate of mutation. Due to the mutations, the virus evolves at a rapid pace that helps them to survive better inside the host. One of the hotspots of pharmacological interventions is to inhibit binding of virus with the host cells, which is mediated by Spike glycoprotein of SARS-CoV-2 and ACE2 receptors present on the human cells. This study was conducted with an aim to identify and characterise the mutation (s) present in the Spike glycoprotein of the SARS-CoV-2. Towards this, an
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article
ISSN	2452-0144
ISSN	2452-0144
DOI	10.1016/j.genrep.2020.100891
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Article: Protective efficacy of

Kumar, Arun / Kumar, Vikas / Akhouri, Vivek / Kumar, Ranjit / Ali, Mohammad / Rashmi, Tuhin / Chand, Gyanendra Bahadur / Singh, Sushil Kumar / Ghosh, Ashok Kumar

Toxicological research

2022 Volume 38, Issue 4, Page(s) 437–447

Abstract: Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been ... ...

Abstract	Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic exposure through drinking water to humans leads to major public health related issues. There have been very meagre studies which reported that, the plant constituents proved to exhibit protective effect from arsenicosis. Therefore, the present study aims to evaluate the protective efficacy of
Language	English
Publishing date	2022-03-16
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2727978-9
ISSN	2234-2753 ; 1976-8257
ISSN (online)	2234-2753
ISSN	1976-8257
DOI	10.1007/s43188-022-00123-7
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Article ; Online: Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

PeerJ

2020 Volume 8, Page(s) e9492

Abstract	The rapid development of the SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for effective antivirals. SARS-CoV-2 is an RNA virus that has an inherently high mutation rate. These mutations drive viral evolution and genome variability, thereby facilitating viruses to have rapid antigenic shifting to evade host immunity and to develop drug resistance. Viral RNA-dependent RNA polymerases (RdRp) perform viral genome duplication and RNA synthesis. Therefore, we compared the available RdRp sequences of SARS-CoV-2 from Indian isolates and the ‘Wuhan wet sea food market virus’ sequence to identify, if any, variation between them. Our data revealed the occurrence of seven mutations in Indian isolates of SARS-CoV-2. The secondary structure prediction analysis of these seven mutations shows that three of them cause alteration in the structure of RdRp. Furthermore, we did protein modelling studies to show that these mutations can potentially alter the stability of the RdRp protein. Therefore, we propose that RdRp mutations in Indian SARS-CoV-2 isolates might have functional consequences that can interfere with RdRp targeting pharmacological agents.
Keywords	General Biochemistry, Genetics and Molecular Biology ; General Neuroscience ; General Agricultural and Biological Sciences ; General Medicine ; covid19
Language	English
Publisher	PeerJ
Publishing country	us
Document type	Article ; Online
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.9492
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Identification of twenty-five mutations in surface glycoprotein (Spike) of SARS-CoV-2 among Indian isolates and their impact on protein dynamics

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

Gene Reports

Abstract: SARS-CoV-2, the causative agent of the COVID-19 pandemic, is an RNA virus that has inherent high rate of mutation Due to the mutations, the virus evolves at a rapid pace that helps them to survive better inside the host One of the hotspots of ... ...

Abstract	SARS-CoV-2, the causative agent of the COVID-19 pandemic, is an RNA virus that has inherent high rate of mutation Due to the mutations, the virus evolves at a rapid pace that helps them to survive better inside the host One of the hotspots of pharmacological interventions is to inhibit binding of virus with the host cells, which is mediated by Spike glycoprotein of SARS-CoV-2 and ACE2 receptors present on the human cells This study was conducted with an aim to identify and characterise the mutation (s) present in the Spike glycoprotein of the SARS-CoV-2 Towards this, an in silico methodology was used, and the mutations on Spike glycoprotein were identified by comparing the Spike glycoprotein of first reported sequence from Wuhan wet seafood market virus with the available sequences of SARS-CoV-2 from Indian isolates Our analysis revealed the presence of twenty-five mutations in Spike glycoprotein among Indian SARS-CoV-2 isolates These mutations spread all over the protein and can be clustered at least into four distinct positions Further, mutations at eleven positions exhibited alterations in the secondary structure of the polypeptide chain We also investigated the influence of these mutations on overall protein dynamics and have shown that they affect the dynamic stability of the Spike glycoprotein
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #799069
Database	COVID19

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Article ; Online: Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

bioRxiv

Abstract: The rapid development of SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for the effective antivirals. SARS-CoV-2 is an RNA virus that has an inherent high mutation rate. These ... ...

Abstract	The rapid development of SARS-CoV-2 mediated COVID-19 pandemic has been the cause of significant health concern, highlighting the immediate need for the effective antivirals. SARS-CoV-2 is an RNA virus that has an inherent high mutation rate. These mutations drive viral evolution and genome variability, thereby, facilitating viruses to have rapid antigenic shifting to evade host immunity and to develop drug resistance. Viral RNA-dependent RNA polymerases (RdRp) perform viral genome duplication and RNA synthesis. Therefore, we compared the available RdRp sequences of SARS-CoV-2 from Indian isolates and ‘Wuhan wet sea food market virus’ sequence to identify, if any, variation between them. We report seven mutations observed in Indian SARS-CoV-2 isolates and three unique mutations that showed changes in the secondary structure of the RdRp protein at region of mutation. We also studied molecular dynamics using normal mode analyses and found that these mutations alter the stability of RdRp protein. Therefore, we propose that RdRp mutations in Indian SARS-CoV-2 isolates might have functional consequences that can interfere with RdRp targeting pharmacological agents.
Keywords	covid19
Publisher	BioRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.05.05.079939
Database	COVID19

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Article ; Online: Identification of twenty-five mutations in surface glycoprotein (Spike) of SARS-CoV-2 among Indian isolates and their impact on protein dynamics

Chand, Gyanendra Bahadur / Banerjee, Atanu / Azad, Gajendra Kumar

Gene Reports

2020 Volume 21, Page(s) 100891

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2452-0144
DOI	10.1016/j.genrep.2020.100891
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach.

Kumar, Arun / Kumar, Rishav / Rahman, Md Samiur / Ali, Mohammad / Kumar, Ranjit / Nupur, Neha / Gaurav, Aman / Raj, Vikram / Anand, Gautam / Niraj, Pintoo Kumar / Kumar, Nirmal / Srivastava, Abhinav / Biswapriya, Akhouri / Chand, Gyanendra Bahadur / Kumar, Dhruv / Rashmi, Tuhin / Kumar, Santosh / Sakamoto, Maiko / Ghosh, Ashok Kumar

Environmental science and pollution research international

2021 Volume 28, Issue 32, Page(s) 43923–43934

Abstract: Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial ... ...

Abstract	Arsenic poisoning through groundwater is the world's greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar, out of 38 districts, 18 districts are exceptionally influenced with groundwater arsenic defilement. In the present study, we have assessed the current situation of arsenic exposure in Sabalpur village of Saran district of Bihar after reporting of breast, renal, skin and thyroid cancer cases from this village along with typical symptoms of arsenicosis. Such cancer patients were identified at our institute and were taken for the study. The present investigation deals with the quantification of arsenic in groundwater, hair and nail samples of subjects as well as the survey of entire village to know the overall health status of the village people. A total of n=128 household handpump water samples as well as n=128 human hair and nail samples were collected from over n=520 households. Using the graphite furnace atomic absorption spectrophotometer (GF-AAS), all the samples were analysed. The investigation resulted that the 61% of the analysed samples particularly the groundwater had the arsenic levels more than the permissible limit of WHO (> 10 μg/L) with 244.20 μg/L as the highest arsenic contamination in one of the handpump water sample. The exposure effect of hair sample was worst as 88% of all the collected samples were having high arsenic levels more than the permissible limit (> 0.2 mg/Kg). In case of nail samples, 92% of the samples were having high arsenic concentration more than the permissible limit (> 0.5 mg/Kg). The health survey study revealed high magnitude of disease burden in the exposed population with symptoms such as asthma, anaemia, hepatomegaly, diabetes, cardiac problem, skin fungal infections, breathlessness and mental disability. Few cancer cases of renal, skin, breast and cervix were also found among the exposed population of this village. The percentage of cancer cases in this village was 0.94% that was low, but it would be an aggravated situation in the near future if people will continue drinking arsenic-contaminated water. Therefore, a mitigation intervention was carried out in March 2020 by installing an arsenic filter plant. The health situation in the village in the present scenario is hope to improve in the coming years. However, motivation and awareness among the village population are still required.
MeSH term(s)	Arsenic/analysis ; Arsenic Poisoning/epidemiology ; Female ; Groundwater ; Humans ; India/epidemiology ; Polyvinyls ; Water Pollutants, Chemical/analysis ; Water Supply
Chemical Substances	Polyvinyls ; Water Pollutants, Chemical ; Saran (9011-06-7) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2021-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-13521-5
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Article: Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach

Kumar, Arun / Kumar, Rishav / Rahman, Md. Samiur / Ali, Mohammad / Kumar, Ranjit / Nupur, Neha / Gaurav, Aman / Raj, Vikram / Anand, Gautam / Niraj, Pintoo Kumar / Kumar, Nirmal / Srivastava, Abhinav / Biswapriya, Akhouri / Chand, Gyanendra Bahadur / Kumar, Dhruv / Rashmi, Tuhin / Kumar, Santosh / Sakamoto, Maiko / Ghosh, Ashok Kumar

Environmental science and pollution research. 2021 Aug., v. 28, no. 32

2021

Abstract: Arsenic poisoning through groundwater is the world’s greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial ... ...

Abstract	Arsenic poisoning through groundwater is the world’s greatest normal groundwater catastrophe which got an immense effect on worldwide general wellbeing. India is confronting the outcomes of arsenic poisoning in the zone of Ganga Brahmaputra alluvial plains. In Bihar, out of 38 districts, 18 districts are exceptionally influenced with groundwater arsenic defilement. In the present study, we have assessed the current situation of arsenic exposure in Sabalpur village of Saran district of Bihar after reporting of breast, renal, skin and thyroid cancer cases from this village along with typical symptoms of arsenicosis. Such cancer patients were identified at our institute and were taken for the study. The present investigation deals with the quantification of arsenic in groundwater, hair and nail samples of subjects as well as the survey of entire village to know the overall health status of the village people. A total of n=128 household handpump water samples as well as n=128 human hair and nail samples were collected from over n=520 households. Using the graphite furnace atomic absorption spectrophotometer (GF-AAS), all the samples were analysed. The investigation resulted that the 61% of the analysed samples particularly the groundwater had the arsenic levels more than the permissible limit of WHO (> 10 μg/L) with 244.20 μg/L as the highest arsenic contamination in one of the handpump water sample. The exposure effect of hair sample was worst as 88% of all the collected samples were having high arsenic levels more than the permissible limit (> 0.2 mg/Kg). In case of nail samples, 92% of the samples were having high arsenic concentration more than the permissible limit (> 0.5 mg/Kg). The health survey study revealed high magnitude of disease burden in the exposed population with symptoms such as asthma, anaemia, hepatomegaly, diabetes, cardiac problem, skin fungal infections, breathlessness and mental disability. Few cancer cases of renal, skin, breast and cervix were also found among the exposed population of this village. The percentage of cancer cases in this village was 0.94% that was low, but it would be an aggravated situation in the near future if people will continue drinking arsenic-contaminated water. Therefore, a mitigation intervention was carried out in March 2020 by installing an arsenic filter plant. The health situation in the village in the present scenario is hope to improve in the coming years. However, motivation and awareness among the village population are still required.
Keywords	anemia ; arsenic ; asthma ; at-risk population ; atomic absorption spectrometry ; breasts ; burden of disease ; cervix ; diabetes ; fungi ; groundwater ; hairs ; health status ; health surveys ; motivation ; people ; pollution ; research ; thyroid neoplasms ; villages ; India
Language	English
Dates of publication	2021-08
Size	p. 43923-43934.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-13521-5
Database	NAL-Catalogue (AGRICOLA)

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