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  1. Article ; Online: Disparities in Overdose Deaths: Looking Back at Larochelle and Colleagues' 2021 Paper.

    Volkow, Nora D / Han, Beth / Chandler, Redonna K

    American journal of public health

    2024  Volume 114, Issue 6, Page(s) 553–555

    MeSH term(s) Humans ; Drug Overdose/mortality ; United States/epidemiology ; Health Status Disparities
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Editorial ; Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2024.307659
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  2. Article ; Online: Need for comprehensive and timely data to address the opioid overdose epidemic without a blindfold.

    Volkow, Nora D / Chandler, Redonna K / Villani, Jennifer

    Addiction (Abingdon, England)

    2022  Volume 117, Issue 8, Page(s) 2132–2134

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Drug Overdose/drug therapy ; Drug Overdose/epidemiology ; Humans ; Naloxone/therapeutic use ; Opiate Overdose ; Opioid-Related Disorders/epidemiology
    Chemical Substances Analgesics, Opioid ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Editorial
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.15957
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  3. Article ; Online: Telemedicine Buprenorphine Initiation and Retention in Opioid Use Disorder Treatment for Medicaid Enrollees.

    Hammerslag, Lindsey R / Mack, Aimee / Chandler, Redonna K / Fanucchi, Laura C / Feaster, Daniel J / LaRochelle, Marc R / Lofwall, Michelle R / Nau, Michael / Villani, Jennifer / Walsh, Sharon L / Westgate, Philip M / Slavova, Svetla / Talbert, Jeffery C

    JAMA network open

    2023  Volume 6, Issue 10, Page(s) e2336914

    Abstract: Importance: Early COVID-19 mitigation strategies placed an additional burden on individuals seeking care for opioid use disorder (OUD). Telemedicine provided a way to initiate and maintain transmucosal buprenorphine treatment of OUD.: Objective: To ... ...

    Abstract Importance: Early COVID-19 mitigation strategies placed an additional burden on individuals seeking care for opioid use disorder (OUD). Telemedicine provided a way to initiate and maintain transmucosal buprenorphine treatment of OUD.
    Objective: To examine associations between transmucosal buprenorphine OUD treatment modality (telemedicine vs traditional) during the COVID-19 public health emergency and the health outcomes of treatment retention and opioid-related nonfatal overdose.
    Design, setting, and participants: This retrospective cohort study was conducted using Medicaid claims and enrollment data from November 1, 2019, to December 31, 2020, for individuals aged 18 to 64 years from Kentucky and Ohio. Data were collected and analyzed in June 2022, with data updated during revision in August 2023.
    Exposures: The primary exposure of interest was the modality of the transmucosal buprenorphine OUD treatment initiation. Relevant patient demographic and comorbidity characteristics were included in regression models.
    Main outcomes and measures: There were 2 main outcomes of interest: retention in treatment after initiation and opioid-related nonfatal overdose after initiation. For outcomes measured after initiation, a 90-day follow-up period was used. The main analysis used a new-user study design; transmucosal buprenorphine OUD treatment initiation was defined as initiation after more than a 60-day gap in buprenorphine treatment. In addition, uptake of telemedicine for buprenorphine was examined, overall and within patients initiating treatment, across quarters in 2020.
    Results: This study included 41 266 individuals in Kentucky (21 269 women [51.5%]; mean [SD] age, 37.9 [9.0] years) and 50 648 individuals in Ohio (26 425 women [52.2%]; mean [SD] age, 37.1 [9.3] years) who received buprenorphine in 2020, with 18 250 and 24 741 people initiating buprenorphine in Kentucky and Ohio, respectively. Telemedicine buprenorphine initiations increased sharply at the beginning of 2020. Compared with nontelemedicine initiation, telemedicine initiation was associated with better odds of 90-day retention with buprenorphine in both states (Kentucky: adjusted odds ratio, 1.13 [95% CI, 1.01-1.27]; Ohio: adjusted odds ratio, 1.19 [95% CI, 1.06-1.32]) in a regression analysis adjusting for patient demographic and comorbidity characteristics. Telemedicine initiation was not associated with opioid-related nonfatal overdose (Kentucky: adjusted odds ratio, 0.89 [95% CI, 0.56-1.40]; Ohio: adjusted odds ratio, 1.08 [95% CI, 0.83-1.41]).
    Conclusions and relevance: In this cohort study of Medicaid enrollees receiving buprenorphine for OUD, telemedicine buprenorphine initiation was associated with retention in treatment early during the COVID-19 pandemic. These findings add to the literature demonstrating positive outcomes associated with the use of telemedicine for treatment of OUD.
    MeSH term(s) United States/epidemiology ; Humans ; Female ; Adult ; Buprenorphine/therapeutic use ; Analgesics, Opioid/therapeutic use ; Medicaid ; Opiate Substitution Treatment ; Cohort Studies ; Retrospective Studies ; Pandemics ; COVID-19/complications ; Opioid-Related Disorders/epidemiology ; Telemedicine ; Opiate Overdose
    Chemical Substances Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.36914
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  4. Article ; Online: Addressing opioid overdose deaths: The vision for the HEALing communities study.

    Chandler, Redonna K / Villani, Jennifer / Clarke, Thomas / McCance-Katz, Elinore F / Volkow, Nora D

    Drug and alcohol dependence

    2020  Volume 217, Page(s) 108329

    Abstract: The United States is facing two devastating public health crises- the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the ... ...

    Abstract The United States is facing two devastating public health crises- the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the HEALing Communities Study (HCS) was developed by the National Institutes of Health (NIH) and the Substance Abuse and Mental Health Services Administration (SAMHSA) as part of the Helping to End Addiction Long-termSM Initiative (National Institutes of Health, 2020). The goal for this research was to reduce opioid overdose deaths by 40 % in three years by enhancing and integrating the delivery of multiple evidence-based practices (EBPs) with proven effectiveness in reducing opioid overdose deaths across health care, justice, and community settings. This paper describes the initial vision, goals, and objectives of this initiative; the impact of COVID-19; and the potential for knowledge to be generated from HCS at the intersection of an unrelenting epidemic of opioid misuse and overdoses and the ravishing COVID-19 pandemic.
    MeSH term(s) Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; COVID-19/epidemiology ; COVID-19/prevention & control ; Evidence-Based Practice/methods ; Evidence-Based Practice/trends ; Humans ; Opiate Overdose/diagnosis ; Opiate Overdose/mortality ; Opiate Overdose/prevention & control ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/mortality ; Pandemics ; Public Health/methods ; Public Health/trends ; United States/epidemiology ; United States Substance Abuse and Mental Health Services Administration/trends
    Chemical Substances Analgesics, Opioid
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2020.108329
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  5. Article ; Online: Implementing Effective Substance Abuse Treatments in General Medical Settings: Mapping the Research Terrain.

    Ducharme, Lori J / Chandler, Redonna K / Harris, Alex H S

    Journal of substance abuse treatment

    2015  Volume 60, Page(s) 110–118

    Abstract: The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Drug Abuse (NIDA), and Veterans Health Administration (VHA) share an interest in promoting high quality, rigorous health services research to improve the availability ... ...

    Abstract The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Drug Abuse (NIDA), and Veterans Health Administration (VHA) share an interest in promoting high quality, rigorous health services research to improve the availability and utilization of evidence-based treatment for substance use disorders (SUD). Recent and continuing changes in the healthcare policy and funding environments prioritize the integration of evidence-based substance abuse treatments into primary care and general medical settings. This area is a prime candidate for implementation research. Recent and ongoing implementation projects funded by these agencies are reviewed. Research in five areas is highlighted: screening and brief intervention for risky drinking; screening and brief intervention for tobacco use; uptake of FDA-approved addiction pharmacotherapies; safe opioid prescribing; and disease management. Gaps in the portfolios, and priorities for future research, are described.
    MeSH term(s) Delivery of Health Care, Integrated/standards ; Evidence-Based Practice/standards ; Health Services Research/standards ; Humans ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2015-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605923-5
    ISSN 1873-6483 ; 0740-5472
    ISSN (online) 1873-6483
    ISSN 0740-5472
    DOI 10.1016/j.jsat.2015.06.020
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  6. Article: Addressing opioid overdose deaths: The vision for the HEALing communities study

    Chandler, Redonna K / Villani, Jennifer / Clarke, Thomas / McCance-Katz, Elinore F / Volkow, Nora D

    Drug Alcohol Depend

    Abstract: The United States is facing two devastating public health crises- the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the ... ...

    Abstract The United States is facing two devastating public health crises- the opioid epidemic and the COVID-19 pandemic. Within this context, one of the most ambitious implementation studies in addiction research is moving forward. Launched in May 2019, the HEALing Communities Study (HCS) was developed by the National Institutes of Health (NIH) and the Substance Abuse and Mental Health Services Administration (SAMHSA) as part of the Helping to End Addiction Long-termSM Initiative (National Institutes of Health, 2020). The goal for this research was to reduce opioid overdose deaths by 40 % in three years by enhancing and integrating the delivery of multiple evidence-based practices (EBPs) with proven effectiveness in reducing opioid overdose deaths across health care, justice, and community settings. This paper describes the initial vision, goals, and objectives of this initiative; the impact of COVID-19; and the potential for knowledge to be generated from HCS at the intersection of an unrelenting epidemic of opioid misuse and overdoses and the ravishing COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #806984
    Database COVID19

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  7. Article: Implementing drug abuse treatment services in criminal justice settings: Introduction to the CJ-DATS study protocol series.

    Ducharme, Lori J / Chandler, Redonna K / Wiley, Tisha R A

    Health & justice

    2014  Volume 1, Issue 1, Page(s) 5

    Abstract: Background: Despite a growing pipeline of effective clinical treatments, there remains a persistent research-to-practice gap in drug abuse services. Delivery of effective treatment services is especially lacking in the U.S. criminal justice system, ... ...

    Abstract Background: Despite a growing pipeline of effective clinical treatments, there remains a persistent research-to-practice gap in drug abuse services. Delivery of effective treatment services is especially lacking in the U.S. criminal justice system, where half of all incarcerated persons meet the need for drug abuse or dependence, yet few receive needed care. Structural, financial, philosophical and other barriers slow the pace of adoption of available evidence-based practices. These challenges led to the development of a multi-site cooperative research endeavor known as the Criminal Justice Drug Abuse Treatment Studies (CJ-DATS), funded by the National Institute on Drug Abuse (NIDA). CJ-DATS engages university-based research teams, criminal justice agencies, and community-based treatment providers in implementation research studies to test strategies for enhancing treatment service delivery to offender populations.
    Methods: This Introduction reviews the mission of NIDA, the structure and goals of the CJ-DATS cooperative, and the implementation studies being conducted by the participating organizations. The component Study Protocols in this article collection are then described.
    Discussion: CJ-DATS applies implementation science perspectives and methods to address a vexing problem - the need to link offender populations with effective treatment for drug abuse, HIV, and other related conditions for which they are at high risk. Applying these principles to the U.S. criminal justice system is an innovative extension of lessons that have been learned in mainstream healthcare settings. This collection is offered as both an introduction to NIDA's work in this area, as well as a window onto the challenges of conducting health services research in settings in which improving public health is not the organization's core mission.
    Language English
    Publishing date 2014-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740401-8
    ISSN 2194-7899
    ISSN 2194-7899
    DOI 10.1186/2194-7899-1-5
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  8. Article ; Online: Modifications to the HEALing Communities Study in response to COVID-19 related disruptions.

    Walters, Scott T / Chandler, Redonna K / Clarke, Thomas / El-Bassel, Nabila / Glasgow, Lashawn M / Jackson, Rebecca D / Oga, Emmanuel A / Samet, Jeffrey H / Walsh, Sharon L / Zarkin, Gary A

    Drug and alcohol dependence

    2021  Volume 222, Page(s) 108669

    Language English
    Publishing date 2021-03-13
    Publishing country Ireland
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 519918-9
    ISSN 1879-0046 ; 0376-8716
    ISSN (online) 1879-0046
    ISSN 0376-8716
    DOI 10.1016/j.drugalcdep.2021.108669
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  9. Article ; Online: Needed: Longitudinal Research That Can Inform Dynamic Models for the Treatment of Addiction as a Disease.

    Hilton, Thomas F / Chandler, Redonna K / Compton, Wilson M

    Evaluation review

    2012  Volume 32, Issue 1, Page(s) 3–6

    Language English
    Publishing date 2012-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1500138-6
    ISSN 1552-3926 ; 0193-841X ; 0145-4692
    ISSN (online) 1552-3926
    ISSN 0193-841X ; 0145-4692
    DOI 10.1177/0193841X07309581
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  10. Article ; Online: Treating drug abuse and addiction in the criminal justice system: improving public health and safety.

    Chandler, Redonna K / Fletcher, Bennett W / Volkow, Nora D

    JAMA

    2009  Volume 301, Issue 2, Page(s) 183–190

    Abstract: Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities ...

    Abstract Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities that reflect, in part, disrupted behavior ensuing from brain changes triggered by repeated drug use. Treating drug-involved offenders provides a unique opportunity to decrease substance abuse and reduce associated criminal behavior. Emerging neuroscience has the potential to transform traditional sanction-oriented public safety approaches by providing new therapeutic strategies against addiction that could be used in the criminal justice system. We summarize relevant neuroscientific findings and evidence-based principles of addiction treatment that, if implemented in the criminal justice system, could help improve public heath and reduce criminal behavior.
    MeSH term(s) Brain/physiology ; Crime ; Health Services Accessibility ; Humans ; Mental Health Services ; Prisons/statistics & numerical data ; Public Health ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy ; United States/epidemiology
    Language English
    Publishing date 2009-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2008.976
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