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  1. Article: A short term comparative evaluation of the efficacy of diode laser with desensitizing toothpastes and mouthwashes in the treatment of dentinal hypersensitivity.

    Acharya, Anirudh B / Chandrashekar, Apoorva / Thakur, Srinath

    Journal of clinical and experimental dentistry

    2022  Volume 14, Issue 3, Page(s) e229–e234

    Abstract: Background: Treatment of dentinal hypersensitivity (DH) has always been challenging with a wide variety of therapeutic options, in-office and home care. The study objective was to compare the clinical efficacy of diode laser [DL] with four commercially ... ...

    Abstract Background: Treatment of dentinal hypersensitivity (DH) has always been challenging with a wide variety of therapeutic options, in-office and home care. The study objective was to compare the clinical efficacy of diode laser [DL] with four commercially available desensitizing agents (two toothpastes and two mouthwashes) in the treatment of DH.
    Material and methods: This study involved 75 participants (25-45 years) who were categorized as Group 1 (n=15) treated with DL, and Groups 2, 3,4 and 5 (n=15 in each) who were prescribed 3% potassium nitrate mouth rinse, a herbal mouth rinse, potassium nitrate tooth paste and a herbal tooth paste, respectively. DH was assessed by air blast stimulation using air blast syringe, and evaluation of DH was done based on the patient's subjective response using the Visual Analog Scale (VAS) at baseline, 1 week and 1 month.
    Results: DL and the desensitizing agents showed significant reduction in DH at 1 month when compared with baseline, except potassium nitrate mouth wash. However, DL showed more percentage reduction in DH when compared with potassium nitrate tooth paste, herbal mouth wash and paste.
    Conclusions: The study implies that even though all five groups showed improvement in terms of DH reduction, DL showed the best results among all the groups.
    Language English
    Publishing date 2022-03-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.59063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serum sTWEAK levels in chronic periodontitis and type 2 diabetes mellitus.

    Acharya, Anirudh B / Chandrashekar, Apoorva / Acharya, Swetha / Shettar, Leena / Thakur, Srinath

    Diabetes & metabolic syndrome

    2019  Volume 13, Issue 2, Page(s) 1609–1613

    Abstract: Aim: The two-way relationship between diabetes mellitus and periodontitis has been extensively studied with various interconnected biomarkers sharing a link. Soluble Tumour Necrosis Factor-like Weak inducer of apoptosis (sTWEAK) is gaining attention as ... ...

    Abstract Aim: The two-way relationship between diabetes mellitus and periodontitis has been extensively studied with various interconnected biomarkers sharing a link. Soluble Tumour Necrosis Factor-like Weak inducer of apoptosis (sTWEAK) is gaining attention as an important mediator in chronic inflammatory diseases. Thus, the aim of this study was to detect, estimate and compare the levels of sTWEAK in the serum of health, chronic periodontitis (CP), and CP with type 2 diabetes mellitus (T2DM).
    Materials and methods: Forty-five participants between 18 and 65 years were divided into groups of 15 each as Group 1: healthy, Group 2: CP, and Group 3: CP + T2DM. Clinical periodontal parameters and glycemic status were assessed. sTWEAK in serum was estimated using a commercially available ELISA kit. The data was statistically analyzed.
    Results: sTWEAK was detected in all participants. Significant differences were observed between the groups for sTWEAK; highest in health, lower in CP and lowest in CP + T2DM. In the diseased groups, the clinical and glycemic parameters correlated positively with each other, whereas sTWEAK correlated negatively with each of the parameters.
    Conclusion: The literature reports lower concentrations of systemic sTWEAK in T2DM which may be comparable to our observations in CP + T2DM when compared to health and its negative correlation with all the parameters suggesting an association with both clinical periodontal parameters and glycemic levels. However, serum sTWEAK levels may not be necessarily elevated in periodontitis as previously reported, and hence has the potential to be studied extensively for clarification with its association with T2DM.
    MeSH term(s) Adult ; Biomarkers/blood ; Case-Control Studies ; Chronic Periodontitis/blood ; Chronic Periodontitis/diagnosis ; Cytokine TWEAK/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis
    Chemical Substances Biomarkers ; Cytokine TWEAK ; TNFSF12 protein, human
    Language English
    Publishing date 2019-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2019.03.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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