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  1. Article ; Online: Commentary: Anatomic resection after neoadjuvant TKI therapy-To be forewarned.

    Chang, Andrew C

    JTCVS techniques

    2021  Volume 7, Page(s) 298

    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.02.047
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  2. Article ; Online: ASO Perspectives: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer: Never Stop Questioning.

    Schneider, Bryan J / Chang, Andrew C

    Annals of surgical oncology

    2022  Volume 29, Issue 5, Page(s) 2735–2738

    Abstract: This ASO perspective reviews the findings of a randomized placebo-controlled, clinical trial evaluating adjuvant nivolumab in esophageal or gastroesophageal junction carcinoma, reported recently by the Checkmate 577 investigators. The use of ... ...

    Abstract This ASO perspective reviews the findings of a randomized placebo-controlled, clinical trial evaluating adjuvant nivolumab in esophageal or gastroesophageal junction carcinoma, reported recently by the Checkmate 577 investigators. The use of postoperative immunotherapy represents a significant paradigm shift for managing patients who have had limited evidence-based treatment options after completing neoadjuvant chemoradiation followed by resection for these aggressive malignancies.
    MeSH term(s) Humans ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/pathology ; Neoadjuvant Therapy ; Nivolumab/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Randomized Controlled Trials as Topic
    Chemical Substances Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-02-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11276-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Author's response to invited commentary "a perspective on the Society of Thoracic Surgeons Composite Score for evaluating esophagectomy for esophageal cancer".

    Chang, Andrew C

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 9, Page(s) S1129–S1130

    Language English
    Publishing date 2018-05-30
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.03.96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Centralizing Esophagectomy to Improve Outcomes and Enhance Clinical Research: Invited Expert Review.

    Chang, Andrew C

    The Annals of thoracic surgery

    2018  Volume 106, Issue 3, Page(s) 916–923

    Abstract: Since the 1970s, studies have demonstrated a strong association between operative volume and outcomes such as death and complications, particularly for complex cancer resections such as esophagectomy. The denouement has been to suggest that this ... ...

    Abstract Since the 1970s, studies have demonstrated a strong association between operative volume and outcomes such as death and complications, particularly for complex cancer resections such as esophagectomy. The denouement has been to suggest that this operation should be directed toward specialized centers of esophageal cancer care, with operative volume thresholds being the primary basis for evidence-based hospital referral. This article reviews early efforts to centralize esophagectomy, as reported from other countries such as England, Canada, and the Netherlands, as well as the potential effect on access to care from instituting such policies in the United States.
    MeSH term(s) Canada ; Cancer Care Facilities/organization & administration ; Centralized Hospital Services/organization & administration ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagectomy/mortality ; Hospitals, High-Volume ; Humans ; Netherlands ; Organizational Innovation ; Outcome Assessment (Health Care) ; Quality Improvement ; Regional Health Planning/organization & administration ; Survival Analysis ; Treatment Outcome ; United Kingdom ; United States
    Language English
    Publishing date 2018-05-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2018.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 252: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Invited Commentary.

    Weir, William / Chang, Andrew C

    Journal of the American College of Surgeons

    2021  Volume 232, Issue 4, Page(s) 605–606

    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.12.032
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    Uk I Zs.61: Show issues Location:
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  6. Article ; Online: The Landmark Series: Multimodal Therapy for Esophageal Cancer.

    Demarest, Caitlin T / Chang, Andrew C

    Annals of surgical oncology

    2021  Volume 28, Issue 6, Page(s) 3375–3382

    Abstract: Introduction: Esophagectomy is the mainstay of treatment for patients with resectable esophageal cancer, and chemotherapy and chemoradiation have become essential adjuncts to improve survival. Controversy remains regarding the optimal perioperative ... ...

    Abstract Introduction: Esophagectomy is the mainstay of treatment for patients with resectable esophageal cancer, and chemotherapy and chemoradiation have become essential adjuncts to improve survival. Controversy remains regarding the optimal perioperative therapy.
    Methods: This review focuses on three landmark, randomized, controlled trials that have greatly influenced esophageal cancer management and established chemotherapy and chemoradiotherapy as standard of care: Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial (MAGIC); The United Kingdom Medical Research Council Esophageal Cancer Trial (OEO2); and Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS).
    Results: The findings from these landmark studies are reviewed and summarized.
    Conclusion: Chemotherapy regimens are heterogeneous but centered around platinum-based therapy and should be included in the management for all appropriate patients. Ongoing and future studies will further delineate the roles of various chemo- and chemoradiotherapy regimens and also will investigate the promising area of immunotherapy in the treatment of esophageal cancer.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Esophageal Neoplasms/therapy ; Esophagectomy ; Humans ; Neoadjuvant Therapy ; Randomized Controlled Trials as Topic ; United Kingdom
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09565-5
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    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in

    Yadav, Dilip Kumar / Chang, Andrew C / Grooms, Noa W F / Chung, Samuel H / Gabel, Christopher V

    eLife

    2024  Volume 13

    Abstract: Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown ...

    Abstract Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown that modulation of O-linked β-N-acetylglucosamine (O-GlcNAc) signaling, a ubiquitous post-translational modification that acts as a cellular nutrient sensor, can significantly enhance in vivo neuron regeneration. Here, we define the specific metabolic pathway by which O-GlcNAc transferase (
    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Signal Transduction ; Neurons/metabolism ; Protein Processing, Post-Translational ; Carbon/metabolism ; N-Acetylglucosaminyltransferases/genetics ; N-Acetylglucosaminyltransferases/metabolism ; Acetylglucosamine/metabolism
    Chemical Substances Carbon (7440-44-0) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-) ; Acetylglucosamine (V956696549)
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86478
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  8. Article: Rural Women Have a Prolonged Recovery Process after Esophagectomy.

    Schroeder, Julia / Lagisetty, Kiran / Lynch, William / Lin, Jules / Chang, Andrew C / Reddy, Rishindra M

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background: Gender and geographic access to care play a large role in health disparities in esophageal cancer care. The aim of our study was to evaluate disparities in peri-operative outcomes for patients undergoing esophagectomy based on gender and ... ...

    Abstract Background: Gender and geographic access to care play a large role in health disparities in esophageal cancer care. The aim of our study was to evaluate disparities in peri-operative outcomes for patients undergoing esophagectomy based on gender and geographic location.
    Methods: A retrospective cohort of prospectively collected data from patients who underwent esophagectomy from 2003 to 2022 was identified and analyzed based on gender and county, which were aggregated into existing state-level "metropolitan" versus "rural" designations. The demographics, pre-operative treatment, surgical complications, post-operative outcomes, and length of stay (LOS) of each group were analyzed using chi-squared, paired
    Results: Of the 1545 patients, men (83.6%) and women (16.4%) experienced similar rates of post-operative complications, but women experienced significantly longer hospital (
    Conclusions: Rural female patients undergoing esophagectomy were more likely to have a longer inpatient recovery process compared with their female metropolitan or male counterparts, suggesting a need for more targeted interventions in this population.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061078
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  9. Article ; Online: Surgical Citizenship: Engagement in Surgical Organizations.

    Patel, Himanshu J / Peters, Stefanie L / Hamilton, Barbara / Chang, Andrew C

    Thoracic surgery clinics

    2023  Volume 34, Issue 1, Page(s) 99–104

    Abstract: As leaders, cardiothoracic surgeons must learn about and undergo transitions during the stages of a successful career. The authors discuss the process of transitions and the roles of networks to support professional transitions. The role of engagement in ...

    Abstract As leaders, cardiothoracic surgeons must learn about and undergo transitions during the stages of a successful career. The authors discuss the process of transitions and the roles of networks to support professional transitions. The role of engagement in surgical organizations to create these networks and help support professional transitions is also explored. Finally, the authors describe how our engagement in surgical organizations can successfully impact our specialty of cardiothoracic surgery.
    MeSH term(s) Humans ; Citizenship ; Learning ; Surgeons
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2149218-9
    ISSN 1558-5069 ; 1547-4127
    ISSN (online) 1558-5069
    ISSN 1547-4127
    DOI 10.1016/j.thorsurg.2023.09.001
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    Se 1358: Show issues Location:
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  10. Article ; Online: Commentary: Up, down, right, left: Addressing the shortage of donor lungs for transplantation.

    Wakeam, Elliot / Chang, Andrew C

    JTCVS techniques

    2020  Volume 4, Page(s) 398

    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Editorial
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2020.08.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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