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  1. Article: A novel smart photoelectric lock system: Speech transmitted by laser and speech to text.

    Guo, Cheng-Yan / Hsieh, Tung-Li / Chang, Chia-Chi / Perng, Jau-Woei

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e14510

    Abstract: We propose a circuit that modulates a speech signal to a laser, using which the speech signal can be transmitted using the laser. Also, it shows the use of a platform based on embedded ARM (Advanced RISC Machine), running a small deep learning model ... ...

    Abstract We propose a circuit that modulates a speech signal to a laser, using which the speech signal can be transmitted using the laser. Also, it shows the use of a platform based on embedded ARM (Advanced RISC Machine), running a small deep learning model based on TDNN (Time delay neural network) and LSTM (Long short-term memory), and converting speech to text, and use the text cipher for unlocking. This research implements a smart lock system that can set a pre-record speech cipher and verify the similarity through a laser transmission speech cipher to unlock it. In our experiment result, the English speech of laser transmission can reach a WER (Word error rate) of 14.06% through the deep learning model to recognize the content of the speech cipher. We also design a similarity comparison algorithm based on LCS (Longest common subsequence) to compare the character set of the laser transmission speech compare and the prerecord speech cipher to calculate the similarity rate. Through the similarity comparison algorithm, when the WER is 27.27%, the male speech samples used in this study still have a 95% unlocking success rate, while the female speech samples have a 100% unlocking success rate. Compared with only using automatic speech recognition (ASR) to unlock, the method we propose is to compare the similarity of the content of speech cipher. The method significantly improves the unlocking fault tolerance of using lasers to transmit audio. Therefore, by using the laser to transmit the speech cipher, the usability of the photoelectric smart lock system has been significantly improved. At the same time, the characteristics of the laser are not easy to eavesdrop on the cipher, which can also improve security.
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A novel smart photoelectric lock system: Speech transmitted by laser and speech to text

    Guo, Cheng-Yan / Hsieh, Tung-Li / Chang, Chia-Chi / Perng, Jau-Woei

    Heliyon. 2023 Mar., v. 9, no. 3 p.e14510-

    2023  

    Abstract: We propose a circuit that modulates a speech signal to a laser, using which the speech signal can be transmitted using the laser. Also, it shows the use of a platform based on embedded ARM (Advanced RISC Machine), running a small deep learning model ... ...

    Abstract We propose a circuit that modulates a speech signal to a laser, using which the speech signal can be transmitted using the laser. Also, it shows the use of a platform based on embedded ARM (Advanced RISC Machine), running a small deep learning model based on TDNN (Time delay neural network) and LSTM (Long short-term memory), and converting speech to text, and use the text cipher for unlocking. This research implements a smart lock system that can set a pre-record speech cipher and verify the similarity through a laser transmission speech cipher to unlock it. In our experiment result, the English speech of laser transmission can reach a WER (Word error rate) of 14.06% through the deep learning model to recognize the content of the speech cipher. We also design a similarity comparison algorithm based on LCS (Longest common subsequence) to compare the character set of the laser transmission speech compare and the prerecord speech cipher to calculate the similarity rate. Through the similarity comparison algorithm, when the WER is 27.27%, the male speech samples used in this study still have a 95% unlocking success rate, while the female speech samples have a 100% unlocking success rate. Compared with only using automatic speech recognition (ASR) to unlock, the method we propose is to compare the similarity of the content of speech cipher. The method significantly improves the unlocking fault tolerance of using lasers to transmit audio. Therefore, by using the laser to transmit the speech cipher, the usability of the photoelectric smart lock system has been significantly improved. At the same time, the characteristics of the laser are not easy to eavesdrop on the cipher, which can also improve security.
    Keywords algorithms ; females ; males ; neural networks ; speech ; Photoelectric smart lock ; TDNN ; LSTM ; LCS ; Speech recognition
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14510
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Assessment of a Calibration-Free Method of Cuffless Blood Pressure Measurement: A Pilot Study.

    Guo, Cheng-Yan / Chang, Chia-Chi / Wang, Kuan-Jen / Hsieh, Tung-Li

    IEEE journal of translational engineering in health and medicine

    2022  Volume 11, Page(s) 318–329

    Abstract: This study proposes a low-cost, high-sensitivity sensor of beat-to-beat local pulse wave velocity (PWV), to be used in a cuffless blood pressure monitor (BPM).: Objective: We design an adaptive algorithm to detect the feature of the pulse wave, making ...

    Abstract This study proposes a low-cost, high-sensitivity sensor of beat-to-beat local pulse wave velocity (PWV), to be used in a cuffless blood pressure monitor (BPM).
    Objective: We design an adaptive algorithm to detect the feature of the pulse wave, making it possible for two sensors to measure the local PWV in the radial artery at a short distance. Unlike the cuffless BPM that needs to use a regression model for calibration.
    Method: We encapsulate the piezoelectric sensor material in a cavity and design an analog front-end circuit. This study used color ultrasound imaging equipment to measure radial arterial parameters, including the diameter and wall thickness, to aid the estimation of blood pressure (BP) using the Moens-Korteweg (MK) equation of hemodynamics.
    Results: We compared the blood pressure estimated by the MK equation with the reference BP measured using an aneroid sphygmomanometer in a test group of 32 people, resulting in a mean difference of systolic BP of -0.63 mmHg, and a standard deviation of ±5.14 mmHg, a mean difference of mean arterial pressure (MAP) of 0.97 mmHg, with a standard deviation of ±3.54 mmHg, and a mean difference of diastolic BP of -1.14 mmHg, with a standard deviation of ±4.08 mmHg. This study has verified its compliance with ISO 81060-2.
    Conclusions: A new type of wearable continuous calibration-free BPM can replace the situation that requires the use of traditional ambulatory BPM and reduce patient discomfort.
    Clinical impact: In this study can provide long-term continuous blood pressure monitoring in the hospital.
    MeSH term(s) Humans ; Blood Pressure/physiology ; Pilot Projects ; Calibration ; Pulse Wave Analysis ; Radial Artery
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2696555-0
    ISSN 2168-2372 ; 2168-2372
    ISSN (online) 2168-2372
    ISSN 2168-2372
    DOI 10.1109/JTEHM.2022.3209754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of microbiota in allogeneic hematopoietic stem cell transplantation.

    Chang, Chia-Chi / Hayase, Eiko / Jenq, Robert R

    Expert opinion on biological therapy

    2021  Volume 21, Issue 8, Page(s) 1121–1131

    Abstract: Introduction: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that ... ...

    Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that often occurs following allo-HSCT. Recently, improvements in methods to characterize the microbiota have led to a greater appreciation for how frequently and profoundly an alteration in microbial composition, or dysbiosis, can occur in allo-HSCT recipients to better decipher the complex interplay between microbiota and allo-HSCT outcomes.
    Areas covered: This article reviews the current knowledge of the microbiota's impact on allo-HSCT outcomes, including effects of microbiota-derived metabolites, and crosstalk between commensals and the allogeneic immune response. This article also summarizes the effects of HSCT and transplant-related procedures on microbiota, and recent developments in interventional strategies.
    Expert opinion: A growing body of literature indicates that the composition of the intestinal microbiota can function as a predictive biomarker for the risk and severity of acute GVHD, as well as overall survival, in patients undergoing allo-HSCT. Mechanisms underpinning these associations, however, are not well understood, and clinical strategies that modulate the microbiome to improve outcomes have yet to be fully developed. There is an unmet need to determine mechanisms to improve the efficacy of allo-HSCT.
    MeSH term(s) Dysbiosis ; Gastrointestinal Microbiome ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Microbiota
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2021.1872541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Podcasts, the pandemic, and a paradigm shift in medical careers.

    Chu, Cheng-Feng / Chang, Chia-Chi / Lin, Yu-Hsuan

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2021  Volume 121, Issue 1 Pt 1, Page(s) 1–2

    MeSH term(s) Educational Measurement ; Humans ; Pandemics
    Language English
    Publishing date 2021-08-24
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2021.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [A Postoperative Nursing Experience Applying Swanson`s Caring Theory in a Teenager With Pectus Excavatum].

    Lee, Pin-Chieh / Hsiao, Meng-Ping / Chang, Chia-Chi

    Hu li za zhi The journal of nursing

    2021  Volume 68, Issue 6, Page(s) 99–104

    Abstract: A nursing experience applying Swanson`s caring theory in the care of a teenage patient who received Nuss procedure for his pectus excavatum is described in this article. After the operation, the patient suffered from postoperative pain, lack of knowledge, ...

    Abstract A nursing experience applying Swanson`s caring theory in the care of a teenage patient who received Nuss procedure for his pectus excavatum is described in this article. After the operation, the patient suffered from postoperative pain, lack of knowledge, and body-image disturbance. These symptoms influenced the patient`s physical and mental health, and prompted the author to do an in-depth investigation and discussion of this case. The nursing period lasted from July 3rd to 10th, 2019. The author conducted a comprehensive nursing assessment using observation, interviews, listening, and telephone interviews. The major problems identified were acute pain, lack of knowledge, and body-image disturbance. During the nursing period, the author established a good therapeutic relationship with the patient. The author applied Swanson`s caring theory to understand the patient`s healthcare needs and provide appropriate care. The author discussed the treatment direction with the patient, applied cognitive-behavioral strategies to relieve pain, educated the patient on developing and implementing individualized rehabilitation plans to establish correct posture in daily activities, and helped the patient adapt to post-operative changes in appearance and maintain a positive attitude toward the future. The age gap between the author and the patient required that the author spend additional time communicating with the patient to encourage him to open up his mind. It is recommended that hospitals offer youth communication skills lessons for nurses to enhance their communication and care skills with people of different age groups. In sharing this nursing experience, we hope to provide medical staff with a reference for caring for adolescent patients with disease-related body-image disturbance.
    MeSH term(s) Adolescent ; Communication ; Funnel Chest/surgery ; Humans ; Male ; Nursing Theory
    Language Chinese
    Publishing date 2021-11-27
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ISSN 0047-262X
    ISSN 0047-262X
    DOI 10.6224/JN.202112_68(6).13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: High-density lipoprotein protects vascular endothelial cells from indoxyl sulfate insults through its antioxidant ability.

    Chen, Ching / Chang, Chia-Chi / Lee, I-Ta / Huang, Chun-Yao / Lin, Feng-Yen / Lin, Shing-Jong / Chen, Jaw-Wen / Chang, Ting-Ting

    Cell cycle (Georgetown, Tex.)

    2024  Volume 22, Issue 21-22, Page(s) 2409–2423

    Abstract: Chronic kidney disease (CKD) patients have a high risk of cardiovascular disease. Indoxyl sulfate (IS) is a uremic toxin that has been shown to inhibit nitric oxide production and cause cell senescence by inducing oxidative stress. High-density ... ...

    Abstract Chronic kidney disease (CKD) patients have a high risk of cardiovascular disease. Indoxyl sulfate (IS) is a uremic toxin that has been shown to inhibit nitric oxide production and cause cell senescence by inducing oxidative stress. High-density lipoprotein (HDL) has a protective effect on the cardiovascular system; however, its impacts on IS-damaged endothelial cells are still unknown. This study aimed to explore the effects of exogenous supplement of HDL on vascular endothelial cells in a uremia-mimic environment. Tube formation, migration, adhesion, and senescence assays were used to evaluate the cell function of human aortic endothelial cells (HAECs). Reactive oxygen species generation was measured by using Amplex red assay. L-NAME and MCI186 were used as a nitric oxide synthase inhibitor and a free radical scavenger, respectively. HDL exerted anti-inflammatory and antioxidant effects via HIF-1α/HO-1 activation and IL-1β/TNF-α/IL-6 inhibition in IS-stimulated HAECs. HDL improved angiogenesis ability through upregulating Akt/eNOS/VEGF/SDF-1 in IS-stimulated HAECs. HDL decreased endothelial adhesiveness via downregulating VCAM-1 and ICAM-1 in IS-stimulated HAECs. Furthermore, HDL reduced cellular senescence via upregulating SIRT1 and downregulating p53 in IS-stimulated HAECs. Importantly, the above beneficial effects of HDL were mainly due to its antioxidant ability. In conclusion, HDL exerted a comprehensive protective effect on vascular endothelial cells against damage from IS through its antioxidant ability. The results of this study might provide a theoretical basis for potential HDL supplementation in CKD patients with endothelial damage.
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Lipoproteins, HDL/pharmacology ; Lipoproteins, HDL/metabolism ; Indican/pharmacology ; Endothelial Cells/metabolism ; Renal Insufficiency, Chronic/metabolism
    Chemical Substances Antioxidants ; Lipoproteins, HDL ; Indican (N187WK1Y1J)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2023.2296184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protocol for efficient human MSC chondrogenesis via Wnt antagonism instead of TGF-β.

    Hsieh, Chen-Chan / Chang, Chia-Chi / Hsu, Pei-Ju / Chen, Linyi / Yen, B Linju

    STAR protocols

    2023  Volume 4, Issue 4, Page(s) 102728

    Abstract: To better implement mesenchymal stem cell (MSC)-based therapy toward cartilage diseases, a more efficient and less off-target chondrogenesis protocol is needed. Here, we present a protocol to induce human MSC chondrogenesis via Wnt antagonism. We ... ...

    Abstract To better implement mesenchymal stem cell (MSC)-based therapy toward cartilage diseases, a more efficient and less off-target chondrogenesis protocol is needed. Here, we present a protocol to induce human MSC chondrogenesis via Wnt antagonism. We describe steps for pellet formation, Wnt antagonism-based chondrogenic induction, and refreshing the differentiation medium. We detail procedures for characterizing MSC chondrogenesis. By using Wnt antagonism instead of conventional transforming growth factor β-based induction, this protocol avoids the potential for induction of chondrocyte hypertrophy/osteogenesis or other lineages. For complete details on the use and execution of this protocol, please refer to Hsieh et al. (2023).
    MeSH term(s) Humans ; Transforming Growth Factor beta/metabolism ; Chondrogenesis ; Cell Differentiation ; Immunologic Factors
    Chemical Substances Transforming Growth Factor beta ; Immunologic Factors
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Psychometrics and measurement invariance: Health Literacy Scale for Vietnamese and Indonesian married immigrants.

    Kuo, Shu-Fen / Yeh, Yueh-Chen / Chang, Chia-Chi / Lin, Yu-Fang / Wang, Shu-Yi

    Journal of advanced nursing

    2022  Volume 78, Issue 6, Page(s) 1836–1847

    Abstract: Aims: To examine the psychometrics and measurement invariance of the Short-Form Health Literacy 12-item questionnaire (HL-SF12) among Vietnamese and Indonesian married immigrants.: Design: A cross-sectional survey design.: Methods: In total, 1171 ... ...

    Abstract Aims: To examine the psychometrics and measurement invariance of the Short-Form Health Literacy 12-item questionnaire (HL-SF12) among Vietnamese and Indonesian married immigrants.
    Design: A cross-sectional survey design.
    Methods: In total, 1171 Vietnamese and Indonesian married immigrants were enrolled between September 2019 and December 2019. An exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to verify the structural validity of the suggested factor structure. The multiple-group CFA (MGCFA) used a series of hierarchical nested-in models as a measurement invariance test which confirmed the adequacy of the model fit at each stage.
    Results/findings: The Kaiser-Meyer-Olkin coefficient was 0.898, and the Bartlett test of sphericity was statistically significant (χ
    Conclusions: The HL-SF12 scale showed acceptable theoretically supported structural validity, equivalent measurement invariance and reliable internal consistency among Vietnamese and Indonesian married immigrants. Measurements of immigrants' HL using the HL-SF12 could be integrated into future immigrant health policies.
    Impact: As the first study of the measurement invariance of the HL-SF12 instrument among immigrants. Related factors of immigrants' HL can be further explored to increase immigrants' health and empowerment.
    MeSH term(s) Asians ; Cross-Sectional Studies ; Emigrants and Immigrants ; Factor Analysis, Statistical ; Health Literacy ; Humans ; Indonesia ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 197634-5
    ISSN 1365-2648 ; 0309-2402
    ISSN (online) 1365-2648
    ISSN 0309-2402
    DOI 10.1111/jan.15241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Synergistic Performance of Composite Supercapacitors between Carbon Nanohorn and Conducting Polymer

    Chang, Chia Chi / Toyoko Imae

    ACS sustainable chemistry & engineering. 2018 Feb. 15, v. 6, no. 4

    2018  

    Abstract: This paper described the electrochmical behavior of composites of carbon nanohorns (CNHs) with conducting polymers [polyaniline (PA) and polypyrrole (PP)]. The materials at different weight ratios (monomer:CNH = 1:0, 1:0.33, 1:1, 1:3, and 0:1) were ... ...

    Abstract This paper described the electrochmical behavior of composites of carbon nanohorns (CNHs) with conducting polymers [polyaniline (PA) and polypyrrole (PP)]. The materials at different weight ratios (monomer:CNH = 1:0, 1:0.33, 1:1, 1:3, and 0:1) were prepared by the in situ polymerization method. In the case of PA-series electrodes, the specific capacitance was a maximum (762 F/g at scan rate of 5 mV/s). Meanwhile, in the PP-series electrodes, the specific capacitance gradually decreased from 769 F/g at 5 mV/s for 1:0 (pyrrole:CNH) upon increasing the content of CNHs. However, the charge transfer resistance behaved completely contrary to the dependence of specific capacitance on the composite ratio. These electrochemical results revealed the strong synergistic effect between PA and CNHs of the PA-series composites, being facilitated by fast charge transfer, small internal resistance, and preferable mechanical properties and resulting in the improved capacitance performances. Furthermore, since the composites of both polymers at 1:3 (monomer:CNH) ratio showed an excellent capacitance retention, even after 5000 cycles, both polymers strengthened their cycling stability after the hybridization with CNHs.
    Keywords capacitance ; carbon ; electrochemistry ; electrodes ; mechanical properties ; polymerization ; polymers ; pyrroles ; synergism
    Language English
    Dates of publication 2018-0215
    Size p. 5162-5172.
    Publishing place American Chemical Society
    Document type Article
    ISSN 2168-0485
    DOI 10.1021/acssuschemeng.7b04813
    Database NAL-Catalogue (AGRICOLA)

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