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Article ; Online: The hemostatic effect and wound healing of novel collagen-containing polyester dressing.

Chang, Chih-Tsung

Journal of biomaterials science. Polymer edition

2023 Volume 34, Issue 15, Page(s) 2124–2143

Abstract: Collagen plays an important role in hemostasis and tissue repair processes. Traditional passive wound dressings like gauze, bandage, and cotton wool could hardly fit the open wounds and exerted no active effect on wound healing. Even worse, they would ... ...

Abstract	Collagen plays an important role in hemostasis and tissue repair processes. Traditional passive wound dressings like gauze, bandage, and cotton wool could hardly fit the open wounds and exerted no active effect on wound healing. Even worse, they would adhere to the skin tissue, causing dehydration and second injury upon replacement. Polyester is commonly used in the medical field and is a safe and inexpensive polymer. Due to the hydrophobic surface, polyester does not adhere to tissue; however, polyester does not have the hemostatic properties. We designed a material composed of collagen and polyester, encapsulated hydrolyzed collagen in polyester particles, and made collagen-polyester non-woven fabric by melt blowing method, The collagen content was 1% and the collagen-polyester dressing exhibited a hydrophobic nature, preventing moisture from sticking to its surface. The purpose of this study was to compare the hemostatic effect of collagen-polyester nonwovens with conventional polyester pads, and to observe the adhesion of the pads to the wound. The wound healing and shrinkage rates of collagen-polyester dressings and conventional pads were compared in a rat wound healing test. The hemostatic test showed that the polyester pads containing 1% collagen significantly shortened the bleeding time compared with the traditional polyester pads, and retained the hydrophobicity and non-adhesion properties. The collagen-polyester dressing had better angiogenesis and granulation degree than the control group on the 14th day, and reduced the wound shrinkage rate. Collagen polyester dressings have excellent hemostasis, regeneration, shrinkage reduction and non-adhering for wounds. Overall, the novel collagen-containing polyester dressing is ideal choice for wound dressings.
MeSH term(s)	Rats ; Animals ; Hemostatics/pharmacology ; Polyesters/pharmacology ; Wound Healing ; Collagen/pharmacology ; Bandages ; Hemostasis
Chemical Substances	Hemostatics ; Polyesters ; Collagen (9007-34-5)
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1014190-x
ISSN	1568-5624 ; 1568-5616 ; 0920-5063
ISSN (online)	1568-5624 ; 1568-5616
ISSN	0920-5063
DOI	10.1080/09205063.2023.2230842
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Article ; Online: Effects of various cross-linked collagen scaffolds on wound healing in rats model by deep-learning CNN.

Chang, Chih-Tsung / Huang, Chun-Hui

Computer methods in biomechanics and biomedical engineering

2024 , Page(s) 1–17

Abstract: Scar tissue is connective tissue formed on the wound during the wound-healing process. The most significant distinction between scar tissue and normal tissue is the appearance of covalent cross-linking and the amount of collagen fibers in the tissue. ... ...

Abstract	Scar tissue is connective tissue formed on the wound during the wound-healing process. The most significant distinction between scar tissue and normal tissue is the appearance of covalent cross-linking and the amount of collagen fibers in the tissue. This study investigates the efficacy of four types of collagen scaffolds in promoting wound healing and regeneration in a Sprague-Dawley murine model-the histomorphology analysis of collagen scaffolds and developing a deep learning model for accurate tissue classification. Four female rats (
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2071764-7
ISSN	1476-8259 ; 1025-5842
ISSN (online)	1476-8259
ISSN	1025-5842
DOI	10.1080/10255842.2024.2315141
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Article ; Online: A novel method for the detection of VEP signals from frontal region.

Chang, Chih-Tsung / Huang, Christina

The International journal of neuroscience

2017 Volume 128, Issue 6, Page(s) 520–529

Abstract: Purpose: This paper studies the feasibility of frontal positioning of electrode to detect electroencephalographic signals.: Methods: The experiments were conducted using a board with light-emitting diodes (LEDs) designed to stimulate SSVEP and FVEP. ... ...

Abstract	Purpose: This paper studies the feasibility of frontal positioning of electrode to detect electroencephalographic signals. Methods: The experiments were conducted using a board with light-emitting diodes (LEDs) designed to stimulate SSVEP and FVEP. The flashing frequencies were conducted at 15, 23, and 31 Hz. We used the Quick Amp brain wave amplifier to collect brain wave signals at a sampling rate of 1 kHz using a frequency filter band of 10-100 Hz. Results: We found that the energy power of VEP will gradually increase from Oz position to Fp2 position. We analyze the data, proving that the Fp2 position can also be used to collect VEP data. Conclusions: Traditional measurements at the Oz location are limited because of the interference from human hair, and an additional electrode is required to detect eye movement and filter this electro-oculogram signal. Our proposed method can effectively acquire critical visually evoked potential and electro-oculogram signals without the electrode at the Oz location, which require extensive preparation of removing hair strands. We also reduced the number of electrodes used in receiving electroencephalographic signals. The frontal electrode positioning could be a remarkable breakthrough to design brain computer interface.
MeSH term(s)	Adult ; Electroencephalography/methods ; Electrooculography/methods ; Evoked Potentials, Visual/physiology ; Female ; Fourier Analysis ; Frontal Lobe/physiology ; Humans ; Male ; Visual Perception/physiology
Language	English
Publishing date	2017-11-16
Publishing country	England
Document type	Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2017.1398749
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Article: Syntheses of (+)-Complanadine A and Lycodine Derivatives by Regioselective [2 + 2 + 2] Cycloadditions

Yuan, Changxia / Chang Chih-Tsung / Siegel Dionicio

Journal of organic chemistry. 2013 June 07, v. 78, no. 11

2013

Abstract: The dimeric alkaloid complanadine A has shown promise in regenerative science, promoting neuronal growth by inducing the secretion of growth factors from glial cells. Through the use of tandem, cobalt-mediated [2 + 2 + 2] cycloaddition reactions, two ... ...

Abstract	The dimeric alkaloid complanadine A has shown promise in regenerative science, promoting neuronal growth by inducing the secretion of growth factors from glial cells. Through the use of tandem, cobalt-mediated [2 + 2 + 2] cycloaddition reactions, two synthetic routes have been developed with different sequences for the formation of the unsymmetric bipyridyl core. The regioselective formation of each of the pyridines was achieved based on the inherent selectivity of the molecules or by reversing the regioselectivity through the addition of Lewis bases. This strategy has been successfully employed to provide laboratory access to complanadine A as well as structurally related compounds possessing the lycodine core.
Keywords	alkaloids ; chemical derivatives ; cycloaddition reactions ; growth factors ; Lewis bases ; neuroglia ; neurons ; organic chemistry ; pyridines ; regioselectivity ; secretion ; synthesis
Language	English
Dates of publication	2013-0607
Size	p. 5647-5668.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021%2Fjo400695c
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Article ; Online: Syntheses of (+)-complanadine A and lycodine derivatives by regioselective [2 + 2 + 2] cycloadditions.

Yuan, Changxia / Chang, Chih-Tsung / Siegel, Dionicio

The Journal of organic chemistry

2013 Volume 78, Issue 11, Page(s) 5647–5668

Abstract	The dimeric alkaloid complanadine A has shown promise in regenerative science, promoting neuronal growth by inducing the secretion of growth factors from glial cells. Through the use of tandem, cobalt-mediated [2 + 2 + 2] cycloaddition reactions, two synthetic routes have been developed with different sequences for the formation of the unsymmetric bipyridyl core. The regioselective formation of each of the pyridines was achieved based on the inherent selectivity of the molecules or by reversing the regioselectivity through the addition of Lewis bases. This strategy has been successfully employed to provide laboratory access to complanadine A as well as structurally related compounds possessing the lycodine core.
MeSH term(s)	Cyclization ; Heterocyclic Compounds, 4 or More Rings/chemical synthesis ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Molecular Conformation ; Stereoisomerism
Chemical Substances	Heterocyclic Compounds, 4 or More Rings ; complanadine A ; lycodine (7K0NX2M1NN)
Language	English
Publishing date	2013-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo400695c
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Article ; Online: Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion.

Yuan, Changxia / Chang, Chih-Tsung / Axelrod, Abram / Siegel, Dionicio

Journal of the American Chemical Society

2010 Volume 132, Issue 17, Page(s) 5924–5925

Abstract: A total synthesis of the Lycopodium alkaloid (+)-complanadine A is described. Complanadine A has been shown to induce the secretion of neurotrophic factors from 1321N1 cells, promoting the differentiation of PC-12 cells. The use of a simplifying metal ... ...

Abstract	A total synthesis of the Lycopodium alkaloid (+)-complanadine A is described. Complanadine A has been shown to induce the secretion of neurotrophic factors from 1321N1 cells, promoting the differentiation of PC-12 cells. The use of a simplifying metal mediated [2+2+2] + [2+2+2] sequence using a silyl-substituted diyne and 2 equiv of the corresponding alkyne-nitrile has provided rapid access to the natural product.
MeSH term(s)	Animals ; Cell Differentiation ; Cells, Cultured ; Heterocyclic Compounds, 4 or More Rings/chemical synthesis ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Lycopodium/metabolism ; Nerve Growth Factors/secretion ; Neuroglia/drug effects ; Neuroglia/secretion ; Rats
Chemical Substances	Heterocyclic Compounds, 4 or More Rings ; Nerve Growth Factors ; complanadine A
Language	English
Publishing date	2010-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja101956x
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Article ; Online: 5-Oxo-ETE receptor antagonists.

Gore, Vivek / Patel, Pranav / Chang, Chih-Tsung / Sivendran, Sashikala / Kang, Namin / Ouedraogo, Yannick P / Gravel, Sylvie / Powell, William S / Rokach, Joshua

Journal of medicinal chemistry

2013 Volume 56, Issue 9, Page(s) 3725–3732

Abstract: 5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor ... ...

Abstract	5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.
MeSH term(s)	Arachidonic Acids/metabolism ; Drug Design ; Humans ; Indoles/chemistry ; Indoles/pharmacology ; Inhibitory Concentration 50 ; Receptors, Eicosanoid/antagonists & inhibitors
Chemical Substances	Arachidonic Acids ; Indoles ; Receptors, Eicosanoid ; 5-oxo-6,8,11,14-eicosatetraenoic acid (126432-17-5)
Language	English
Publishing date	2013-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm400480j
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Article: Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane.

Patel, Pranav / Chang, Chih-Tsung / Kang, Namin / Lee, Gue-Jae / Powell, William S / Rokach, Joshua

Tetrahedron letters

2007 Volume 48, Issue 30, Page(s) 5289–5292

Abstract: Traditionally silyl groups are deprotected with acids and fluorides. These methods are, however, less discriminating when multi-silyl groups are present in the same molecule resulting in lower yields of desired products. The manipulation of these ... ...

Abstract	Traditionally silyl groups are deprotected with acids and fluorides. These methods are, however, less discriminating when multi-silyl groups are present in the same molecule resulting in lower yields of desired products. The manipulation of these functions during the total synthesis of natural products, e.g. prostaglandins and isoprostanes, requires the selective protection and deprotection of these groups.We are reporting here on a mild, selective and efficient method for the reductive deprotection of silyl groups using Wilkinson's catalyst/catechol borane or catechol borane alone.
Language	English
Publishing date	2007-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	204287-3
ISSN	1873-3581 ; 0040-4039
ISSN (online)	1873-3581
ISSN	0040-4039
DOI	10.1016/j.tetlet.2007.05.118
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Article ; Online: A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI.

Chang, Chih-Tsung / Patel, Pranav / Gore, Vivek / Song, Wen-Liang / Lawson, John A / Powell, William S / Fitzgerald, Garret A / Rokach, Joshua

Bioorganic & medicinal chemistry letters

2009 Volume 19, Issue 23, Page(s) 6755–6758

Abstract: The total and stereospecific synthesis of d(4)-5-epi-8,12-iso-iPF(3alpha)-VI 55 and d(4)-8,12-iso-iPF(3alpha)-VI 64, EPA-derived all-syn-isoprostanes (iPs), has been accomplished. Because of issues related to volatility and yield with some of the primary ...

Abstract	The total and stereospecific synthesis of d(4)-5-epi-8,12-iso-iPF(3alpha)-VI 55 and d(4)-8,12-iso-iPF(3alpha)-VI 64, EPA-derived all-syn-isoprostanes (iPs), has been accomplished. Because of issues related to volatility and yield with some of the primary deuterated synthons an improved synthesis is presented. These two deuterated analogs were used to discover and quantify the presence of the corresponding endogenous isoprostanes in human urine. These assays may serve as a valuable index of oxidative stress in population with omega-3 fatty acid enriched diets containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and may also be useful as an index of the severity of inflammatory diseases such as atherosclerosis and Alzheimer's disease.
MeSH term(s)	Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/chemical synthesis ; Eicosapentaenoic Acid/pharmacology ; Eicosapentaenoic Acid/urine ; Humans ; Isoprostanes/chemical synthesis ; Isoprostanes/pharmacology ; Isoprostanes/urine ; Molecular Structure ; Stereoisomerism
Chemical Substances	8,12-iso-iPF3alpha-VI ; Isoprostanes ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2009-09-29
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2009.09.099
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Article: Novel Eicosapentaenoic Acid-derived F₃-isoprostanes as Biomarkers of Lipid Peroxidation

Song, Wen-Liang / Paschos, Georgios / Fries, Susanne / Reilly, Muredach P / Yu, Ying / Rokach, Joshua / Chang, Chih-Tsung / Patel, Pranav / Lawson, John A / FitzGerald, Garret A

Journal of biological chemistry. 2009 Aug. 28, v. 284, no. 35

2009

Abstract: Isoprostanes (iPs) are prostaglandin (PG) isomers generated by free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs). Urinary F₂-iPs, PGF₂α isomers derived from arachidonic acid (AA) are used as indices of lipid peroxidation in vivo. ...

Abstract	Isoprostanes (iPs) are prostaglandin (PG) isomers generated by free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs). Urinary F₂-iPs, PGF₂α isomers derived from arachidonic acid (AA) are used as indices of lipid peroxidation in vivo. We now report the characterization of two major F₃-iPs, 5-epi-8,12-iso-iPF₃α-VI and 8,12-iso-iPF₃α-VI, derived from the ω-3 fatty acid, eicosapentaenoic acid (EPA). Although the potential therapeutic benefits of EPA receive much attention, a shift toward a diet rich in ω-3 PUFAs may also predispose to enhanced lipid peroxidation. Urinary 5-epi-8,12-iso-iPF₃α-VI and 8,12-iso-iPF₃α-VI are highly correlated and unaltered by cyclooxygenase inhibition in humans. Fish oil dose-dependently elevates urinary F₃-iPs in mice and a shift in dietary ω-3/ω-6 PUFAs is reflected by an increasing slope [m] of the line relating urinary 8, 12-iso-iPF₃α-VI and 8,12-iso-iPF₂α-VI. Administration of bacterial lipopolysaccharide evokes a reversible increase in both urinary 8,12-iso-iPF₃α-VI and 8,12-iso-iPF₂α-VI in humans on an ad lib diet. However, while excretion of the iPs is highly correlated (R² median = 0.8), [m] varies by an order of magnitude, reflecting marked inter-individual variability in the relative peroxidation of ω-3 versus ω-6 substrates. Clustered analysis of F₂- and F₃-iPs refines assessment of the oxidant stress response to an inflammatory stimulus in vivo by integrating variability in dietary intake of ω-3/ω-6 PUFAs.
Language	English
Dates of publication	2009-0828
Size	p. 23636-23643.
Publishing place	American Society for Biochemistry and Molecular Biology
Document type	Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
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