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  1. Article ; Online: EGFR Tyrosine Kinase Inhibitor-Associated Interstitial Lung Disease During the Coronavirus Disease 2019 Pandemic.

    Chang, Hsu-Liang / Chen, Yen-Hsu / Taiwan, Hsin-Chu / Yang, Chih-Jen

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2020  Volume 15, Issue 8, Page(s) e129–e131

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus/isolation & purification ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Diagnosis, Differential ; ErbB Receptors/antagonists & inhibitors ; Humans ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/pathology ; Lung Diseases, Interstitial/virology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; SARS-CoV-2
    Chemical Substances Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2020.04.029
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  2. Article: Establishing Quality of Life in Southern Taiwan COPD Patients Using Long-Acting Bronchodilator.

    Chin, Pik-Qi / Sheu, Chau-Chyun / Tsai, Jong-Rung / Chang, Hsu-Liang / Lee, Li-Yao / Chen, Chung-Yu

    Patient preference and adherence

    2022  Volume 16, Page(s) 875–886

    Abstract: Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these ... ...

    Abstract Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these patients.
    Methods: This cross-sectional study included outpatient participants aged 35 years old and older who were receiving long-acting bronchodilator treatment in one of two hospitals in Southern Taiwan. Participants were categorized according to their Global Initiative for Obstructive Lung Disease (GOLD) classification as either their COPD group, based on symptoms and exacerbation risk, or their COPD stage, based on spirometry results. Patients' HRQoL was assessed using the St. George's Respiratory Questionnaire score (SGRQ), World Health Organization Quality of Life Quality of Life-BREF (WHOQOL-BREF), and EQ-5D-5L. The total scores of the SGRQ, WHOQOL-BREF, EQ-5D utility index, and EQ-VAS were presented as mean ± standard deviation (SD) among different combination treatments. Univariate and multivariate analyses were used to explore the association of patients' baseline characteristics and environmental factors with HRQoL.
    Results: A total of 218 patients were enrolled in the study. The distribution of patients using GOLD group classification were as follows: 73.39% in group A, 20.19% group B, 1.83% group C and 4.59% group D. Triple therapy patients mostly showed a lower quality of life than other combination therapies, regardless of the GOLD classification system. However, only the SGRQ scores of GOLD groups A and B were significantly different when using different drug combinations (p-value = 0.0072 and 0.0430, respectively). The COPD assessment test (CAT) score, a questionnaire to assess impact of COPD on health status, was found to be associated with all the questionnaires.
    Conclusion: The HRQoL is impaired in patients with COPD, and it deteriorates with an increase of severity. The CAT was the strongest predictor of HRQoL.
    Language English
    Publishing date 2022-04-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S355023
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  3. Article ; Online: Ultrasensitive Strain Sensor Utilizing a AgF-AgNW Hybrid Nanocomposite for Breath Monitoring and Pulmonary Function Analysis.

    Kumar, Amit / Rakesh Kumar, R K / Shaikh, Muhammad Omar / Lu, Cheng-Huan / Yang, Jia-Yu / Chang, Hsu-Liang / Chuang, Cheng-Hsin

    ACS applied materials & interfaces

    2022  

    Abstract: Breath monitoring and pulmonary function analysis have been the prime focus of wearable smart sensors owing to the COVID-19 outbreak. Currently used lung function meters in hospitals are prone to spread the virus and can result in the transmission of the ...

    Abstract Breath monitoring and pulmonary function analysis have been the prime focus of wearable smart sensors owing to the COVID-19 outbreak. Currently used lung function meters in hospitals are prone to spread the virus and can result in the transmission of the disease. Herein, we have reported the first-ever wearable patch-type strain sensor for enabling real-time lung function measurements (such as forced volume capacity (FVC) and forced expiratory volume (FEV) along with breath monitoring), which can avoid the spread of the virus. The noninvasive and highly sensitive strain sensor utilizes the synergistic effect of two-dimensional (2D) silver flakes (AgFs) and one-dimensional (1D) silver nanowires (AgNWs), where AgFs create multiple electron transmission paths and AgNWs generate percolation networks in the nanocomposite. The nanocomposite-based strain sensor possesses a high optimized conductivity of 7721 Sm
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c17756
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  4. Article ; Online: Rifampin may decrease the efficacy of crizotinib in lung cancer treatment.

    Chang, Ching-Hsiung / Chang, Hsu-Liang / Hsu, Jui-Feng / Yang, Chih-Jen

    The Kaohsiung journal of medical sciences

    2019  Volume 35, Issue 9, Page(s) 580–581

    MeSH term(s) Aged ; Crizotinib/therapeutic use ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Male ; Rifampin/adverse effects ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Crizotinib (53AH36668S) ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2019-05-02
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12078
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  5. Article ; Online: Checkpoint inhibitor pneumonitis mimicking COVID-19 infection during the COVID-19 pandemic.

    Chang, Hsu-Liang / Wei, Po-Ju / Wu, Kuan-Li / Huang, Hung-Ling / Yang, Chih-Jen

    Lung cancer (Amsterdam, Netherlands)

    2020  Volume 146, Page(s) 376–377

    MeSH term(s) Antineoplastic Agents/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; Betacoronavirus ; COVID-19 ; CTLA-4 Antigen/antagonists & inhibitors ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Genes, cdc/drug effects ; Humans ; Immunotherapy ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Lung Neoplasms/epidemiology ; Lung Neoplasms/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; SARS-CoV-2
    Chemical Substances Antineoplastic Agents ; B7-H1 Antigen ; CD274 protein, human ; CTLA-4 Antigen ; CTLA4 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country Ireland
    Document type Letter
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2020.06.013
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    Zs.MO 423: Show issues

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  6. Article: EGFR Tyrosine Kinase Inhibitor-Associated Interstitial Lung Disease During the Coronavirus Disease 2019 Pandemic

    Chang, Hsu-Liang / Chen, Yen-Hsu / Taiwan, Hsin-Chu / Yang, Chih-Jen

    J Thorac Oncol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #591110
    Database COVID19

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  7. Article ; Online: The extracts of

    Chang, Hsu-Liang / Kuo, Yi-Hsuan / Wu, Li-Hsien / Chang, Chih-Min / Cheng, Kai-Jen / Tyan, Yu-Chang / Lee, Che-Hsin

    International journal of medical sciences

    2020  Volume 17, Issue 7, Page(s) 939–945

    Abstract: A polysaccharide isolated from the radix ... ...

    Abstract A polysaccharide isolated from the radix of
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/immunology ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Astragalus propinquus/chemistry ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Cisplatin/administration & dosage ; Coculture Techniques ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/immunology ; Leukemia/drug therapy ; Leukemia/immunology ; Mice, Inbred BALB C ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/immunology ; Plant Extracts/immunology ; Plant Extracts/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Tumor Escape/drug effects
    Chemical Substances Antineoplastic Agents, Phytogenic ; B7-H1 Antigen ; Cd274 protein, mouse ; Plant Extracts ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-03-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.42978
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  8. Article ; Online: Big data integration and analytics to prevent a potential hospital outbreak of COVID-19 in Taiwan.

    Chen, Fang-Ming / Feng, Ming-Chu / Chen, Tun-Chieh / Hsieh, Min-Han / Kuo, Shin-Huei / Chang, Hsu-Liang / Yang, Chih-Jen / Chen, Yen-Hsu

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2020  Volume 54, Issue 1, Page(s) 129–130

    MeSH term(s) Big Data ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Contact Tracing ; Disease Outbreaks/prevention & control ; Hospitals ; Humans ; Infection Control/methods ; Taiwan/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2020.04.010
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  9. Article ; Online: Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review.

    Yang, Chih-Jen / Wei, Yu-Jui / Chang, Hsu-Liang / Chang, Pi-Yu / Tsai, Chung-Chen / Chen, Yen-Hsu / Hsueh, Po-Ren

    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

    2020  Volume 54, Issue 1, Page(s) 27–36

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2- ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China. Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2. Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use. In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19).
    MeSH term(s) Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/analogs & derivatives ; Alanine/administration & dosage ; Alanine/analogs & derivatives ; Antiviral Agents/administration & dosage ; COVID-19/drug therapy ; COVID-19/epidemiology ; China/epidemiology ; Clinical Trials as Topic ; Humans ; Pandemics ; Randomized Controlled Trials as Topic ; SARS-CoV-2/drug effects
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1497590-7
    ISSN 1995-9133 ; 1684-1182 ; 0253-2662
    ISSN (online) 1995-9133
    ISSN 1684-1182 ; 0253-2662
    DOI 10.1016/j.jmii.2020.09.002
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  10. Article: Checkpoint inhibitor pneumonitis mimicking COVID-19 infection during the COVID-19 pandemic

    Chang, Hsu-Liang / Wei, Po-Ju / Wu, Kuan-Li / Huang, Hung-Ling / Yang, Chih-Jen

    Lung Cancer

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #601984
    Database COVID19

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