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  1. Article ; Online: Asperustins A-J: Austocystins with Immunosuppressive and Cytotoxic Activities from

    Chang, Jin-Ling / Gan, Yu-Tian / Zhou, Yin-Hui / Peng, Xiao-Gang / Xie, Zuo-Ye / Meng, Xianggao / Li, Shu-Ming / Ruan, Han-Li

    Journal of natural products

    2024  Volume 87, Issue 4, Page(s) 966–975

    Abstract: Ten new ( ...

    Abstract Ten new (
    MeSH term(s) Aspergillus/chemistry ; Humans ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/isolation & purification ; Molecular Structure ; Crystallography, X-Ray ; Interleukin-6/metabolism ; Anthraquinones/pharmacology ; Anthraquinones/chemistry ; Animals ; Drug Screening Assays, Antitumor ; T-Lymphocytes/drug effects ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cell Proliferation/drug effects
    Chemical Substances Immunosuppressive Agents ; Interleukin-6 ; Anthraquinones ; Antineoplastic Agents
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c01243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Peniandranoids A-E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a

    Chang, Jin-Ling / Gan, Yu-Tian / Peng, Xiao-Gang / Ouyang, Qian-Xi / Pei, Jiao / Ruan, Han-Li

    Journal of natural products

    2023  Volume 86, Issue 1, Page(s) 66–75

    Abstract: Peniandranoids A-E ( ...

    Abstract Peniandranoids A-E (
    MeSH term(s) Molecular Structure ; Influenza A Virus, H1N1 Subtype ; Penicillium/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Polyketides
    Chemical Substances Antiviral Agents ; Polyketides
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diaporaustalides A-L, Austalide Meroterpenoids from a Plant Endophytic

    Chang, Jin-Ling / Pei, Jiao / Zhou, Yin-Hui / Ouyang, Qian-Xi / Qin, Chun-Lun / Hu, Jia-Yun / Meng, Xiang-Gao / Ruan, Han-Li

    Journal of natural products

    2023  Volume 87, Issue 1, Page(s) 141–151

    Abstract: Twelve new austalide meroterpenoids ( ...

    Abstract Twelve new austalide meroterpenoids (
    MeSH term(s) Molecular Structure ; Lipopolysaccharides/pharmacology ; Fungi ; Crystallography, X-Ray ; Circular Dichroism
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aspersteroids A–C, Three Rearranged Ergostane-type Steroids from Aspergillus ustus NRRL 275

    Liu, Lin / Duan, Fang-Fang / Gao, Ying / Peng, Xiao-Gang / Chang, Jin-Ling / Chen, Juan / Ruan, Han-Li

    Organic letters. 2021 Dec. 09, v. 23, no. 24

    2021  

    Abstract: Aspersteroid A (1), a highly rearranged 1(10 → 6)-abeo-18,22-cyclosterol, together with two new 18,22-cyclosterols (2 and 3), was isolated from the culture extract of Aspergillus ustus NRRL 275. Their structures were determined by spectroscopic analysis, ...

    Abstract Aspersteroid A (1), a highly rearranged 1(10 → 6)-abeo-18,22-cyclosterol, together with two new 18,22-cyclosterols (2 and 3), was isolated from the culture extract of Aspergillus ustus NRRL 275. Their structures were determined by spectroscopic analysis, X-ray diffraction, modified Mosher’s method, and Rh₂(OCOCF₃)₄-induced electronic circular dichroism experiments. Compound 1 represents a new carbon skeleton with an uncommon 6/6/6/5/5 ring system, which is presumably biosynthesized from A-ring scission, double 1,2-shifts, and C-18/C-22 cyclization. Compound 1 exhibited potent immunosuppressive and antimicrobial activities.
    Keywords Aspergillus ; X-ray diffraction ; biosynthesis ; carbon ; circular dichroism spectroscopy ; cleavage (chemistry) ; immunosuppression ; spectral analysis
    Language English
    Dates of publication 2021-1209
    Size p. 9620-9624.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.1c03863
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Antimicrobial Furancarboxylic Acids from a Penicillium sp

    Chang, Jin-Ling / Xu, Hong-Zhe / Zhou, Jia / Zhou, Ming / Zhang, Xuke / Guo, Yuanqiang / Ruan, Han-Li

    Journal of natural products. 2020 Dec. 14, v. 83, no. 12

    2020  

    Abstract: Ten novel (1, 2, 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b) furancarboxylic acids including four pairs of epimers (3a, 3b; 4a, 4b; 5a, 5b; 6a, 6b), together with seven known analogues (7a, 7b, 8a, 8b, 9a, 9b, and 10), were isolated from the fermentation of the ... ...

    Abstract Ten novel (1, 2, 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b) furancarboxylic acids including four pairs of epimers (3a, 3b; 4a, 4b; 5a, 5b; 6a, 6b), together with seven known analogues (7a, 7b, 8a, 8b, 9a, 9b, and 10), were isolated from the fermentation of the soil-derived fungus Penicillium sp. sb62. Their structures were established on the basis of spectroscopic data analysis, and the absolute configurations were determined by time-dependent density functional theory electronic circular dichroism calculations, comparison of the specific optical rotation values, and modified Mosher’s method. Compounds 1–4 represent the first class of natural furancarboxylic acids featuring a thiophene moiety. Compounds 1–7 showed antimicrobial inhibitory activities against Escherichia coli, Staphylococcus aureus, and Candida albicans with MIC values ranging from 0.9 to 7.0 μg/mL, from 1.7 to 3.5 μg/mL, and from 3.3 to 7.0 μg/mL, respectively.
    Keywords Candida albicans ; Escherichia coli ; Penicillium ; Staphylococcus aureus ; circular dichroism spectroscopy ; density functional theory ; fermentation ; fungi ; moieties ; spectral analysis ; thiophene
    Language English
    Dates of publication 2020-1214
    Size p. 3606-3613.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00758
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Aspersteroids A-C, Three Rearranged Ergostane-type Steroids from

    Liu, Lin / Duan, Fang-Fang / Gao, Ying / Peng, Xiao-Gang / Chang, Jin-Ling / Chen, Juan / Ruan, Han-Li

    Organic letters

    2021  Volume 23, Issue 24, Page(s) 9620–9624

    Abstract: Aspersteroid A ( ...

    Abstract Aspersteroid A (
    MeSH term(s) Aspergillus
    Language English
    Publishing date 2021-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c03863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Resorcylic Acid Lactones from an

    Zhou, Jia / Gao, Ying / Chang, Jin-Ling / Yu, Heng-Yi / Chen, Juan / Zhou, Ming / Meng, Xiang-Gao / Ruan, Han-Li

    Journal of natural products

    2020  Volume 83, Issue 5, Page(s) 1505–1514

    Abstract: Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs ( ...

    Abstract Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.9b01167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Antimicrobial Furancarboxylic Acids from a

    Chang, Jin-Ling / Xu, Hong-Zhe / Zhou, Jia / Zhou, Ming / Zhang, Xuke / Guo, Yuanqiang / Ruan, Han-Li

    Journal of natural products

    2020  Volume 83, Issue 12, Page(s) 3606–3613

    Abstract: Ten novel ( ...

    Abstract Ten novel (
    MeSH term(s) Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Candida albicans/drug effects ; Carboxylic Acids/chemistry ; Carboxylic Acids/isolation & purification ; Escherichia coli/drug effects ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Molecular Structure ; Penicillium/chemistry ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Infective Agents ; Carboxylic Acids
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c00758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from

    Peng, Xiao-Gang / Liu, Junjun / Gao, Ying / Cheng, Fang / Chang, Jin-Ling / Chen, Juan / Duan, Fang-Fang / Ruan, Han-Li

    Organic letters

    2020  Volume 22, Issue 24, Page(s) 9665–9669

    Abstract: Four novel rearranged cytochalasans ( ...

    Abstract Four novel rearranged cytochalasans (
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Biochemical Phenomena ; Chaetomium/chemistry ; Cytochalasins/chemistry ; Cytochalasins/isolation & purification ; Cytochalasins/pharmacology ; Drug Screening Assays, Antitumor ; Molecular Structure
    Chemical Substances Antineoplastic Agents ; Cytochalasins
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c03623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from Chaetomium globosum P2-2-2

    Peng, Xiao-Gang / Liu, Junjun / Gao, Ying / Cheng, Fang / Chang, Jin-Ling / Chen, Juan / Duan, Fang-Fang / Ruan, Han-Li

    Organic letters. 2020 Dec. 03, v. 22, no. 24

    2020  

    Abstract: Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.2¹⁷,¹⁹.0¹⁵,¹⁹]henicosane core. Spiropchaeglobosin A (2) was ... ...

    Abstract Four novel rearranged cytochalasans (1–4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.2¹⁷,¹⁹.0¹⁵,¹⁹]henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring a novel spiro[5.10]hexadecane unit. Pchaeglobosals A (3) and B (4) featured a unique 5/5/13 fused tricyclic ring system. Compounds 1–4 were tested for their antiproliferative, apoptosis, cell cycle arrest, and TRAIL-resistance-overcoming activities on cancer cell lines.
    Keywords Chaetomium globosum ; apoptosis ; cell cycle checkpoints ; endophytes ; fungi ; hexadecane ; neoplasm cells
    Language English
    Dates of publication 2020-1203
    Size p. 9665-9669.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.0c03623
    Database NAL-Catalogue (AGRICOLA)

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