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  1. Article ; Online: When Constrained by Constraints: Thinking Outside of the Box in Both Technology and Biology.

    Chang, Joe Y

    International journal of radiation oncology, biology, physics

    2021  Volume 110, Issue 2, Page(s) 266–267

    MeSH term(s) Biology ; Humans ; Technology
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.10.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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  2. Article ; Online: Reconciling the discrepancies in randomized data of combining immunotherapy and radiation therapy: Not all radiotherapy is created equal.

    Chang, Joe Y / Verma, Vivek / Weichselbaum, Ralph R

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 201, Page(s) 113972

    Abstract: It remains highly unclear and debatable whether combining radiotherapy (RT) and immune checkpoint blocker (ICB) therapy yields improved outcomes compared to either modality alone. Whereas some randomized data have shown improved outcomes, others have not. ...

    Abstract It remains highly unclear and debatable whether combining radiotherapy (RT) and immune checkpoint blocker (ICB) therapy yields improved outcomes compared to either modality alone. Whereas some randomized data have shown improved outcomes, others have not. As a result of these conflicting data, it is essential to reconcile differences in the data and postulate reasons thereof. This work seeks to address these discrepancies, and uses the lessons learned from both positive and negative trials, including the most cutting-edge data available, in order to guide future clinical trial design and clarify the ideal/expected role of combinatorial therapy going forward. Because RT offers two distinct contributions (cytoreductive (local) effects & immune-stimulating (systemic) effects), RT should complement immunotherapy by addressing immunotherapy-resistant clones, and immunotherapy should complement RT by addressing RT-resistant or out-of-field clones. RT is not merely a single "drug", but rather a constellation of diverse "drugs" that can be varied based on dose regimens, previous systemic therapy regimens, number of irradiated sites, treatment intent/location/timing, tumor biology, and individual patient immunological circumstances. These factors are discussed as an important explanation for the discrepancies in results of various randomized trials in heterogeneous populations and clinical settings, and these discrepancies may continue until trials of more uniform circumstances are designed to use particular RT paradigms that meaningfully add value to systemic therapy.
    MeSH term(s) Humans ; Combined Modality Therapy ; Immunotherapy/methods ; Radiosurgery/methods
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.113972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  3. Article ; Online: Optimize Local Therapy for Oligometastatic and Oligoprogressive Non-Small Cell Lung Cancer to Enhance Survival.

    Chang, Joe Y / Verma, Vivek

    Journal of the National Comprehensive Cancer Network : JNCCN

    2022  Volume 20, Issue 5, Page(s) 531–539

    Abstract: Metastatic non-small cell lung cancer (NSCLC) is highly heterogeneous, and there are patients with limited areas of metastases (oligometastases) or progression (oligoprogression) whose natural history and prognosis can be considerably more favorable. As ... ...

    Abstract Metastatic non-small cell lung cancer (NSCLC) is highly heterogeneous, and there are patients with limited areas of metastases (oligometastases) or progression (oligoprogression) whose natural history and prognosis can be considerably more favorable. As a result, local therapy may offer these patients a chance at clinically meaningful disease control and/or cure. This review begins by describing the current status of the existing prospective data, including evidence of overall survival improvements from multiple randomized trials. Given the nascence of this realm, the review then examines ongoing controversies and unresolved issues regarding local therapy for oligometastatic and oligoprogression. First, the role of local therapy in the setting of targeted therapies and immunotherapy is discussed, because most published randomized trials of local therapy have been performed in the context of chemotherapy, which is no longer the standard of care for most patients with metastatic NSCLC. Refining patient selection for local therapy is then reviewed, including clinical factors (such as control of the primary and regional lymph node sites, the heterogeneous definitions of oligometastases/oligoprogression, and the underrepresentation of brain metastases in existing randomized data) and novel pathologic/molecular biomarkers. Next, because there also remains no consensus regarding the optimal modality of local therapy, the advantages and disadvantages of stereotactic radiotherapy, surgery, and other ablative techniques are discussed. Subsequently, methods to optimize radiotherapy are examined, including controversies regarding the optimal dose/fractionation and timing/sequencing scheme. A discussion regarding potentially extending the existing data to polymetastatic NSCLC follows. The review concludes with remarks regarding prudently designing randomized trials of local therapy going forward, including the benefits and drawbacks of specific endpoints meriting further testing in this unique population.
    MeSH term(s) Brain Neoplasms/secondary ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms/pathology ; Prospective Studies ; Radiosurgery/methods
    Language English
    Publishing date 2022-05-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2021.7117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6365: Show issues Location:
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  4. Article ; Online: In Reply to Hurmuz and Ozyigit.

    Chang, Joe Y

    International journal of radiation oncology, biology, physics

    2018  Volume 101, Issue 3, Page(s) 745

    Language English
    Publishing date 2018-08-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.03.038
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  5. Article: Could the clinical target volume be omitted for radiotherapy of locally advanced non-small cell lung cancer in the modern era?

    Verma, Vivek / Chang, Joe Y

    Translational lung cancer research

    2021  Volume 10, Issue 1, Page(s) 5–8

    Language English
    Publishing date 2021-02-10
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-2020-19
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  6. Article ; Online: Immunotherapy for the Neoadjuvant Management of Resectable Intrathoracic Cancers: Let's Not Forget Radiotherapy.

    Chang, Joe Y / Verma, Vivek / Weichselbaum, Ralph R

    JAMA oncology

    2022  Volume 8, Issue 3, Page(s) 333–334

    MeSH term(s) Humans ; Immunologic Factors ; Immunotherapy ; Neoadjuvant Therapy ; Neoplasms ; Radiation Oncology
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.6641
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  7. Article ; Online: Radiotherapy plus immune checkpoint blockade in PD(L)-1-resistant metastatic NSCLC.

    Chang, Joe Y / Verma, Vivek / Welsh, James W / Formenti, Silvia C

    The Lancet. Oncology

    2022  Volume 23, Issue 4, Page(s) e156

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/drug therapy ; Lung Neoplasms/radiotherapy ; Radiation Oncology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00134-6
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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  8. Article ; Online: Intensity-modulated radiotherapy, not 3 dimensional conformal, is the preferred technique for treating locally advanced lung cancer.

    Chang, Joe Y

    Seminars in radiation oncology

    2015  Volume 25, Issue 2, Page(s) 110–116

    Abstract: When used to treat lung cancer, intensity-modulated radiotherapy (IMRT) can deliver higher dose to the targets and spare more critical organs in lung cancer than can 3-dimensional conformal radiotherapy. However, tumor-motion management and optimized ... ...

    Abstract When used to treat lung cancer, intensity-modulated radiotherapy (IMRT) can deliver higher dose to the targets and spare more critical organs in lung cancer than can 3-dimensional conformal radiotherapy. However, tumor-motion management and optimized radiotherapy planning based on 4-dimensional computed tomography scanning are crucial to maximize the benefit of IMRT and to eliminate or minimize potential uncertainties. This article summarizes these strategies and reviews published findings supporting the safety and efficacy of IMRT for lung cancer.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/radiotherapy ; Chemoradiotherapy ; Evidence-Based Medicine ; Humans ; Lung Neoplasms/radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal ; Radiotherapy, Intensity-Modulated/methods ; Survival Rate
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2014.11.002
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    Zs.A 3654: Show issues Location:
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  9. Article: Stereotactic ablative radiotherapy: aim for a cure of cancer.

    Chang, Joe Y

    Annals of translational medicine

    2014  Volume 3, Issue 1, Page(s) 12

    Language English
    Publishing date 2014-12-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.3978/j.issn.2305-5839.2014.11.17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In reply to Oskan.

    Chang, Joe Y

    International journal of radiation oncology, biology, physics

    2014  Volume 89, Issue 5, Page(s) 1142

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/surgery ; Female ; Humans ; Lung Neoplasms/surgery ; Male ; Radiosurgery/methods
    Language English
    Publishing date 2014-08-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2014.04.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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