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Article ; Online: Risk assessment of malignant transformation of oral leukoplakia in patients with previous oral squamous cell carcinoma.

Yang, S-W / Lee, Y-C / Lee, Y-S / Chang, L-C / Lai, Y-R

International journal of oral and maxillofacial surgery

2022 Volume 51, Issue 11, Page(s) 1394–1400

Abstract: The aim of this study was to identify the risk factors associated with developing oral squamous cell carcinoma (OSCC) from surgically excised oral leukoplakia (OL) in patients with previous oral cavity cancer. Clinicopathological data of 84 patients who ... ...

Abstract	The aim of this study was to identify the risk factors associated with developing oral squamous cell carcinoma (OSCC) from surgically excised oral leukoplakia (OL) in patients with previous oral cavity cancer. Clinicopathological data of 84 patients who were treated for OL between July 2002 and July 2020 and who had previously received treatment for OSCC were reviewed retrospectively. The follow-up time ranged from 0.69 to 17.99 years (mean 6.78 ± 4.25 years). The overall cumulative malignant transformation rate was 25% and the annual transformation rate was 5.73%. Kaplan-Meier survival analysis and the log-rank test showed that Candida infection (P = 0.010) was a risk factor associated with malignant transformation. In the multivariate Cox regression analysis, tongue and floor of the mouth as the location of the leukoplakia (P = 0.039), multifocal lesions of OL (P = 0.047), and Candida infection (P = 0.018) were the three independent prognostic factors related to the development of OSCC from the treated OL. A cautious approach to OL of the tongue with Candida infection or multifocal disease in this group of patients would be appropriate.
MeSH term(s)	Humans ; Mouth Neoplasms/surgery ; Mouth Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck ; Retrospective Studies ; Leukoplakia, Oral ; Cell Transformation, Neoplastic/pathology ; Risk Assessment ; Head and Neck Neoplasms ; Candidiasis
Language	English
Publishing date	2022-03-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2022.02.006
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Article ; Online: IgG4-related myositis.

Tsai, M-K / Kuo, C-W / Chang, L-C

QJM : monthly journal of the Association of Physicians

2019 Volume 112, Issue 11, Page(s) 872–873

MeSH term(s)	Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnosis ; Leg/diagnostic imaging ; Middle Aged ; Muscle, Skeletal/pathology ; Myositis/etiology ; Myositis/pathology ; Tomography, X-Ray Computed
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcz195
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Article ; Online: Replies to Comments on "Aquifer Characterization Using Fiber Bragg Grating Multi-Level Monitoring System" by Leven and Barrash.

Wang, Y-L / Chang, L-C / Liu, F / Ho, Y-T / Wang, T B / Yeh, T-C J / Tsai, J-P

Ground water

2022 Volume 60, Issue 6, Page(s) 705–706

MeSH term(s)	Groundwater ; Temperature
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Letter
ZDB-ID	246212-6
ISSN	1745-6584 ; 0017-467X
ISSN (online)	1745-6584
ISSN	0017-467X
DOI	10.1111/gwat.13234
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Article ; Online: Host Genetic Associations with Salivary Microbiome in Oral Cancer.

Yang, S F / Lin, C W / Chuang, C Y / Lee, Y C / Chung, W H / Lai, H C / Chang, L C / Su, S C

Journal of dental research

2021 Volume 101, Issue 5, Page(s) 590–598

Abstract: Despite the growing recognition of a host genetic effect on shaping gut microbiota composition, the genetic determinants of oral microbiota remain largely unexplored, especially in the context of oral diseases. Here, we performed a microbiome genome-wide ...

Abstract	Despite the growing recognition of a host genetic effect on shaping gut microbiota composition, the genetic determinants of oral microbiota remain largely unexplored, especially in the context of oral diseases. Here, we performed a microbiome genome-wide association study in 2 independent cohorts of patients with oral squamous cell carcinoma (OSCC,
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Genome-Wide Association Study ; Head and Neck Neoplasms ; Humans ; Microbiota/genetics ; Mouth Neoplasms/pathology ; RNA, Ribosomal, 16S/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/00220345211051967
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Article: First Report of Association of Mucor circinelloides on Noni (Morinda citrifolia) in Hawaii.

Nishijima, K A / Wall, M M / Chang, L C / Wei, Y / Wong, D K W

Plant disease

2019 Volume 95, Issue 3, Page(s) 360

Abstract: Noni (Morinda citrifolia) is a popular medicinal plant found in tropical or subtropical regions of the world. The fruit and juice extracts have properties that are reportedly therapeutic for diabetes, high blood pressure, and certain types of cancer (1,4) ...

Abstract	Noni (Morinda citrifolia) is a popular medicinal plant found in tropical or subtropical regions of the world. The fruit and juice extracts have properties that are reportedly therapeutic for diabetes, high blood pressure, and certain types of cancer (1,4). In our studies on noni juice produced from fruit collected from the Kohala and Puna districts of the island of Hawaii from 2008 to 2010, Mucor circinelloides f. sp. circinelloides was isolated from 85% of 157 juice samples and observed with up to 75% incidence on fruit surfaces during fermentation processing in glass jars. Fungal growth, appearing 14 to 21 days in storage at 22°C, was pale yellow to tan brown and was associated with wounded surfaces. Single-spore strains, KN 06-2 (2006; ripe fruit puree) and KN 08-08 (2008; fermented juice; CBS 124110), identified by Centraalbureau voor Schimmelcultures by molecular methods were 97.3% similar in internal transcribed spacer sequence to the type strain (CBS 195.68). M. circinelloides f. sp. circinelloides strains (KN 08-08, KN 09-06, or KN 10-02) (2008 to 2010; fermented juice) were inoculated by pipetting an aliquot of 100 μl of fungus strain spore suspension (1 × 10
Language	English
Publishing date	2019-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-11-10-0815
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Article ; Online: Heat-shock-induced glucose transporter 4 in the slow-twitch muscle of rats.

Wu, P-F / Luo, S-C / Chang, L-C

Physiological research

2014 Volume 64, Issue 4, Page(s) 523–530

Abstract: In this study, lipoic acid and heat shock treatments were applied to C(2)C(12) myotubes and Sprague-Dawley rats to investigate changes in the heat shock protein 70 (HSP70) and glucose transporter 4 (GLUT4) in 4 different skeletal muscle groups. The ... ...

Abstract	In this study, lipoic acid and heat shock treatments were applied to C(2)C(12) myotubes and Sprague-Dawley rats to investigate changes in the heat shock protein 70 (HSP70) and glucose transporter 4 (GLUT4) in 4 different skeletal muscle groups. The results of western blotting indicated that treatment of lipoic acid for 24 h, heat-shock and combined lipoic acid and heat-shock which all increased the level of HSP70 substantially in C(2)C(12) myotubes. However, either lipoic acid or heat-shock did not increase the level of GLUT4 in C(2)C(12) myotubes. In an in vitro migration assay, lipoic acid increased wound migration only when it was applied for 3 h. Moreover, our in vivo results revealed that lipoic acid did not increase HSP70 and GLUT4 in all 4 different skeletal muscles. Furthermore, heat-shock increased HSP70 in all 4 different muscle groups, and heat-shock treatment alone increased the GLUT4 in the soleus muscle only, suggesting that the GLUT4 increased by heat-shock was slow-twitch muscle specific. Collectively, our results indicated that heat-shock is critical factor that modulates GLUT4 and HSP70 in the skeletal muscle of rats.
MeSH term(s)	Animals ; Cell Line ; Glucose Transporter Type 4/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Response/physiology ; Male ; Muscle Fibers, Slow-Twitch/physiology ; Muscle, Skeletal/physiology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Glucose Transporter Type 4 ; HSP70 Heat-Shock Proteins ; Slc2a4 protein, rat
Language	English
Publishing date	2014-12-03
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1073141-6
ISSN	1802-9973 ; 0369-9463 ; 0862-8408
ISSN (online)	1802-9973
ISSN	0369-9463 ; 0862-8408
DOI	10.33549/physiolres.932757
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Article ; Online: Strengthening teachers' abilities to implement a vision health program in Taiwanese schools.

Chang, L C / Liao, L L / Chen, M I / Niu, Y Z / Hsieh, P L

Health education research

2017 Volume 32, Issue 5, Page(s) 437–447

Abstract: We designed a school-based, nationwide program called the 'New Era in Eye Health' to strengthen teacher training and to examine whether the existence of a government vision care policy influenced teachers' vision care knowledge and students' behavior. ... ...

Abstract	We designed a school-based, nationwide program called the 'New Era in Eye Health' to strengthen teacher training and to examine whether the existence of a government vision care policy influenced teachers' vision care knowledge and students' behavior. Baseline data and 3-month follow-up data were compared. A random sample of teachers (n = 660) from school vision health clusters in 22 cities/counties in Taiwan were invited to participate in our study and 436 agreed to participate (response rate = 66.1%). The mean age of participant teachers was 41.2 years, while the length of service mean was 14.6 years. For monitoring teacher outcomes, five cities/counties were selected as the intensely monitored group based on certain criteria. Sunlight diaries (n = 5434) were distributed and 3342 (61.5%) were returned. Teachers showed significant improvements in knowledge and behavior on the school vision health questionnaire. At the 3-month follow-up, the number of recesses as recorded by students' 'sunlight diary' increased. When teachers had better knowledge and behavior, recesses also increased. This study provided valuable insights to guide dissemination efforts for school vision health interventions and to help teachers implement research into their school vision health activities.
MeSH term(s)	Adult ; Faculty/education ; Faculty/organization & administration ; Health Promotion ; Humans ; Male ; Random Allocation ; School Health Services ; Students ; Surveys and Questionnaires ; Taiwan ; Vision Screening
Language	English
Publishing date	2017--01
Publishing country	England
Document type	Journal Article
ZDB-ID	632781-3
ISSN	1465-3648 ; 0268-1153
ISSN (online)	1465-3648
ISSN	0268-1153
DOI	10.1093/her/cyx057
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Book ; Online: Observations of thermosphere and ionosphere changes due to the dissipative 6.5-day wave in the lower thermosphere

Gan, Q. / Yue, J. / Chang, L. C. / Wang, W. B. / Zhang, S. D. / Du, J.

eISSN: 1432-0576

2018

Abstract: In the current work, temperature and wind data from the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite during the years 2002–2007 were used to describe the seasonal variations of the westward propagating 6.5-day planetary ... ...

Abstract	In the current work, temperature and wind data from the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite during the years 2002–2007 were used to describe the seasonal variations of the westward propagating 6.5-day planetary wave in the mesosphere and lower thermosphere (MLT). Thermospheric composition data from the TIMED satellite and ionospheric total electron content (TEC) from the International Global Navigation Satellite System (GNSS) Service were then employed to carry out two case studies on the effect of this dissipating wave on the thermosphere/ionosphere. In both cases, there were westward anomalies of ~ 30–40 m s −1 in zonal wind in the MLT region that were caused by momentum deposition of the 6.5-day wave, which had peak activity during equinoxes. The westward zonal wind anomalies led to extra poleward meridional flows in both hemispheres. Meanwhile, there were evident overall reductions of thermospheric column density O / N 2 ratio and ionospheric TEC with magnitudes of up to 16–24 % during these two strong 6.5-day wave events. Based on the temporal correlation between O / N 2 and TEC reductions, as well as the extra poleward meridional circulations associated with the 6.5-day waves, we conclude that the dissipative 6.5-day wave in the lower thermosphere can cause changes in the thermosphere/ionosphere via the mixing effect, similar to the quasi-two-day wave (QTDW) as predicted by Yue and Wang (2014).
Subject code	551
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
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Article ; Online: Active Volcanism Revealed from a Seismicity Conduit in the Long-resting Tatun Volcano Group of Northern Taiwan.

Pu, H C / Lin, C H / Lai, Y C / Shih, M H / Chang, L C / Lee, H F / Lee, P T / Hong, G T / Li, Y H / Chang, W Y / Lo, C H

Scientific reports

2020 Volume 10, Issue 1, Page(s) 6153

Abstract: Abundant earthquakes clustered within a particular zone often reflect an active geological feature, such as clustering seismicity along a fault zone and a huge number of volcanic-earthquakes around the erupting conduit. Herein we perform a double- ... ...

Abstract	Abundant earthquakes clustered within a particular zone often reflect an active geological feature, such as clustering seismicity along a fault zone and a huge number of volcanic-earthquakes around the erupting conduit. Herein we perform a double-difference tomographic inversion and relocate the seismicity at the long-resting Tatun volcano group (TVG) in northern Taiwan. A dramatic improvement of the earthquake location model surprisingly show that, from 2014 to 2017, two clustered seismic zones are identified in the TVG. One major group of events (>1000) persistently clustered within a ~500 m diameter vertical conduit with a ~2 km height. The clustering seismicity conduit is just located nearby Dayoukeng, one of the strongest fumaroles in the TVG, and is connected to a fracture zone characterized by low Vp/Vs in the shallow crust. The other group of events is clustered within a sphere-like zone beneath Mt. Chihsin around the depths between 0.5 km and 2 km. Both seismic zones are probably triggered by the significantly volcanic gases and fluids ascending from the deep magma reservoir. Combined with a variety of results from literature, the seismicity conduit near the strong fumarole is the evidence for an active volcano and also identifies a likely pathway for ascending magma if the TVG erupts again in the future. But possibility of developing different magma pathways at other clustered seismic zones such as beneath Mt. Chihsin may not be totally excluded.
Language	English
Publishing date	2020-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-63270-7
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Article ; Online: Outcome of excision of oral erythroplakia.

Yang, S W / Lee, Y S / Chang, L C / Hsieh, T Y / Chen, T A

The British journal of oral & maxillofacial surgery

2015 Volume 53, Issue 2, Page(s) 142–147

Abstract: Oral erythroplakia is a precancerous lesion with high malignant potential, and resection is the recommended treatment. We designed a retrospective study to analyse the outcome of treatment in patients who had operations for oral erythroplakia. A total of ...

Abstract	Oral erythroplakia is a precancerous lesion with high malignant potential, and resection is the recommended treatment. We designed a retrospective study to analyse the outcome of treatment in patients who had operations for oral erythroplakia. A total of 84 patients (74 men and 10 women, mean (SD) age 54 (12) years, range 29-83) were enrolled. Histopathologically the diagnoses were invasive carcinoma (n=3), dysplasia/carcinoma in situ (n=61), and squamous hyperplasia (n=20), and all patients were treated by carbon dioxide laser excision. There was no postoperative malignant transformation, but invasive carcinoma found after initial excision (n=3) was treated by further radical excision. The mean (SD) follow-up period was 46 (29) months (range 1-124), The postoperative recurrent rate was 14/84 (16.7%). The area of oral erythroplakia was the only factor associated with postoperative recurrence on univariate analysis, and was also the only independent factor that predicted postoperative recurrence in multivariate logistic regression analysis. An area exceeding 80 mm2 had the best predictive value (sensitivity=0.71, specificity=0.67) with a 5.1 times increased risk (odds ratio=5.1, CI 95% 1.45 to 18.05, p=0.01) of recurrence. Laser excision is effective for oral erythroplakia that is still confined to dysplasia of any degree, with low morbidity. The area of oral erythroplakia is a predictive factor for postoperative recurrence.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking ; Areca ; Carcinoma in Situ/surgery ; Erythroplasia/pathology ; Erythroplasia/surgery ; Female ; Follow-Up Studies ; Humans ; Hyperplasia ; Laser Therapy/methods ; Lasers, Gas/therapeutic use ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/pathology ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Smoking ; Treatment Outcome
Language	English
Publishing date	2015-02
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2014.10.016
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