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Article ; Online: Sandwich-structured electrospun pH-responsive dental pastes for anti-caries

Lang, Yuna / Wang, Baolin / Chang, Ming-Wei / Sun, Renyuan / Zhang, Longfei

Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023 July, v. 668 p.131399-

2023

Abstract: Dental caries is the most common chronic infectious disease in the human oral cavity and current anti-caries drugs may cause drug resistance and microecological imbalance. In this study, a sandwich-structured electrospun pH-responsive dental paste was ... ...

Abstract	Dental caries is the most common chronic infectious disease in the human oral cavity and current anti-caries drugs may cause drug resistance and microecological imbalance. In this study, a sandwich-structured electrospun pH-responsive dental paste was engineered via the layer-by-layer electrospinning technique. The top and bottom layers of the dental paste were pH-sensitive layers prepared with Methylmethacrylate polymers IV (E100), and the middle layer was the polylactic acid (PLA) membrane loading with sodium fluorides (NaF). Herein, the surface morphology, chemical as well as physical properties, drug release behaviors, biocompatibility and antibacterial properties of the dental paste were investigated. It was found that the sandwich liked structure enhanced the mechanical properties of the dental paste. The drug release curves of NaF-loaded dental pastes showed that NaF released rapidly and massively in the simulated oral fluid with a risk of dental caries. While in the simulated healthy oral fluid, NaF released slowly and in small amounts. And the dental paste maintained excellent hydrophobic, biocompatibility and antibacterial properties against Streptococcus mutans. Therefore, this sandwich-structured dental paste could respond to pH environment and achieve anti-caries smartly, indicating clinical potential in caries prevention.
Keywords	Streptococcus mutans ; biocompatibility ; dental caries ; drug resistance ; drugs ; humans ; hydrophobicity ; infectious diseases ; methylmethacrylate ; mouth ; pH ; polylactic acid ; risk ; sodium ; Electrospinning ; Dental pastes ; PH responsive ; Sandwich structure
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2023.131399
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma.

Chang, Jui-Jen / Wang, Yi-Chen / Yang, Shu-Hui / Wu, Ju-Yu / Chang, Ming-Wei / Wang, Hui-Min David

International journal of nanomedicine

2024 Volume 19, Page(s) 2395–2407

Abstract: Background: Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin ... ...

Abstract	Background: Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer. Methods: Astaxanthin was selected as an anticancer drug due to our previous research finding that astaxanthin has extremely high antioxidant, anti-ultraviolet damage, and anti-tumor properties. The manufacturing method of the astaxanthin nanovesicle carrier is to mix melanoma cells and astaxanthin in an appropriate ratio and then remove the genetic material and inflammatory factors of cancer cells by extrusion. Results: In terms of results, after the co-culture of astaxanthin nanovesicles and melanoma cancer cells, it was confirmed that the ability of astaxanthin nanovesicles to inhibit the growth and metastasis of melanoma cancer cells was significantly better than the same amount of astaxanthin alone, and it had no effect on normal Human cells are also effective. There was no apparent harm on normal cells, indicating the ability of the vesicles to be selectively transported. Conclusion: Our findings illustrated the potential of astaxanthin nanovesicles as an anticancer drug.
MeSH term(s)	Humans ; Melanoma/drug therapy ; Antineoplastic Agents/pharmacology ; Cell Membrane ; Nanoparticles ; Xanthophylls
Chemical Substances	astaxanthine (8XPW32PR7I) ; Antineoplastic Agents ; Xanthophylls
Language	English
Publishing date	2024-03-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S439476
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Article ; Online: Leveraging Oriented Lateral Walls of Nerve Guidance Conduit with Core-Shell MWCNTs Fibers for Peripheral Nerve Regeneration.

Sun, Renyuan / Lang, Yuna / Chang, Ming-Wei / Zhao, Mingkang / Li, Chao / Liu, Shiheng / Wang, Baolin

Advanced healthcare materials

2024 , Page(s) e2303867

Abstract: Peripheral nerve regeneration and functional recovery rely on the chemical, physical, and structural properties of nerve guidance conduits (NGCs). However, the limited support for long-distance nerve regeneration and axonal guidance has hindered the ... ...

Abstract	Peripheral nerve regeneration and functional recovery rely on the chemical, physical, and structural properties of nerve guidance conduits (NGCs). However, the limited support for long-distance nerve regeneration and axonal guidance has hindered the widespread use of NGCs. This study introduces a novel nerve guidance conduit with oriented lateral walls, incorporating multi-walled carbon nanotubes (MWCNTs) within core-shell fibers prepared in a single step using a modified electrohydrodynamic (EHD) printing technique to promote peripheral nerve regeneration. The structured conduit demonstrated exceptional stability, mechanical properties, and biocompatibility, significantly enhancing the functionality of NGCs. In vitro cell studies revealed that RSC96 cells adhered and proliferated effectively along the oriented fibers, demonstrating a favorable response to the distinctive architectures and properties. Subsequently, a rat sciatic nerve injury model demonstrated effective efficacy in promoting peripheral nerve regeneration and functional recovery. Tissue analysis and functional testing highlighted the significant impact of MWCNT concentration in enhancing peripheral nerve regeneration and confirming well-matured aligned axonal growth, muscle recovery, and higher densities of myelinated axons. These findings demonstrate the potential of oriented lateral architectures with coaxial MWCNT fibers as a promising approach to support long-distance regeneration and encourage directional nerve growth for peripheral nerve repair in clinical applications.
Language	English
Publishing date	2024-01-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202303867
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Article ; Online: Recent advances towards overcoming the blood-brain barrier.

Ali, Amna / Sohail Arshad, Muhammad / Ahmad Khan, Mahtab / Chang, Ming-Wei / Ahmad, Zeeshan

Drug discovery today

2023 Volume 28, Issue 10, Page(s) 103735

Abstract: The blood-brain barrier (BBB) is a protective element of the neurovascular unit (NVU) surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex, which play a fundamental role in brain homeostasis. Due to its impeccable ... ...

Abstract	The blood-brain barrier (BBB) is a protective element of the neurovascular unit (NVU) surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex, which play a fundamental role in brain homeostasis. Due to its impeccable structural architecture, the BBB is referred to as the brain's gatekeeper, a near-impenetrable barrier to therapeutics. This review summarises the significant strides that have been made in the last 5 years towards circumventing the BBB and developing efficient drug delivery systems. Challenges associated with several CNS disorders related to BBB failure and exploitation of this unique NVU component for targeted treatment of brain-related disorders are also discussed.
MeSH term(s)	Humans ; Blood-Brain Barrier ; Brain ; Brain Diseases ; Astrocytes ; Biological Transport
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2023.103735
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Article: Influence of Critical Parameters on Cytotoxicity Induced by Mesoporous Silica Nanoparticles.

Ahmadi, Amirsadra / Sokunbi, Moses / Patel, Trisha / Chang, Ming-Wei / Ahmad, Zeeshan / Singh, Neenu

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed ... ...

Abstract	Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal-Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn's procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12122016
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Article: High Precision 3D Printing for Micro to Nano Scale Biomedical and Electronic Devices.

Muldoon, Kirsty / Song, Yanhua / Ahmad, Zeeshan / Chen, Xing / Chang, Ming-Wei

Micromachines

2022 Volume 13, Issue 4

Abstract: Three dimensional printing (3DP), or additive manufacturing, is an exponentially growing process in the fabrication of various technologies with applications in sectors such as electronics, biomedical, pharmaceutical and tissue engineering. Micro and ... ...

Abstract	Three dimensional printing (3DP), or additive manufacturing, is an exponentially growing process in the fabrication of various technologies with applications in sectors such as electronics, biomedical, pharmaceutical and tissue engineering. Micro and nano scale printing is encouraging the innovation of the aforementioned sectors, due to the ability to control design, material and chemical properties at a highly precise level, which is advantageous in creating a high surface area to volume ratio and altering the overall products' mechanical and physical properties. In this review, micro/-nano printing technology, mainly related to lithography, inkjet and electrohydrodynamic (EHD) printing and their biomedical and electronic applications will be discussed. The current limitations to micro/-nano printing methods will be examined, covering the difficulty in achieving controlled structures at the miniscule micro and nano scale required for specific applications.
Language	English
Publishing date	2022-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13040642
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Book ; Online: ASQA

Stelmakh, Ivan / Luan, Yi / Dhingra, Bhuwan / Chang, Ming-Wei

Factoid Questions Meet Long-Form Answers

2022

Abstract: An abundance of datasets and availability of reliable evaluation metrics have resulted in strong progress in factoid question answering (QA). This progress, however, does not easily transfer to the task of long-form QA, where the goal is to answer ... ...

Abstract	An abundance of datasets and availability of reliable evaluation metrics have resulted in strong progress in factoid question answering (QA). This progress, however, does not easily transfer to the task of long-form QA, where the goal is to answer questions that require in-depth explanations. The hurdles include (i) a lack of high-quality data, and (ii) the absence of a well-defined notion of the answer's quality. In this work, we address these problems by (i) releasing a novel dataset and a task that we call ASQA (Answer Summaries for Questions which are Ambiguous); and (ii) proposing a reliable metric for measuring performance on ASQA. Our task focuses on factoid questions that are ambiguous, that is, have different correct answers depending on interpretation. Answers to ambiguous questions should synthesize factual information from multiple sources into a long-form summary that resolves the ambiguity. In contrast to existing long-form QA tasks (such as ELI5), ASQA admits a clear notion of correctness: a user faced with a good summary should be able to answer different interpretations of the original ambiguous question. We use this notion of correctness to define an automated metric of performance for ASQA. Our analysis demonstrates an agreement between this metric and human judgments, and reveals a considerable gap between human performance and strong baselines. Comment: A minor bug in computing the ROUGE score was fixed. The fix did not result in any changes in observations and conclusions
Keywords	Computer Science - Computation and Language
Subject code	400
Publishing date	2022-04-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: QUEST

Malaviya, Chaitanya / Shaw, Peter / Chang, Ming-Wei / Lee, Kenton / Toutanova, Kristina

A Retrieval Dataset of Entity-Seeking Queries with Implicit Set Operations

2023

Abstract: Formulating selective information needs results in queries that implicitly specify set operations, such as intersection, union, and difference. For instance, one might search for "shorebirds that are not sandpipers" or "science-fiction films shot in ... ...

Abstract	Formulating selective information needs results in queries that implicitly specify set operations, such as intersection, union, and difference. For instance, one might search for "shorebirds that are not sandpipers" or "science-fiction films shot in England". To study the ability of retrieval systems to meet such information needs, we construct QUEST, a dataset of 3357 natural language queries with implicit set operations, that map to a set of entities corresponding to Wikipedia documents. The dataset challenges models to match multiple constraints mentioned in queries with corresponding evidence in documents and correctly perform various set operations. The dataset is constructed semi-automatically using Wikipedia category names. Queries are automatically composed from individual categories, then paraphrased and further validated for naturalness and fluency by crowdworkers. Crowdworkers also assess the relevance of entities based on their documents and highlight attribution of query constraints to spans of document text. We analyze several modern retrieval systems, finding that they often struggle on such queries. Queries involving negation and conjunction are particularly challenging and systems are further challenged with combinations of these operations. Comment: ACL 2023; Dataset available at https://github.com/google-research/language/tree/master/language/quest
Keywords	Computer Science - Computation and Language
Subject code	005
Publishing date	2023-05-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Microparticle Formation via Tri-needle Coaxial Electrospray at Stable Jetting Modes

Yao, Zhi-Cheng / Zhang, Chunchen / Ahmad, Zeeshan / Peng, Yu / Chang, Ming-Wei

Industrial & engineering chemistry process design and development. 2020 July 20, v. 59, no. 32

2020

Abstract: Multilayered structured organic particles have had an extensive impact on a wide array of biomedical applications not limited to drug delivery, imaging, and biosensing. A tri-needle coaxial electrospraying system was utilized to engineer multilayered ... ...

Abstract	Multilayered structured organic particles have had an extensive impact on a wide array of biomedical applications not limited to drug delivery, imaging, and biosensing. A tri-needle coaxial electrospraying system was utilized to engineer multilayered polymeric particles in a one-step, facile process at ambient temperatures. The effect of the dominant processing parameters on the development of a conical cusp that eventually ejects an ultrathin liquid ligament was first explored here. Subsequently, the validation of the intermediate solutions that possessed different conductivities on stabilizing jetting modes and the resulting particle morphology was also investigated. Polycaprolactone (PCL) solutions with different molecular weights were selected as the outer layer using fluids with various conductivities. Five different formulations were studied as the intermediate layers: PCL in acetic acid, ethyl cellulose in acetic acid, ethyl cellulose in dichloromethane, ethyl cellulose in ethanol, and silicone oil and polyvinyl pyrrolidone in water. The results systematically demonstrated that the processing parameters (type of polymer, polymer molecular weight, solution concentration, flow rate, applied voltage, and collector distance) play a significant role in the formation of the stable Taylor cone. This study further identified that the coaxial arrangement of three needles successfully produced multilayered microspheres with uniform size distribution.
Keywords	acetic acid ; electric potential difference ; electrospraying ; ethanol ; ethyl cellulose ; ligaments ; liquids ; methylene chloride ; microparticles ; molecular weight ; oils ; polyvinylpyrrolidone ; process design ; silicone
Language	English
Dates of publication	2020-0720
Size	p. 14423-14432.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.0c02677
Database	NAL-Catalogue (AGRICOLA)

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Article: Optimization conversion of chitosan from Ganoderma lucidum spore powder using ultrasound‐assisted deacetylation: Influence of processing parameters

Zhu, Li‐Fang / Chen, Xing / Wu, Zijing / Wang, Guangkun / Ahmad, Zeeshan / Chang, Ming‐Wei

Journal of food processing and preservation. 2020 Jan., v. 44, no. 1

2020

Abstract: Chitosan is an extremely valuable polysaccharide and usually obtained from crustacean byproduct. In this work, a new non‐animal source chitosan is obtained from fungal precursors (Ganoderma lucidum spore powders, GLSP) using ultrasound‐assisted ... ...

Abstract	Chitosan is an extremely valuable polysaccharide and usually obtained from crustacean byproduct. In this work, a new non‐animal source chitosan is obtained from fungal precursors (Ganoderma lucidum spore powders, GLSP) using ultrasound‐assisted deacetylation (USAD), and the effects of processing parameters (irradiation time, solid‐to‐liquid ratio, NaOH concentration, and irradiation power) on the DD (degree of deacetylation) of chitosan were investigated. The highest DD value was obtained at irradiation parameters of 20 min, 10% (g:ml) NaOH, 1:25 (g:ml), and 80 W. In addition, the difference in surface morphology, chemical groups, thermal stability, and crystallinity of the resulting chitosan with the treatment of various irradiation times was examined using the SEM, FTIR, TG, and XRD. The results show a new promising herbal source of edible chitosan and the potential material for biomedical applications. PRACTICAL APPLICATIONS: The chitosan obtained from Ganoderma lucidum spore powders (GLSP) possessed many priorities over the chitosan from shells of crustaceans, which involves a multi‐faceted procedure with several economical and consumer related aspects. In the current work, chitosan is obtained from an herbal source GLSP using ultrasound treatment and the effect of processing parameters on chitosan was investigated. The findings show the development of chitosan from an herbal source with potential in functional food applications.
Keywords	Crustacea ; Fourier transform infrared spectroscopy ; Ganoderma lucidum ; X-ray diffraction ; byproducts ; chitosan ; crystal structure ; functional foods ; fungi ; irradiation ; powders ; scanning electron microscopy ; sodium hydroxide ; spores ; thermal stability ; thermogravimetry ; ultrasonic treatment
Language	English
Dates of publication	2020-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.14297
Database	NAL-Catalogue (AGRICOLA)

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