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Article ; Online: Polygonum barbatum extract reduces colorectal cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition via YAP and β-catenin pathway regulation.

Chang, Pi-Kai / Yen, I-Chuan / Tsai, Wei-Cheng / Lee, Shih-Yu

2023 Volume 13, Issue 1, Page(s) 18368

Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide with novel therapeutic developmental challenges. Polygonum barbatum has anticancer potential, but its mechanism(s) are unclear. This study investigates the inhibitory effect of P. barbatum ...

Abstract	Colorectal cancer (CRC) is the third most common cancer worldwide with novel therapeutic developmental challenges. Polygonum barbatum has anticancer potential, but its mechanism(s) are unclear. This study investigates the inhibitory effect of P. barbatum on human CRC cells. Polygonum barbatum extract (PBE) and quercetin standard HPLC fingerprints were determined using analytical RP-HPLC and evaluations were completed using the human colon cancer cell line HCT-116 (KRAS
MeSH term(s)	Humans ; beta Catenin/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Polygonum ; Plant Extracts/pharmacology
Chemical Substances	beta Catenin ; Plant Extracts
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45630-1
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Article ; Online: Proteinuria as a Nascent Predictor of Frailty Among People With Metabolic Syndrome: A Retrospective Observational Study.

Chang, Pi-Kai / Chao, Yuan-Ping / Wu, Li-Wei

Frontiers in public health

2022 Volume 10, Page(s) 847533

Abstract: Frailty is a commonly occurring geriatric condition that increases the risk of adverse health outcomes. The factors and predictors behind frailty are not yet well understood. A better understanding of these factors can enable prevention of frailty in ... ...

Abstract	Frailty is a commonly occurring geriatric condition that increases the risk of adverse health outcomes. The factors and predictors behind frailty are not yet well understood. A better understanding of these factors can enable prevention of frailty in elderly patients. The objective of this study was to determine the association between proteinuria and frailty in US individuals with metabolic syndrome (MetS). Data from the National Health and Nutrition Examination Survey III (NHANES III, 1988-1994) conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention. This is a cross-sectional study, and proteinuria and frailty were measured only once at enrollment. The study included 2,272 participants with MetS aged 40-90 years from the NHANES III. The participants underwent assessments to evaluate frailty and frailty components (low body weight, weakness, exhaustion, low physical activity, and slow walking). Proteinuria was represented as albumin-to-creatinine ratio (ACR) (mg/g) and divided into tertiles: T1-normal range (ACR <30 mg/g), T2-microalbuminuria (ACR 30-299 mg/g), and T3-macroalbuminuria (ACR ≥ 300 mg/g). We applied multiple logistic regression to determine the odds ratios (ORs) of frailty for T2 vs. T1 and T3 vs. T1 in both sexes. In the adjusted analysis for male participants, the ORs of frailty for T2 and T3 vs. T1 were 3.106 (95% confidence interval [CI] = 1.078-8.948,
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/epidemiology ; Humans ; Male ; Metabolic Syndrome/epidemiology ; Middle Aged ; Nutrition Surveys ; Proteinuria/epidemiology
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.847533
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Article ; Online: Dopamine transporter is downregulated and its association with chaperone protein Hsc70 is enhanced by activation of dopamine D

Chang, Pi-Kai / Chien, Kun-Yi / Chen, Jin-Chung

Brain research bulletin

2020 Volume 165, Page(s) 263–271

Abstract: Synaptic dopamine (DA) concentrations are largely determined by the activities of presynaptic ... ...

Abstract	Synaptic dopamine (DA) concentrations are largely determined by the activities of presynaptic D
MeSH term(s)	Animals ; Dopamine Agonists/pharmacology ; Dopamine Plasma Membrane Transport Proteins/genetics ; Dopamine Plasma Membrane Transport Proteins/metabolism ; HEK293 Cells ; HSC70 Heat-Shock Proteins/genetics ; HSC70 Heat-Shock Proteins/metabolism ; Humans ; Indoles/pharmacology ; Mice ; Neurons/drug effects ; Neurons/metabolism ; Phosphorylation/drug effects ; Prosencephalon/drug effects ; Prosencephalon/metabolism ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/metabolism ; Synaptosomes/drug effects ; Synaptosomes/metabolism
Chemical Substances	Dopamine Agonists ; Dopamine Plasma Membrane Transport Proteins ; HSC70 Heat-Shock Proteins ; Indoles ; Receptors, Dopamine D3 ; ropinirole (030PYR8953)
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2020.10.005
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Article ; Online: Synaptic loss and progression in mice infected with Angiostrongylus cantonensis in the early stage.

Jhan, Kai-Yuan / Chang, Pi-Kai / Cheng, Chien-Ju / Jung, Shih-Ming / Wang, Lian-Chen

Journal of neuroinflammation

2022 Volume 19, Issue 1, Page(s) 85

Abstract: Background: Angiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal outcomes in severe cases. In ...

Abstract	Background: Angiostrongylus cantonensis is also known as rat lungworm. Infection with this parasite is a zoonosis that can cause eosinophilic meningitis and/or eosinophilic meningoencephalitis in humans and may lead to fatal outcomes in severe cases. In this study, we explored the mechanisms of the impairments in the cognitive functions of mice infected with A. cantonensis. Methods: In infected mice with different infective intensities at different timepoint postinfection, loss and recovery of cognitive functions such as learning and memory abilities were determined. Neuronal death and damage to synaptic structures were analyzed by Western blotting and IHC in infected mice with different infection intensities at different timepoint postinfection. Results: The results of behavioral tests, pathological examinations, and Golgi staining showed that nerve damage caused by infection in mice occurred earlier than pathological changes of the brain. BDNF was expressed on 14 day post-infection. Cleaved caspase-3 increased significantly in the late stage of infection. However, IHC on NeuN indicated that no significant changes in the number of neurons were found between the infected and uninfected groups. Conclusions: The synaptic loss caused by the infection of A. cantonensis provides a possible explanation for the impairment of cognitive functions in mice. The loss of cognitive functions may occur before severe immunological and pathological changes in the infected host.
MeSH term(s)	Angiostrongylus cantonensis ; Animals ; Brain/pathology ; Disease Models, Animal ; Meningitis ; Mice ; Rats ; Strongylida Infections
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-022-02436-8
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Article ; Online: Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex.

Chu, Po-Chun / Huang, Chen-Syuan / Chang, Pi-Kai / Chen, Rou-Shayn / Chen, Ko-Ting / Hsieh, Tsung-Hsun / Liu, Hao-Li

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Transcranial focused ultrasound (tFUS) is a novel neuromodulating technique. It has been demonstrated that the neuromodulatory effects can be induced by weak ultrasound exposure levels (spatial-peak temporal average intensity, ... ...

Abstract	Transcranial focused ultrasound (tFUS) is a novel neuromodulating technique. It has been demonstrated that the neuromodulatory effects can be induced by weak ultrasound exposure levels (spatial-peak temporal average intensity, I
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Motor Cortex/diagnostic imaging ; Motor Cortex/physiology ; Ultrasonography ; Transcranial Magnetic Stimulation ; GABAergic Neurons ; Evoked Potentials, Motor
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032578
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Article ; Online: Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study.

Li, Yen-Wei / Kao, Tung-Wei / Chang, Pi-Kai / Chen, Wei-Liang / Wu, Li-Wei

Scientific reports

2021 Volume 11, Issue 1, Page(s) 9900

Abstract: Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) ...

Abstract	Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medical inspection at Tri-Service General Hospital (TSGH) in Taiwan, had been enrolled in this study. Atherogenic index of plasma (AIP) was a logarithmically transformed ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C). Through multivariate regression analyses, the hazard ratio (HR) of AIP for MetS, hypertension and T2DM were illustrated. AIP revealed significant association with all the aforementioned diseases through the entire three models for both genders. Additionally, AIP revealed significant correlation which remained still after fully adjustment in MetS, hypertension, and T2DM groups for subjects aged 40-64-year-old. Nevertheless, for participants aged above 65-year-old, AIP only demonstrated significant association in MetS group. Our results explore the promising value of AIP to determine the high-risk subjects, especially meddle-aged ones, having MetS, hypertension, and T2DM in the present and the future.
MeSH term(s)	Adult ; Age Factors ; Aged ; Atherosclerosis/blood ; Atherosclerosis/complications ; Atherosclerosis/diagnosis ; Cholesterol, HDL/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Female ; Humans ; Hypertension/blood ; Hypertension/epidemiology ; Hypertension/etiology ; Lipoproteins, HDL/blood ; Longitudinal Studies ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Middle Aged ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors ; Taiwan/epidemiology ; Triglycerides/blood
Chemical Substances	Cholesterol, HDL ; HDL-triglyceride ; Lipoproteins, HDL ; Triglycerides
Language	English
Publishing date	2021-05-10
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89307-z
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Article ; Online: Mid-arm muscle circumference: A significant factor of all-cause and cancer mortalities in individuals with elevated platelet-to-lymphocyte ratio.

Chang, Pi-Kai / Chen, Wei-Liang / Wu, Li-Wei

PloS one

2018 Volume 13, Issue 12, Page(s) e0208750

Abstract: Platelet-to-lymphocyte ratio (PLR) is an inflammatory maker, and high PLR is associated with mortality in several diseases. The predictors of mortality in individuals with high PLR is still lacking. Our aims were to assess if mid-arm muscle circumference ...

Abstract	Platelet-to-lymphocyte ratio (PLR) is an inflammatory maker, and high PLR is associated with mortality in several diseases. The predictors of mortality in individuals with high PLR is still lacking. Our aims were to assess if mid-arm muscle circumference (MAMC) can predict all-cause mortality, cancer mortality, and cardiovascular mortality in individuals with high PLR. Adult participants from the National Health and Nutrition Examination Survey III (1988-1994) were included. All participants were divided into low PLR and high PLR groups with the cut-off point being the median PLR level, and each group was evaluated for risk factors of mortality. MAMC was divided into tertiles and the general characteristics of the study population related to MAMC were evaluated. The study included 14,221 adults with 6,701 (47.1%) male and 7,520 (52.9%) female participants. The median PLR ratio was 122. Higher levels of systolic blood pressure, total triglycerides, total cholesterol, low-density lipoprotein, C-reactive protein, uric acid, and glucose, as well as a higher age, were associated with increased risk of mortality in both groups. After adjusting for all the covariates, in the higher PLR group, the highest MAMC tertile was significantly associated with lower hazard ratios for all-cause and cancer mortalities compared with the lowest MAMC tertile. However, this association was not observed in the low PLR group. The highest MAMC tertile showed protective effects from all-cause and cancer mortalities compared with the lowest MAMC tertile in individuals with PLR ≥ 122. In conclusion, the highest MAMC tertile was significantly associated with decreasing HRs for all-cause and cancer mortalities compared with the lowest MAMC tertile in individuals with elevated PLR.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arm/pathology ; Blood Cell Count ; Blood Platelets ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/pathology ; Female ; Follow-Up Studies ; Humans ; Lymphocytes ; Male ; Middle Aged ; Mortality ; Muscle, Skeletal/pathology ; Neoplasms/blood ; Neoplasms/mortality ; Neoplasms/pathology ; Nutrition Surveys ; Organ Size ; Young Adult
Language	English
Publishing date	2018-12-13
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0208750
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Article ; Online: Dopamine D3 receptor blockade rescues hyper-dopamine activity-induced deficit in novel object recognition memory.

Chang, Pi-Kai / Yu, Lung / Chen, Jin-Chung

Neuropharmacology

2018 Volume 133, Page(s) 216–223

Abstract: Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain ... ...

Abstract	Patients afflicted with bipolar disorder demonstrate significant impairments in recognition and episodic memory during acute depressive and manic episodes. These impairments and the related pathophysiology may result from over-activation of the brain dopamine (DA) system. In order to model overactive DA transmission in a well-established novel object recognition (NOR) memory test, we used DA transporter knockdown (DAT-KD) mice, which exhibit reduced DAT expression and display hyper-dopaminergic phenotypes. DAT-KD mice exhibited impaired NOR memory compared to wild-type (WT) mice. This impairment was prevented by administration of FAUC365, a DA D
MeSH term(s)	Analysis of Variance ; Animals ; Disease Models, Animal ; Dopamine/metabolism ; Dopamine Antagonists/therapeutic use ; Dopamine Plasma Membrane Transport Proteins/deficiency ; Dopamine Plasma Membrane Transport Proteins/genetics ; Indoles/therapeutic use ; Maze Learning/drug effects ; Memory Disorders/drug therapy ; Memory Disorders/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Piperazines/therapeutic use ; Piperidines/therapeutic use ; Receptors, Dopamine D3/deficiency ; Receptors, Dopamine D3/genetics ; Recognition (Psychology)/drug effects ; Thiophenes/therapeutic use
Chemical Substances	(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate) ; Dopamine Antagonists ; Dopamine Plasma Membrane Transport Proteins ; FAUC 365 ; Indoles ; Piperazines ; Piperidines ; Receptors, Dopamine D3 ; Thiophenes ; 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole (81226-60-0) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2018-02-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2018.01.046
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Ui I Zs.242: Show issues

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Article ; Online: Evaluation of safety and early efficacy of AAV gene therapy in mouse models of vanishing white matter disease.

Herstine, Jessica A / Chang, Pi-Kai / Chornyy, Sergiy / Stevenson, Tamara J / Sunshine, Alex C / Nokhrina, Ksenia / Rediger, Jessica / Wentz, Julia / Vetter, Tatyana A / Scholl, Erika / Holaway, Caleb / Pyne, Nettie K / Bratasz, Anna / Yeoh, Stewart / Flanigan, Kevin M / Bonkowsky, Joshua L / Bradbury, Allison M

Molecular therapy : the journal of the American Society of Gene Therapy

2024

Abstract: Leukoencephalopathy with vanishing white matter (VWM) is a progressive incurable white matter disease that most commonly occurs in childhood and presents with ataxia, spasticity, neurological degeneration, seizures, and premature death. A distinctive ... ...

Abstract	Leukoencephalopathy with vanishing white matter (VWM) is a progressive incurable white matter disease that most commonly occurs in childhood and presents with ataxia, spasticity, neurological degeneration, seizures, and premature death. A distinctive feature is episodes of rapid neurological deterioration provoked by stressors such as infection, seizures, or trauma. VWM is caused by autosomal recessive mutations in one of five genes that encode the eukaryotic initiation factor 2B complex, which is necessary for protein translation and regulation of the integrated stress response. The majority of mutations are in EIF2B5. Astrocytic dysfunction is central to pathophysiology, thereby constituting a potential therapeutic target. Herein we characterize two VWM murine models and investigate astrocyte-targeted adeno-associated virus serotype 9 (AAV9)-mediated EIF2B5 gene supplementation therapy as a therapeutic option for VWM. Our results demonstrate significant rescue in body weight, motor function, gait normalization, life extension, and finally, evidence that gene supplementation attenuates demyelination. Last, the greatest rescue results from a vector using a modified glial fibrillary acidic protein (GFAP) promoter-AAV9-gfaABC(1)D-EIF2B5-thereby supporting that astrocytic targeting is critical for disease correction. In conclusion, we demonstrate safety and early efficacy through treatment with a translatable astrocyte-targeted gene supplementation therapy for a disease that has no cure.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2024.03.034
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Zs.A 5640: Show issues

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Article: Susceptibility to Colorectal Cancer Based on HSD17B4 rs721673 and rs721675 Polymorphisms and Alcohol Intake among Taiwan Biobank Participants: A Retrospective Case Control Study Using the Nationwide Claims Data.

Lin, Tzu-Chiao / Chuang, Min-Hua / Hsiung, Chia-Ni / Chang, Pi-Kai / Sun, Chien-An / Yang, Tsan / Chou, Yu-Ching / Hu, Je-Ming / Hsu, Chih-Hsiung

Journal of personalized medicine

2023 Volume 13, Issue 4

Abstract: Colorectal cancer (CRC) is a major public health issue, and there are limited studies on the association between 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) polymorphism and CRC. We used two national databases from Taiwan to examine whether HSD17B4 ...

Abstract	Colorectal cancer (CRC) is a major public health issue, and there are limited studies on the association between 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) polymorphism and CRC. We used two national databases from Taiwan to examine whether HSD17B4 rs721673, rs721675, and alcohol intake were independently and interactively correlated with CRC development. We linked the Taiwan Biobank (TWB) participants' health and lifestyle information and genotypic data from 2012 to 2018 to the National Health Insurance Database (NHIRD) to confirm their medical records. We performed a genome-wide association study (GWAS) using data from 145 new incident CRC cases and matched 1316 healthy, non-CRC individuals. We calculated the odds ratios (OR) and 95% confidence intervals (CI) for CRC based on multiple logistic regression analyses.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13040576
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