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Article: Special issue: Taiwan model against COVID-19.

Chang, Shan-Chwen / Fang, Chi-Tai

Journal of the Formosan Medical Association = Taiwan yi zhi

2024 Volume 123 Suppl 1, Page(s) S1

MeSH term(s)	Humans ; COVID-19 ; Taiwan/epidemiology ; SARS-CoV-2
Language	English
Publishing date	2024-01-03
Publishing country	Singapore
Document type	Editorial
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2024.01.002
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Article: Response to comments on "Serological response and safety of heterologous ChAdOx1-nCoV-19/mRNA-1273 prime-boost vaccination".

Sheng, Wang-Huei / Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2022 Volume 122, Issue 1, Page(s) 83

MeSH term(s)	Humans ; 2019-nCoV Vaccine mRNA-1273
Chemical Substances	2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
Language	English
Publishing date	2022-09-15
Publishing country	Singapore
Document type	Letter ; Comment
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2022.09.002
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Article: Achievements of COVID-19 vaccination programs: Taiwanese perspective.

Sheng, Wang-Huei / Hsieh, Szu-Min / Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 123 Suppl 1, Page(s) S70–S76

Abstract: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health crisis. The specific characteristics of aerosol transmission in the latent period and the contagiousness of SARS-CoV-2 ... ...

Abstract	The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health crisis. The specific characteristics of aerosol transmission in the latent period and the contagiousness of SARS-CoV-2 lead to rapid spread of infection in the community. Vaccination is the most effective method for preventing infection and severe outcomes. As of December 1, 2022, 88% of the Taiwanese population had received at least two doses of COVID-19 vaccines. Heterologous vaccination with ChAdOx1-mRNA-based or ChAdOx1-protein-based vaccines has been found to elicit higher immunogenicity than homologous vaccination with ChAdOx1-ChAdOx1 vaccines. A longitudinal cohort study revealed that 8-12-week intervals between the two heterologous vaccine doses of the primary series led to good immunogenicity and that the vaccines were safe. A third booster dose of mRNA vaccine is being encouraged to evoke effective immune responses against variants of concern. A novel domestic recombinant protein subunit vaccine (MVC-COV1901) was manufactured and authorized for emergency use in Taiwan. It has shown a good safety profile, with promising neutralizing antibody titers against SARS-CoV-2. Given the global pandemic due to emerging novel variants of SARS-CoV-2, booster COVID-19 vaccines and appropriate intervals between booster doses need to be investigated.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines ; SARS-CoV-2/genetics ; Longitudinal Studies ; Vaccination ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral
Language	English
Publishing date	2023-04-27
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.04.017
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Article: Antiviral therapy of coronavirus disease 2019 (COVID-19).

Chen, Pao-Yu / Wang, Jann-Tay / Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 123 Suppl 1, Page(s) S47–S54

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has reached a turning point. The non-pharmaceutical interventions for preventing COVID-19 are lifting. Vaccination uptake is increasing in general, but this strategy is continuously challenged by the rapid ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has reached a turning point. The non-pharmaceutical interventions for preventing COVID-19 are lifting. Vaccination uptake is increasing in general, but this strategy is continuously challenged by the rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of note, the Omicron subvariants spread globally for at least one year, and the most recently developed subvariants show strong immune evasion to preexisting immunity, either from previous infection, vaccination or both. Therefore, early and appropriate antiviral agents to treat patients at risk for severe COVID-19 or death is crucial to decrease morbidities and mortalities, to restore the healthcare capacities and to facilitate a return to the new normal. Current antiviral therapy for COVID-19 consist of neutralizing monoclonal antibodies (mAbs) and direct antiviral agents. Each agent has been proved for early ambulatory treatment of COIVD-19, but suffer from variable effectiveness and limitations due to patients' comorbidities, drug properties, or antiviral resistance. Besides, some specific mAbs are indicated for prophylaxis of COVID-19 before or after close contact with confirmed COVID-19 patients. This review article summarizes the evidence and unmet needs of the currently available antiviral agents for management of COVID-19 in the context of the Omicron subvariants.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Antibodies, Monoclonal ; Drug Resistance, Viral ; Antiviral Agents/therapeutic use
Chemical Substances	Antibodies, Monoclonal ; Antiviral Agents
Language	English
Publishing date	2023-09-02
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.08.029
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Article: Correlation of adverse effects and antibody responses following homologous and heterologous COVID-19 prime-boost vaccinations.

Cheng, Aristine / Sheng, Wang-Huei / Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 122, Issue 5, Page(s) 434–435

MeSH term(s)	Humans ; Antibody Formation ; COVID-19/prevention & control ; Vaccination/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Iatrogenic Disease ; Antibodies, Viral
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-01-03
Publishing country	Singapore
Document type	Letter ; Comment
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2022.12.020
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Article ; Online: Excess mortality and long-term disability from healthcare-associated carbapenem-resistant Acinetobacter baumannii infections: A nationwide population-based matched cohort study.

Su, Chiu-Hsia / Chien, Li-Jung / Fang, Chi-Tai / Chang, Shan-Chwen

PloS one

2023 Volume 18, Issue 9, Page(s) e0291059

Abstract: Background: Carbapenem resistance is perceived as a clinical challenge in the management of debilitated and immunocompromised patients who eventually will die from underlying diseases. We aimed to examine whether carbapenem resistance per se, rather ... ...

Abstract	Background: Carbapenem resistance is perceived as a clinical challenge in the management of debilitated and immunocompromised patients who eventually will die from underlying diseases. We aimed to examine whether carbapenem resistance per se, rather than the underlying diseases, negatively affect outcomes, by comparing the excess mortality and morbidity from healthcare-associated infections (HAIs) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-susceptible A. baumannii (CSAB). Methods: This was a nationwide retrospective matched cohort study of hospitalized patients in 96 hospitals which participated in Taiwan Nosocomial Infection Surveillance (TNIS). A total of 2,213 patients with A. baumannii HAIs were individually matched to 4,426 patients without HAIs. Main outcomes were excess risks for one-year all-cause mortality and one-year new-onset chronic ventilator dependence or dialysis-dependent end-stage renal disease. Results: Excess one-year mortality was 27.2% in CRAB patients, compared with their matched uninfected inpatients, as well as 15.4% in CSAB patients (also compared with their matched uninfected inpatients), resulting in an attributable mortality of 11.8% (P <0.001) associated with carbapenem resistance. The excess risk associated with carbapenem resistance for new-onset chronic ventilator dependence was 5.2% (P <0.001). Carbapenem resistance was also associated with an extra cost of $2,511 per case of A. baumannii HAIs (P <0.001). Conclusion: Carbapenem resistance is associated with a significant disease burden in terms of excess mortality, long-term ventilator dependence, and medical cost. Further studies on effects of antimicrobial stewardship programs in decreasing this burden are warranted.
MeSH term(s)	Humans ; Acinetobacter baumannii ; Cohort Studies ; Renal Dialysis ; Retrospective Studies ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Delivery of Health Care
Chemical Substances	Carbapenems
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291059
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Article: Raising clinical awareness for better dengue fever outbreak control.

Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2015 Volume 114, Issue 11, Page(s) 1025–1026

MeSH term(s)	Dengue/epidemiology ; Dengue/prevention & control ; Disease Outbreaks/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Taiwan/epidemiology
Language	English
Publishing date	2015-11
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2015.10.006
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Article ; Online: Single-Center Experience of Control of Ventilator-Circuit-Transmitted

Shen, Bing-Jie / Wang, Jann-Tay / Chang, Hou-Tai / Chang, Shan-Chwen / Liao, Chun-Hsing

Tropical medicine and infectious disease

2023 Volume 8, Issue 7

Abstract: Burkholderia ... ...

Abstract	Burkholderia cepacia
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8070335
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Article ; Online: Coronavirus disease 2019 (COVID-19) universal admission screening in patients and companions in Taiwan from May 2021 to June 2022: A nationwide multicenter study.

Wu, Hao-Hsin / Su, Chiu-Hsia / Chien, Li-Jung / Tseng, Shu-Hui / Chang, Shan-Chwen

Infection control and hospital epidemiology

2023 Volume 45, Issue 1, Page(s) 68–74

Abstract: Objective: Universal admission screening and follow-up symptom-based testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may play critical roles in controlling nosocomial transmission. We describe the performance of test strategies ... ...

Abstract	Objective: Universal admission screening and follow-up symptom-based testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may play critical roles in controlling nosocomial transmission. We describe the performance of test strategies for inpatients and their companions during various disease incidences in Taiwan. Design: Retrospective population-based cohort study. Setting: The study was conducted across 476 hospitals in Taiwan. Methods: The data for both testing strategies by reverse transcription-polymerase chain reaction for SARS-CoV-2 in newly admitted patients and their companions during May 2021-June 2022 were extracted and analyzed. Results: The positivity rate of universal admission screening was 0.76% (14,640 of 1,928,676) for patients and 0.37% (5,372 of 1,438,944) for companions. The weekly community incidences of period 1 (May 2021-June 2021), period 2 (July 2021-March 2022), and period 3 (April 2022-June 2022) were 6.57, 0.27, and 1,261, respectively, per 100,000 population. The positivity rates of universal admission screening for patients and companions (4.39% and 2.18%) in period 3 were higher than those in periods 1 (0.29% and 0.04%) and 2 (0.03% and 0.003%) (all Conclusions: Universal admission screening and follow-up symptom-based testing is important for reducing nosocomial transmission. Implementing universal admission screening at an appropriate time would balance the benefits with costs and potential unintended harms.
MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Retrospective Studies ; Cohort Studies ; Taiwan/epidemiology ; Inpatients ; Cross Infection/epidemiology
Language	English
Publishing date	2023-07-18
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2023.144
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Article: COVID-19 outbreaks in long-term care facilities-a nationwide population-based cohort study in Taiwan, May-July 2021.

Wu, Hao-Hsin / Chien, Li-Jung / Su, Chiu-Hsia / Tseng, Shu-Hui / Chang, Shan-Chwen

Journal of the Formosan Medical Association = Taiwan yi zhi

2023 Volume 122, Issue 12, Page(s) 1331–1337

Abstract: Background/purpose: Long-term care facilities (LTCFs) are high-risk settings for the novel coronavirus disease (COVID-19). The aim of the study was to describe the extent and the impacts of 2021 COVID-19 outbreaks on LTCFs in Taiwan.: Methods: We ... ...

Abstract	Background/purpose: Long-term care facilities (LTCFs) are high-risk settings for the novel coronavirus disease (COVID-19). The aim of the study was to describe the extent and the impacts of 2021 COVID-19 outbreaks on LTCFs in Taiwan. Methods: We retrospectively analyzed the data of each COVID-19 outbreak in LTCFs from May 15 to July 31, 2021 in Taiwan. We characterized the features of LTCFs with outbreaks and compared the characteristics of infected staff members and residents of the affected LTCFs. Results: COVID-19 outbreaks were reported in 16 LTCFs (0.9%). The outbreak was significantly associated with LTCFs with ≥50 beds [adjusted odds ratio (aOR), 6.3; 95%confidence interval [CI], 1.9-21.1] and location of Taipei metropolitan area (aOR, 4.6; 95%CI, 1.7-12.8). Resident cases accounted for 75.4% (203/269) of confirmed cases affected by outbreaks. The 30-day all-cause mortality was 24.2% for residents only and was significantly associated with age ≥65 years [adjusted hazard ratio (aHR, 4.3; 95%CI, 1.7-10.5)], presence of symptoms on diagnosis (aHR, 2.2; 95%CI, 1.3-3.7), and LTCF occupancy rate ≥80% (aHR, 3.0, 95%CI, 1.3-7.4). Conclusion: COVID-19 outbreaks have a critical impact on residents in LTCFs owing to the advanced age and high prevalence of chronic comorbidities in this population. Multi-pronged infection control measures and mass testing are vital for mitigating COVID-19 transmission in LTCFs.
MeSH term(s)	Humans ; Aged ; Long-Term Care ; COVID-19/epidemiology ; Taiwan/epidemiology ; Retrospective Studies ; Cohort Studies ; Disease Outbreaks/prevention & control
Language	English
Publishing date	2023-06-13
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2023.06.008
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