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  1. Article: Gender-related issues in a Taiwanese university medical science laboratory setting: a qualitative analysis.

    Tseng, Chun-Yi / Chang, Shu-Ching

    Frontiers in psychology

    2023  Volume 14, Page(s) 1178921

    Abstract: Introduction: This paper provides a glimpse into gender issues in a university-based medical science laboratory setting in northern Taiwan. In this study, gender issues with respect to perceptions regarding gender, the degree of gender neutrality in the ...

    Abstract Introduction: This paper provides a glimpse into gender issues in a university-based medical science laboratory setting in northern Taiwan. In this study, gender issues with respect to perceptions regarding gender, the degree of gender neutrality in the work environment, and the influence of gender on researchers' academic careers were analyzed.
    Methods: From July to August 2021, semistructured interviews to understand the perspectives of five faculty members at Chang Gung University School of Medicine regarding gender issues were conducted. The data were transcribed verbatim and analyzed thematically. Subsequently, coding was performed using ATLAS.ti Web (Version 4.0.10).
    Results and discussion: It was found that gender is not perceived to correlate with performance in the medical sciences. Although the medical science laboratories in the study institution are mostly gender-neutral, instances of discrimination might have been concealed elsewhere because of underreporting. Nevertheless, medical science research culture in Chang Gung University appears to promote respect and equality owing to increased general awareness regarding such issues as well as robust policies that protect women's rights and promote gender equality. Marriage, motherhood, and family obligations remain key challenges to the academic career of female scientists in the institution. To achieve more equitable representation of male and female scientists as well as to prevent female scientists from leaving medical science laboratories in Taiwan, institutional and national policies that provide tailored support for female scientists intending to start families must continue to be implemented.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1178921
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  2. Article ; Online: Intervention to reduce loneliness among older adults in the community: Making friends with volunteers.

    Hsu, Hui-Chuan / Chang, Shu-Ching / Liang, Chun-Yu / Ting, Jie-Rong

    Geriatrics & gerontology international

    2024  Volume 24 Suppl 1, Page(s) 240–245

    Abstract: Aim: This study aimed to examine the effects of providing a program that introduced volunteers to make friends with older adults to reduce loneliness and increase loneliness literacy.: Methods: Eight community development associations in Taiwan ... ...

    Abstract Aim: This study aimed to examine the effects of providing a program that introduced volunteers to make friends with older adults to reduce loneliness and increase loneliness literacy.
    Methods: Eight community development associations in Taiwan participated in the study. In the first stage, older people living alone or with only a spouse, or those with a family, but without substantial interactions, were screened for loneliness. Older adults with a higher risk of loneliness were given priority to be invited to participate in this intervention. This 3-month intervention program was designed by each community development association and delivered at the older adults' homes. A total of 87 older persons completed both waves of the interviews.
    Results: Loneliness was reduced (UCLA-6 Loneliness Scale scores decreased from 13.5 to 11.6), and loneliness literacy improved (loneliness literacy scores increased from 38.9 to 42.0) compared with what it was before the program. In a generalized linear model, when controlling for covariates, loneliness was reduced, but not significantly (B = -0.934, P > 0.05), whereas loneliness literacy improved significantly for older participants (B = 2.088, P < 0.05).
    Conclusions: Making friends with older adults who are lonely might improve their loneliness literacy. Geriatr Gerontol Int 2024; 24: 240-245.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Loneliness ; Friends ; Homes for the Aged ; Volunteers ; Taiwan ; Social Isolation
    Language English
    Publishing date 2024-02-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14828
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  3. Article ; Online: Hiding private information in private information protection liquid crystal displays using periodical waveplates and pixel quaternity.

    Liu, Cheng-Kai / Chang, Shu-Ching / Juang, Yung-Shiang / Cheng, Ko-Ting

    Optics express

    2023  Volume 31, Issue 2, Page(s) 2445–2455

    Abstract: A method to hide private information (PI) in private information protection liquid crystal displays (PIPLCDs) using periodical waveplates and pixel quaternity is reported in this study. The PIPLCD structure and its operation mechanism are conceptually ... ...

    Abstract A method to hide private information (PI) in private information protection liquid crystal displays (PIPLCDs) using periodical waveplates and pixel quaternity is reported in this study. The PIPLCD structure and its operation mechanism are conceptually elucidated. Users employing wide-view broadband circular polarizers (WVBCPs) can see PI hidden in images displayed on the PIPLCDs in PIP mode. However, people who do not use WVBCPs can only see the displayed images but not the PI at almost any viewing angles. The issues of the PIPLCD in PIP mode and possible fabrications of the periodical waveplates are also discussed.
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.478555
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  4. Article ; Online: Muscle mass cross-sectional area is associated with survival outcomes in malignant pleural disease related to lung cancer.

    Meggyesy, Austin M / Wilshire, Candice L / Chang, Shu-Ching / Gorden, Jed A / Gilbert, Christopher R

    Respiratory medicine

    2023  Volume 217, Page(s) 107371

    Abstract: Introduction: Malignant pleural effusions are common in advanced malignancy and associated with overall poor survival. The presence of sarcopenia (decreased muscle mass) is associated with poor outcomes in numerous disease states, however, its ... ...

    Abstract Introduction: Malignant pleural effusions are common in advanced malignancy and associated with overall poor survival. The presence of sarcopenia (decreased muscle mass) is associated with poor outcomes in numerous disease states, however, its relationship to malignant pleural disease has not been defined. We sought to understand if there was an association between decreased survival and decreased muscle mass in patients with malignant pleural effusion.
    Methods: Patients with malignant pleural disease undergoing indwelling tunneled pleural catheter placement were retrospectively reviewed. Computed tomography was reviewed and cross-sectional area of pectoralis and paraspinous muscle areas were calculated. Overall survival and associations with muscle mass were calculated.
    Results: A total of 309 patients were available for analysis, with a median age of 67 years and the majority female (58%). The median survival was 129 days from initial pleural drainage to death. Regression analysis and Kaplan-Meier survival analysis did not reveal an association with survival and muscle mass for the entire population. However, Kaplan-Meier survival analysis of the lung cancer subgroup revealed the presence of decreased muscle mass and decreased survival time.
    Conclusion: The presence of decreased muscle mass within a lung cancer population that has malignant pleural effusions are associated with decreased survival. However, the presence of decreased muscle mass within a heterogenous population of malignant pleural disease was not associated with decreased overall survival time. Further study of the role that sarcopenia may play in malignant pleural disease is warranted.
    MeSH term(s) Humans ; Female ; Aged ; Pleural Effusion, Malignant/diagnostic imaging ; Retrospective Studies ; Sarcopenia/complications ; Sarcopenia/diagnostic imaging ; Catheters, Indwelling ; Lung Neoplasms/complications ; Drainage/methods ; Muscles
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107371
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  5. Article ; Online: The Use of Intrapleural Thrombolytic or Fibrinolytic Therapy, or Both, via Indwelling Tunneled Pleural Catheters With or Without Concurrent Anticoagulation Use.

    Gilbert, Christopher R / Wilshire, Candice L / Chang, Shu-Ching / Gorden, Jed A

    Chest

    2021  Volume 160, Issue 2, Page(s) 776–783

    Abstract: Background: Indwelling tunneled pleural catheters (IPCs) are used regularly for recurrent pleural effusion management. Catheter obstruction is not uncommon, often requiring intrapleural medications instillation (ie, alteplase) to restore flow. The ... ...

    Abstract Background: Indwelling tunneled pleural catheters (IPCs) are used regularly for recurrent pleural effusion management. Catheter obstruction is not uncommon, often requiring intrapleural medications instillation (ie, alteplase) to restore flow. The safety profile of intrapleural medications has been reported previously; however, most studies exclude anticoagulated patients.
    Research question: What is the safety profile of intrapleural alteplase, dornase alfa, or both when used in patients with IPCs, including in those who may be undergoing active anticoagulation?
    Study design and methods: Retrospective review of patients with previously placed IPCs from January 2009 through February 2020 undergoing intrapleural alteplase therapy. Basic demographics, laboratory studies, anticoagulation medication use, and complications were collected. Descriptive statistics were used to report demographics and outcomes. Univariate Firth's logistic regression analyses were used to identify factors associated with complications, followed by multivariate regression analyses.
    Results: A total of 94 patients underwent IPC placement and intrapleural instillation. The median age of patients was 66.1 years (interquartile range, 57.6-74.9 years). Intrapleural medications were administered 71 times in 30 anticoagulated patients and 172 times in 64 patients who were not anticoagulated. A total of 20 complications were identified in 18 patients, with one patient experiencing more than one complication. Five bleeding complications occurred with no significant increased risk with anticoagulation use (in 2 anticoagulated patients and 3 patients who were not anticoagulated; P = .092). Multivariate Firth's logistic regression demonstrated that alteplase dose (P = .04) and anticoagulation use (P = .05) were associated with any complication, but were not associated with bleeding complications.
    Interpretation: We report a relatively low incidence of complications and, in particular, bleeding complications in patients receiving intrapleural alteplase for nondraining IPCs. Bleeding episodes occurred in five of 94 patients (5.3%) with no apparent increased risk of bleeding complication, regardless of whether receiving anticoagulation. Additional study is warranted to identify risk factors for complications, in particular bleeding complications, in this patient population.
    MeSH term(s) Aged ; Anticoagulants/administration & dosage ; Catheters, Indwelling ; Deoxyribonuclease I/administration & dosage ; Female ; Fibrinolytic Agents/administration & dosage ; Humans ; Male ; Middle Aged ; Pleural Effusion/drug therapy ; Recombinant Proteins/administration & dosage ; Retrospective Studies ; Thrombolytic Therapy/methods ; Tissue Plasminogen Activator/administration & dosage
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Recombinant Proteins ; Deoxyribonuclease I (EC 3.1.21.1) ; dornase alfa (EC 3.1.21.1) ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.03.023
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  6. Article ; Online: Impact of Locoregional Treatment on Survival in Young Patients with Early-Stage Breast Cancer undergoing Upfront Surgery.

    Orozco, Javier I J / Keller, Jennifer K / Chang, Shu-Ching / Fancher, Crystal E / Grumley, Janie G

    Annals of surgical oncology

    2022  Volume 29, Issue 10, Page(s) 6299–6310

    Abstract: Background: Randomized, controlled trials comparing breast-conserving therapy (BCT) with mastectomy have demonstrated equivalent overall survival (OS), but recent observational studies have shown improved OS in patients undergoing BCT. These studies ... ...

    Abstract Background: Randomized, controlled trials comparing breast-conserving therapy (BCT) with mastectomy have demonstrated equivalent overall survival (OS), but recent observational studies have shown improved OS in patients undergoing BCT. These studies provide limited data on young patients who are traditionally offered mastectomy due to perceived higher disease risk. This study examines the OS in a contemporary series of young women with breast cancer undergoing upfront BCT compared with mastectomy.
    Methods: Women ≤40 years old with primary invasive T1-T2, N0-N1 breast cancer were identified from the National Cancer Database between 2006 and 2016. Patient cohorts were based according to locoregional treatment: BCT, mastectomy alone (Mx), and mastectomy with radiotherapy (Mx/RT). Kaplan-Meier method followed by Cox proportional-hazards regression with inverse probability of treatment weighting (IPTW) were performed to account for treatment selection bias effects in OS.
    Results: A total of 15,611 patients met the study criteria; 9,509 patients (60.9%) had BCT, 4,020 (25.8%) had Mx/RT, and 2,082 (13.3%) had Mx alone. The median follow-up was 4.6 years (interquartile range [IQR] 3.0-6.4). After IPTW-adjustment, the 5-year OS was similar for BCT (95%), Mx (95%), and Mx/RT (94%), and there was no significant difference in OS in Mx (hazard ratio [HR] = 1.16, 95% confidence interval [CI] 0.90-1.51) and Mx/RT (HR = 1.08, 95% CI 0.88-1.34) compared with BCT. Mx/RT was associated with decreased survival in patients with pT2N0 (HR = 1.78, 95% CI 1.12-2.84).
    Conclusions: Among young patients with early-stage breast cancer, overall survival was equivalent regardless of surgical approach. Breast-conserving therapy remains a safe option in young women despite the clinical tendency to offer upfront mastectomy in young patients.
    MeSH term(s) Adult ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Female ; Humans ; Mastectomy/methods ; Mastectomy, Segmental/methods ; Proportional Hazards Models
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12190-z
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    Zs.A 4042: Show issues Location:
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  7. Article: Characterization of Lymph Node Tumor Burden in Node-Positive Prostate Cancer Patients after Robotic-Assisted Radical Prostatectomy with Extended Pelvic Lymph Node Dissection.

    Gottlieb, Josh / Chang, Shu-Ching / Choe, Jane / Grunkemeier, Gary L / Hanes, Douglas A / Krasne, David / Hoon, Dave S B / Wilson, Timothy G

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Background: Prostate cancer (PCa) nodal staging does not account for lymph node (LN) tumor burden. The LN anatomical compartment involved with the tumor or the quantified extent of extranodal extension (ENE) have not yet been studied in relation to ... ...

    Abstract Background: Prostate cancer (PCa) nodal staging does not account for lymph node (LN) tumor burden. The LN anatomical compartment involved with the tumor or the quantified extent of extranodal extension (ENE) have not yet been studied in relation to biochemical recurrence-free survival (BRFS).
    Methods: Histopathological slides of 66 pN1 PCa patients who underwent extended pelvic lymph node dissection were reviewed. We recorded metrics to quantify LN tumor burden. We also characterized the LN anatomical compartments involved and quantified the extent of ENE.
    Results: The median follow-up time was 38 months. The median number of total LNs obtained per patient was 30 (IQR 23-37). In the risk-adjusted cox regression model, the following variables were associated with BRFS: mean size of the largest LN deposit per patient (log2: adjusted hazard ratio (aHR) = 1.91,
    Conclusion: LN tumor burden is associated with BRFS. The LN anatomical compartments and the quantified extent of ENE did not show significant association with BRFS.
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143707
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  8. Article ; Online: Correction: Predicting Regional Lymph Node Recurrence in the Modern Age of Tumor-Positive Sentinel Node Melanoma: The Role of the First Postoperative Ultrasound.

    Keller, Jennifer / Stern, Stacey / Chang, Shu-Ching / Marcus, Rebecca / Weiss, Jessica / Nassoiy, Sean / Christopher, Wade / Fischer, Trevan / Essner, Richard

    Annals of surgical oncology

    2023  Volume 30, Issue 6, Page(s) 3656–3657

    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13186-z
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  9. Article: Skew-normal antedependence models for skewed longitudinal data.

    Chang, Shu-Ching / Zimmerman, Dale L

    Biometrika

    2016  Volume 103, Issue 2, Page(s) 363–376

    Abstract: Antedependence models, also known as transition models, have proven to be useful for longitudinal data exhibiting serial correlation, especially when the variances and/or same-lag correlations are time-varying. Statistical inference procedures associated ...

    Abstract Antedependence models, also known as transition models, have proven to be useful for longitudinal data exhibiting serial correlation, especially when the variances and/or same-lag correlations are time-varying. Statistical inference procedures associated with normal antedependence models are well-developed and have many nice properties, but they are not appropriate for longitudinal data that exhibit considerable skewness. We propose two direct extensions of normal antedependence models to skew-normal antedependence models. The first is obtained by imposing antedependence on a multivariate skew-normal distribution, and the second is a sequential autoregressive model with skew-normal innovations. For both models, necessary and sufficient conditions for [Formula: see text]th-order antedependence are established, and likelihood-based estimation and testing procedures for models satisfying those conditions are developed. The procedures are applied to simulated data and to real data from a study of cattle growth.
    Language English
    Publishing date 2016-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119-8
    ISSN 1464-3510 ; 0006-3444
    ISSN (online) 1464-3510
    ISSN 0006-3444
    DOI 10.1093/biomet/asw006
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  10. Article ; Online: Perfluoroalkyl Carboxylic Acids Interact with the Human Bile Acid Transporter NTCP.

    Ruggiero, Melissa J / Miller, Haley / Idowu, Jessica Y / Zitzow, Jeremiah D / Chang, Shu-Ching / Hagenbuch, Bruno

    Livers

    2021  Volume 1, Issue 4, Page(s) 221–229

    Abstract: ... ...

    Abstract Na
    Language English
    Publishing date 2021-10-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-4389
    ISSN (online) 2673-4389
    DOI 10.3390/livers1040017
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