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Article: SIV clearance from neonatal macaques following transient CCR5 depletion.

Deere, Jesse D / Merriam, David / Leggat, Kawthar Machmach / Chang, Wen-Lan William / Méndez-Lagares, Gema / Kieu, Hung / Dutra, Joseph / Fontaine, Justin / Lu, Wenze / Chin, Ning / Chen, Connie / Tran, Bryant Chi-Thien / Salinas, Jessica / Miller, Corey N / Deeks, Steven G / Lifson, Jeffrey D / Engelman, Kathleen / Magnani, Diogo / Reimann, Keith /
Stevenson, Mario / Hartigan-O'Connor, Dennis J

bioRxiv : the preprint server for biology

2023  

Abstract: Treatment of people with HIV (PWH) with antiretroviral therapy (ART) results in sustained suppression of viremia, but HIV persists indefinitely as integrated provirus in CD4-expressing cells. Intact persistent provirus, the "rebound competent viral ... ...

Abstract Treatment of people with HIV (PWH) with antiretroviral therapy (ART) results in sustained suppression of viremia, but HIV persists indefinitely as integrated provirus in CD4-expressing cells. Intact persistent provirus, the "rebound competent viral reservoir" (RCVR), is the primary obstacle to achieving a cure. Most variants of HIV enter CD4
Language English
Publishing date 2023-05-01
Publishing country United States
Document type Preprint
DOI 10.1101/2023.05.01.533682
Database MEDical Literature Analysis and Retrieval System OnLINE

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