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  1. Article ; Online: P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner.

    Chang, Yao-Yao / Huan, Qiu-Chan / Peng, Jiao / Bi, Wen-Chun / Zhai, Li-Xiang / Chen, Yan / Lamb, Jonathan R / Shen, Xiang-Chun / Bian, Zhao-Xiang / Wu, Hai-Qiang / Cheng, Yong-Xian / Xiao, Hai-Tao

    Frontiers in immunology

    2022  Volume 13, Page(s) 820524

    Abstract: P2Y1 receptor is a G-protein-coupled receptor that plays a critical role in the immune response of inflammatory bowel diseases. However, its regulatory effects on ... ...

    Abstract P2Y1 receptor is a G-protein-coupled receptor that plays a critical role in the immune response of inflammatory bowel diseases. However, its regulatory effects on CD4
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Animals ; Cell Differentiation ; Colitis/chemically induced ; Colitis/metabolism ; Inflammation/metabolism ; Interleukin-17/metabolism ; Mice ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Th17 Cells
    Chemical Substances Interleukin-17 ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.820524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches.

    Zhai, Lixiang / Peng, Jiao / Zhuang, Min / Chang, Yao-Yao / Cheng, Ka Wing / Ning, Zi-Wan / Huang, Tao / Lin, Chengyuan / Wong, Hoi Leong Xavier / Lam, Yan Y / Tan, Hor Yue / Xiao, Hai-Tao / Bian, Zhao-Xiang

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2022  Volume 99, Page(s) 154001

    Abstract: Background: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ... ...

    Abstract Background: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ulcerative colitis (UC). In a previous study, we have reported ZWBQD mitigates the severity of dextran sulfate sodium (DSS)-induced colitis in mice.
    Hypothesis: In this study, we aimed to understand the systemic actions and underlying mechanisms of ZWBQD on experimental colitis in mice.
    Methods: We used multi-omics techniques and immunoblotting approach to study the pharmacological actions and mechanisms of ZWBQD in DSS-induced chronic colitic mice.
    Results: We showed that ZWBQD exhibited potent anti-inflammatory properties and significantly protected DSS-induced colitic mice against colon injury by regulating the PI3K-AKT, MAPK signaling pathway and NF-κB signaling pathways. We also revealed that ZWBQD significantly ameliorated gut microbiota dysbiosis and abnormalities of tryptophan catabolites induced by DSS.
    Conclusions: We demonstrated that the therapeutic effects of ZWBQD on experimental colitis are mediated by regulating multiple signaling pathways and modulation of gut microbiota. Our study employed an integrative strategy to elucidate novel mechanisms of ZWBQD, which provides new insights into the development of Chinese herbal medicine-based therapeutics for UC.
    Language English
    Publishing date 2022-02-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Therapeutic effects and mechanisms of Zhen-Wu-Bu-Qi Decoction on dextran sulfate sodium-induced chronic colitis in mice assessed by multi-omics approaches

    Zhai, Lixiang / Peng, Jiao / Zhuang, Min / Chang, Yao-yao / Cheng, Ka Wing / Ning, Zi-wan / Huang, Tao / Lin, Chengyuan / Wong, Hoi Leong Xavier / Lam, Yan Y. / Tan, Hor Yue / Xiao, Hai-tao / Bian, Zhao-xiang

    Phytomedicine. 2022 May, v. 99

    2022  

    Abstract: Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ulcerative colitis ( ... ...

    Abstract Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis Recens, Radix Codonopsis and Rhizoma Coptidis, is used for treating ulcerative colitis (UC). In a previous study, we have reported ZWBQD mitigates the severity of dextran sulfate sodium (DSS)-induced colitis in mice. In this study, we aimed to understand the systemic actions and underlying mechanisms of ZWBQD on experimental colitis in mice. We used multi-omics techniques and immunoblotting approach to study the pharmacological actions and mechanisms of ZWBQD in DSS-induced chronic colitic mice. We showed that ZWBQD exhibited potent anti-inflammatory properties and significantly protected DSS-induced colitic mice against colon injury by regulating the PI3K-AKT, MAPK signaling pathway and NF-κB signaling pathways. We also revealed that ZWBQD significantly ameliorated gut microbiota dysbiosis and abnormalities of tryptophan catabolites induced by DSS. We demonstrated that the therapeutic effects of ZWBQD on experimental colitis are mediated by regulating multiple signaling pathways and modulation of gut microbiota. Our study employed an integrative strategy to elucidate novel mechanisms of ZWBQD, which provides new insights into the development of Chinese herbal medicine-based therapeutics for UC.
    Keywords Codonopsis ; Oriental traditional medicine ; Paeonia ; Poria ; colon ; dextran sulfate ; dysbiosis ; immunoblotting ; intestinal microorganisms ; metabolites ; multiomics ; rhizomes ; therapeutics ; tryptophan ; ulcerative colitis
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2022.154001
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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