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  1. AU="Chang, Yinshui"
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  1. Article ; Online: Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.

    Xiao, Hongkui / Ulmert, Isabel / Bach, Luisa / Huber, Johanna / Narasimhan, Hamsa / Kurochkin, Ilia / Chang, Yinshui / Holst, Signe / Mörbe, Urs / Zhang, Lili / Schlitzer, Andreas / Pereira, Carlos-Filipe / Schraml, Barbara U / Baumjohann, Dirk / Lahl, Katharina

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3554

    Abstract: Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters ... ...

    Abstract Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific deletion of the transcriptional repressor Bcl6 in mice alters the phenotype and transcriptome of cDC1 and cDC2, while their lineage identity is preserved. Bcl6-deficient cDC1 are diminished in the periphery but maintain their ability to cross-present antigen to CD8
    MeSH term(s) Animals ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-bcl-6/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Mice ; Citrobacter rodentium/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Gene Deletion ; Spleen/immunology ; Spleen/cytology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Proto-Oncogene Proteins c-bcl-6 ; Bcl6 protein, mouse
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46966-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fingolimod Profoundly Reduces Frequencies and Alters Subset Composition of Circulating T Follicular Helper Cells in Multiple Sclerosis Patients.

    Huber, Johanna E / Chang, Yinshui / Meinl, Ingrid / Kümpfel, Tania / Meinl, Edgar / Baumjohann, Dirk

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 204, Issue 5, Page(s) 1101–1110

    Abstract: Fingolimod is an effective treatment for relapsing-remitting multiple sclerosis. It is well established that fingolimod, a modulator of the sphingosine-1-phosphate pathway, restrains the egress of ... ...

    Abstract Fingolimod is an effective treatment for relapsing-remitting multiple sclerosis. It is well established that fingolimod, a modulator of the sphingosine-1-phosphate pathway, restrains the egress of CCR7
    MeSH term(s) B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Female ; Fingolimod Hydrochloride/administration & dosage ; Humans ; Immunologic Memory/drug effects ; Male ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/pathology ; Receptors, CXCR5/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology
    Chemical Substances CXCR5 protein, human ; Receptors, CXCR5 ; Fingolimod Hydrochloride (G926EC510T)
    Language English
    Publishing date 2020-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1900955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  3. Article ; Online: T cell-expressed microRNAs critically regulate germinal center T follicular helper cell function and maintenance in acute viral infection in mice.

    Zeiträg, Julia / Dahlström, Frank / Chang, Yinshui / Alterauge, Dominik / Richter, Daniel / Niemietz, Julia / Baumjohann, Dirk

    European journal of immunology

    2020  Volume 51, Issue 2, Page(s) 408–413

    Abstract: Constitutive T cell-intrinsic miRNA expression is required for the differentiation of naïve ... ...

    Abstract Constitutive T cell-intrinsic miRNA expression is required for the differentiation of naïve CD4
    MeSH term(s) Animals ; Antigens/immunology ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Germinal Center/immunology ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic choriomeningitis virus/immunology ; Mice ; MicroRNAs/immunology ; T Follicular Helper Cells/immunology ; T-Lymphocytes, Regulatory/immunology ; Th1 Cells
    Chemical Substances Antigens ; MicroRNAs
    Language English
    Publishing date 2020-11-02
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  4. Article ; Online: TGF-β specifies T

    Chang, Yinshui / Bach, Luisa / Hasiuk, Marko / Wen, Lifen / Elmzzahi, Tarek / Tsui, Carlson / Gutiérrez-Melo, Nicolás / Steffen, Teresa / Utzschneider, Daniel T / Raj, Timsse / Jost, Paul Jonas / Heink, Sylvia / Cheng, Jingyuan / Burton, Oliver T / Zeiträg, Julia / Alterauge, Dominik / Dahlström, Frank / Becker, Jennifer-Christin / Kastl, Melanie /
    Symeonidis, Konstantinos / van Uelft, Martina / Becker, Matthias / Reschke, Sarah / Krebs, Stefan / Blum, Helmut / Abdullah, Zeinab / Paeschke, Katrin / Ohnmacht, Caspar / Neumann, Christian / Liston, Adrian / Meissner, Felix / Korn, Thomas / Hasenauer, Jan / Heissmeyer, Vigo / Beyer, Marc / Kallies, Axel / Jeker, Lukas T / Baumjohann, Dirk

    Science immunology

    2024  Volume 9, Issue 93, Page(s) eadd4818

    Abstract: T follicular helper ( ... ...

    Abstract T follicular helper (T
    MeSH term(s) Animals ; Mice ; T-Lymphocytes, Helper-Inducer ; Transforming Growth Factor beta/metabolism ; B-Lymphocytes ; CD4-Positive T-Lymphocytes ; Cell Differentiation ; Proto-Oncogene Proteins c-maf/metabolism
    Chemical Substances Transforming Growth Factor beta ; Maf protein, mouse ; Proto-Oncogene Proteins c-maf
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.add4818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma.

    Bräunlein, Eva / Lupoli, Gaia / Füchsl, Franziska / Abualrous, Esam T / de Andrade Krätzig, Niklas / Gosmann, Dario / Wietbrock, Lukas / Lange, Sebastian / Engleitner, Thomas / Lan, Huan / Audehm, Stefan / Effenberger, Manuel / Boxberg, Melanie / Steiger, Katja / Chang, Yinshui / Yu, Kai / Atay, Cigdem / Bassermann, Florian / Weichert, Wilko /
    Busch, Dirk H / Rad, Roland / Freund, Christian / Antes, Iris / Krackhardt, Angela M

    Journal for immunotherapy of cancer

    2021  Volume 9, Issue 9

    Abstract: Background: Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in ... ...

    Abstract Background: Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well understood. In a case study of metastatic malignant melanoma, we aimed to perform an in-depth characterization of neoantigens and respective T-cell responses in the context of immune checkpoint modulation.
    Methods: Three neoantigens, which we identified either by immunopeptidomics or in silico prediction, were investigated using binding affinity analyses and structural simulations. We isolated seven T-cell receptors (TCRs) from the patient's immune repertoire recognizing these antigens. TCRs were compared in vitro by multiparametric analyses including functional avidity, multicytokine secretion, and cross-reactivity screenings. A xenograft mouse model served to study in vivo functionality of selected TCRs. We investigated the patient's TCR repertoire in blood and different tumor-related tissues over 3 years using TCR beta deep sequencing.
    Results: Selected mutated peptide ligands with proven immunogenicity showed similar binding affinities to the human leukocyte antigen complex and comparable disparity to their wild-type counterparts in molecular dynamic simulations. Nevertheless, isolated TCRs recognizing these antigens demonstrated distinct patterns in functionality and frequency. TCRs with lower functional avidity showed at least equal antitumor immune responses in vivo. Moreover, they occurred at high frequencies and particularly demonstrated long-term persistence within tumor tissues, lymph nodes and various blood samples associated with a reduced activation pattern on primary in vitro stimulation.
    Conclusions: We performed a so far unique fine characterization of neoantigen-specific T-cell responses revealing defined reactivity patterns of neoantigen-specific TCRs. Our data highlight qualitative differences of these TCRs associated with function and longevity of respective T cells. Such features need to be considered for further optimization of neoantigen targeting including adoptive T-cell therapies using TCR-transgenic T cells.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Humans ; Immunotherapy/methods ; Melanoma/immunology ; Mice ; Receptors, Antigen, T-Cell/immunology
    Chemical Substances Antigens, Neoplasm ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2021-002754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).

    Cossarizza, Andrea / Chang, Hyun-Dong / Radbruch, Andreas / Abrignani, Sergio / Addo, Richard / Akdis, Mübeccel / Andrä, Immanuel / Andreata, Francesco / Annunziato, Francesco / Arranz, Eduardo / Bacher, Petra / Bari, Sudipto / Barnaba, Vincenzo / Barros-Martins, Joana / Baumjohann, Dirk / Beccaria, Cristian G / Bernardo, David / Boardman, Dominic A / Borger, Jessica /
    Böttcher, Chotima / Brockmann, Leonie / Burns, Marie / Busch, Dirk H / Cameron, Garth / Cammarata, Ilenia / Cassotta, Antonino / Chang, Yinshui / Chirdo, Fernando Gabriel / Christakou, Eleni / Čičin-Šain, Luka / Cook, Laura / Corbett, Alexandra J / Cornelis, Rebecca / Cosmi, Lorenzo / Davey, Martin S / De Biasi, Sara / De Simone, Gabriele / Del Zotto, Genny / Delacher, Michael / Di Rosa, Francesca / Di Santo, James / Diefenbach, Andreas / Dong, Jun / Dörner, Thomas / Dress, Regine J / Dutertre, Charles-Antoine / Eckle, Sidonia B G / Eede, Pascale / Evrard, Maximilien / Falk, Christine S / Feuerer, Markus / Fillatreau, Simon / Fiz-Lopez, Aida / Follo, Marie / Foulds, Gemma A / Fröbel, Julia / Gagliani, Nicola / Galletti, Giovanni / Gangaev, Anastasia / Garbi, Natalio / Garrote, José Antonio / Geginat, Jens / Gherardin, Nicholas A / Gibellini, Lara / Ginhoux, Florent / Godfrey, Dale I / Gruarin, Paola / Haftmann, Claudia / Hansmann, Leo / Harpur, Christopher M / Hayday, Adrian C / Heine, Guido / Hernández, Daniela Carolina / Herrmann, Martin / Hoelsken, Oliver / Huang, Qing / Huber, Samuel / Huber, Johanna E / Huehn, Jochen / Hundemer, Michael / Hwang, William Y K / Iannacone, Matteo / Ivison, Sabine M / Jäck, Hans-Martin / Jani, Peter K / Keller, Baerbel / Kessler, Nina / Ketelaars, Steven / Knop, Laura / Knopf, Jasmin / Koay, Hui-Fern / Kobow, Katja / Kriegsmann, Katharina / Kristyanto, H / Krueger, Andreas / Kuehne, Jenny F / Kunze-Schumacher, Heike / Kvistborg, Pia / Kwok, Immanuel / Latorre, Daniela / Lenz, Daniel / Levings, Megan K / Lino, Andreia C / Liotta, Francesco / Long, Heather M / Lugli, Enrico / MacDonald, Katherine N / Maggi, Laura / Maini, Mala K / Mair, Florian / Manta, Calin / Manz, Rudolf Armin / Mashreghi, Mir-Farzin / Mazzoni, Alessio / McCluskey, James / Mei, Henrik E / Melchers, Fritz / Melzer, Susanne / Mielenz, Dirk / Monin, Leticia / Moretta, Lorenzo / Multhoff, Gabriele / Muñoz, Luis Enrique / Muñoz-Ruiz, Miguel / Muscate, Franziska / Natalini, Ambra / Neumann, Katrin / Ng, Lai Guan / Niedobitek, Antonia / Niemz, Jana / Almeida, Larissa Nogueira / Notarbartolo, Samuele / Ostendorf, Lennard / Pallett, Laura J / Patel, Amit A / Percin, Gulce Itir / Peruzzi, Giovanna / Pinti, Marcello / Pockley, A Graham / Pracht, Katharina / Prinz, Immo / Pujol-Autonell, Irma / Pulvirenti, Nadia / Quatrini, Linda / Quinn, Kylie M / Radbruch, Helena / Rhys, Hefin / Rodrigo, Maria B / Romagnani, Chiara / Saggau, Carina / Sakaguchi, Shimon / Sallusto, Federica / Sanderink, Lieke / Sandrock, Inga / Schauer, Christine / Scheffold, Alexander / Scherer, Hans U / Schiemann, Matthias / Schildberg, Frank A / Schober, Kilian / Schoen, Janina / Schuh, Wolfgang / Schüler, Thomas / Schulz, Axel R / Schulz, Sebastian / Schulze, Julia / Simonetti, Sonia / Singh, Jeeshan / Sitnik, Katarzyna M / Stark, Regina / Starossom, Sarah / Stehle, Christina / Szelinski, Franziska / Tan, Leonard / Tarnok, Attila / Tornack, Julia / Tree, Timothy I M / van Beek, Jasper J P / van de Veen, Willem / van Gisbergen, Klaas / Vasco, Chiara / Verheyden, Nikita A / von Borstel, Anouk / Ward-Hartstonge, Kirsten A / Warnatz, Klaus / Waskow, Claudia / Wiedemann, Annika / Wilharm, Anneke / Wing, James / Wirz, Oliver / Wittner, Jens / Yang, Jennie H M / Yang, Juhao

    European journal of immunology

    2021  Volume 51, Issue 12, Page(s) 2708–3145

    Abstract: The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell ... ...

    Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Chronic Disease ; Flow Cytometry ; Humans ; Infections/immunology ; Mice ; Neoplasms/immunology ; Practice Guidelines as Topic
    Language English
    Publishing date 2021-12-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202170126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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