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Book ; Online: Diagrammatic approach to excitonic effects on nonlinear optical response

Chang, Yu-Tzu / Chan, Yang-Hao

2023

Abstract: Optical responses of atomically thin 2D materials are greatly influenced by electron-hole interactions. It is by far established that exciton signatures can be well-identified in the optical absorption spectrum of quasi-2D materials. However, the same ... ...

Abstract	Optical responses of atomically thin 2D materials are greatly influenced by electron-hole interactions. It is by far established that exciton signatures can be well-identified in the optical absorption spectrum of quasi-2D materials. However, the same level of understanding of excitonic effects on nonlinear optical responses and the ability to compute them accurately is still much desired. Based on the functional integral formalisms and working in the velocity gauge, we introduce a convenient Feynman diagram approach for calculating nonlinear responses including excitonic effects. By dressing electron-photon interactions with electron-hole ladder diagrams, we derive an expression for second-order optical responses and provide a comprehensive description of excitonic effects. We apply our approach to a monolayer h-BN model and show qualitative changes in the second harmonic generation spectrum when comparing with results assuming independent particles. Our approach can be readily extended to higher order optical responses and is feasible for first-principles calculations.
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
Subject code	535
Publishing date	2023-10-27
Publishing country	us
Document type	Book ; Online
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Article: Estimation of lifetime productivity loss from patients with chronic diseases: methods and empirical evidence of end-stage kidney disease from Taiwan.

Wang, Fuhmei / Hwang, Jing-Shiang / Huang, Wen-Yen / Chang, Yu-Tzu / Wang, Jung-Der

Health economics review

2024 Volume 14, Issue 1, Page(s) 10

Abstract: Objective: Studies that examine the broad allocation of resources, regardless of who bears the costs, should ideally estimate costs from a societal perspective. We have successfully integrated survival rates, employment ratios, and earnings to address ... ...

Abstract	Objective: Studies that examine the broad allocation of resources, regardless of who bears the costs, should ideally estimate costs from a societal perspective. We have successfully integrated survival rates, employment ratios, and earnings to address the significant challenge of evaluating societal value through productivity assessments of patients with end-stage kidney disease (ESKD) in Taiwan. Methods: Using a theoretical framework, we interconnected two nationwide databases: the Taiwan National Health Insurance (NHI) and the Taiwan Mortality Registry from 2000 to 2017. Due to the statutory retirement age of 65, we collected data on all patients (83,358) aged 25-64 years diagnosed with ESKD and undergoing maintenance dialysis. We estimated the lifetime survival function through a rolling extrapolation algorithm, which was then combined with the monthly employment ratio and wages to calculate the lifetime employment duration and productivity up to the legal retirement age of ESKD patients. These were compared with sex-, age-, and calendar year-matched referents to determine the loss of employment duration and productivity of ESKD patients. Results: ESKD patients experienced a loss of approximately 25-56% in lifetime employment duration and a larger loss of about 32-66% in lifetime productivity after adjustments for different age, sex, and calendar year. The annual productivity loss per male (female) ESKD patient relative to that of the age-and calendar year-matched referent ranges from 75.5% to 82.1% (82.3% to 90.3%). During the periods when they are able to work (over the on-the-job duration) male ESKD patients lose between 34 and 56% of their income, and female ESKD patients lose between 39 and 68% of their income, compared to the age-and calendar year-matched referents. The loss of lifetime productivity is a combination of reduced lifetime employment duration, functional disability, absenteeism, and presenteeism at the workplace. The loss related to presenteeism is implied by the reduced wages. Conclusions: In addition to the loss of employment duration, we have empirically demonstrated the lifetime loss of productivity in patients with ESKD, also indicating the "presenteeism" resulted from inability to perform their job with full capacity over long-term periods.
Language	English
Publishing date	2024-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2634483-X
ISSN	2191-1991
ISSN	2191-1991
DOI	10.1186/s13561-024-00480-z
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Article ; Online: Hyperosmolar Hyperglycemic Crisis After Burn Injury in a Patient With Advanced Amyotrophic Lateral Sclerosis: A Case Report.

Lin, Meng-Wei / Chang, Yu-Tzu / Hsueh, Yuan-Yu

Annals of plastic surgery

2022 Volume 89, Issue 4, Page(s) 373–375

Abstract: Abstract: Metabolic disturbance in patients of amyotrophic lateral sclerosis is a rare presentation that might be related to disease progression and outcomes. Hypermetabolic status after major burn injury remains a critical issue in the modern medical ... ...

Abstract	Abstract: Metabolic disturbance in patients of amyotrophic lateral sclerosis is a rare presentation that might be related to disease progression and outcomes. Hypermetabolic status after major burn injury remains a critical issue in the modern medical care. Here, we present a rare case of a patient sporadic amyotrophic lateral sclerosis who suffered from minor burn injury (8% total body surface area), developing critical hyperosmolar hyperglycemic state during early hospitalization. Newly diagnosed diabetes is established and found related to the underlying disease of this patient. The accumulative metabolic alteration among vulnerable patients of amyotrophic lateral sclerosis and burn injury is noteworthy. Judicious monitoring of fluid and metabolic status helps to prevent the occurrence of acute hyperosmolar hyperglycemic state.
MeSH term(s)	Amyotrophic Lateral Sclerosis/complications ; Burns/complications ; Disease Progression ; Humans ; Hyperglycemic Hyperosmolar Nonketotic Coma/complications ; Hyperglycemic Hyperosmolar Nonketotic Coma/diagnosis
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003293
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Article ; Online: How a winding-down oil refinery park impacts air quality nearby?

Hsu, Chin-Yu / Chang, Yu-Tzu / Lin, Cheng-Ju

Environment international

2022 Volume 169, Page(s) 107533

Abstract: It is always difficult to compare, let alone estimate, the difference of air pollutant concentrations before and after closure of a major source because the pollutants cannot be traced or predicted after entering the ambient. Indeed, we are not aware of ... ...

Abstract	It is always difficult to compare, let alone estimate, the difference of air pollutant concentrations before and after closure of a major source because the pollutants cannot be traced or predicted after entering the ambient. Indeed, we are not aware of any studies specifically related to the air pollutants impacted by a winding-down source. In this work, we applied nine years (2010-2018) online measurement of air pollutants (including PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/analysis ; China ; Environmental Monitoring/methods ; Nitrogen Dioxide/analysis ; Oil and Gas Industry ; Ozone/analysis ; Particulate Matter/analysis ; Solvents/analysis ; Vehicle Emissions/analysis ; Volatile Organic Compounds/analysis
Chemical Substances	Air Pollutants ; Particulate Matter ; Solvents ; Vehicle Emissions ; Volatile Organic Compounds ; Ozone (66H7ZZK23N) ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2022-09-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107533
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Article ; Online: The effectiveness of child-centered play therapy for executive functions in children with attention-deficit/hyperactivity disorder.

Wong, Tsz-Yan / Chang, Yu-Tzu / Wang, Ming-Yu / Chang, Yun-Hsuan

Clinical child psychology and psychiatry

2022 Volume 28, Issue 3, Page(s) 877–894

Abstract: Introduction: Child-centered play therapy (CCPT) is a practical and recommended non-medication intervention for children with Attention-deficit/hyperactivity disorder (ADHD) but the mechanism in between is unclear.: Aim: This study proposed to ... ...

Abstract	Introduction: Child-centered play therapy (CCPT) is a practical and recommended non-medication intervention for children with Attention-deficit/hyperactivity disorder (ADHD) but the mechanism in between is unclear. Aim: This study proposed to examine the effectiveness of CCPT on neuropsychological deficits and behavioral symptoms in ADHD. Methods: Participants with ADHD diagnosis were referred from senior child and adolescent psychiatrists, and typical developmental children (TD) were recruited from community as a control group. All participants' executive functions were evaluated using Cambridge Neuropsychological Test Automated Battery. First of all, the participants were evaluated using Child Behavior Checklist (CBCL) by their parents. The ADHD participants were assigned into CCPT (ADHDc) and waitlist (ADHDw) group; and the ADHDc group then received CCPT weekly for 12 sessions, while the ADHDw continuously received their regular treatment (i.e., medication treatment or other alternative treatments) as usual. Results: Total 52 participants were recruited (17 with ADHD and 35 typically developed children, TD). The results showed that overall the ADHD groups had worse neuropsychological performance and more behavioural disturbance than did the TD (
MeSH term(s)	Adolescent ; Humans ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Executive Function ; Play Therapy ; Attention Deficit and Disruptive Behavior Disorders ; Parents
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1324235-0
ISSN	1461-7021 ; 1359-1045
ISSN (online)	1461-7021
ISSN	1359-1045
DOI	10.1177/13591045221128399
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Article ; Online: Targeting DNA Damage Response and Immune Checkpoint for Anticancer Therapy.

Huang, Jau-Ling / Chang, Yu-Tzu / Hong, Zhen-Yang / Lin, Chang-Shen

International journal of molecular sciences

2022 Volume 23, Issue 6

Abstract: Deficiency in DNA damage response (DDR) genes leads to impaired DNA repair functions that will induce genomic instability and facilitate cancer development. However, alterations of DDR genes can serve as biomarkers for the selection of suitable patients ... ...

Abstract	Deficiency in DNA damage response (DDR) genes leads to impaired DNA repair functions that will induce genomic instability and facilitate cancer development. However, alterations of DDR genes can serve as biomarkers for the selection of suitable patients to receive specific therapeutics, such as immune checkpoint blockade (ICB) therapy. In addition, certain altered DDR genes can be ideal therapeutic targets through adapting the mechanism of synthetic lethality. Recent studies indicate that targeting DDR can improve cancer immunotherapy by modulating the immune response mediated by cGAS-STING-interferon signaling. Investigations of the interplay of DDR-targeting and ICB therapies provide more effective treatment options for cancer patients. This review introduces the mechanisms of DDR and discusses their crucial roles in cancer therapy based on the concepts of synthetic lethality and ICB. The contemporary clinical trials of DDR-targeting and ICB therapies in breast, colorectal, and pancreatic cancers are included.
MeSH term(s)	DNA Damage ; DNA Repair ; Humans ; Immunity ; Immunotherapy ; Neoplasms/drug therapy ; Neoplasms/genetics
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23063238
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Article ; Online: Preterm birth and small for gestational age potentiate the association between maternal hypertensive pregnancy and childhood autism spectrum disorder.

Wang, Lan-Wan / Lin, Hung-Chih / Tsai, Ming-Luen / Chang, Yu-Tzu / Chang, Yu-Chia

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9606

Abstract: Children of mothers with hypertensive disorders of pregnancy (HDP) have high rates of preterm-birth (gestational age < 37 weeks) and small-for-gestational-age (SGA), both of which are risk factors of autism spectrum disorder (ASD). This study tested the ...

Abstract	Children of mothers with hypertensive disorders of pregnancy (HDP) have high rates of preterm-birth (gestational age < 37 weeks) and small-for-gestational-age (SGA), both of which are risk factors of autism spectrum disorder (ASD). This study tested the multiple-hit hypothesis that preterm-birth and SGA in the neonatal period might potentiate the antenatal impact of HDP to increase childhood ASD hazards, and HDP might not be a major contributor. The propensity-score-matched cohort enrolled 18,131 mother-child pairs with HDP and 90,655 normotensive controls between 2004 and 2011. Children with siblings born to the same mothers were excluded for analysis to reduce the potential familial-genetic influence. HDP were classified into chronic-hypertension, gestational-hypertension, preeclampsia, and preeclampsia-with-chronic-hypertension. Using the normotensive group as the reference, the associations between HDP subgroups and the cumulative ASD risks were assessed with hazard ratios, and the effects of preterm-birth and SGA on the associations were examined. The HDP group had a higher cumulative rate of ASD (1.5%) than the normotensive group (1.2%). Preterm-birth and SGA exerted moderating effects to aggravate ASD hazards in children exposed to chronic-hypertension or gestational-hypertension. None of HDP types significantly contributed to ASD after adjustments. In conclusion, antenatal HDP exposure might predispose to ASD outcome through susceptibility to the impact of preterm-birth and SGA.
MeSH term(s)	Child ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Infant ; Pre-Eclampsia ; Premature Birth/epidemiology ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/etiology ; Gestational Age ; Hypertension, Pregnancy-Induced/epidemiology ; Mothers
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36787-w
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Article ; Online: Maternal hypertensive pregnancy disorders increase childhood intellectual disability hazards independently from preterm birth and small for gestational age.

Wang, Lan-Wan / Lin, Hung-Chih / Tsai, Ming-Luen / Chang, Yu-Tzu / Chang, Yu-Chia

Early human development

2023 Volume 185, Page(s) 105856

Abstract: Background: Children of mothers with hypertensive-disorders-of-pregnancy (HDP) have high rates of preterm-birth (<37 weeks' gestation) and small-for-gestational-age (SGA), both of which are risk factors of intellectual disability (ID).: Aims: To test ...

Abstract	Background: Children of mothers with hypertensive-disorders-of-pregnancy (HDP) have high rates of preterm-birth (<37 weeks' gestation) and small-for-gestational-age (SGA), both of which are risk factors of intellectual disability (ID). Aims: To test the multiple-hit hypothesis that preterm-birth and SGA in the neonatal period might potentiate the antenatal impact of HDP to increase childhood ID hazards, and HDP might not have independent effects. Methods: This population-based cohort study enrolled 1,417,373 mother-child pairs between 2004 and 2011. A total of 19,457 pairs with HDP were identified and propensity-score-matched with 97,285 normotensive controls. Children were followed up for ID outcome until 6-13 years of age. HDP were classified into chronic-hypertension, gestational-hypertension, preeclampsia, and preeclampsia-with-chronic-hypertension. Using the normotensive group as the reference, the associations between HDP subgroups and ID hazards were assessed with adjusted hazard ratios (aHR) and 95 % confidence intervals (CI), and the effects of preterm-birth and SGA on the associations were examined. Results: The HDP group had higher cumulative rates of ID (1.6 %) than the normotensive group (0.9 %), particularly the subgroup of preeclampsia-with-chronic-hypertension (2.4 %), followed by preeclampsia (1.7 %), chronic-hypertension (1.5 %) and gestational hypertension (1.0 %). Preterm-birth and SGA exerted aggravating effects on ID hazards in children exposed to any HDP. After adjustments, maternal chronic-hypertension (aHR 1.59, 95 % CI 1.28-1.97), preeclampsia (1.52, 1.26-1.83), and preeclampsia-with-chronic-hypertension (1.86, 1.38-2.51) independently contributed to ID outcome. Conclusions: Maternal HDP other than gestational hypertension increased offspring's ID hazards independently from the potentiating hits of preterm-birth and SGA, implicating long-lasting influence of in-utero HDP exposure on children's cognitive development.
MeSH term(s)	Child ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Pre-Eclampsia ; Hypertension, Pregnancy-Induced/epidemiology ; Premature Birth/epidemiology ; Cohort Studies ; Gestational Age ; Intellectual Disability/epidemiology
Language	English
Publishing date	2023-09-03
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2023.105856
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Article ; Online: Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR transport to the lysosome.

Chu, Shao-Ling / Huang, Jia-Rong / Chang, Yu-Tzu / Yao, Shu-Yun / Yang, Jia-Shu / Hsu, Victor W / Hsu, Jia-Wei

Nature communications

2024 Volume 15, Issue 1, Page(s) 1021

Abstract: The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular events, including growth, differentiation, and motility. A major mechanism of downregulating EGFR function involves its endocytic transport to the lysosome. Sorting of ...

Abstract	The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular events, including growth, differentiation, and motility. A major mechanism of downregulating EGFR function involves its endocytic transport to the lysosome. Sorting of proteins into intracellular pathways involves cargo adaptors recognizing sorting signals on cargo proteins. A dileucine-based sorting signal has been identified previously for the sorting of endosomal EGFR to the lysosome, but a cargo adaptor that recognizes this signal remains unknown. Here, we find that phosphoglycerate kinase 1 (PGK1) is recruited to endosomal membrane upon its phosphorylation, where it binds to the dileucine sorting signal in EGFR to promote the lysosomal transport of this receptor. We also elucidate two mechanisms that act in concert to promote PGK1 recruitment to endosomal membrane, a lipid-based mechanism that involves phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and a protein-based mechanism that involves hepatocyte growth factor receptor substrate (Hrs). These findings reveal an unexpected function for a metabolic enzyme and advance the mechanistic understanding of how EGFR is transported to the lysosome.
MeSH term(s)	Phosphoglycerate Kinase/metabolism ; ErbB Receptors/metabolism ; Endosomes/metabolism ; Proteins/metabolism ; Lysosomes/metabolism ; Protein Transport/physiology ; Endosomal Sorting Complexes Required for Transport/metabolism
Chemical Substances	Phosphoglycerate Kinase (EC 2.7.2.3) ; ErbB Receptors (EC 2.7.10.1) ; Proteins ; Endosomal Sorting Complexes Required for Transport
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45443-4
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Article ; Online: Preterm birth increases cerebral palsy hazards in children of mothers with chronic hypertension in pregnancy.

Huang, Yi-Chien / Lin, Hung-Chih / Chang, Yu-Tzu / Tsai, Ming-Luen / Chang, Yu-Chia / Wang, Lan-Wan

Pediatrics and neonatology

2024

Abstract: Background: Children of mothers with chronic-hypertension in pregnancy have high rates of preterm-birth (<37 weeks of gestation) and small-for-gestational-age (SGA), both of which are risk factors of cerebral palsy (CP). This study investigated the ... ...

Abstract	Background: Children of mothers with chronic-hypertension in pregnancy have high rates of preterm-birth (<37 weeks of gestation) and small-for-gestational-age (SGA), both of which are risk factors of cerebral palsy (CP). This study investigated the cumulative risks of CP in children exposed to maternal chronic-hypertension vs. other types of hypertensive-disorders-of-pregnancy (HDP), and whether preterm-birth and SGA potentiate the antenatal impact of chronic-hypertension to increase CP hazards. Methods: This population-based cohort study enrolled 1,417,373 mother-child pairs with singleton live births between 2004 and 2011 from the Taiwan Maternal and Child Health Database. A total of 19,457 pairs with HDP were identified and propensity-score-matched with 97,285 normotensive controls. Children were followed up for CP outcome until age 6-13 years. HDP were classified into chronic-hypertension, gestational-hypertension, preeclampsia, and preeclampsia-with-chronic-hypertension. Using the normotensive group as the reference, the associations between chronic-hypertension and CP hazard were assessed with adjusted hazard ratios (HR) and 95% confidence intervals (CI) in Cox proportional hazards regression models, and the effects of preterm-birth and SGA on the associations were examined. Results: The HDP group had higher rates of CP (0.8%) than the normotensive group (0.5%), particularly the subgroup of preeclampsia-with-chronic-hypertension (1.0%), followed by preeclampsia (0.9%), chronic-hypertension (0.7%) and gestational-hypertension (0.6%). Preterm-birth, but not SGA, exerted moderating effects to increase CP risks in children exposed to maternal chronic-hypertension. Before adjustments, chronic-hypertension alone had no substantial contribution to CP hazard (HR 1.35, 95% CI 1.00-1.83), while preeclampsia alone (1.64, 1.28-2.11) or with superimposed-chronic-hypertension (1.83, 1.16-2.89) had significant effects. After including preterm-birth in the multivariable model, the CP hazard for chronic-hypertension alone rather than other types of HDP was raised and became significant (1.56, 1.15-2.12), and the significance remained after stepwise adjustments in the final model (1.74, 1.16-2.60). Conclusions: Preterm-birth might potentiate CP hazards in children of mothers with chronic-hypertension in pregnancy.
Language	English
Publishing date	2024-03-24
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/j.pedneo.2023.10.009
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