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  1. AU="Changjin Lee"
  2. AU="Hyunsoo Lee"
  3. AU=Sinha Ian
  4. AU="Bird, M F"

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  1. Artikel ; Online: Prospective comparative analysis of noninvasive body temperature monitoring using zero heat flux technology (SpotOn sensor) compared with esophageal temperature monitoring during pediatric surgery.

    Bo-Hyun Sang / Changjin Lee / Da Yeong Lee

    PLoS ONE, Vol 17, Iss 8, p e

    2022  Band 0272720

    Abstract: Maintaining body temperature in pediatric patients is critical, but it is often difficult to use currently accepted core temperature measurement methods. Several studies have validated the use of the SpotOn sensor for measuring core temperature in adults, ...

    Abstract Maintaining body temperature in pediatric patients is critical, but it is often difficult to use currently accepted core temperature measurement methods. Several studies have validated the use of the SpotOn sensor for measuring core temperature in adults, but studies on pediatric patients are still lacking. The aim of this study was to investigate the accuracy of the SpotOn sensor compared with that of esophageal temperature measurement in pediatric patients intraoperatively. Children aged 1-8 years with American Society of Anesthesiology Physical Condition Classification I or II scheduled to undergo elective ear surgery for at least 30 min under general anesthesia were enrolled. Body core temperature was measured every 15 min after induction till the end of anesthesia with an esophageal probe, axillary probe, and SpotOn sensor. We included 49 patients, providing a total 466 paired measurements. Analysis of Pearson rank correlation between SpotOn and esophageal pairs showed a correlation coefficient (r) of 0.93 (95% confidence interval [CI] 0.92-0.94). Analysis of Pearson rank correlation between esophageal and axillary pairs gave a correlation coefficient (r) of 0.89 (95% CI 0.87-0.91). Between the SpotOn and esophageal groups, Bland-Altman analysis revealed a bias (SD, 95% limits of agreement) of -0.07 (0.17 [-0.41-0.28]). Between the esophageal and axillary groups, Bland-Altman analysis showed a bias (SD, 95% limits of agreement) of 0.45 (0.22 [0-0.89]). In pediatric patients during surgery, the SpotOn sensor showed high correlation and agreement with the esophageal probe, which is a representative core temperature measurement method.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 541
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Risk factors for severe postpartum hemorrhage requiring blood transfusion after cesarean delivery for twin pregnancy

    Gi Hyeon Seo / Jong Yeop Kim / Da Yeong Lee / Changjin Lee / Jiyoung Lee

    Anesthesia and Pain Medicine, Vol 18, Iss 4, Pp 367-

    a nationwide cohort study

    2023  Band 375

    Abstract: Background Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality. Twin pregnancy and cesarean delivery are well-known risk factors for PPH. However, few studies have investigated PPH risk factors in mothers who have undergone ...

    Abstract Background Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality. Twin pregnancy and cesarean delivery are well-known risk factors for PPH. However, few studies have investigated PPH risk factors in mothers who have undergone cesarean delivery for twin pregnancies. Therefore, this study investigated the risk factors associated with severe PPH after cesarean delivery for twin pregnancies. Methods We searched and reviewed the Korean Health Insurance Review and Assessment Service’s claims data from July 2008 to June 2021 using the code corresponding to cesarean delivery for twin pregnancy. Severe PPH was defined as hemorrhage requiring red blood cell (RBC) transfusion during the peripartum period. The risk factors associated with severe PPH were identified among the procedure and diagnosis code variables and analyzed using univariate and multivariate logistic regressions. Results We analyzed 31,074 cesarean deliveries for twin pregnancies, and 4,892 patients who underwent cesarean deliveries for twin pregnancies and received RBC transfusions for severe PPH were included. According to the multivariate analysis, placental disorders (odds ratio, 4.50; 95% confidence interval, 4.09–4.95; P < 0.001), general anesthesia (2.33, 2.18–2.49; P < 0.001), preeclampsia (2.20, 1.99–2.43; P < 0.001), hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (2.12, 1.22–3.68; P = 0.008), induction failure (1.37, 1.07–1.76; P = 0.014), and hypertension (1.31, 1.18–1.44; P < 0.001) predicted severe PPH. Conclusions Placental disorders, hypertensive disorders such as preeclampsia and HELLP syndrome, and induction failure increased the risk of severe PPH after cesarean delivery for twin pregnancy.
    Schlagwörter blood transfusion ; cesarean section ; morbidity ; national cohort ; postpartum hemorrhage ; pregnancy ; twin ; Anesthesiology ; RD78.3-87.3 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag Korean Society of Anesthesiologists
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Visible-Light-Responsive High-Detectivity Organic Photodetectors with a 1 μm Thick Active Layer

    Park, Jong Baek / Jong-Woon Ha / Sung Cheol Yoon / Changjin Lee / In Hwan Jung / Do-Hoon Hwang

    ACS applied materials & interfaces. 2018 Oct. 17, v. 10, no. 44

    2018  

    Abstract: Organic photodetectors (OPDs) are attracting attention for use in flexible and portable electronic applications such as image sensors, remote sensing, optical communications, and medical sensors because of their strong photon responsivity in thin films ... ...

    Abstract Organic photodetectors (OPDs) are attracting attention for use in flexible and portable electronic applications such as image sensors, remote sensing, optical communications, and medical sensors because of their strong photon responsivity in thin films over a broad range of wavelengths. In particular, the efficient photon-to-current conversion of OPDs under visible light allows their use in indirect X-ray detectors using scintillators to convert X-rays to visible light. The polymer poly(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b′]dithiophene-co-5-(2-hexyldecyl)-1,3-bis(6-octylthieno[3,2-b]thiophen-2-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione) (PBDTT-8ttTPD) shows strong absorption bands in the region of 500–650 nm, as well as high hole mobility, which provides excellent photoresponsivity and photon-to-current conversion efficiency. A p–n junction photodetector was fabricated by blending PBDTT-8ttTPD and [6,6]-phenyl C₇₁ butyric acid methyl ester (PC₇₁BM) and varying the thickness of the active layer (260–1100 nm). The PBDTT-8ttTPD:PC₇₁BM-based OPDs show promising photodetecting properties having a low dark current of 3.72 × 10–⁹ A cm–² and high responsivity of 0.39 A W–¹ because of the well-controlled morphology, high molar absorption coefficient, and excellent carrier mobility of the PBDTT-8ttTPD:PC₇₁BM layer. Consequently, the specific detectivity of the PBDTT-8ttTPD-based OPD devices was 1.13 × 10¹³ Jones at −2 V on irradiation with a light-emitting diode (530 nm wavelength) with a power density of 55.6 μW cm–².
    Schlagwörter X-radiation ; absorbance ; absorption ; butyric acid ; detectors ; irradiation ; light emitting diodes ; mixing ; photons ; polymers ; remote sensing ; wavelengths
    Sprache Englisch
    Erscheinungsverlauf 2018-1017
    Umfang p. 38294-38301.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1944-8252
    DOI 10.1021/acsami.8b13550
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel: 4-Diphenylaminocarbazole: Switching Substituent Position for Voltage Reduction and Efficiency Enhancement of OLEDs

    Ameen, Shahid / Seul Bee Lee / Yong Guk Lee / Sung Cheol Yoon / Jaemin Lee / Changjin Lee

    ACS applied materials & interfaces. 2018 Feb. 26, v. 10, no. 10

    2018  

    Abstract: Simple but exceptionally efficient 4-diphenylaminocarbazole host material, 4-DPACz, is presented and compared with its positional isomer, 1-DPACz. The shift of diphenylamino substituent from the 1-position to 4-position of carbazole resulted in an ... ...

    Abstract Simple but exceptionally efficient 4-diphenylaminocarbazole host material, 4-DPACz, is presented and compared with its positional isomer, 1-DPACz. The shift of diphenylamino substituent from the 1-position to 4-position of carbazole resulted in an increase in the HOMO energy level as well as an increase in triplet energy level. Having a high triplet energy level (2.76 eV) and well-matched HOMO energy level (−5.61 eV), 4-DPACz showed reduced driving voltage and higher efficiencies for solution-processed green PhOLEDs compated to PVK as well as 1-DPACz. Maximum luminous, power, and external quantum efficiencies reaching to 47.9 cd A–¹, 25.2 lm W–¹, and 14.3%, respectively, were achieved with a device configuration of [ITO/PEDOT:PSS/4-DPACz:Ir(mppy)₃/TPBi/CsF/Al]. Additional enhancement of efficiencies of 4-DPACz was verified when incorporating another dopant, Ir(Si-bppy)₂(acac), resulting in 59.1 cd A–¹, 29.5 lm W–¹, and 15.8%. Furthermore, reduced efficiency roll-off was clearly observed for 4-DPACz compared with PVK. Such improved device characteristics of 4-DPACz were attributed to its high hole mobility and charge balance inside the emitting layer therof. The excellent results using such a simple-structured 4-DPACz could promote various applications of this 4-DPACz unit as a building block structure for further possible oligomeric, dendritic, and polymeric materials.
    Schlagwörter aluminum ; electric power ; energy ; polymers ; positional isomers
    Sprache Englisch
    Erscheinungsverlauf 2018-0226
    Umfang p. 8893-8900.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1944-8252
    DOI 10.1021/acsami.7b18044
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.

    Sung Won Lee / Hyun Jung Park / Sung Ho Jeon / Changjin Lee / Rho Hyun Seong / Se-Ho Park / Seokmann Hong

    PLoS ONE, Vol 10, Iss 7, p e

    2015  Band 0132329

    Abstract: Although SWI3-related gene (SRG3), a chromatin remodeling factor, is critical for various biological processes including early embryogenesis and thymocyte development, it is unclear whether SRG3 is involved in the differentiation of CD4+ T cells, the key ...

    Abstract Although SWI3-related gene (SRG3), a chromatin remodeling factor, is critical for various biological processes including early embryogenesis and thymocyte development, it is unclear whether SRG3 is involved in the differentiation of CD4+ T cells, the key mediator of adaptive immune responses. Because it is known that experimental autoimmune encephalomyelitis (EAE) development is determined by the activation of CD4+ T helper cells, here, we investigated the role of SRG3 in EAE development using SRG3 transgenic mouse models exhibiting two distinct SRG3 expression patterns: SRG3 expression driven by either the CD2 or β-actin promoter. We found that the outcome of EAE development was completely different depending on the expression pattern of SRG3. The specific over-expression of SRG3 using the CD2 promoter facilitated EAE via the induction of Th1 and Th17 cells, whereas the ubiquitous over-expression of SRG3 using the β-actin promoter inhibited EAE by promoting Th2 differentiation and suppressing Th1 and Th17 differentiation. In addition, the ubiquitous over-expression of SRG3 polarized CD4+ T cell differentiation towards the Th2 phenotype by converting dendritic cells (DCs) or macrophages to Th2 types. SRG3 over-expression not only reduced pro-inflammatory cytokine production by DCs but also shifted macrophages from the inducible nitric oxide synthase (iNOS)-expressing M1 phenotype to the arginase-1-expressing M2 phenotype during EAE. In addition, Th2 differentiation in β-actin-SRG3 Tg mice during EAE was associated with an increase in the basophil and mast cell populations and in IL4 production. Furthermore, the increased frequency of Treg cells in the spinal cord of β-actin-SRG3 Tg mice might induce the suppression of and accelerate the recovery from EAE symptoms. Taken together, our results provide the first evidence supporting the development of a new therapeutic strategy for EAE involving the modulation of SRG3 expression to induce M2 and Th2 polarization, thereby inhibiting inflammatory immune responses.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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