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  1. AU="Changyang Xing"
  2. AU="Sarovich, Derek S"
  3. AU="Joseph P. Zackular"
  4. AU="Maes, Evelyn"
  5. AU="Haixiang Zhou"
  6. AU="Choi, Jinyong"
  7. AU="González-Mansilla, Ana"
  8. AU="Cho Kilwon"
  9. AU="Rachide Onadja, Palamanga Abdoul"
  10. AU="Bertacca, Sofia"
  11. AU="Bansal, Ayush"
  12. AU="Liao, Naikai"
  13. AU="Gomes, Lux Attiê Santos"
  14. AU="İdil Su Canıtez"
  15. AU="Baptiste Duceau"
  16. AU="Pedro Seoane-Zonjic"
  17. AU="Guthridge, Carla J"
  18. AU=Meena Netra P.
  19. AU="Boustany, Tara"

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  1. Artikel ; Online: Ultrasound Responsive Nanovaccine Armed with Engineered Cancer Cell Membrane and RNA to Prevent Foreseeable Metastasis

    Wenqi Sun / Panpan Ji / Tian Zhou / Zhelong Li / Changyang Xing / Liang Zhang / Mengying Wei / Guodong Yang / Lijun Yuan

    Advanced Science, Vol 10, Iss 19, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti‐tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. ...

    Abstract Abstract Cancer vaccine has been considered as a promising immunotherapy by inducing specific anti‐tumor immune response. Rational vaccination at suitable time to efficiently present tumor associated antigen will boost tumor immunity and is badly needed. Here, a poly (lactic‐co‐glycolic acid) (PLGA)‐based cancer vaccine of nanoscale is designed, in which engineered tumor cell membrane proteins, mRNAs, and sonosensitizer chlorin e6 (Ce6) are encapsulated at high efficiency. The nanosized vaccine can be efficiently delivered into antigen presentation cells (APCs) in lymph nodes after subcutaneous injection. In the APCs, the encapsulated cell membrane and RNA from engineered cells, which have disturbed splicing resembling the metastatic cells, provide neoantigens of metastatic cancer in advance. Moreover, the sonosensitizer Ce6 together with ultrasound irradiation promotes mRNA escape from endosome, and augments antigen presentation. Through 4T1 syngeneic mouse model, it has been proved that the proposed nanovaccine is efficient to elicit antitumor immunity and thus prevent cancer metastasis.
    Schlagwörter alternative splicing ; antigen presentation ; cancer vaccine ; sonosensitizer ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension

    Chen Wang / Changyang Xing / Zhelong Li / Yunnan Liu / Qiaoying Li / Yixiao Wang / Jiao Hu / Lijun Yuan / Guodong Yang

    Bioactive Materials, Vol 8, Iss , Pp 494-

    2022  Band 504

    Abstract: Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure, and its physiopathologic mechanism is still not fully understood. We here aimed to explore whether extracellular vesicle (EV) mediated intercellular communication ...

    Abstract Arterial stiffness due to the vessel remodeling is closely linked to raised blood pressure, and its physiopathologic mechanism is still not fully understood. We here aimed to explore whether extracellular vesicle (EV) mediated intercellular communication between endothelium and smooth muscle cell contribute to the blood vessel remodeling under hypertension. We here revealed that the arterial endothelial cells robustly secreted EV, which in turn could be circulated and/or directly taken up by the subendothelial smooth muscle cells (SMC). Under hypertension, the EV secretion increased and the miRNA profile changed significantly mainly due to the raised mechanical force and subsequent enhanced reactive oxygen species generation. Among the miRNA cargos in the EV, miR-320d/423-5p were found increased most significantly. In vivo delivery of miR-320d/423-5p mimics via engineered EV increased their expression in arterial vessels, recapitulating the phenotype in hypertension. In contrast, therapeutic delivery of miR-320d/423-5p inhibitors via engineered EV alleviated the phenotype in spontaneous hypertension rat model. Together, we have found that the injured endothelium due to the raised mechanical force in hypertension contributes to the arterial wall remodeling via the secreted EV. Our study has not only provided novel insights on the mechanism of hypertension associated blood vessel wall remodeling, but also shed light on therapeutic intervention of hypertension associated vascular diseases.
    Schlagwörter Hypertension ; Extracellular vesicles ; Endothelial cell ; Smooth muscle cell ; Phenotype switch ; microRNA ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Lung ultrasound findings in patients with COVID-19 pneumonia

    Changyang Xing / Qiaoying Li / Hong Du / Wenzhen Kang / Jianqi Lian / Lijun Yuan

    Critical Care, Vol 24, Iss 1, Pp 1-

    2020  Band 3

    Schlagwörter COVID-19 ; Lung ultrasound ; SARS-CoV-2 ; Deep vein thrombosis ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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