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  1. Article ; Online: Development of a new series of thioacetal based fluorescence chemosensors for highly sensitive determination of Hg

    Piyanuch, Pornthip / Aryamueang, Sirimongkon / Khrootkaew, Tunyawat / Mahingsadet, Kingsak / Chansaenpak, Kantapat / Kamkaew, Anyanee

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2024  Volume 317, Page(s) 124429

    Abstract: Mercury ion is one of the most harmful metal ions with significant hazards to the environment and human health. Thus, the development of innovative, sensitive, and selective sensors to help address the detrimental impacts of heavy metal contamination is ... ...

    Abstract Mercury ion is one of the most harmful metal ions with significant hazards to the environment and human health. Thus, the development of innovative, sensitive, and selective sensors to help address the detrimental impacts of heavy metal contamination is necessary. In this work, we present three new chemosensors based on the deprotection reaction of the thioacetal group for distinguishing Hg
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2024.124429
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  2. Article ; Online: Unraveling the photophysical characteristics and biological applications of vinyl sulfones as viscosity sensors.

    Khaikate, Onnicha / Pewklang, Thitima / Khrootkaew, Tunyawat / Chansaenpak, Kantapat / Muangsopa, Prapassara / Kuhakarn, Chutima / Kamkaew, Anyanee

    RSC advances

    2023  Volume 13, Issue 24, Page(s) 16671–16677

    Abstract: For the first time, a series of vinyl sulfone- ... ...

    Abstract For the first time, a series of vinyl sulfone-NH
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra02354k
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  3. Article ; Online: Hybrid Cyanine/Methotrexate Nanoparticles for Synergistic PDT/Chemotherapy of Breast Cancer.

    Muangsopa, Prapassara / Chansaenpak, Kantapat / Kampaengsri, Sastiya / Saetiew, Jadsada / Noisa, Parinya / Meemon, Panomsak / Kamkaew, Anyanee

    ACS applied bio materials

    2023  Volume 6, Issue 2, Page(s) 603–614

    Abstract: Typically, nanomedicine was prepared using a nanocarrier to load cargo for specific purposes. In this work, a carrier-free nanosystem for imaging and photodynamic (PDT)/chemo combination therapy was developed using simple self-assembly of a dye and a ... ...

    Abstract Typically, nanomedicine was prepared using a nanocarrier to load cargo for specific purposes. In this work, a carrier-free nanosystem for imaging and photodynamic (PDT)/chemo combination therapy was developed using simple self-assembly of a dye and a chemotherapeutic agent. The resulting nanoparticles (
    MeSH term(s) Humans ; Animals ; Mice ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Methotrexate ; Photochemotherapy/methods ; Combined Modality Therapy ; Nanoparticles/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c00893
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  4. Article ; Online: Enhancing Glucose Biosensing with Graphene Oxide and Ferrocene-Modified Linear Poly(ethylenimine).

    Monkrathok, Jirawan / Janphuang, Pattanaphong / Suphachiaraphan, Somphong / Kampaengsri, Sastiya / Kamkaew, Anyanee / Chansaenpak, Kantapat / Lisnund, Sireerat / Blay, Vincent / Pinyou, Piyanut

    Biosensors

    2024  Volume 14, Issue 4

    Abstract: We designed and optimized a glucose biosensor system based on a screen-printed electrode modified with the NAD-GDH enzyme. To enhance the electroactive surface area and improve the electron transfer efficiency, we introduced graphene oxide (GO) and ... ...

    Abstract We designed and optimized a glucose biosensor system based on a screen-printed electrode modified with the NAD-GDH enzyme. To enhance the electroactive surface area and improve the electron transfer efficiency, we introduced graphene oxide (GO) and ferrocene-modified linear poly(ethylenimine) (LPEI-Fc) onto the biosensor surface. This strategic modification exploits the electrostatic interaction between graphene oxide, which possesses a negative charge, and LPEI-Fc, which is positively charged. This interaction results in increased catalytic current during glucose oxidation and helps improve the overall glucose detection sensitivity by amperometry. We integrated the developed glucose sensor into a flow injection (FI) system. This integration facilitates a swift and reproducible detection of glucose, and it also mitigates the risk of contamination during the analyses. The incorporation of an FI system improves the efficiency of the biosensor, ensuring precise and reliable results in a short time. The proposed sensor was operated at a constant applied potential of 0.35 V. After optimizing the system, a linear calibration curve was obtained for the concentration range of 1.0-40 mM (R
    MeSH term(s) Graphite/chemistry ; Biosensing Techniques ; Metallocenes/chemistry ; Ferrous Compounds/chemistry ; Polyethyleneimine/chemistry ; Glucose/analysis ; Electrodes ; Oxidation-Reduction
    Chemical Substances Graphite (7782-42-5) ; Metallocenes ; Ferrous Compounds ; ferrocene (U96PKG90JQ) ; Polyethyleneimine (9002-98-6) ; Glucose (IY9XDZ35W2) ; graphene oxide
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14040161
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  5. Article ; Online: Revolutionary Pyrazole-based Aza-BODIPY: Harnessing Photothermal Power Against Cancer Cells and Bacteria.

    Pewklang, Thitima / Saiyasombat, Worakrit / Chueakwon, Piyasiri / Ouengwanarat, Bongkot / Chansaenpak, Kantapat / Kampaengsri, Sastiya / Lai, Rung-Yi / Kamkaew, Anyanee

    Chembiochem : a European journal of chemical biology

    2024  Volume 25, Issue 3, Page(s) e202300653

    Abstract: In the realm of cancer therapy and treatment of bacterial infection, photothermal therapy (PTT) stands out as a potential strategy. The challenge, however, is to create photothermal agents that can perform both imaging and PTT, a so-called theranostic ... ...

    Abstract In the realm of cancer therapy and treatment of bacterial infection, photothermal therapy (PTT) stands out as a potential strategy. The challenge, however, is to create photothermal agents that can perform both imaging and PTT, a so-called theranostic agent. Photothermal agents that absorb and emit in the near-infrared region (750-900 nm) have recently received a lot of attention due to the extensive penetration of NIR light in biological tissues. In this study, we combined pyrazole with aza-BODIPY (PY-AZB) to develop a novel photothermal agent. PY-AZB demonstrated great photostability with a photothermal conversion efficiency (PCE) of up to 33 %. Additionally, PY-AZB can permeate cancer cells at a fast accumulation rate in less than 6 hours, according to the confocal images. Furthermore, in vitro photothermal therapy results showed that PY-AZB effectively eliminated cancer cells by up to 70 %. Interestingly, PY-AZB exhibited antibacterial activities against both gram-negative bacteria, Escherichia coli 780, and gram-positive bacteria, Staphylococcus aureus 1466. The results exhibit a satisfactory bactericidal effect against bacteria, with a killing efficiency of up to 100 % upon laser irradiation. As a result, PY-AZB may provide a viable option for photothermal treatment.
    MeSH term(s) Phototherapy ; Photochemotherapy ; Boron Compounds/pharmacology ; Boron Compounds/therapeutic use ; Escherichia coli ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Neoplasms/drug therapy
    Chemical Substances azaBDPBA compound ; Boron Compounds ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300653
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  6. Article ; Online: BODIPY-Based Fluorescent Probes for Selective Visualization of Endogenous Hypochlorous Acid in Living Cells via Triazolopyridine Formation.

    Hiranmartsuwan, Peraya / Wangngae, Sirilak / Nootem, Jukkrit / Kamkaew, Anyanee / Daengngern, Rathawat / Wattanathana, Worawat / Chansaenpak, Kantapat

    Biosensors

    2022  Volume 12, Issue 11

    Abstract: In this work, the two pyridylhydrazone-tethered BODIPY compounds ( ...

    Abstract In this work, the two pyridylhydrazone-tethered BODIPY compounds (
    MeSH term(s) Mice ; Animals ; Hypochlorous Acid/analysis ; Hypochlorous Acid/chemistry ; Fluorescent Dyes/chemistry ; Boron Compounds/chemistry ; Fluorescence
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Fluorescent Dyes ; Boron Compounds
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12110923
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  7. Article: Aza-BODIPY based carbonic anhydrase IX: Strategy to overcome hypoxia limitation in photodynamic therapy.

    Pewklang, Thitima / Chansaenpak, Kantapat / Bakar, Siti Nursyahirah / Lai, Rung-Yi / Kue, Chin Siang / Kamkaew, Anyanee

    Frontiers in chemistry

    2022  Volume 10, Page(s) 1015883

    Abstract: Hypoxia caused by photodynamic therapy (PDT) is a major hurdle to cancer treatment since it can promote recurrence and progression by activating angiogenic factors, lowering therapeutic efficacy dramatically. In this work, AZB-I- ... ...

    Abstract Hypoxia caused by photodynamic therapy (PDT) is a major hurdle to cancer treatment since it can promote recurrence and progression by activating angiogenic factors, lowering therapeutic efficacy dramatically. In this work, AZB-I-CAIX
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.1015883
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  8. Article ; Online: Near-Infrared Fluorescent Heptamethine Cyanine Dyes for COX-2 Targeted Photodynamic Cancer Therapy.

    Wangngae, Sirilak / Siriwibool, Siriwalee / Chansaenpak, Kantapat / Wet-Osot, Sirawit / Lai, Rung-Yi / Kamkaew, Anyanee

    ChemMedChem

    2022  Volume 17, Issue 9, Page(s) e202100780

    Abstract: We designed and synthesized two heptamethine cyanine-based theranostic probes that aimed to target COX-2 in cancer cells. One is I-IR799-CXB, in which I-IR799 is conjugated to the COX-2-specific inhibitor, celecoxib, and another is I-IR799-IMC, where the ...

    Abstract We designed and synthesized two heptamethine cyanine-based theranostic probes that aimed to target COX-2 in cancer cells. One is I-IR799-CXB, in which I-IR799 is conjugated to the COX-2-specific inhibitor, celecoxib, and another is I-IR799-IMC, where the non-selective COX inhibitor, indomethacin, was used. I-IR799 is a heptamethine cyanine derivative that can be activated by near-infrared light for photodynamic therapy (PDT) purposes. I-IR799-CXB and I-IR799-IMC were tested for their cancer-targeting capacity and photodynamic efficiency toward hepatocellular carcinoma (HepG2) cells relative to normal liver cells, alpha mouse liver 12 (AML12) cells. Interestingly, after conjugation, I-IR799-IMC exhibited better tumour targetability and PDT efficiency than I-IR799-CXB.
    MeSH term(s) Animals ; Carbocyanines/pharmacology ; Coloring Agents ; Cyclooxygenase 2 ; Fluorescent Dyes/pharmacology ; Mice ; Neoplasms ; Photochemotherapy
    Chemical Substances Carbocyanines ; Coloring Agents ; Fluorescent Dyes ; heptamethine cyanine dye ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2022-02-17
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202100780
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    Zs.A 6280: Show issues Location:
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  9. Article ; Online: A facile method for generating polypyrrole microcapsules and their application in electrochemical sensing.

    Pinyou, Piyanut / Blay, Vincent / Monkrathok, Jirawan / Janphuang, Pattanaphong / Chansaenpak, Kantapat / Pansalee, Jaruwan / Lisnund, Sireerat

    Mikrochimica acta

    2022  Volume 189, Issue 11, Page(s) 410

    Abstract: A facile and rapid strategy to generate polypyrrole microcapsules is reported. The strategy is compatible with a vortex mixer and with a microfluidic chip for droplet generation, allowing a > 100-fold reduction in particle size. The sub-micron particle ... ...

    Abstract A facile and rapid strategy to generate polypyrrole microcapsules is reported. The strategy is compatible with a vortex mixer and with a microfluidic chip for droplet generation, allowing a > 100-fold reduction in particle size. The sub-micron particle sizes obtained can also be tuned to some extent based on the chip geometry. The capsules can be kept stably in solution and can be transferred onto electrochemical devices. As an application example, we casted the polypyrrole capsules generated onto screen-printed electrodes, leading to a significant increase in their electroactive surface area and capacitance. The electrodes were further modified with glucose dehydrogenase (GDH) to fabricate glucose biosensors. The introduction of polypyrrole microcapsules increased the dynamic range of the glucose sensor to ca. 300% compared with that of the electrode without polypyrrole microcapsules. The resulting glucose sensor is operated at a constant applied potential of 0.20 V vs. Ag/AgCl (3 M KCl) in an air-equilibrated electrolyte. At this potential, the sensor showed a linear range from 1.0 to 9.0 mM glucose with a sensitivity of 3.23 µA cm
    MeSH term(s) Capsules ; Glucose ; Glucose 1-Dehydrogenase ; Polymers/chemistry ; Pyrroles/chemistry ; Reproducibility of Results ; Solvents ; Surface-Active Agents
    Chemical Substances Capsules ; Polymers ; Pyrroles ; Solvents ; Surface-Active Agents ; polypyrrole (30604-81-0) ; Glucose 1-Dehydrogenase (EC 1.1.1.47) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-10-08
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-022-05512-1
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  10. Article ; Online: Hemicyanine-based pH-responsive probes for rapid hypoxia detection in cancer cells.

    Wangngae, Sirilak / Chansaenpak, Kantapat / Khrootkaew, Tunyawat / Lai, Rung-Yi / Kamkaew, Anyanee

    Bioorganic chemistry

    2022  Volume 129, Page(s) 106173

    Abstract: As pH-sensitive and hypoxia-responsive probes, three hemicyanine derivatives based on vanillin and the indole ring (Val-Hcys) were synthesized. The fluorescence of the probes can be activated at acidic pH using the amide functionalized sidechains. ... ...

    Abstract As pH-sensitive and hypoxia-responsive probes, three hemicyanine derivatives based on vanillin and the indole ring (Val-Hcys) were synthesized. The fluorescence of the probes can be activated at acidic pH using the amide functionalized sidechains. Furthermore, when Val-Hcys were incubated with hypoxic cells for 5 min, the fluorescent signals significantly increased when compared to normoxia cells (4-fold enhancement, maximum at 180 min). In addition, Val-Hcys tend to accumulate in lysosomes and mitochondria, two important organelles involved in cell mitophagy. Surprisingly, Val-Hcys improved cell viability in hypoxic conditions. As a result, this study demonstrates the utility of Val-Hcys as pH-responsive probes for detecting hypoxic areas.
    MeSH term(s) Humans ; Fluorescent Dyes ; Hydrogen-Ion Concentration ; HeLa Cells ; Hypoxia ; Neoplasms
    Chemical Substances tetramethylene hemicyanine ; Fluorescent Dyes
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2022.106173
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    Zs.A 4207: Show issues Location:
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