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  1. Article: Abscess formation in ovarian endometriomas after failure of mifepristone-induced abortion.

    Chao, A S / Chang, S D / Wang, C J / Chao, A / Wang, T H

    Clinical and experimental obstetrics & gynecology

    2018  Volume 43, Issue 5, Page(s) 766–768

    Abstract: Objective: To report a case of abscess formation in bilateral ovarian endometriomas after failure of mifepristone-induced abortion.: Case report: A-36-year-old multiparous woman with bilateral ovarian endometriomas conceived spontaneously and ... ...

    Abstract Objective: To report a case of abscess formation in bilateral ovarian endometriomas after failure of mifepristone-induced abortion.
    Case report: A-36-year-old multiparous woman with bilateral ovarian endometriomas conceived spontaneously and received mifepristone to induce an abortion at 35 days' gestation. Fever and lower abdominal pain occurred 28 days after the abortion. The patient then underwent surgical curettage for an incomplete abortion complicated by endometritis. Her symptoms and signs became aggravated, and computed tomography showed a large ovarian abscess. She underwent laparoscopic drainage of the abscess plus the enucleation of the ovarian endometriomas, and received intravenous antibiotic treatment. She resumed menstruation one month later and was doing well at the 11-month follow-up.
    Conclusion: This case demonstrates the importance of combining antibiotic therapy with mifepristone to induce abortions in women with known ovarian endometriomas.
    MeSH term(s) Abortifacient Agents, Steroidal/pharmacology ; Abortion, Incomplete ; Abortion, Induced/adverse effects ; Abscess/etiology ; Adult ; Endometriosis/complications ; Female ; Humans ; Mifepristone/pharmacology ; Ovarian Diseases/etiology ; Pregnancy
    Chemical Substances Abortifacient Agents, Steroidal ; Mifepristone (320T6RNW1F)
    Language English
    Publishing date 2018-05-30
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754459-5
    ISSN 0390-6663
    ISSN 0390-6663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1678: Show issues Location:
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  2. Article ; Online: Secular trends in incidence and recurrence rates of hip fracture: a nationwide population-based study.

    Chen, F-P / Shyu, Y-C / Fu, T-S / Sun, C-C / Chao, A-S / Tsai, T-L / Huang, T-S

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2017  Volume 28, Issue 3, Page(s) 811–818

    Abstract: We assessed the incidence of hip fracture and second hip fractures in Taiwan from 2001 to 2012. Age-standardized incidence rates decreased after 2005. However, mortality rate after first hip fracture was substantial compared to second hip fracture rate ... ...

    Abstract We assessed the incidence of hip fracture and second hip fractures in Taiwan from 2001 to 2012. Age-standardized incidence rates decreased after 2005. However, mortality rate after first hip fracture was substantial compared to second hip fracture rate in a competing risk model.
    Introduction: The aim of the study is to assess the incidence rates (IRs) of hip fractures, including changes in trends and medical costs, and second hip fractures in the Taiwanese population.
    Methods: The number of hip fractures and the associated medical costs were obtained from the annual report of the Ministry of Health and Welfare, Taiwan, for individuals ≥50 years of age. The data of population at risk were retrieved from annual population reports from the Ministry of the Interior, Taiwan. The incidence of second hip fractures was evaluated from the National Health Insurance Research Database of Taiwan for insured individuals aged ≥50 years from 2001 to 2011 with follow-up until 2013 using a competing risk model.
    Results: The IR for the entire population increased from 332.7 to 336.5 per 100,000 person-years during 2001-2005 and decreased thereafter. This secular change was driven by a decrease in hip fractures for both men and women. The 10-year cumulative incidence rate of second hip fracture was 11.2% (95% CI 11.0-11.5%) in women and 7.9% (95% CI 7.6-8.1%) in men. Adjusted by consumer price index (CPI), the costs of hospitalization due to hip fracture increased from NTD 1.17 billion in 2001 to NTD 1.43 billion in 2012. However, the CPI-adjusted costs of each admission decreased from NTD 74944 in 2001 to NTD 65791 in 2012.
    Conclusions: Since 2006, the IR of hip fractures has been declining in Taiwan. The 10-year cumulative IR of mortality is substantial for individuals who with first hip fracture.
    MeSH term(s) Age Distribution ; Aged ; Aged, 80 and over ; Databases, Factual ; Female ; Health Care Costs/statistics & numerical data ; Health Care Costs/trends ; Hip Fractures/economics ; Hip Fractures/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Osteoporotic Fractures/economics ; Osteoporotic Fractures/epidemiology ; Recurrence ; Sex Distribution ; Taiwan/epidemiology
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-016-3820-3
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    Zs.A 3163: Show issues Location:
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  3. Article: Clinical management of a quadruplet pregnancy combining a triplet pregnancy with a classical hydatidiform mole: case report and review of literature.

    Chao, A S / Tsai, T C / Soong, Y K

    Prenatal diagnosis

    1999  Volume 19, Issue 11, Page(s) 1073–1076

    Abstract: A 28-year-old Taiwanese woman who had received ovulation induction by clomiphene citrate (CC), follicular-stimulating hormone (FSH), and human chorionic gonadotrophin (hCG) treatment was diagnosed with a quadruplet pregnancy containing a hydatidiform ... ...

    Abstract A 28-year-old Taiwanese woman who had received ovulation induction by clomiphene citrate (CC), follicular-stimulating hormone (FSH), and human chorionic gonadotrophin (hCG) treatment was diagnosed with a quadruplet pregnancy containing a hydatidiform mole and three fetuses at nine weeks' gestation. Expectant management failed to achieve any viable neonate due to massive antepartum haemorrhage and preterm delivery at 25 weeks' gestation. Five other cases previously reported involving quadruplets or triplets with a complete hydatidiform mole and two or three fetuses are reviewed. All cases ended as premature non-viable fetuses. Analysis of the clinical features, management, and outcome both in our patient and these reports suggest that more efficacious treatment planning, such as selective feticide, should be considered in order to improve the likelihood of attaining an advanced gestational age for a single fetus.
    MeSH term(s) Abortion, Spontaneous ; Adult ; Diagnosis, Differential ; Female ; Humans ; Hydatidiform Mole/diagnostic imaging ; Infertility, Female/drug therapy ; Ovulation Induction/adverse effects ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnostic imaging ; Pregnancy, Multiple ; Triplets ; Ultrasonography, Prenatal ; Uterine Neoplasms/diagnostic imaging
    Language English
    Publishing date 1999-11
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 82031-3
    ISSN 1097-0223 ; 0197-3851
    ISSN (online) 1097-0223
    ISSN 0197-3851
    DOI 10.1002/(sici)1097-0223(199911)19:11<1073::aid-pd702>3.0.co;2-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1625: Show issues Location:
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  4. Article ; Online: Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a meta-analysis.

    Chao, A S / Chao, A / Wang, T H / Chang, Y C / Chang, Y L / Hsieh, C C / Lien, R / Su, W J

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

    2008  Volume 31, Issue 3, Page(s) 289–295

    Abstract: Objectives: Rhabdomyoma, the most common primary fetal cardiac tumor, is often associated with tuberous sclerosis (TS). We aimed to evaluate outcome in cases diagnosed with fetal cardiac rhabdomyoma.: Methods: This study presents 11 cases with fetal ... ...

    Abstract Objectives: Rhabdomyoma, the most common primary fetal cardiac tumor, is often associated with tuberous sclerosis (TS). We aimed to evaluate outcome in cases diagnosed with fetal cardiac rhabdomyoma.
    Methods: This study presents 11 cases with fetal cardiac rhabdomyoma. In addition, all relevant published cases of antenatally diagnosed cardiac rhabdomyoma since 1982 were identified from MEDLINE. We evaluated the following risk factors associated with clinical impact and perinatal outcome: family history of TS, gestational age at diagnosis, tumor size, site and number of tumors, tumor progression, and associated intracardiac and extracardiac anomalies.
    Results: In this meta-analysis, 138 cases, including nine newly added by us, were categorized into Group A (107 live babies) and Group B (16 neonatal deaths and 15 intrauterine fetal deaths). Univariate analysis showed that large cardiac tumors (P < 0.0001), fetal dysrhythmia (P < 0.0001) and hydrops (P < 0.0001) were strong predictors of neonatal outcome. Tumor size >or= 20 mm (relative risk (RR), 20.6; 95% CI, 2.2-195.9; P = 0.009) and fetal dysrhythmia (RR, 13.6; 95% CI, 2.9-62.3; P = 0.001) were significantly associated with neonatal morbidity. TS, present in 85/133 (63.9%) cases, was significantly associated with multiple cardiac tumors (P < 0.0001) and family history of TS (P = 0.02).
    Conclusions: Large tumor size and hydrops are significantly associated with poor neonatal outcome, whereas family history of TS and multiple fetal cardiac tumors are associated with TS. Any sonographic detection of a fetal cardiac tumor should warrant further investigation for the possible presence of associated disorders.
    MeSH term(s) Echocardiography ; Female ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/pathology ; Fetal Heart/pathology ; Gestational Age ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Humans ; Infant ; Multivariate Analysis ; Pregnancy ; Pregnancy Outcome ; Prognosis ; Rhabdomyoma/diagnostic imaging ; Rhabdomyoma/pathology ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/diagnostic imaging ; Tuberous Sclerosis/genetics ; Ultrasonography, Prenatal/methods
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1073183-0
    ISSN 1469-0705 ; 0960-7692
    ISSN (online) 1469-0705
    ISSN 0960-7692
    DOI 10.1002/uog.5264
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    Zs.A 3214: Show issues Location:
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  5. Article ; Online: Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.

    Chao, A / Lin, C-Y / Lee, Y-S / Tsai, C-L / Wei, P-C / Hsueh, S / Wu, T-I / Tsai, C-N / Wang, C-J / Chao, A-S / Wang, T-H / Lai, C-H

    Oncogene

    2012  Volume 31, Issue 6, Page(s) 764–775

    Abstract: MicroRNAs (miRNAs) play important roles in tumorigenesis by regulating oncogenes and tumor-suppressor genes. In this study, miR-187 and miR-200a were found to be expressed at higher levels in ovarian cancers than in benign tumors. In patients with ... ...

    Abstract MicroRNAs (miRNAs) play important roles in tumorigenesis by regulating oncogenes and tumor-suppressor genes. In this study, miR-187 and miR-200a were found to be expressed at higher levels in ovarian cancers than in benign tumors. In patients with ovarian cancer, however, higher levels of miR-187 and miR-200a expression were paradoxically associated with better OS and recurrence-free survival. Further, multivariate analysis showed that miR-187 served as an independent prognostic factor for patients with ovarian cancer (n=176). Computational prediction and microarray results indicated that miR-187 directly targeted Disabled homolog-2 (Dab2), and luciferase reporter assays confirmed that the target site of miR-187 was located at the 3'-UTR of the Dab2 gene. Generally considered as a tumor-suppressor gene, Dab2 may actually promote tumor progression in advanced cancers through epithelial-to-mesenchymal transition (EMT). Ectopic expression of miR-187 in cancer cells promoted cell proliferation, but continued overexpression of miR-187 suppressed Dab2 and inhibited migration. Suppression of miR-187 upregulated Dab2, which, by inhibiting E-cadherin levels while stimulating vimentin and phospho-FAK levels, promoted EMT. Reduced ovarian cancer Dab2 histoscores correlated with high miR-187 levels and improved outcomes of patients. Collectively, these results demonstrate distinct dual roles of Dab2 in cell proliferation and tumor progression. In the initial steps of tumorigenesis, upregulated miR-187 suppresses Dab2, promoting cell proliferation. During the later stages, however, continued increased levels of miR-187 inhibits the Dab2-dependent EMT that is associated with tumor invasiveness, which is presumed to be the reason why cancers with high miR-187 levels were associated with better survivals.
    MeSH term(s) 3' Untranslated Regions/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adult ; Blotting, Western ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Multivariate Analysis ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Prognosis ; RNA, Antisense/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Analysis ; Time Factors ; Tumor Suppressor Proteins
    Chemical Substances 3' Untranslated Regions ; Adaptor Proteins, Signal Transducing ; Cadherins ; DAB2 protein, human ; MIRN187 microRNA, human ; MIRN200 microRNA, human ; MicroRNAs ; RNA, Antisense ; Tumor Suppressor Proteins
    Language English
    Publishing date 2012-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/onc.2011.269
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    Zs.A 2218: Show issues Location:
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  6. Article: Isolated fetal ascites: five cases report.

    Horng, S G / Chao, A S / Cheng, P J / Soong, Y K

    Changgeng yi xue za zhi

    1998  Volume 21, Issue 1, Page(s) 72–77

    Abstract: Isolated fetal ascites is a rare abnormality that can be detected prenatally by sonography. Fetuses with transient or isolated ascites were reported to have a good outcome if the specific etiology is confirmed and the appropriate treatment is given. In ... ...

    Abstract Isolated fetal ascites is a rare abnormality that can be detected prenatally by sonography. Fetuses with transient or isolated ascites were reported to have a good outcome if the specific etiology is confirmed and the appropriate treatment is given. In this report, we present 5 cases of nonimmune fetal ascites of different etiologies and obstetric managements. Fetuses that presented with generalized hydrops, chromosomal abnormalities and viral etiologies were excluded. Four of the fetuses survived without major neonatal complications, which included one chyloperitoneum, one meconium peritonitis and 2 idiopathic causes. Spontaneous resolution occurred in three cases. The one treated with prenatal paracentesis did not experience respiratory distress after birth but the other who did not undergo the procedure showed neonatal respiratory distress. The only neonatal mortality was a case involving intestinal obstruction who developed necrotizing enterocolitis four days after the surgery. Nonimmune fetal ascites can have a good outcome by using ultrasound in establishing the specific prenatal diagnosis and surveillance.
    MeSH term(s) Adult ; Ascites/diagnostic imaging ; Female ; Fetal Diseases/diagnostic imaging ; Humans ; Pregnancy ; Ultrasonography, Prenatal
    Language English
    Publishing date 1998-03
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article
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  7. Article: The detection of right-sided congenital diaphragmatic hernia in monozygotic twins on prenatal ultrasonography.

    Chao, A S / Cheng, P J / Hsueh, C / Soong, Y K

    The journal of obstetrics and gynaecology research

    1997  Volume 23, Issue 2, Page(s) 153–155

    Abstract: The diagnosis of a pair of monozygotic twins with right-sided diaphragmatic hernia under ultrasound is described. Aspects of heredity, diagnosis and management are discussed. ...

    Abstract The diagnosis of a pair of monozygotic twins with right-sided diaphragmatic hernia under ultrasound is described. Aspects of heredity, diagnosis and management are discussed.
    MeSH term(s) Diseases in Twins ; Female ; Fetal Diseases/diagnostic imaging ; Gestational Age ; Hernia, Diaphragmatic/diagnostic imaging ; Hernias, Diaphragmatic, Congenital ; Humans ; Male ; Pregnancy ; Twins, Monozygotic ; Ultrasonography, Prenatal
    Language English
    Publishing date 1997-04
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/j.1447-0756.1997.tb00824.x
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    Zs.A 1810: Show issues Location:
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  8. Article: Postmenopausal tuboovarian abscess.

    Chao, A S / Chang, S Y / Soong, Y K

    Changgeng yi xue za zhi

    1992  Volume 15, Issue 3, Page(s) 128–133

    Abstract: Twenty postmenopausal women with tuboovarian abscess were surgically managed at CGMH during 1981 to 1991. Fever with lower abdominal pain were the most common symptoms and signs. Laboratory, sonographic & roentgenologic studies helped in detecting and in ...

    Abstract Twenty postmenopausal women with tuboovarian abscess were surgically managed at CGMH during 1981 to 1991. Fever with lower abdominal pain were the most common symptoms and signs. Laboratory, sonographic & roentgenologic studies helped in detecting and in making a correct preoperative diagnosis of the origin of the inflammatory complex. Half of the patients had postmenopausal bleeding or discharge. Six tuboovarian abscesses were ruptured at the time of surgery and of these had prolonged hospitalization due to complications. Among the six complications, 2 suffered from intraoperative bowel injury, 2 had postoperative wound infection, 1 colonocutaneous fistula and 1 sigmoid stricture. Abdominal total hysterectomy was tried in all the cases but the surgical procedure was changed to subtotal hysterectomy in two and bilateral salpingo-oophorectomy in one. Septic condition and suspicion of ruptured abscess are indications for immediate operation. No major medical complication developed in the post-operative period. However, the early detection and treatment of unruptured tuboovarian abscess had less surgery related complications and had a shorter mean length of hospitalization.
    MeSH term(s) Abscess/pathology ; Abscess/surgery ; Aged ; Aged, 80 and over ; Fallopian Tube Diseases/pathology ; Fallopian Tube Diseases/surgery ; Female ; Humans ; Menopause ; Middle Aged ; Ovarian Diseases/pathology ; Ovarian Diseases/surgery
    Language English
    Publishing date 1992-09
    Publishing country China (Republic : 1949- )
    Document type Journal Article
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  9. Article: Interphase FISH--assisted second-trimester termination of a trisomy 21 fetus in an IVF-ET twin pregnancy. A case report.

    Chang, S D / Chao, A S / Lai, Y M / Liu, H Y / Soong, Y K

    The Journal of reproductive medicine

    2001  Volume 46, Issue 12, Page(s) 1063–1066

    Abstract: Background: When confronting a dizygotic pregnancy with one fetus affected with chromosomal aberrations, most couples would opt for selective termination of the affected twin.: Case: Routine genetic amniocentesis was performed for an in vitro ... ...

    Abstract Background: When confronting a dizygotic pregnancy with one fetus affected with chromosomal aberrations, most couples would opt for selective termination of the affected twin.
    Case: Routine genetic amniocentesis was performed for an in vitro fertilization-embryo transfer twin pregnancy at 18 weeks' gestation due to advanced maternal age. After two weeks, cytogenetic analysis revealed that both twins were male and one was affected with trisomy 21. At that time, ultrasound examination could not tell them apart with certainty. With the aid of interphase fluorescence in situ hybridization (FISH), we had no trouble locating the affected twin and performed feticide successfully with an intracardiac potassium chloride injection. At 37 weeks of gestation, a normal male was delivered along with a macerated trisomy 21 fetus.
    Conclusion: In a dizygotic twin pregnancy discordant for chromosome aberrations, when ultrasound cannot distinguish the affected twin, performing interphase FISH with an appropriate chromosome probe proves very useful in quickly and accurately locating the chromosomally abnormal twin for selective termination.
    MeSH term(s) Adult ; Diagnosis, Differential ; Down Syndrome/genetics ; Female ; Fertilization in Vitro ; Humans ; In Situ Hybridization, Fluorescence ; Infant, Newborn ; Interphase ; Male ; Pregnancy ; Pregnancy Outcome ; Pregnancy Reduction, Multifetal ; Pregnancy Trimester, Second ; Twins, Dizygotic/genetics
    Language English
    Publishing date 2001-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390916-5
    ISSN 1943-3565 ; 0024-7758
    ISSN (online) 1943-3565
    ISSN 0024-7758
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    Zs.A 817: Show issues Location:
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  10. Article: Ritodrine-induced leukopenia: a case report and literature review.

    Wu, C D / Chao, A S / Cheng, P J / Soong, Y K

    Changgeng yi xue za zhi

    1996  Volume 19, Issue 4, Page(s) 388–391

    Abstract: Ritodrine hydrochloride, a beta 2-adrenergic receptor agonist, has been widely applied in the treatment of premature labor for many years and generally considered as a safe medication. It can however induce some serious side effects, such as pulmonary ... ...

    Abstract Ritodrine hydrochloride, a beta 2-adrenergic receptor agonist, has been widely applied in the treatment of premature labor for many years and generally considered as a safe medication. It can however induce some serious side effects, such as pulmonary edema, myocardial ischemia, ketoacidosis, miscellaneous metabolic alterations, and leukopenia. This report presents a rare case of leukopenia in a Chinese woman as a result of low dose continuous intravenous infusion of ritodrine, in which the white blood cell count dropped rapidly and recovered quickly following the cessation of administration. The rapid and spontaneous reversal of leukopenia was most probably due to early recognition and intervention of this drug-induced side effect.
    MeSH term(s) Adolescent ; Adrenergic beta-Agonists/adverse effects ; Female ; Humans ; Leukopenia/chemically induced ; Pregnancy ; Ritodrine/adverse effects ; Tocolytic Agents/adverse effects
    Chemical Substances Adrenergic beta-Agonists ; Tocolytic Agents ; Ritodrine (I0Q6O6740J)
    Language English
    Publishing date 1996-12
    Publishing country China (Republic : 1949- )
    Document type Case Reports ; Journal Article ; Review
    Database MEDical Literature Analysis and Retrieval System OnLINE

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