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Book ; Online: Recent Advances in Asthma Research and Treatments

Chapoval, Svetlana P.

2022

Keywords	Respiratory medicine
Language	0\|e
Size	1 electronic resource (108 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021612950
ISBN	9781839692079 ; 1839692073
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Dendritic Cells

Chapoval, Svetlana P

2018

Keywords	Immunology ; cancer, immunotherapy, biocompatibility, magnesium, cell therapy, titanium
Language	English
Size	1 electronic resource (138 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030646458
ISBN	9781838817879 ; 1838817875
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.

Chapoval, Svetlana P / Gao, Hongjuan / Fanaroff, Rachel / Keegan, Achsah D

Frontiers in immunology

2024 Volume 14, Page(s) 1297354

Abstract: We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type ...

Abstract	We investigated the effect of global Plexin B1 deficiency on allergic airway responses to house dust mite (HDM) or ovalbumin (OVA). In the HDM model, there were higher Th2 cytokine levels in the BALF of Plexin B1 knock-out (KO) mice compared to wild type (WT), and tissue inflammation and mucus production were modestly enhanced. In the OVA model, Plexin B1 deficiency led to increases in lung inflammation, mucus production, and lung Th2 cytokines accompanied by dysregulated mucin gene expression without affecting anti-OVA IgE/IgG1 levels. Spleen cells from Plexin B1 KO mice proliferated more robustly than WT cells
MeSH term(s)	Animals ; Mice ; Cytokines ; Dermatophagoides pteronyssinus ; Hypersensitivity ; Inflammation ; Interleukin-4 ; Mucins ; Nerve Tissue Proteins/metabolism ; Ovalbumin ; Pneumonia ; T-Lymphocytes, Regulatory ; Receptors, Cell Surface/metabolism
Chemical Substances	Cytokines ; Interleukin-4 (207137-56-2) ; Mucins ; Nerve Tissue Proteins ; Ovalbumin (9006-59-1) ; Plxnb1 protein, mouse ; Receptors, Cell Surface
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1297354
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuroimmune semaphorins as costimulatory molecules and beyond.

Chapoval, Svetlana P

Molecular medicine (Cambridge, Mass.)

2018 Volume 24, Issue 1, Page(s) 13

Abstract: Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as ... ...

Abstract	Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as "neuroimmune semaphorins". They have been shown to regulate T cell activation by serving as costimulatory molecules. Similar to classical costimulatory molecules, neuroimmune semaphorins are either constitutively or inducibly expressed on immune cells. In contrast to the classical costimulatory molecule function, the action of neuroimmune semaphorins requires the presence of two signals, the first one provided by TCR/MHC engagement, and the second one provided by B7/CD28 interaction. Thus, neuroimmune semaphorins serve as a "signal three" for immune cell activation and regulate the overall intensity of immune response. The current knowledge on their structures, multiple receptors, specific cell/tissue/organ expression, and distinct functions in different diseases are summarized and discussed in this review.
MeSH term(s)	Animals ; Humans ; Nervous System/immunology ; Semaphorins/chemistry ; Semaphorins/immunology ; Semaphorins/metabolism
Chemical Substances	Semaphorins
Language	English
Publishing date	2018-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-018-0014-9
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Article ; Online: Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.

Chapoval, Svetlana P / Keegan, Achsah D

Molecular medicine (Cambridge, Mass.)

2021 Volume 27, Issue 1, Page(s) 162

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike-NRP1 interaction to combat virus infectivity and severe disease manifestations.
MeSH term(s)	Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/epidemiology ; COVID-19/etiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/virology ; Female ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/immunology ; Humans ; Infant ; Molecular Targeted Therapy/methods ; Neuropilin-1/chemistry ; Neuropilin-1/immunology ; Neuropilin-1/metabolism ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Pregnancy Complications, Infectious/virology ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; NRP1 protein, human ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Neuropilin-1 (144713-63-3) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-12-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-021-00423-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.

Chapoval, Svetlana P

Arthritis research & therapy

2015 Volume 17, Page(s) 313

Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial ... ...

Abstract	Rheumatoid arthritis (RA) is a systemic autoimmune disease manifesting in joint destruction. The recognized hallmark of RA pathogenesis is the involvement of immune cells which produce many mediators potentiating an inflammatory environment. RA synovial fibroblasts (RASFs) contribute significantly to disease progression by initiating and regulating many pathways of joint destruction. Detailed molecular insights into RASF biology may lead to identification of important therapeutic targets. The discovery of common molecular targets for joint resident and inflammatory cells may help to develop the most effective therapeutic strategy. One such pathway includes semaphorin 4A as reported in a recent article in Arthritis Research & Therapy.
MeSH term(s)	Arthritis, Rheumatoid/genetics ; Female ; Fibroblasts/metabolism ; Gene Expression/genetics ; Humans ; Male ; Semaphorins/genetics ; Synovial Membrane/metabolism
Chemical Substances	Semaphorins
Language	English
Publishing date	2015-11-06
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-015-0846-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

Iyer, Apoorva S / Chapoval, Svetlana P

International journal of molecular sciences

2018 Volume 20, Issue 1

Abstract: Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons ... ...

Abstract	Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal, and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro- or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Carcinogenesis/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism ; Semaphorins/genetics ; Semaphorins/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; SEMA4A protein, human ; Semaphorins ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2018-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20010124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identifying Function Determining Residues in Neuroimmune Semaphorin 4A.

Chapoval, Svetlana P / Lee, Mariah / Lemmer, Aaron / Ajayi, Oluwaseyi / Qi, Xiulan / Neuwald, Andrew F / Keegan, Achsah D

International journal of molecular sciences

2022 Volume 23, Issue 6

Abstract: Semaphorin 4A (Sema4A) exerts a stabilizing effect on human Treg cells in PBMC and CD4+ T cell cultures by engaging Plexin B1. Sema4A deficient mice display enhanced allergic airway inflammation accompanied by fewer Treg cells, while Sema4D deficient ... ...

Abstract	Semaphorin 4A (Sema4A) exerts a stabilizing effect on human Treg cells in PBMC and CD4+ T cell cultures by engaging Plexin B1. Sema4A deficient mice display enhanced allergic airway inflammation accompanied by fewer Treg cells, while Sema4D deficient mice displayed reduced inflammation and increased Treg cell numbers even though both Sema4 subfamily members engage Plexin B1. The main objectives of this study were: 1. To compare the in vitro effects of Sema4A and Sema4D proteins on human Treg cells; and 2. To identify function-determining residues in Sema4A critical for binding to Plexin B1 based on Sema4D homology modeling. We report here that Sema4A and Sema4D display opposite effects on human Treg cells in in vitro PBMC cultures; Sema4D inhibited the CD4+CD25+Foxp3+ cell numbers and CD25/Foxp3 expression. Sema4A and Sema4D competitively bind to Plexin B1 in vitro and hence may be doing so in vivo as well. Bayesian Partitioning with Pattern Selection (BPPS) partitioned 4505 Sema domains from diverse organisms into subgroups based on distinguishing sequence patterns that are likely responsible for functional differences. BPPS groups Sema3 and Sema4 into one family and further separates Sema4A and Sema4D into distinct subfamilies. Residues distinctive of the Sema3,4 family and of Sema4A (and by homology of Sema4D) tend to cluster around the Plexin B1 binding site. This suggests that the residues both common to and distinctive of Sema4A and Sema4D may mediate binding to Plexin B1, with subfamily residues mediating functional specificity. We mutated the Sema4A-specific residues M198 and F223 to alanine; notably, F223 in Sema4A corresponds to alanine in Sema4D. Mutant proteins were assayed for Plexin B1-binding and Treg stimulation activities. The F223A mutant was unable to stimulate Treg stability in in vitro PBMC cultures despite binding Plexin B1 with an affinity similar to the WT protein. This research is a first step in generating potent mutant Sema4A molecules with stimulatory function for Treg cells with a view to designing immunotherapeutics for asthma.
MeSH term(s)	Alanine ; Animals ; Bayes Theorem ; Forkhead Transcription Factors/genetics ; Humans ; Inflammation ; Leukocytes, Mononuclear/metabolism ; Mice ; Nerve Tissue Proteins/metabolism ; Semaphorins/metabolism
Chemical Substances	Forkhead Transcription Factors ; Nerve Tissue Proteins ; SEMA4A protein, human ; Semaphorins ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23063024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.

Chapoval, Svetlana P / Hritzo, Molly / Qi, Xiulan / Tamagnone, Luca / Golding, Amit / Keegan, Achsah D

ImmunoHorizons

2019 Volume 3, Issue 2, Page(s) 71–87

Abstract: We previously reported that neuroimmune semaphorin (Sema) 4A regulates the severity of experimental allergic asthma and increases regulatory T (Treg) cell numbers in vivo; however, the mechanisms of Sema4A action remain unknown. It was also reported that ...

Abstract	We previously reported that neuroimmune semaphorin (Sema) 4A regulates the severity of experimental allergic asthma and increases regulatory T (Treg) cell numbers in vivo; however, the mechanisms of Sema4A action remain unknown. It was also reported that Sema4A controls murine Treg cell function and survival acting through neuropilin 1 (NRP-1) receptor. To clarify Sema4A action on human T cells, we employed T cell lines (HuT78 and HuT102), human PBMCs, and CD4
MeSH term(s)	Antibodies ; Asthma/immunology ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Forkhead Transcription Factors/metabolism ; Humans ; Interleukin-2/metabolism ; Interleukin-2 Receptor alpha Subunit/metabolism ; Nerve Tissue Proteins/immunology ; Nerve Tissue Proteins/metabolism ; Neuropilin-1/metabolism ; Phenotype ; Receptors, Cell Surface/immunology ; Receptors, Cell Surface/metabolism ; Semaphorins/metabolism ; Semaphorins/pharmacology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
Chemical Substances	Antibodies ; FOXP3 protein, human ; Forkhead Transcription Factors ; IL2RA protein, human ; Interleukin-2 ; Interleukin-2 Receptor alpha Subunit ; Nerve Tissue Proteins ; PLXNB1 protein, human ; Receptors, Cell Surface ; SEMA4A protein, human ; Semaphorins ; Transforming Growth Factor beta ; Neuropilin-1 (144713-63-3)
Language	English
Publishing date	2019-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.1800026
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Article ; Online: Semaphorins 4A and 4D in chronic inflammatory diseases.

Chapoval, Svetlana P / Vadasz, Zahava / Chapoval, Andrei I / Toubi, Elias

Inflammation research : official journal of the European Histamine Research Society ... [et al.

2017 Volume 66, Issue 2, Page(s) 111–117

Abstract: Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, ...

Abstract	Long-term inflammatory processes directed at a particular endogenous or exogenous antigen, or sometimes of unknown etiology, form the pathogenetic basis for many debilitating conditions, such as cardiovascular, pulmonary, autoimmune, neurologic diseases, and cancer. Recent discoveries of neuroimmune semaphorins 4A and 4D (Sema4A and Sema4D, respectively) expression and function in the immune system and their key regulatory roles in fine tuning of inflammatory processes made them the molecules of interest for a potential immunotherapy. In this short review, we discuss the current knowledge in the Sema4A and Sema4D actions in chronic inflammation underlying the outlined above diseases.
MeSH term(s)	Animals ; Antigens, CD/immunology ; Arthritis, Rheumatoid/immunology ; Asthma/immunology ; Atherosclerosis/immunology ; Humans ; Inflammatory Bowel Diseases/immunology ; Lupus Erythematosus, Systemic/immunology ; Multiple Sclerosis/immunology ; Myocarditis/immunology ; Neoplasms/immunology ; Nerve Tissue Proteins/immunology ; Receptors, Cell Surface/immunology ; Semaphorins/immunology
Chemical Substances	Antigens, CD ; CD100 antigen ; Nerve Tissue Proteins ; PLXNB1 protein, human ; Receptors, Cell Surface ; SEMA4A protein, human ; Semaphorins
Language	English
Publishing date	2017-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1221794-3
ISSN	1420-908X ; 1023-3830
ISSN (online)	1420-908X
ISSN	1023-3830
DOI	10.1007/s00011-016-0983-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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