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  1. AU="Chapuis, J"
  2. AU="Berta, László"
  3. AU="Barzilay, Regina"
  4. AU="Schmidt, Michael Rahbek"
  5. AU=Tack J
  6. AU="Oh, Hye Min"
  7. AU=Gaffen Sarah L AU=Gaffen Sarah L
  8. AU="Schmitt, Christine"
  9. AU="McKay, Jackie"
  10. AU="Bellissimo, Catherine A"
  11. AU="Desai, Urja"
  12. AU="Chini, Maria Giovanna"
  13. AU="Xiao, Difei"
  14. AU="Ryan, Chris"
  15. AU="Omar Bazighifan"
  16. AU="Corominas Galbany, Jordi"
  17. AU=Fox Norma E
  18. AU="Hamilton, Shelia M"
  19. AU="Nichols, J Wylie"
  20. AU="Pesce R."
  21. AU="Gambitta, P"
  22. AU="Imran, Aqeel"
  23. AU="Sharma, Yashoda"
  24. AU="Kosai, Jordyn"
  25. AU="Aroca Ferri, María"
  26. AU="Laba, Stephanie"
  27. AU="Kim, Ye-Sel"

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  1. Artikel: Mutiger politischer Aufbruch.

    Chapuis, Jacques

    Krankenpflege. Soins infirmiers

    2018  Band 110, Heft 4, Seite(n) 15

    Titelübersetzung in process.
    Mesh-Begriff(e) Forecasting ; Geriatric Nursing/education ; Geriatric Nursing/manpower ; Health Services Needs and Demand/trends ; Humans ; Politics ; Population Dynamics ; Schools, Nursing/trends ; Switzerland
    Sprache Deutsch
    Erscheinungsdatum 2018-11-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Il coraggio di lanciarsi in politica.

    Chapuis, Jacques

    Krankenpflege. Soins infirmiers

    2018  Band 110, Heft 4, Seite(n) 80

    Titelübersetzung in process.
    Sprache Italienisch
    Erscheinungsdatum 2018-11-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: <<Le courage de se lancer en politique>>.

    Chapuis, Jacques

    Krankenpflege. Soins infirmiers

    2018  Band 110, Heft 4, Seite(n) 62

    Titelübersetzung in process.
    Sprache Französisch
    Erscheinungsdatum 2018-11-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: "Mutiger politischer Aufbrauch" : SBK-Volksinitiative für eine starke Pflege

    Chapuis, Jacques

    Krankenpflege SBK = Soins infirmières = Cure infermieristiche

    2017  Band 110, Heft 4, Seite(n) 15

    Schlagwörter Volksinitiative
    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Datenquelle Literaturdatenbank des Gesundheitswesens

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  5. Artikel: Les enfants de Virginia.

    Chapuis, Jacques

    Krankenpflege. Soins infirmiers

    2014  Band 107, Heft 1, Seite(n) 56–61, 76–80

    Titelübersetzung The children of Virginia.
    Mesh-Begriff(e) Clinical Competence ; Computer Simulation/trends ; Curriculum/trends ; Education, Nursing/trends ; Faculty, Nursing ; Humans ; Inservice Training/trends ; Internship, Nonmedical/trends ; Manikins ; Nursing Theory ; Social Change ; Students, Nursing ; Switzerland
    Sprache Italienisch
    Erscheinungsdatum 2014
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 80459-9
    ISSN 0253-0465
    ISSN 0253-0465
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals.

    Dourlen, Pierre / Chapuis, Julien / Lambert, Jean-Charles

    Current genetic medicine reports

    2018  Band 6, Heft 3, Seite(n) 107–115

    Abstract: Purpose of review: The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. For Alzheimer's disease (AD), more than 20 risk loci have been identified. ... ...

    Abstract Purpose of review: The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. For Alzheimer's disease (AD), more than 20 risk loci have been identified. However, we are now facing three new challenges: (i) identifying the functional SNP or SNPs in each locus, (ii) identifying the causal gene(s) in each locus, and (iii) understanding these genes' contribution to pathogenesis.
    Recent findings: To address these issues and thus functionally characterize GWAS signals, a number of high-throughput strategies have been implemented in cell-based and whole-animal models. Here, we review high-throughput screening, high-content screening, and the use of the
    Summary: We describe how these strategies have been successfully used to functionally characterize the genes in GWAS-defined risk loci. In the future, these strategies should help to translate GWAS data into knowledge and treatments.
    Sprache Englisch
    Erscheinungsdatum 2018-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2167-4876
    ISSN 2167-4876
    DOI 10.1007/s40142-018-0141-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Anticholinergic Drugs and Oral Health-related Quality of Life in Patients with Schizophrenia: A Pilot Study.

    Chapuis, Justine / Siu-Paredes, Francesca / Pavageau, Claire / Amador, Gilles / Rude, Nathalie / Denis, Frédéric

    Translational neuroscience

    2020  Band 11, Seite(n) 10–16

    Abstract: Objective: The aim of this study was to explore, in a sample population of people with schizophrenia (PWS), the role of the anticholinergic burden on the perception of oral health-related quality of life (OHrQoL) in France.: Methods: A pilot study ... ...

    Abstract Objective: The aim of this study was to explore, in a sample population of people with schizophrenia (PWS), the role of the anticholinergic burden on the perception of oral health-related quality of life (OHrQoL) in France.
    Methods: A pilot study was performed between March 2014 and January 2016. PWS were recruited from a population in Côte d'Or department in France. Dental status was investigated using the Decayed, Missing, or Filled Teeth (DMFT) index, the Xerostomia Index (XI), and the Global Oral Health Assessment Index (GOHAI) for OHrQoL. The anticholinergic impregnation score was recorded using the anticholinergic impregnation scale (AIS).
    Results: A sample of 62 people was selected. The DMFT score was 16.5± 8.7, the XI score was 22.9±7.8, the GOHAI score was 43.0±8.8, and the AIS score was 3.1±2.8. In total, 169 drugs were prescribed to the people of our sample, and 114 different anticholinergic drugs were observed. The most frequently used anticholinergic drugs (51.40%), in the study had a low antimuscarinic potency (1 point according to AIS scale). The multiple linear regression model showed that the OHrQoL scores were significantly lower when the DMFT scores, XI score, and anticholinergic scores were high.
    Conclusions: This pilot study highlighted the potential role of the anticholinergic burden on the OHrQoL of PWS. A study with a validated specific scale for the OHrQoL and a standard anticholinergic burden scale should be conducted to clarify the role of anticholinergic drugs on the OHrQoL for PWS.
    Sprache Englisch
    Erscheinungsdatum 2020-02-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2020-0003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.

    Coulon, Audrey / Siedlecki-Wullich, Dolores / Najdek, Chloé / Gelle, Carla / Ayral, Anne-Marie / Demiautte, Florie / Lambert, Erwan / Vandeputte, Alexandre / Brodin, Priscille / Mendes, Tiago / Lambert, Jean-Charles / Kilinc, Devrim / Dumont, Julie / Chapuis, Julien

    Current protocols

    2023  Band 3, Heft 10, Seite(n) e904

    Abstract: The synapse, which represents the structural and functional basis of neuronal communication, is one of the first elements affected in several neurodegenerative diseases. To better understand the potential role of gene expression in synapse loss, we ... ...

    Abstract The synapse, which represents the structural and functional basis of neuronal communication, is one of the first elements affected in several neurodegenerative diseases. To better understand the potential role of gene expression in synapse loss, we developed an original high-content screening (HCS) model capable of quantitatively assessing the impact of gene silencing on synaptic density. Our approach is based on a model of primary neuronal cultures (PNCs) from the neonatal rat hippocampus, whose mature synapses are visualized by the relative localization of the presynaptic protein Synaptophysin with the postsynaptic protein Homer1. The heterogeneity of PNCs and the small sizes of the synaptic structures pose technical challenges associated with the level of automation necessary for HCS studies. We overcame these technical challenges, automated the processes of image analysis and data analysis, and carried out tests under real-world conditions to demonstrate the robustness of the model developed. In this article, we describe the screening of a custom library of 198 shRNAs in PNCs in the 384-well plate format. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Culture of primary hippocampal rat neurons in 384-well plates Basic Protocol 2: Lentiviral shRNA transduction of primary neuronal culture in 384-well plates Basic Protocol 3: Immunostaining of the neuronal network and synaptic markers in 384-well plates Basic Protocol 4: Image acquisition using a high-throughput reader Basic Protocol 5: Image segmentation and analysis Basic Protocol 6: Synaptic density analysis.
    Mesh-Begriff(e) Animals ; Rats ; Automation ; Bone Plates ; Culture ; Data Analysis ; Neurons ; RNA, Small Interfering
    Chemische Substanzen RNA, Small Interfering
    Sprache Englisch
    Erscheinungsdatum 2023-10-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.904
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Proximity Ligation Assay: A Tool to Study Endogenous Interactions Between Tau and Its Neuronal Partners.

    Bretteville, Alexis / Demiautte, Florie / Chapuis, Julien

    Methods in molecular biology (Clifton, N.J.)

    2017  Band 1523, Seite(n) 297–305

    Abstract: Tau is a microtubule associated protein (MAP) that is expressed in neurons of the central nervous system. Tau proteins are deregulated in a group of pathologies, including Alzheimer's disease, commonly called tauopathies. Therefore intensive research has ...

    Abstract Tau is a microtubule associated protein (MAP) that is expressed in neurons of the central nervous system. Tau proteins are deregulated in a group of pathologies, including Alzheimer's disease, commonly called tauopathies. Therefore intensive research has been conducted to understand both the regulation of Tau and its involvement in neuronal cellular pathways. Since its originally described interactor tubulin, Tau has been described to interact with several other proteins, including tyrosine kinases (Src, Fyn, Lck) and Phospholipase C-γ. In this chapter, we describe the use of proximity ligation assay as a versatile method to study the endogenous interaction of Tau with these different neuronal partners and use the recently identified Tau interactor Bin1 as case study.
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6598-4_18
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Acetylcholine-retardation (manganocholine) in circulatory disorders in medical practice.

    CHAPUIS, J P

    Helvetica medica acta

    2007  Band 16, Heft 3-4, Seite(n) 318–321

    Titelübersetzung Acétylcholine-retard (manganocholine) dans les affections circulatoires en pratique médicale.
    Mesh-Begriff(e) Blood Circulation ; Choline/analogs & derivatives
    Chemische Substanzen Choline (N91BDP6H0X)
    Sprache Französisch
    Erscheinungsdatum 2007-12-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 502699-4
    ISSN 0018-0203
    ISSN 0018-0203
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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