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Article ; Online: A rare cause of tracheopleural fistula following minimally invasive oesophagectomy.

Davakis, S / Charalampopoulos, G / Liakakos, T / Charalabopoulos, A

Annals of the Royal College of Surgeons of England

2022 Volume 105, Issue 3, Page(s) 288–290

Abstract: Totally minimally invasive oesophagectomy (TMIE) has been utilised to reduce respiratory and cardiac complications, offering favourable clinical and oncological outcomes. A 62-year-old male patient underwent two-stage TMIE for a Siewert type I tumour. ... ...

Abstract	Totally minimally invasive oesophagectomy (TMIE) has been utilised to reduce respiratory and cardiac complications, offering favourable clinical and oncological outcomes. A 62-year-old male patient underwent two-stage TMIE for a Siewert type I tumour. During thoracoscopic oesophageal mobilisation and lymphadenectomy, a 10-mm bone-like mass was recognised and dissected along the subcarinal nodes, revealing a 2-3mm opening on the inferomedial aspect of the right main bronchus. The airway opening was repaired after conversion. This is the first report of an accessory cardiac bronchus encountered during oesophagectomy. Recognition of its characteristic position and features may result in early diagnosis and avoidance of a potentially lethal injury.
MeSH term(s)	Male ; Humans ; Middle Aged ; Esophageal Neoplasms/pathology ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Lymph Node Excision ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Treatment Outcome
Language	English
Publishing date	2022-10-14
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2022.0104
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Article ; Online: Laparoscopic repair of late perforation following Heller myotomy due to overeating.

Davakis, S / Syllaios, A / Meropouli, A / Mpaili, E / Charalabopoulos, A

Annals of the Royal College of Surgeons of England

2020 Volume 102, Issue 5, Page(s) e97–e99

Abstract: Laparoscopic Heller myotomy is the mainstay surgical treatment of oesophageal achalasia and has proven to be safe and effective over the course of time. Oesophageal perforation after myotomy can be a serious complication with devastating outcomes. Most ... ...

Abstract	Laparoscopic Heller myotomy is the mainstay surgical treatment of oesophageal achalasia and has proven to be safe and effective over the course of time. Oesophageal perforation after myotomy can be a serious complication with devastating outcomes. Most commonly, mucosal perforation are detected intraoperatively or early postoperatively. We present an extremely rare case of late oesophageal perforation in a 28-year-old man treated with laparoscopic Heller myotomy for type II oesophageal achalasia, and its successful minimally invasive repair with laparoscopic primary suturing.
MeSH term(s)	Adult ; Esophageal Achalasia/surgery ; Esophageal Perforation/diagnostic imaging ; Esophageal Perforation/etiology ; Esophageal Perforation/surgery ; Heller Myotomy/adverse effects ; Humans ; Hyperphagia/complications ; Laparoscopy ; Male ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology ; Pneumoperitoneum/surgery ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Suture Techniques ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2020-02-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2020.0021
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Article ; Online: Considerations for the treatment of esophageal cancer during the COVID-19 pandemic.

Davakis, Spyridon / Karamouzis, Michail / Ziogas, Dimitrios / Charalabopoulos, Alexandros

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2021 Volume 26, Issue 3, Page(s) 1171

MeSH term(s)	COVID-19/complications ; COVID-19/transmission ; COVID-19/virology ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/virology ; Humans ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-07-16
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article ; Online: Associations of long non-coding RNAs HOTAIR, LINC00951, POLR2E and HULC polymorphisms with the risk of esophageal and esophagogastric junction cancer in a western population: a case-control study.

Baili, Efstratia / Gazouli, Maria / Lazaris, Andreas C / Kanavidis, Prodromos / Boura, Maria / Michalinos, Adamantios / Charalabopoulos, Alexandros / Liakakos, Theodore / Alexandrou, Andreas

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 249

Abstract: Background: The incidence of single-nucleotide-polymorphisms with malignant potential in esophageal cancer tissues has only been sparsely investigated in the west. Hence, we explored the contribution of four long non-coding RNAs' polymorphisms HOTAIR ... ...

Abstract	Background: The incidence of single-nucleotide-polymorphisms with malignant potential in esophageal cancer tissues has only been sparsely investigated in the west. Hence, we explored the contribution of four long non-coding RNAs' polymorphisms HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016 and HULC rs7763881 in esophageal cancer susceptibility. Methods and results: Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated for esophageal/esophagogastric junction carcinoma during 25/03/2014-25/09/2018 were processed. Demographic data, histopathological parameters, surgical and oncological outcomes were collected. DNA findings of the abovementioned population were compared with 121 healthy community controls. Both populations were of European/Greek ancestry. Sixty-seven patients underwent Ivor Lewis/McKeown esophagectomy for either squamous cell esophageal carcinoma (N = 6) or esophageal/esophagogastric junction Siewert I or II adenocarcinoma (N = 61). Twenty-eight patients were subjected to extended total gastrectomy for esophagogastric junction Siewert III adenocarcinoma. Neither LINC00951 rs11752942 nor HULC rs7763881 polymorphisms were detected more frequently in esophageal cancer patients compared with healthy community subjects. A significantly higher presence of HOTAIR rs920778 TT genotype in esophagogastric junction Siewert I/II adenocarcinoma was identified. POLR2E rs3787016 C allele and CC genotypes were overrepresented in the control group, and when found in esophageal cancer carriers were associated with earlier disease stages, as well as with minor lymph node involvement and lesser metastatic potential. Conclusions: HOTAIR rs920778 may serve as a potential therapeutic suppression target, while POLR2E rs3787016 may represent a valuable biomarker to evaluate esophageal cancer predisposition and predict treatment response and prognosis. Clinical implications of these findings need to be verified with further prospective studies with larger sample-size.
MeSH term(s)	Humans ; Case-Control Studies ; Esophagectomy ; Prospective Studies ; Esophagogastric Junction ; Esophageal Neoplasms/genetics ; Adenocarcinoma ; Polymorphism, Single Nucleotide/genetics ; DNA-Directed RNA Polymerases
Chemical Substances	POLR2E protein, human (EC 2.7.7.6) ; DNA-Directed RNA Polymerases (EC 2.7.7.6)
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09206-0
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Article: Genetic Impact of HOTAIR, LINC00951, POLR2E and HULC Polymorphisms in Histopathological and Laboratory Prognostic Factors in Esophageal Cancer in the West: A Case-Control Study.

Baili, Efstratia / Gazouli, Maria / Lazaris, Andreas C / Kanavidis, Prodromos / Boura, Maria / Michalinos, Adamantios / Charalabopoulos, Alexandros / Liakakos, Theodore / Alexandrou, Andreas

Cancers

2024 Volume 16, Issue 3

Abstract: Long non-coding RNAs' HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already ...

Abstract	Long non-coding RNAs' HOTAIR rs920778, LINC00951 rs11752942, POLR2E rs3787016, and HULC rs7763881 are progressively reported having a close genetic affinity with esophageal carcinogenesis in the East. Nonetheless, their correlation with variables already endorsed as significant prognostic factors in terms of staging, guiding treatment and predicting recurrence, metastasis, and survival have yet to be explored. Herein, we investigated their prognostic value by correlating them with clinicopathological and laboratory prognostic markers in esophageal cancer in the West. Formalin-fixed paraffin-embedded tissue specimens from 95 consecutive patients operated on for esophageal cancer between 2014 and 2018 were compared with 121 healthy community controls. HULC was not detected differently in any of the cancer prognostic subgroups. LINC00951 was underrepresented in Ca19.9 elevated subgroup. HOTAIR was more frequent in both worse differentiation grade and positive Signet-Ring-Cell and Ca19.9 subgroups. POLR2E was identified less frequently in Adenocarcinoma, Signet-Ring-Cell, and Diffuse histologies, as well as in Perineural, Lymphovascular, and Perivascular Invasion positive, while it was overrepresented in CEA positive subgroup. These lncRNAs polymorphisms may hold great potential not only as future therapeutic agents but also as novel markers for predictive analysis of esophageal cancer risk, clinical outcome, and survival. Clinical implications of these findings need to be validated with prospective larger sample-size studies.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16030537
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Article ; Online: Minimally invasive oesophagectomy and emerging complications: intercostal lung hernia.

Davakis, S / Syllaios, A / Mpaili, E / Sdralis, E / Charalabopoulos, A

Annals of the Royal College of Surgeons of England

2019 Volume 102, Issue 3, Page(s) e73–e74

Abstract: Lung herniation is a rare entity, defined as a protrusion of the lung above the normal confines of thorax; it is caused by increased intrathoracic pressure and defects or weakness of the chest wall. Intercostal lung hernia can occur spontaneously or ... ...

Abstract	Lung herniation is a rare entity, defined as a protrusion of the lung above the normal confines of thorax; it is caused by increased intrathoracic pressure and defects or weakness of the chest wall. Intercostal lung hernia can occur spontaneously or following thoracic trauma or surgery. Postoperative hernias are more commonly associated with less extensive surgical procedures, such as thoracoscopic surgery or mini-thoracotomy incisions, rather than with major thoracic procedures. We describe the first reported case of postoperative intercostal lung hernia following two-stage totally minimally invasive oesophagectomy for cancer, together with its successful surgical repair.
MeSH term(s)	Adenocarcinoma/surgery ; Aged ; Esophageal Neoplasms/surgery ; Esophagectomy/adverse effects ; Esophagectomy/methods ; Hernia/etiology ; Hernia/therapy ; Herniorrhaphy/methods ; Humans ; Lung Diseases/etiology ; Lung Diseases/surgery ; Male ; Minimally Invasive Surgical Procedures/adverse effects ; Postoperative Complications ; Reoperation ; Thoracotomy/methods
Language	English
Publishing date	2019-12-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2019.0163
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Article: High mortality rate of oesophageal perforation is associated with delayed hospital admission : a prospective observational case series study.

Petousis, S / Margioula-Siarkou, C / Lorenzi, B / Charalabopoulos, A / Sdralis, E K

Acta gastro-enterologica Belgica

2020 Volume 83, Issue 1, Page(s) 11–14

Abstract: Background: To assess mortality rate of oesophageal perforation cases and study their etiology, diagnosis and management in a single specialized UK centre.: Patients and methods: A prospective observational study was performed between January 2012 ... ...

Abstract	Background: To assess mortality rate of oesophageal perforation cases and study their etiology, diagnosis and management in a single specialized UK centre. Patients and methods: A prospective observational study was performed between January 2012 and January 2015. All consecutive patients admitted with acute iatrogenic or spontaneous esophageal perforation were included. Anastomotic leak patients were excluded. Patients were managed conservatively, endoscopically, surgically or with a combination of the above. Primary outcome was mortality rate and its association with time to hospital admission. Secondary outcomes were nature of perforation, anatomic location, type of management as well as length of hospital stay and surgical complication rate. Results: There were 13 cases included. Mean patients' age was 58.3 years. Overall 90-day mortality rate was 38.4% (n=5), while 30-day mortality rate 30.8% (n=4). Admission within 24 hours of perforation was recorded in 69.2% of patients (n=9). The main anatomic location of perforation was the lower third of the esophagus in 53.8% (n=7). Operative management was adopted in 53.8% of cases (n=7). Mean hospital stay was 58.3 days. Mean follow-up was 3.1 years, while no patient developed any complication from the perforation or surgery. Conclusions: Mortality following esophageal perforation is at approximately 40%, while there is a significant impact of time of presentation on prognosis.
MeSH term(s)	Esophageal Perforation ; Humans ; Mediastinal Diseases ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-03-31
Publishing country	Belgium
Document type	Journal Article ; Observational Study
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
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Article ; Online: The little old lady's hernia.

Kordzadeh, Ali / Charalabopoulos, Alexandros

Surgery

2018 Volume 163, Issue 2, Page(s) 482

MeSH term(s)	Aged, 80 and over ; Female ; Hernia, Obturator/diagnostic imaging ; Humans ; Tomography, X-Ray Computed
Language	English
Publishing date	2018
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2017.08.004
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Article ; Online: A twisted tale.

Walton, Sarah-Jane / Charalabopoulos, Alexandros

ANZ journal of surgery

2018 Volume 89, Issue 10, Page(s) 1329–1330

MeSH term(s)	Adult ; Cecal Diseases/diagnostic imaging ; Female ; Humans ; Intestinal Volvulus/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2018-09-19
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.14702
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Article ; Online: Intrathoracic hand-sewn esophagogastric anastomosis in prone position during totally minimally invasive two-stage esophagectomy for esophageal cancer.

Charalabopoulos, Alexandros / Davakis, Spyridon / Syllaios, Athanasios / Lorenzi, Bruno

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2020 Volume 34, Issue 6

Abstract: Utilization of totally minimally invasive esophagectomy for cancer is on the rise. Esophagogastric anastomosis is mechanically or robotically performed routinely; little report exists of hand-sewn esophagogastric anastomosis. This is the largest so far ... ...

Abstract	Utilization of totally minimally invasive esophagectomy for cancer is on the rise. Esophagogastric anastomosis is mechanically or robotically performed routinely; little report exists of hand-sewn esophagogastric anastomosis. This is the largest so far study with thoracoscopic hand-sewn esophagogastric anastomosis during fully minimally invasive two-stage esophagectomy for esophageal cancer in prone position. Consecutive two-stage totally minimally invasive esophagectomies for cancer were performed by one surgical team, from September 2016 to March 2019. All operations were technically identical in terms of patient positioning, surgical approach, extend of lymphadenectomy and type of anastomosis formed. Primary end points were anastomotic leak and anastomotic stricture rate, while secondary end points were 30-day and 90-day mortality rates. From the overall n = 80 patients, n = 67 were males, while n = 13 were females. Mean age was 64.6 years. Mean length of stay was n = 14 days. There were no conversions to open. Mean operating time was 420 minutes with no blood loss over 200 mL noted. Pulmonary and cardiac complication rate was 23.75% and 2.5%, respectively. Anastomotic leak rate was 2.5%. Anastomotic strictures were seen in 12.5% of cases. 30-day and 90-day mortality rate was 2.5% and 5%, respectively, with none accounted for ischemic conduit complications. Intrathoracic anastomosis in totally minimally invasive esophagectomy is challenging and accountable for most of the mortality associated with the procedure. In thoracoscopic two-stage esophagectomy, a mechanical anastomosis is usually preferred; this is believed to be due to the complexity of manual anastomosis associated with the thoracoscopic approach. We aim to present our series of completely hand-sewn intrathoracic anastomosis utilizing a totally minimally invasive approach with favorable outcomes. With this study, reproducibility of the anastomosis is shown that can potentially favor a change in the practice of esophageal surgeons worldwide.
MeSH term(s)	Anastomosis, Surgical/adverse effects ; Esophageal Neoplasms/surgery ; Esophagectomy/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Patient Positioning ; Prone Position ; Reproducibility of Results ; Treatment Outcome
Language	English
Publishing date	2020-11-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doaa106
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