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  1. Article ; Online: Attitudes and beliefs regarding complementary and alternative medicine in a diverse gynecologic oncology patient population

    Emily A. Miller / Shanice Beaumont / Zhen Ni Zhou / Jesse T. Brewer / Charlene Thomas / Eloise Chapman-Davis / Evelyn Cantillo / Kevin Holcomb / Tara Pua / Melissa K. Frey

    Gynecologic Oncology Reports, Vol 48, Iss , Pp 101232- (2023)

    2023  

    Abstract: Objectives: To measure prevalence of complementary and alternative medicine (CAM) use in a diverse gynecologic oncology patient population and evaluate how attitudes and beliefs regarding CAM relate to demographic factors. Methods: A validated Attitudes ... ...

    Abstract Objectives: To measure prevalence of complementary and alternative medicine (CAM) use in a diverse gynecologic oncology patient population and evaluate how attitudes and beliefs regarding CAM relate to demographic factors. Methods: A validated Attitudes and Beliefs about Complementary and Alternative Medicine (ABCAM) survey was distributed to patients with gynecologic malignancy. Results were evaluated using Pearson's Chi-squared and Fisher's exact tests for categorical variables and Wilcoxon ranks sum and Kruskal-Wallace tests for non-normally distributed variables. Results: One-hundred thirty patients completed the ABCAM survey. Self-reported race and ethnicity included Asian or Pacific Islander (n = 54; 42%), Hispanic/Latino (n = 23; 18%), White (n = 21; 16%), Black or African American (n = 20; 15%), American Indian/Alaska Native (n = 8; 6.2%) and Other (n = 4; 3.1%). Twenty-four respondents (18%) reported use of CAM. There was a significant difference in expected benefits to CAM between respondents of different races/ethnicities (p < 0.001). Black and Asian respondents reported greater expected benefit to CAM. Hispanic/Latino, American Indian/Alaskan Native, and White respondents reported fewer expected benefits. A significant association was found between perceived barriers to CAM and race/ethnicity (p 0.043), with Asian, Hispanic/Latino and White respondents perceiving more barriers while Black and American Indian/Alaskan Natives reported perceiving fewer barriers to CAM. Respondents with incomes greater than $100,000 reported fewer barriers to CAM. Conclusions: Use of CAM among gynecologic oncology patients is lower than previously thought. Income, race, and ethnicity inform patient engagement with CAM and can be used to better tailor the provision of evidence-based CAM interventions to benefit a greater number of gynecologic cancer patients.
    Keywords Complementary medicine ; Alternative medicine ; Gynecologic cancer ; Attitudes and beliefs ; Gynecology and obstetrics ; RG1-991 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 950
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Do people with hereditary cancer syndromes inform their at-risk relatives? A systematic review and meta-analysis

    Muhammad Danyal Ahsan / Sarah R. Levi / Emily M. Webster / Hannah Bergeron / Jenny Lin / Priyanka Narayan / Becky Baltich Nelson / Xuan Li / Rana K. Fowlkes / Jesse T. Brewer / Charlene Thomas / Paul J. Christos / Eloise Chapman-Davis / Evelyn Cantillo / Kevin Holcomb / Ravi N. Sharaf / Melissa K. Frey

    PEC Innovation, Vol 2, Iss , Pp 100138- (2023)

    2023  

    Abstract: Purpose: To evaluate rates of familial disclosure of hereditary cancer syndrome information. Methods: A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines (PROSPERO no.: CRD42020134276). Key electronic databases were ... ...

    Abstract Purpose: To evaluate rates of familial disclosure of hereditary cancer syndrome information. Methods: A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines (PROSPERO no.: CRD42020134276). Key electronic databases were searched to identify studies evaluating hereditary cancer syndrome cascade relative disclosure. Eligible studies were subjected to meta-analysis. Results: Thirty-four studies met inclusion criteria. Among 11,711 included relatives, 70% (95% CI 60 - 78%) were informed of their risk of carrying a cancer-associated pathogenic variant; of 2,875 relatives informed of their risk who were evaluated for uptake of cascade testing, 43% (95% CI 27 - 61%) completed testing. Rates of disclosure were higher among female vs male relatives (79% [95% CI 73% - 84%] vs 67% [95% CI 57% - 75%]) and first-degree vs second-degree relatives (83% [95% CI 77% - 88%] vs 58% [95% CI 45 – 69%]). Conclusion: Nearly one-third of at-risk relatives remain uninformed of their risk of carrying a cancer-associated pathogenic variant. Even among those informed, fewer than half subsequently complete genetic testing, representing a critical missed opportunity for precision cancer prevention. Innovation: Five studies evaluating interventions to improve disclosure rates were generally ineffective. Urgent work is needed to elucidate barriers to relative disclosure by probands to develop targeted interventions that can optimize proband-mediated cascade genetic testing rates.
    Keywords Disclosure ; Cascade genetic testing ; Hereditary cancer syndromes ; Lynch syndrome ; Hereditary breast and ovarian cancer ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

    Ria Goswami / Veronica S. Russell / Joshua J. Tu / Charlene Thomas / Philip Hughes / Francine Kelly / Stephanie N. Langel / Justin Steppe / Scott M. Palmer / Timothy Haystead / Maria Blasi / Sallie R. Permar

    iScience, Vol 24, Iss 12, Pp 103412- (2021)

    2021  

    Abstract: Summary: Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill patients and require intravenous infusions, with limited options for exposed or infected patients with no or mild symptoms. Although vaccines have ... ...

    Abstract Summary: Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill patients and require intravenous infusions, with limited options for exposed or infected patients with no or mild symptoms. Although vaccines have demonstrated protective efficacy, vaccine hesitancy and logistical distribution challenges will delay their ability to end the pandemic. Hence, there is a need for rapidly translatable, easy-to-administer-therapeutics that can prevent SARS-CoV-2 disease progression, when administered in the early stages of infection. We demonstrate that an orally bioavailable Hsp90 inhibitor, SNX-5422, currently in clinical trials as an anti-cancer therapeutic, inhibits SARS-CoV-2 replication in vitro at a high selectivity index. SNX-5422 treatment of human primary airway epithelial cells dampened expression of inflammatory pathways previously associated with poor SARS-CoV-2 disease outcomes. In addition, SNX-5422 interrupted expression of host factors demonstrated to be crucial for SARS-CoV-2 replication. Development of SNX-5422 as SARS-CoV-2-early-therapy will dampen disease severity, resulting in better clinical outcomes and reduced hospitalizations.
    Keywords Therapeutics ; Virology ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price / Céline Bellenguez / Li-San Wang / Seung-Hoan Choi / Denise Harold / Lesley Jones / Peter Holmans / Amy Gerrish / Alexey Vedernikov / Alexander Richards / Anita L DeStefano / Jean-Charles Lambert / Carla A Ibrahim-Verbaas / Adam C Naj / Rebecca Sims / Gyungah Jun / Joshua C Bis / Gary W Beecham / Benjamin Grenier-Boley /
    Giancarlo Russo / Tricia A Thornton-Wells / Nicola Denning / Albert V Smith / Vincent Chouraki / Charlene Thomas / M Arfan Ikram / Diana Zelenika / Badri N Vardarajan / Yoichiro Kamatani / Chiao-Feng Lin / Helena Schmidt / Brian Kunkle / Melanie L Dunstan / Maria Vronskaya / United Kingdom Brain Expression Consortium / Andrew D Johnson / Agustin Ruiz / Marie-Thérèse Bihoreau / Christiane Reitz / Florence Pasquier / Paul Hollingworth / Olivier Hanon / Annette L Fitzpatrick / Joseph D Buxbaum / Dominique Campion / Paul K Crane / Clinton Baldwin / Tim Becker / Vilmundur Gudnason / Carlos Cruchaga

    PLoS ONE, Vol 9, Iss 6, p e

    2014  Volume 94661

    Abstract: BACKGROUND:Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an ...

    Abstract BACKGROUND:Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL FINDINGS:In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10-6) and 14 (IGHV1-67 p = 7.9×10-8) which indexed novel susceptibility loci. SIGNIFICANCE:The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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