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  1. Article ; Online: Neuropsychiatric manifestations are associated with increased mortality in Indian patients with lupus: A single centre retrospective observational study.

    Pinto, Benzeeta / Suresh, Sumatha C / Ramyasri, Kodali / Narayan, Girish / Susan, Deepa / Manuel, Sandra / Wodeyar, Aishwarya / Shivanna, Archana / Janardana, Ramya / Chanakya, Kodishala / Charles, B Sheba / Nanjundaswamy, Sangeetha K / Desai, Anu M / Nadig, Raghunandan / Shobha, Vineeta

    Lupus

    2022  Volume 31, Issue 13, Page(s) 1563–1571

    Abstract: Objective: To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement.: Methods: This was ... ...

    Abstract Objective: To study the prevalence of different NPSLE manifestations in our cohort and to compare clinical and immunological features and outcomes including mortality of patients with NPSLE and SLE controls without NP involvement.
    Methods: This was a retrospective study in a tertiary care referral centre. All patients of SLE seen in the last 10 years and fulfilling the SLICC criteria with neuropsychiatric manifestations as per the ACR definitions were included. Patients of SLE without NP involvement were sequentially assigned as controls in a ratio of 1:2.
    Results: Of the 769 patients diagnosed with SLE from Jan 2011 to December 2020, 128 (16.6%) had NPSLE manifestations as per the ACR definitions. The commonest NPSLE manifestation was seizures (6.5%) followed by cerebrovascular accident (3.9%). NPSLE manifestation occurred at the first presentation of SLE in 99/128 (77.3%) patients and 58 (45.3%) patients had more than one NPSLE manifestation. Lupus anticoagulant and anticardiolipin antibody were tested in 120 patients and were positive in 16 (13.3%) and 12 (10%), respectively. No difference was found in anti-ribosomal
    Conclusions: Seizures and cerebrovascular accidents are the commonest NPSLE syndromes in our patients. The presence of NPSLE was associated with high mortality in Indian patients with lupus.
    MeSH term(s) Humans ; Retrospective Studies ; Lupus Vasculitis, Central Nervous System/diagnosis ; Lupus Coagulation Inhibitor ; Lupus Erythematosus, Systemic/complications ; Antibodies, Anticardiolipin ; Antiphospholipid Syndrome/complications ; Seizures/epidemiology ; Stroke
    Chemical Substances Lupus Coagulation Inhibitor ; Antibodies, Anticardiolipin
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033221127898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3717: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article: Hypomagnesemia in the ICU - Does Correction Matter?

    Charles, B Sheba / Menon, Indira / Girish, T S / Cherian, A M

    The Journal of the Association of Physicians of India

    2016  Volume 64, Issue 11, Page(s) 15–19

    Abstract: Background: Magnesium is a cation that is constantly being rediscovered. A number of studies have linked low magnesium levels to poor outcome of critically ill patients. Despite this hypomagnesemia continues to be under-recognized and uncorrected. There ...

    Abstract Background: Magnesium is a cation that is constantly being rediscovered. A number of studies have linked low magnesium levels to poor outcome of critically ill patients. Despite this hypomagnesemia continues to be under-recognized and uncorrected. There are no studies, in our knowledge, that have assessed the impact of correction of hypomagnesaemia on the outcome of the ICU patient.
    Aims and objective: To determine the standard Mg levels in a healthy population sample and to correlate it with western data. To estimate the admission Mg levels in critically ill patients admitted to the ICU and to determine if routine correction of hypomagnesaemia altered their outcomes as compared with the retrospectively collected data of a similar group of patients admitted to the same ICU prior to the routine testing of Mg levels. This was an observational study carried out in the intensive care unit of a tertiary hospital in south India.
    Results: The mean serum magnesium in a sample of healthy Indian population was noted to be 2.112 mg/dl, which is consistent with that of the western data. Among the critically ill admitted to the medical ICU, the incidence of Hypomagnesemia (defined as serum Mg+2 of ≤1.7mg/dl on admission), was 23.96%. The study group in whom serum Magnesium was routinely corrected, showed a decrease in the mean total duration of icu stay (94.265 vs. 99.443 hours with p=0.78); the need for mechanical ventilation (52.08% vs. 65.625%) and the duration of Mechanical Ventilation (36.64 vs. 58.75 hours with p=0.04). Mortality was significantly higher in the comparison group (p=0.01) (39.6% vs. 22.9%).
    Conclusions: The range of Magnesium levels in a healthy Indian population matches that of the west despite variations in diet and lifestyle. Routine screening and replacement of magnesium in critically ill patients with hypomagnesaemia resulted in reduction of morbidity and statistically significant reduction in overall ICU mortality.
    MeSH term(s) Adolescent ; Adult ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Magnesium/blood ; Magnesium/therapeutic use ; Magnesium Deficiency/blood ; Magnesium Deficiency/drug therapy ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2016-11-01
    Publishing country India
    Document type Journal Article ; Observational Study
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 313: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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