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  1. AU="Charles DeCarli"
  2. AU=Glied Sherry
  3. AU="Kesarwani, Manoj"
  4. AU="Cubas-Atienza, Ana I"
  5. AU="Thickens, Anna S"
  6. AU="Anderson, Emilie"
  7. AU=Starace Fabrizio
  8. AU="Ochin, Evelina"
  9. AU="Gijzen, Linda"
  10. AU="van Groeningen, Kees Jan"
  11. AU="Pakserian, Diana"
  12. AU="Joly-Chevrier, Maxine"
  13. AU="Genovesi, Piero"
  14. AU="Ersöz, Gülden"
  15. AU="Jeffrey J Babon"
  16. AU="Rehana Masood"
  17. AU="Sandra Heskamp"
  18. AU="Omid Sadeghi"
  19. AU="Antaya, Richard"
  20. AU="Papadopoulos, G"
  21. AU="Boughen, Santiago"
  22. AU="Brink, P. L."

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  1. Artikel ; Online: White matter hyperintensities in diverse populations

    Vista Farkhondeh / Charles DeCarli

    Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100204- (2024)

    A systematic review of literature in the United States

    2024  

    Abstract: As the United States’ (US) elderly population becomes increasingly diverse, it is imperative that research studies address cognitive health in diverse populations of older Americans. White Matter Hyperintensities (WMH) are useful imaging findings that ... ...

    Abstract As the United States’ (US) elderly population becomes increasingly diverse, it is imperative that research studies address cognitive health in diverse populations of older Americans. White Matter Hyperintensities (WMH) are useful imaging findings that can be studied in elderly individuals and have been linked to an increased risk of neurological conditions, such as stroke, cognitive impairment, and dementia. We performed a systematic review of literature using PubMed sources to compile all the studies that investigated the prevalence of ethnic and racial differences of WMH burden amongst diverse groups in the US. We identified 23 unique articles that utilized 16 distinct cohorts of which 94 % were prospective, longitudinal studies that included community-based and family-based populations. The overall results were heterogenous in all aspects of data collection and analysis, limiting our ability to run meta-analyses and draw definitive conclusions. General observations suggest increased vascular risk on African American populations, contributing to greater WMH burden in that population. Overall, the findings of this study indicate a need for a standardized approach to investigating WMH in efforts to measure its clinical impact on diverse populations.
    Schlagwörter White matter hyperintensities ; Aging ; Cognitive impairment ; Diversity ; Systematic review ; Specialties of internal medicine ; RC581-951 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Thema/Rubrik (Code) 306
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging

    Einat Granot-Hershkovitz / Rui Xia / Yunju Yang / Brian Spitzer / Wassim Tarraf / Priscilla M. Vásquez / Richard B. Lipton / Martha Daviglus / Maria Argos / Jianwen Cai / Robert Kaplan / Myriam Fornage / Charles DeCarli / Hector M. Gonzalez / Tamar Sofer

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 9

    Abstract: Abstract APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African and Amerindian ancestry- ... ...

    Abstract Abstract APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether African and Amerindian ancestry-enriched genetic variants in the APOE region modify the effect of the APOE-ɛ4 alleles on Mild Cognitive Impairment (MCI) in Hispanics/Latinos. We defined African and Amerindian ancestry-enriched variants as those common in one Hispanic/Latino parental ancestry and rare in the other two. We identified such variants in the APOE region with a predicted moderate impact based on the SnpEff tool. We tested their interaction with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) population and African Americans from the Atherosclerosis Risk In Communities (ARIC) study. We identified 5 Amerindian and 14 African enriched variants with an expected moderate effect. A suggestive significant interaction (p-value = 0.01) was found for one African-enriched variant, rs8112679, located in the ZNF222 gene fourth exon. Our results suggest there are no ancestry-enriched variants with large effect sizes of interaction effects with APOE-ɛ4 on MCI in the APOE region in the Hispanic/Latino population. Further studies are needed in larger datasets to identify potential interactions with smaller effect sizes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

    Daniel R. Wong / Shino D. Magaki / Harry V. Vinters / William H. Yong / Edwin S. Monuki / Christopher K. Williams / Alessandra C. Martini / Charles DeCarli / Chris Khacherian / John P. Graff / Brittany N. Dugger / Michael J. Keiser

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Band 9

    Abstract: Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques ... ...

    Abstract Abstract Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, locality, and counts of cored plaques and cerebral amyloid angiopathy (CAA). We trained this object detector using a repurposed image-tile dataset without any human-drawn bounding boxes. We evaluated the detector on a new manually-annotated dataset of whole slide images (WSIs) from three institutions, four staining procedures, and four human experts. The detector matched the cohort of neuropathology experts, achieving 0.64 (model) vs. 0.64 (cohort) average precision (AP) for cored plaques and 0.75 vs. 0.51 AP for CAAs at a 0.5 IOU threshold. It provided count and locality predictions that approximately correlated with gold-standard human CERAD-like WSI scoring (p = 0.07 ± 0.10). The openly-available model can quickly score WSIs in minutes without a GPU on a standard workstation.
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Author Correction

    Fanny M. Elahi / Danielle Harvey / Marie Altendahl / Nivetha Brathaban / Nicole Fernandes / Kaitlin B. Casaletto / Adam M. Staffaroni / Pauline Maillard / Jason D. Hinman / Bruce L. Miller / Charles DeCarli / Joel H. Kramer / Edward J. Goetzl

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans

    2022  Band 1

    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline

    Ziqi Tang / Kangway V. Chuang / Charles DeCarli / Lee-Way Jin / Laurel Beckett / Michael J. Keiser / Brittany N. Dugger

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: Convolutional neural networks have been applied to various areas of medical imaging and histology. Here the authors develop an automated approach using interpretable neural networks to determine Alzheimer’s disease plaque and cerebral amyloid angiopathy ... ...

    Abstract Convolutional neural networks have been applied to various areas of medical imaging and histology. Here the authors develop an automated approach using interpretable neural networks to determine Alzheimer’s disease plaque and cerebral amyloid angiopathy burden in post-mortem human brain tissue.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline

    Ziqi Tang / Kangway V. Chuang / Charles DeCarli / Lee-Way Jin / Laurel Beckett / Michael J. Keiser / Brittany N. Dugger

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: Convolutional neural networks have been applied to various areas of medical imaging and histology. Here the authors develop an automated approach using interpretable neural networks to determine Alzheimer’s disease plaque and cerebral amyloid angiopathy ... ...

    Abstract Convolutional neural networks have been applied to various areas of medical imaging and histology. Here the authors develop an automated approach using interpretable neural networks to determine Alzheimer’s disease plaque and cerebral amyloid angiopathy burden in post-mortem human brain tissue.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Amyloid-PET imaging offers small improvements in predictions of future cognitive trajectories

    Sarah F. Ackley / Eleanor Hayes-Larson / Willa D. Brenowitz / Kaitlin Swinnerton / Dan Mungas / Evan Fletcher / Baljeet Singh / Rachel A. Whitmer / Charles DeCarli / M. Maria Glymour

    NeuroImage: Clinical, Vol 31, Iss , Pp 102713- (2021)

    2021  

    Abstract: Background: Amyloid β (Aβ) is thought to initiate a cascade of pathology culminating in Alzheimer’s disease-related cognitive decline. Aβ accumulation in brain tissues may begin one to two decades prior to clinical diagnosis of Alzheimer’s disease. Prior ...

    Abstract Background: Amyloid β (Aβ) is thought to initiate a cascade of pathology culminating in Alzheimer’s disease-related cognitive decline. Aβ accumulation in brain tissues may begin one to two decades prior to clinical diagnosis of Alzheimer’s disease. Prior studies have demonstrated that Aβ detected in vivo with positron emission tomography with amyloid ligands (amyloid-PET) predicts contemporaneously measured cognition and future cognitive trajectories. Prior studies have not evaluated the added value of Aβ measures in predicting future cognition when repeated past cognitive measures are available. We evaluated the extent to which amyloid-PET improves prediction of future cognitive changes over and above predictions based only on sociodemographics and past cognitive measures. Methods: We used data from participants in the University of California Davis Alzheimer’s Disease Research cohort who were cognitively normal at baseline, participated in amyloid-PET imaging, and completed at least three cognitive assessments prior to amyloid-PET imaging (N = 132 for memory andN = 135 for executive function). We used sociodemographic and cognitive measures taken prior to amyloid-PET imaging to predict cognitive trajectory after amyloid-PET imaging and assessed whether measures of amyloid burden improved predictions of subsequent cognitive change. Improvements in prediction were characterized as percent reduction in the mean squared error (MSE) in predicted cognition post amyloid-PET and increase in percent variance explained. Results: The base model using only sociodemographics and past cognitive performance explained the majority of variance in both predicted memory measures (55.6%) and executive function measures (74.5%) following amyloid-PET. Adding amyloid positivity to the model reduced the MSE for memory by 0.2%, 95% CI: (0%, 2.6%), p = 0.48 and for executive function by 3.4%, 95% CI: (0.6%, 10.2%), p = 0.002. This corresponded to an increase in the percent variance explained of 0.1%, 95% CI: (0%, 1.2%) for memory and ...
    Schlagwörter Alzheimer’s disease ; amyloid-PET ; Prediction ; Cognitive change ; Longitudinal studies ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Thema/Rubrik (Code) 120
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Lifecourse socioeconomic changes and late-life cognition in a cohort of U.S.-born and U.S. immigrants

    Rachel L. Peterson / Kristen M. George / Paola Gilsanz / Elizabeth Rose Mayeda / M. Maria Glymour / Oanh L. Meyer / Dan M. Mungas / Charles DeCarli / Rachel A. Whitmer

    BMC Public Health, Vol 21, Iss 1, Pp 1-

    findings from the KHANDLE study

    2021  Band 11

    Abstract: Abstract Background Low socioeconomic status (SES) in early and late life has been associated with lower late-life cognition. Less is known about how changes in SES from childhood to late life are associated with late-life cognition, especially among ... ...

    Abstract Abstract Background Low socioeconomic status (SES) in early and late life has been associated with lower late-life cognition. Less is known about how changes in SES from childhood to late life are associated with late-life cognition, especially among diverse populations of older adults. Methods In a multi-ethnic sample (n = 1353) of older adults, we used linear regression to test associations of change in comprehensive measures of SES (financial, cultural, and social domains) from childhood to late life with semantic memory, episodic memory, and executive function. We tested whether the association between SES trajectory and late-life cognition differed by populations who resided in the U.S. during childhood or immigrated to the U.S. as adults. Results Participants with low childhood/high late-life financial capital had better semantic memory (β = 0.18; 95% CI: 0.04, 0.32) versus those with low financial capital in both childhood and late life, regardless of childhood residence. We observed a significant interaction in the association of verbal episodic memory and cultural capital by childhood residence (p = 0.08). Participants with a foreign childhood residence had higher verbal episodic memory if they had low childhood/high late-life cultural capital (β = 0.32; 95% CI: 0.01, 0.63), but lower verbal episodic memory if they had high childhood/low late-life cultural capital (β = − 0.40; 95% CI: − 0.94, 0.13). Having high lifecourse social capital was associated with better verbal episodic memory scores among those with a U.S. childhood (β = 0.34; 95% CI: 0.14, 0.55), but lower verbal episodic memory among those with a foreign childhood (β = − 0.10; 95% CI: − 0.51, 0.31). Conclusions High financial and cultural capital in late life is associated with better cognition, regardless of early childhood SES or childhood residence.
    Schlagwörter Lifecourse ; Socioeconomic status ; Cognitive aging ; Immigrants ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 370
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Different loneliness types, cognitive function, and brain structure in midlife

    Qiushan Tao / Samia C. Akhter-Khan / Ting Fang Alvin Ang / Charles DeCarli / Michael L. Alosco / Jesse Mez / Ronald Killiany / Sherral Devine / Ami Rokach / Indira Swetha Itchapurapu / Xiaoling Zhang / Kathryn L. Lunetta / David C. Steffens / Lindsay A. Farrer / Douglas N. Greve / Rhoda Au / Wei Qiao Qiu

    EClinicalMedicine, Vol 53, Iss , Pp 101643- (2022)

    Findings from the Framingham Heart Study

    2022  

    Abstract: Summary: Background: It remains unclear whether persistent loneliness is related to brain structures that are associated with cognitive decline and development of Alzheimer's disease (AD). This study aimed to investigate the relationships between ... ...

    Abstract Summary: Background: It remains unclear whether persistent loneliness is related to brain structures that are associated with cognitive decline and development of Alzheimer's disease (AD). This study aimed to investigate the relationships between different loneliness types, cognitive functioning, and regional brain volumes. Methods: Loneliness was measured longitudinally, using the item from the Center for Epidemiologic Studies Depression Scale in the Framingham Heart Study, Generation 3, with participants’ average age of 46·3 ± 8·6 years. Robust regression models tested the association between different loneliness types with longitudinal neuropsychological performance (n = 2,609) and regional magnetic resonance imaging brain data (n = 1,829) (2002-2019). Results were stratified for sex, depression, and Apolipoprotein E4 (ApoE4). Findings: Persistent loneliness, but not transient loneliness, was strongly associated with cognitive decline, especially memory and executive function. Persistent loneliness was negatively associated with temporal lobe volume (β = −0.18, 95%CI [−0.32, −0.04], P = 0·01). Among women, persistent loneliness was associated with smaller frontal lobe (β = −0.19, 95%CI [−0.38, −0.01], P = 0·04), temporal lobe (β = −0.20, 95%CI [−0.37, −0.03], P = 0·02), and hippocampus volumes (β = −0.23, 95%CI [−0.40, −0.06], P = 0·007), and larger lateral ventricle volume (β = 0.15, 95%CI [0.02, 0.28], P = 0·03). The higher cumulative loneliness scores across three exams, the smaller parietal, temporal, and hippocampus volumes and larger lateral ventricle were evident, especially in the presence of ApoE4. Interpretation: Persistent loneliness in midlife was associated with atrophy in brain regions responsible for memory and executive dysfunction. Interventions to reduce the chronicity of loneliness may mitigate the risk of age-related cognitive decline and AD. Funding: US National Institute on Aging.
    Schlagwörter Social isolation ; Dementia ; Alzheimer's disease ; Neuroimaging ; Cohort study ; Brain health ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Electrocardiographic left atrial abnormality and silent vascular brain injury

    Madeleine D Hunter / Yeseon Park Moon / Charles DeCarli / Jose Gutierrez / Clinton B Wright / Marco R Di Tullio / Ralph L Sacco / Hooman Kamel / Mitchell S V Elkind

    PLoS ONE, Vol 13, Iss 10, p e

    The Northern Manhattan Study.

    2018  Band 0203774

    Abstract: HYPOTHESIS:We hypothesized that P wave terminal Force in the V1 lead (PTFV1) would be associated with leukoaraiosis and subclinical infarcts, especially cortical infarcts, in a population-based, multi-ethnic cohort. METHODS:PTFV1 was collected manually ... ...

    Abstract HYPOTHESIS:We hypothesized that P wave terminal Force in the V1 lead (PTFV1) would be associated with leukoaraiosis and subclinical infarcts, especially cortical infarcts, in a population-based, multi-ethnic cohort. METHODS:PTFV1 was collected manually from baseline electrocardiograms of clinically stroke-free Northern Manhattan Study participants. Investigators read brain MRIs for superficial infarcts, deep infarcts, and white matter hyperintensity volume (WMHV). WMHV was adjusted for head size and log transformed, achieving a normal distribution. Logistic regression models investigated the association of PTFV1 with cortical and with all subclinical infarcts. Linear regression models examined logWMHV. Models were adjusted for demographics and risk factors. RESULTS:Among 1174 participants with PTFV1 measurements, the mean age at MRI was 70 ± 9 years. Participants were 14.4% white, 17.6% black, and 65.8% Hispanic. Mean PTFV1 was 3587.35 ± 2315.62 μV-ms. Of the 170 subclinical infarcts, 40 were cortical. PTFV1 ≥ 5000 μV-ms was associated with WMHV in a fully adjusted model (mean difference in logWMHV 0.15, 95% confidence interval 0.01-0.28). PTFV1 exhibited a trend toward an association with cortical infarcts (unadjusted OR per SD change logPTFV1 1.30, 95% CI 0.94-1.81), but not with all subclinical infarcts. CONCLUSION:Electrocardiographic evidence of left atrial abnormality was associated with leukoaraiosis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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