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  1. Article ; Online: Commentary: linking outcomes, cost-effectiveness, and reimbursement for vascular intervention: the train is leaving the station.

    Charles Sternbergh, W

    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

    2010  Volume 17, Issue 2, Page(s) 230–231

    MeSH term(s) Angioplasty/economics ; Blood Vessel Prosthesis Implantation/economics ; Carotid Stenosis/economics ; Carotid Stenosis/mortality ; Carotid Stenosis/therapy ; Cost-Benefit Analysis ; Endarterectomy, Carotid/economics ; Humans ; Insurance, Health, Reimbursement/economics ; Stents/economics ; Treatment Outcome
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2006618-1
    ISSN 1545-1550 ; 1526-6028
    ISSN (online) 1545-1550
    ISSN 1526-6028
    DOI 10.1583/09-2938C.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4547: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Non-Adherence to Antihypertensive Guidelines in Patients with Asymptomatic Carotid Stenosis.

    Haley, William / Shawl, Fayaz / Charles Sternbergh, W / Turan, Tanya N / Barrett, Kevin / Voeks, Jenifer / Brott, Thomas / Meschia, James F

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 30, Issue 8, Page(s) 105918

    Abstract: Importance: Hypertension and carotid stenosis are both risk factors for stroke, but the presence of carotid stenosis might dampen enthusiasm for tight control of hypertension because of concerns for hypoperfusion.: Objective: To determine the extent ... ...

    Abstract Importance: Hypertension and carotid stenosis are both risk factors for stroke, but the presence of carotid stenosis might dampen enthusiasm for tight control of hypertension because of concerns for hypoperfusion.
    Objective: To determine the extent to which there are opportunities to potentially improve pharmacotherapy for hypertension in patients known to have asymptomatic high-grade carotid stenosis.
    Design: We examined anti-hypertensive medication prescription and adherence to evidence-based hypertension treatment guidelines in a cross-sectional analysis of baseline data of patients enrolled in a clinical trial.
    Setting: The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) is a multicenter prospective randomized open blinded end-point clinical trial of intensive medical management with or without revascularization by endarterectomy or stenting for asymptomatic high-grade carotid stenosis.
    Participants: 1479 participants (38.6% female; mean age 69.8 years) from 132 clinical centers enrolled in the CREST-2 trial as of April 6, 2020 who were taking ≥1 antihypertensive drug at baseline.
    Exposures: Pharmacotherapy for hypertension.
    Main outcome: Adherence to evidence-based guidelines for treating hypertension.
    Results: Of 1458 participants with complete data, 26% were on one, 31% on 2, and 43% on ≥3 antihypertensive medications at trial entry. Thirty-two percent of participants were prescribed thiazide; 74%, angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB); 38%, calcium channel blocker (CCB); 56%, a beta blocker; 11%, loop diuretic; and 27%, other. Of those prescribed a single antihypertensive medication, the proportion prescribed thiazide was 5%; ACEI or ARB, 55%, and CCB, 11%. The prevalence of guideline-adherent regimens was 34% (95% CI, 31-36%).
    Conclusions and relevance: In a diverse cohort with severe carotid disease and hypertension, non-adherence to hypertension guidelines was common. All preferred classes of antihypertensive drug were under-prescribed. Using staged iterative guideline-based care for hypertension, CREST-2 will characterize drug tolerance and stroke rates under these conditions.
    Trial registration: ClinicalTrials.gov Number NCT02089217.
    MeSH term(s) Aged ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Asymptomatic Diseases ; Blood Pressure/drug effects ; Carotid Stenosis/complications ; Carotid Stenosis/diagnosis ; Carotid Stenosis/physiopathology ; Cross-Sectional Studies ; Drug Prescriptions ; Drug Therapy, Combination ; Drug Utilization/standards ; Female ; Guideline Adherence/standards ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Middle Aged ; North America ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/standards ; Randomized Controlled Trials as Topic ; Spain ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.105918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The effect of gender on early and intermediate results of endovascular aneurysm repair.

    Nordness, Paul J / Carter, Glen / Tonnessen, Britt / Charles Sternbergh, W / Money, Samuel R

    Annals of vascular surgery

    2003  Volume 17, Issue 6, Page(s) 615–621

    Abstract: Results of endovascular aneurysm repair (EVAR) may be gender dependent. Between September 1997 and September 2001, 118 AneuRx aortic grafts were placed for aneurysmal disease. During this period, 17 females and 101 males were treated with this device. A ... ...

    Abstract Results of endovascular aneurysm repair (EVAR) may be gender dependent. Between September 1997 and September 2001, 118 AneuRx aortic grafts were placed for aneurysmal disease. During this period, 17 females and 101 males were treated with this device. A prospective database was maintained and supplemented with retrospectively gathered information to evaluate early and mid-term end points. A total of 113 devices were deployed in 118 attempts. Length of procedure was greater for females (3.3 +/- 1.75 vs. 2.3 +/- 0.8 hr, p = 0.05) and they were more likely to have significant arterial dissections (12% vs. 1%, p = 0.05). The mortality rates at 1 month were 12% for females and 0% for males ( p = 0.02); the complication rates at 1 month were 41% for females and 15% for males ( p = 0.02). Although technical success was not significantly different between the sexes, assisted primary technical success (requiring endovascular assistance) and assisted secondary technical success (requiring open surgical assistance) were significantly different (71% vs. 96%, p = 0.003; and 76% vs. 98%, p = 0.004, respectively). Clinical success at 1 month was 59% for females and 84% for males ( p = 0.02). This difference was also significant when assessing 1-month assisted primary clinical success (59% vs. 90%, p = 0.003) and assisted secondary clinical success as well (71% vs. 96%, p = 0.003). Clinical success and assisted primary clinical success were not different at 6- or 12-month intervals, however, assisted secondary clinical successes differed at both time intervals (56% vs. 83%, p = 0.02; and 56% vs. 81%, p = 0.05, respectively). As-yet undetermined factors appear to predispose females to complications and technical difficulties in the short term. Endovascular and open procedures required to achieve ongoing clinical success in the following months appear to favor males to a greater degree than females.
    MeSH term(s) Aged ; Aortic Aneurysm, Abdominal/mortality ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation ; Cohort Studies ; Databases, Factual/statistics & numerical data ; Female ; Humans ; Male ; Postoperative Complications/mortality ; Retrospective Studies ; Sex Factors ; Stents ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2003-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1007/s10016-003-0072-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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