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  1. Article ; Online: Direct measurement of the structural change associated with amorphous solidification using static scattering of coherent radiation.

    Petersen, Charlotte F / Harrowell, Peter

    The Journal of chemical physics

    2023  Volume 159, Issue 24

    Abstract: In this paper, we demonstrate that the weak temperature dependence of the structure factor of supercooled liquids, a defining feature of the glass transition, is a consequence of the averaging of the scattering intensity due to angular averaging. We show ...

    Abstract In this paper, we demonstrate that the weak temperature dependence of the structure factor of supercooled liquids, a defining feature of the glass transition, is a consequence of the averaging of the scattering intensity due to angular averaging. We show that the speckle at individual wavevectors, calculated from a simulated glass former, exhibits a Debye-Waller factor with a sufficiently large temperature dependence to represent a structural order parameter capable of distinguishing liquid from glass. We also extract from the speckle intensities a quantity proportional to the variance of the local restraint, i.e., a direct experimental measure of the amplitude of structural heterogeneity.
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0177251
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  2. Article: Autologous hematopoietic stem cell transplantation for multiple myeloma in the age of CAR T cell therapy.

    Hughes, Charlotte F M / Shah, Gunjan L / Paul, Barry A

    Frontiers in oncology

    2024  Volume 14, Page(s) 1373548

    Abstract: Chimeric antigen receptor (CAR) T cell therapy has revolutionized the management of relapsed and refractory myeloma, with excellent outcomes and a tolerable safety profile. High dose chemotherapy with autologous hematopoietic stem cell transplantation ( ... ...

    Abstract Chimeric antigen receptor (CAR) T cell therapy has revolutionized the management of relapsed and refractory myeloma, with excellent outcomes and a tolerable safety profile. High dose chemotherapy with autologous hematopoietic stem cell transplantation (AHCT) is established as a mainstream of newly diagnosed multiple myeloma (NDMM) management in patients who are young and fit enough to tolerate such intensity. This standard was developed based on randomized trials comparing AHCT to chemotherapy in the era prior to novel agents. More recently, larger studies have primarily shown a progression free survival (PFS) benefit of upfront AHCT, rather than overall survival (OS) benefit. There is debate about the significance of this lack of OS, acknowledging the potential confounders of the chronic nature of the disease, study design and competing harms and benefits of exposure to AHCT. Indeed upfront AHCT may not be as uniquely beneficial as we once thought, and is not without risk. New quadruple-agent regimens are highly active and effective in achieving a deep response as quantified by measurable residual disease (MRD). The high dose chemotherapy administered with AHCT imposes a burden of short and long-term adverse effects, which may alter the disease course and patient's ability to tolerate future therapies. Some high-risk subgroups may have a more valuable benefit from AHCT, though still ultimately suffer poor outcomes. When compared to the outcomes of CAR T cell therapy, the question of whether AHCT can or indeed should be deferred has become an important topic in the field. Deferring AHCT may be a personalized decision in patients who achieve MRD negativity, which is now well established as a key prognostic factor for PFS and OS. Reserving or re-administering AHCT at relapse is feasible in many cases and holds the promise of resetting the T cell compartment and opening up options for immune reengagement. It is likely that personalized MRD-guided decision making will shape how we sequence in the future, though more studies are required to delineate when this is safe and appropriate.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1373548
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  3. Article ; Online: Camping Alone-Recovering From COVID-19.

    Tisch, Charlotte F

    JAMA

    2020  Volume 324, Issue 14, Page(s) 1399–1400

    MeSH term(s) COVID-19/psychology ; Camping/psychology ; Female ; Humans ; Quarantine/psychology ; Social Isolation/psychology ; Students, Medical
    Keywords covid19
    Language English
    Publishing date 2020-09-13
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.19304
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  4. Article ; Online: Equilibrium distribution functions: connection with microscopic dynamics.

    Petersen, Charlotte F / Searles, Debra J

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 11, Page(s) 6383–6392

    Abstract: Standard textbook derivations of the equilibrium distribution function rely on assumptions that may not satisfy all readers. Here, we present a straightforward approach to derive the equilibrium distribution function from the microscopic dynamics, and ... ...

    Abstract Standard textbook derivations of the equilibrium distribution function rely on assumptions that may not satisfy all readers. Here, we present a straightforward approach to derive the equilibrium distribution function from the microscopic dynamics, and review how it can be used to obtain the expected expressions. In molecular dynamics simulations the equations of motion are often modified to simulate different ensembles or phenomena. We show that in some cases these equations will sample an equilibrium ensemble whereas in other cases they will not. For example, we find that for charged particles driven by a field, an equilibrium distribution is only possible when the system is confined. Furthermore, the approach correctly predicts that neither SLLOD shear flow dynamics nor constant temperature dynamics with a Berendsen thermostat sample any time-independent phase space distributions.
    MeSH term(s) Molecular Dynamics Simulation ; Motion ; Temperature
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d1cp05316g
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  5. Article ; Online: SIADH & Diabetes insipidus: Neues zu Diagnosestellung und Therapie.

    Fenske, Wiebke / Charlotte, Fries

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 17, Page(s) 1096–1103

    Abstract: Dysnatremia is a common occurrence in patients with COVID-19 and is associated with higher mortality and risk for septic conditions. The pathomechanisms are probably multifaceted, but severe hyponatremia may also occur as a result of underlying SIADH or ... ...

    Title translation Update on the diagnosis and management of SIADH and Diabetes insipidus.
    Abstract Dysnatremia is a common occurrence in patients with COVID-19 and is associated with higher mortality and risk for septic conditions. The pathomechanisms are probably multifaceted, but severe hyponatremia may also occur as a result of underlying SIADH or hypocortisolism. Patients with preexisting AVP dysfunction, like SIADH or diabetes insipidus, are at high risk for severe electrolyte imbalances in the event of a COVID-19 infection.The recently growing use of immune checkpoint inhibitors in oncology is associated with a spectrum of endocrine immune-related adverse events (endocrine irAEs). These AEs usually occur unpredictably and may even manifest after discontinuation of the anticancer therapy. Hyponatremia is a common factor of several endocrine irAEs and may serve as a red flag biomarker for possibly underlying endocrine irAEs such as hypophysitis or adrenalitis. New-onset hyponatremia should always prompt a comprehensive diagnostic workup and exclusion of endocrine irAEs before the diagnosis of SIADH is made.Hyponatremia with severe symptoms should be treated with hypertonic (3 %) saline solution to resolve the cerebral edema and prevent from detrimental neurological sequelae. Both rapid intermittent bolus (RIB) therapy and continuous infusion therapy have now been reported to be safe and equally effective. The RIB therapy limits the risk of overcorrection and requires less often re-lowering treatment than continuous infusion therapy.Fluid restriction has long been considered as first-line treatment of chronic hyponatremia due to SIADH. Additional treatment with Furosemid and/or oral NaCl tablets does not improve efficacy but reduces tolerance to therapy.Copeptin-based dynamic tests show higher diagnostic accuracy in the differential diagnosis of patients with hypotonic polyuria polydipsia syndrome than the indirect water deprivation test.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; Diabetes Insipidus ; Diabetes Mellitus ; Diagnosis, Differential ; Humans ; Hyponatremia ; Inappropriate ADH Syndrome ; Polydipsia
    Language German
    Publishing date 2022-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1783-3161
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  6. Article ; Online: Selection pressures on evolution of ribonuclease H explored with rigorous free-energy-based design.

    Hayes, Ryan L / Nixon, Charlotte F / Marqusee, Susan / Brooks, Charles L

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 3, Page(s) e2312029121

    Abstract: Understanding natural protein evolution and designing novel proteins are motivating interest in development of high-throughput methods to explore large sequence spaces. In this work, we demonstrate the application of multisite λ dynamics (MSλD), a ... ...

    Abstract Understanding natural protein evolution and designing novel proteins are motivating interest in development of high-throughput methods to explore large sequence spaces. In this work, we demonstrate the application of multisite λ dynamics (MSλD), a rigorous free energy simulation method, and chemical denaturation experiments to quantify evolutionary selection pressure from sequence-stability relationships and to address questions of design. This study examines a mesophilic phylogenetic clade of ribonuclease H (RNase H), furthering its extensive characterization in earlier studies, focusing on
    MeSH term(s) Escherichia coli/genetics ; Phylogeny ; Computer Simulation ; Consensus Sequence ; Ribonuclease H/genetics
    Chemical Substances Ribonuclease H (EC 3.1.26.4)
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2312029121
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  7. Book ; Online: Direct Measurement of the Structural Change Associated with Amorphous Solidification using Static Scattering of Coherent Radiation

    Petersen, Charlotte F. / Harrowell, Peter

    2023  

    Abstract: In this paper we demonstrate that the weak temperature dependence of structure factor of supercooled liquids, a defining feature of the glass transition, is a consequence of the averaging of the scattering intensity either due to the use of an incoherent ...

    Abstract In this paper we demonstrate that the weak temperature dependence of structure factor of supercooled liquids, a defining feature of the glass transition, is a consequence of the averaging of the scattering intensity either due to the use of an incoherent radiation source or explicit angular averaging. We show that the speckle scattering at individual wavevectors, calculated from a simulated glass former, exhibits a Debye-Waller factor with a sufficiently large temperature dependence to represent a structural order parameter capable of distinguishing liquid from glass. We also extract from the speckle intensities a quantity proportional to the variance of the local restraint, i.e. a direct experimental measure of the amplitude of structural heterogeneity.
    Keywords Condensed Matter - Materials Science ; Condensed Matter - Soft Condensed Matter
    Publishing date 2023-02-23
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Cross-cultural differences in self-reported and behavioural emotional self-awareness between Japan and the UK.

    Huggins, Charlotte F / Williams, Justin H G / Sato, Wataru

    BMC research notes

    2023  Volume 16, Issue 1, Page(s) 380

    Abstract: Objective: How we express and describe emotion is shaped by sociocultural norms. These sociocultural norms may also affect emotional self-awareness, i.e., how we identify and make sense of our own emotions. Previous studies have found lower emotional ... ...

    Abstract Objective: How we express and describe emotion is shaped by sociocultural norms. These sociocultural norms may also affect emotional self-awareness, i.e., how we identify and make sense of our own emotions. Previous studies have found lower emotional self-awareness in East Asian compared to Western samples using self-report measures. However, studies using behavioural methods did not provide clear evidence of reduced emotional self-awareness in East Asian groups. This may be due to different measurement tools capturing different facets of emotional self-awareness.
    Results: To investigate this issue further, we compared the emotional self-awareness of Japanese (n = 29) and United Kingdom (UK) (n = 43) adults using the self-report Toronto Alexithymia Scale (TAS-20), alongside two behavioural measures - the Emotional Consistency Task (EC-Task) and the Photo Emotion Differentiation Task (PED-Task). Japanese adults showed higher TAS-20 scores than UK participants, indicating greater self-reported difficulties with emotional self-awareness. Japanese participants also had lower EC-Task scores than UK adults, indicating a lower ability to differentiate between levels of emotional intensity. PED-Task performance did not show clear group differences. These findings suggest that cross-cultural differences in emotional self-awareness vary with the task used, because different tasks assess distinct aspects of this ability. Future research should attempt to capture these different aspects of emotional self-awareness.
    MeSH term(s) Adult ; Humans ; Self Report ; Japan ; Cross-Cultural Comparison ; Awareness ; Emotions
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-023-06660-0
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  9. Article ; Online: First Rib Stress Fracture in an Adolescent Elite Tennis Player: A Case Report.

    Wahle, Charlotte F / Hart, Christopher M / Beck, Jennifer J

    JBJS case connector

    2023  Volume 13, Issue 1

    Abstract: Case: A 16-year-old, right-hand-dominant, Asian male, elite tennis player presented to the clinic with a 1-month history of left shoulder pain. Originally, the pathology was believed to be shoulder-based, but lack of improvement after several weeks of ... ...

    Abstract Case: A 16-year-old, right-hand-dominant, Asian male, elite tennis player presented to the clinic with a 1-month history of left shoulder pain. Originally, the pathology was believed to be shoulder-based, but lack of improvement after several weeks of therapy warranted further imaging, which ultimately revealed a nondisplaced fracture of the posterior left first rib.
    Conclusion: Stress injuries are not uncommon in the sport of tennis, but atraumatic rib fractures are rare. Given the increase in youth sports specialization and overtraining and other risk factors such as adolescent age and race, it is important to keep rib stress fracture on the differential.
    MeSH term(s) Humans ; Male ; Adolescent ; Fractures, Stress/etiology ; Tennis/injuries ; Ribs/injuries ; Rib Fractures/complications ; Shoulder Pain/etiology
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e22.00519
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  10. Article ; Online: Dopaminergic and norepinephrinergic modulation of endogenous event-related potentials: A systematic review and meta-analysis.

    Warren, Claire V / Kroll, Charlotte F / Kopp, Bruno

    Neuroscience and biobehavioral reviews

    2023  Volume 151, Page(s) 105221

    Abstract: Event-related potentials (ERPs) represent the cortical processing of sensory, motor or cognitive functions invoked by particular events or stimuli. A current theory posits that the catecholaminergic neurotransmitters dopamine (DA) and norepinephrine (NE) ...

    Abstract Event-related potentials (ERPs) represent the cortical processing of sensory, motor or cognitive functions invoked by particular events or stimuli. A current theory posits that the catecholaminergic neurotransmitters dopamine (DA) and norepinephrine (NE) modulate a number of endogenous ERPs during various cognitive processes. This manuscript aims to evaluate a leading neurotransmitter hypothesis with a systematic overview and meta-analysis of pharmacologic DA and NE manipulation of specific ERPs in healthy subjects during executive function. Specifically, the frontally-distributed P3a, N2, and N
    MeSH term(s) Humans ; Dopamine ; Evoked Potentials ; Cognition ; Executive Function ; Electroencephalography ; Event-Related Potentials, P300
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105221
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