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  1. Article ; Online: Changing gears: data-driven velocity zones to support monitoring and research in men's rugby league.

    Cummins, Cloe / Charlton, Glen / Paul, David / Murphy, Aron

    Science & medicine in football

    2022  Volume 8, Issue 1, Page(s) 60–67

    Abstract: Objectives: The study aimed to (1) apply a data-mining approach to league-wide microtechnology data to identify absolute velocity zone thresholds and (2) apply the respective velocity zones to microtechnology data to examine the locomotor demands of ... ...

    Abstract Objectives: The study aimed to (1) apply a data-mining approach to league-wide microtechnology data to identify absolute velocity zone thresholds and (2) apply the respective velocity zones to microtechnology data to examine the locomotor demands of elite match-play.
    Methods: League-wide microtechnology data were collected from elite male rugby league players representing all National Rugby League (NRL) teams (n = 16 teams, one excluded due to a different microtechnology device; n = 4836 files) over one season. To identify four velocity zones, spectral clustering with a beta smoothing cut-off of 0.1 was applied to each players' instantaneous match-play velocity data. Velocity zones for each player were calculated as the median while the overarching velocity zones were determined through an incremental search to minimise root mean square error.
    Results: The velocity zones identified through spectral clustering were 0-13.99 km · h
    Conclusions: The application of spectral clustering (i.e., a data-mining method) to league-wide rugby league microtechnology data yielded insights into the distribution of velocity data, thereby informing the cut-off values which best place similar data points into the same velocity zones. As the identified zones are representative of the intensities of locomotion achieved by elite male rugby league players, it is suggested that when absolute zones are used, the consistent application of the identified zones would facilitate standardisation, longitudinal athlete monitoring as well as comparisons between teams, leagues and published literature.
    MeSH term(s) Humans ; Male ; Rugby ; Football ; Athletic Performance ; Men ; Athletes
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article
    ISSN 2473-4446
    ISSN (online) 2473-4446
    DOI 10.1080/24733938.2022.2152482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeted microlearning: Teaching geriatric medicine to Gen Y and Gen Z junior doctors.

    Thillainadesan, Janani / Charlton, Gabriella / Wang, Jeff

    Australasian journal on ageing

    2022  Volume 41, Issue 4, Page(s) 590–592

    MeSH term(s) Humans ; Aged ; Medical Staff, Hospital ; Geriatrics/education ; Teaching
    Language English
    Publishing date 2022-08-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1457406-8
    ISSN 1741-6612 ; 0726-4240 ; 1440-6381
    ISSN (online) 1741-6612
    ISSN 0726-4240 ; 1440-6381
    DOI 10.1111/ajag.13130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How fast is fast? Defining velocity zones in women's rugby league.

    Cummins, Cloe / Charlton, Glen / Paul, David / Buxton, Simon / Murphy, Aron

    Science & medicine in football

    2022  Volume 7, Issue 2, Page(s) 165–170

    Abstract: Objectives: The study aimed to: 1) apply a data-mining approach to identify velocity zone thresholds for female rugby league players and 2) apply these velocity zones to examine the locomotor demands of match-play.: Methods: Microtechnology data were ...

    Abstract Objectives: The study aimed to: 1) apply a data-mining approach to identify velocity zone thresholds for female rugby league players and 2) apply these velocity zones to examine the locomotor demands of match-play.
    Methods: Microtechnology data were collected from elite female rugby league players representing all National Rugby League Women's teams (n = 85 players; n = 224 files) over one season. Spectral clustering with a beta smoothing cut-off of 0.1 was applied to each player's instantaneous match-play velocity data for the identification of four zones. To account for outliers within repeated data-points, the velocity zones for each player were calculated as the median. The overarching velocity zones were determined through an incremental search to minimise the root mean square error.
    Results: Through a data-mining approach, four velocity zones were determined. Rounded to the nearest 0.5 km.h
    Conclusions: This work informs the velocity zones that could be applied consistently to women's rugby league data within practical (i.e., in the training and monitoring of players) and academic (i.e., as a model for future research to analyse locomotor demands) settings.
    MeSH term(s) Humans ; Female ; Football ; Athletic Performance ; Rugby ; Running ; Geographic Information Systems
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2473-4446
    ISSN (online) 2473-4446
    DOI 10.1080/24733938.2022.2062438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Assessing the Accuracy of Leg Mounted Sensors for Recording Dairy Cow Behavioural Activity at Pasture, in Cubicle Housing and a Straw Yard

    Charlton, Gemma / Gauld, Carrie / Veronesi, Fabio / Rutter, Steven Mark / Bleach, Emma

    Animals. 2022 Mar. 03, v. 12, no. 5

    2022  

    Abstract: The accuracy of CowAlert IceQube sensors (IceRobotics Ltd., Edinburgh, UK) for recording lying duration, standing and lying transitions and number of steps when dairy cows where at pasture, in cubicle housing and in a straw yard, was investigated. ... ...

    Abstract The accuracy of CowAlert IceQube sensors (IceRobotics Ltd., Edinburgh, UK) for recording lying duration, standing and lying transitions and number of steps when dairy cows where at pasture, in cubicle housing and in a straw yard, was investigated. Holstein Friesian cows at Harper Adams University, UK were fitted with IceQube sensors; one on the back left (BL) leg and one on the front left (FL) leg. Cows at pasture (n = 48), in cubicle housing (n = 46) and in a straw yard (n = 45) were visually observed. Data were analysed in two stages: (1) an initial exploratory phase determined the correlation level between sensor measurements andvisual observations. Subsequently, (2) a mixed effects modelling framework was used to check whether sensors provide significantly different measures of cow’s activities compared to the observations. Results indicate that lying and standing times are similar between the observed and recorded times, in all three locations. In terms of sensor placement, significant differences were found between the number of steps recorded between BL and FL on straw and pasture, but all other activities were similar, in each location. The accuracy of CowAlert IceQube sensors on the BL leg gives them the potential to be used as lifelong sensors.
    Keywords Holstein ; dairy cows ; pastures ; straw
    Language English
    Dates of publication 2022-0303
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12050638
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Psuedo-Cor Triatriatum in an Elderly Patient With Dyspnea of Exertion: An Undescribed Condition Characterized by 3-Dimensional Transesophageal Echocardiography.

    Levin, Daniel Brooks / Charlton, Gerald / Snider, Richard / Roldan, Carlos A

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 2324709620987692

    Abstract: A 66-year-old gentleman with no prior cardiac history presented with dyspnea on exertion and chest pain for 1 month. His workup included a transthoracic echocardiogram, which demonstrated findings suggestive of cor triatriatum (C-TAT) with uncertain ... ...

    Abstract A 66-year-old gentleman with no prior cardiac history presented with dyspnea on exertion and chest pain for 1 month. His workup included a transthoracic echocardiogram, which demonstrated findings suggestive of cor triatriatum (C-TAT) with uncertain degree of hemodynamic obstruction. In addition, mild left ventricular systolic dysfunction and segmental wall motion abnormalities suggestive of coronary artery disease were noted. The patient then underwent transesophageal echocardiography (TEE) to define better the structural characteristics and hemodynamic significance of the C-TAT, left and right heart catheterization to assess pressure gradients between the upper and lower left atrial chambers by simultaneous measurement of pulmonary capillary wedge and left ventricular end-diastolic pressures, and coronary angiography. Multiplane 2-dimensional TEE demonstrated an atrial membrane extending from the inferior portion of the interatrial septum to the superior aspect of the lateral atrial wall. This membrane exhibited a medial large oval opening with bidirectional flow and a ≤2 mm Hg gradient. Three-dimensional TEE imaging re-demonstrated this obliquely oriented membrane; however, of most importance, it revealed that the membrane divided the atria into a medial funnel and C-shaped cavity with a large distal oval shape opening and an even larger lateral atrial cavity. These findings were inconsistent with a true C-TAT and rather demonstrated what we defined as a pseudo-C-TAT membrane. Simultaneous right and left heart catheterization confirmed a minimal gradient of 3 to 5 mm Hg and coronary angiography demonstrated severe 3-vessel coronary disease as the primary cause of the patient's clinical syndrome.
    MeSH term(s) Aged ; Cor Triatriatum/complications ; Cor Triatriatum/diagnostic imaging ; Dyspnea/etiology ; Echocardiography ; Echocardiography, Transesophageal ; Humans ; Male ; Physical Exertion
    Language English
    Publishing date 2021-01-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620987692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Calculations on the Ruthenium-Catalyzed Diene and Dienyne Ring-Closing Metathesis Reactions in the Synthesis of Taxol Derivatives.

    Brooks, Samantha / Charlton, Georgina / Letort, Aurélien / Prunet, Joëlle / Bucher, Götz

    The Journal of organic chemistry

    2021  Volume 86, Issue 18, Page(s) 13056–13070

    Abstract: Density-functional and semiempirical calculations (M06, M06L, and PM6) on intermediates in the ring-closing metathesis (RCM) reactions in the synthesis of Taxol derivatives give results in excellent agreement with the results of previous experimental ... ...

    Abstract Density-functional and semiempirical calculations (M06, M06L, and PM6) on intermediates in the ring-closing metathesis (RCM) reactions in the synthesis of Taxol derivatives give results in excellent agreement with the results of previous experimental work. The results suggest that the degree of steric overloading plays a decisive role in determining the outcome (ene-ene or ene-yne-ene metathesis). Due to the rigidity of the Taxol skeleton being formed in the ene-yne-ene cascade reaction, the transition states in its final ene-ene metathesis reaction stage are particularly sensitive to steric effects. Thus, the reaction is predicted to be preferred for one diastereomer of the precursor in which the diol functionality is protected with a compact cyclic carbonate moiety, whereas the use of a bulkier benzoate-protecting group results in activation barriers for Taxol formation that are prohibitive. The reason why one diastereomer of the carbonate-protected precursor undergoes formation of a tricycle via an ene-yne-ene RCM cascade, whereas the other diastereomer undergoes cyclooctene formation via an ene-ene RCM, likely lies in the orientation of the pseudoaxial methyl group on the cyclohexene ring, which in the latter case would unfavorably point toward the reactive center of the Ru-complex, leading to Taxol formation.
    MeSH term(s) Catalysis ; Cyclization ; Paclitaxel ; Polyenes ; Ruthenium
    Chemical Substances Polyenes ; Ruthenium (7UI0TKC3U5) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c01879
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  7. Article: Direct antagonism in mixed bacterial populations.

    CHARLTON, G

    Journal of bacteriology

    2003  Volume 70, Issue 1, Page(s) 56–59

    MeSH term(s) Bacteria
    Language English
    Publishing date 2003-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.70.1.56-59.1955
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Assessing the Accuracy of Leg Mounted Sensors for Recording Dairy Cow Behavioural Activity at Pasture, in Cubicle Housing and a Straw Yard.

    Charlton, Gemma / Gauld, Carrie / Veronesi, Fabio / Rutter, Steven Mark / Bleach, Emma

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 5

    Abstract: The accuracy of CowAlert IceQube sensors (IceRobotics Ltd., Edinburgh, UK) for recording lying duration, standing and lying transitions and number of steps when dairy cows where at pasture, in cubicle housing and in a straw yard, was investigated. ... ...

    Abstract The accuracy of CowAlert IceQube sensors (IceRobotics Ltd., Edinburgh, UK) for recording lying duration, standing and lying transitions and number of steps when dairy cows where at pasture, in cubicle housing and in a straw yard, was investigated. Holstein Friesian cows at Harper Adams University, UK were fitted with IceQube sensors; one on the back left (BL) leg and one on the front left (FL) leg. Cows at pasture (
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12050638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Women's Rugby League: Positional Groups and Peak Locomotor Demands.

    Cummins, Cloe / Charlton, Glen / Paul, David / Shorter, Kath / Buxton, Simon / Caia, Johnpaul / Murphy, Aron

    Frontiers in sports and active living

    2021  Volume 3, Page(s) 648126

    Abstract: The aims of this study were to (a) use a data-based approach to identify positional groups within National Rugby League Women's (NRLW) match-play and (b) quantify the peak locomotor demands of NRLW match-play by positional groups. Microtechnology (Global ...

    Abstract The aims of this study were to (a) use a data-based approach to identify positional groups within National Rugby League Women's (NRLW) match-play and (b) quantify the peak locomotor demands of NRLW match-play by positional groups. Microtechnology (Global Navigational Satellite System [GNSS] and integrated inertial sensors;
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2021.648126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Study of Chronic Infection and Subinfection by the Colon Bacillus : II. On the Degeneration of the Spinal Cord produced by repeated Injections of Cultures of a Colon Bacillus of Low Virulence.

    Charlton, G A

    The Journal of medical research

    2009  Volume 11, Issue 2, Page(s) 507–519

    Language English
    Publishing date 2009-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589048-7
    ISSN 0097-3599
    ISSN 0097-3599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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