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  1. Article ; Online: Eye tracking communication with intubated critically ill patients: a proof-of-concept multicenter pilot study.

    Bodet-Contentin, Laetitia / Szymkowicz, Emilie / Delpierre, Eric / Chartier, Delphine / Gadrez, Pierrick / Muller, Grégoire / Renault, Aurélie / Ehrmann, Stephan

    Minerva anestesiologica

    2022  Volume 88, Issue 9, Page(s) 690–697

    Abstract: Background: Communication is essential to establish patient-caregivers relationship in the intensive care unit. Intubated patients are not able to speak because the tracheal tube prevents vocalization. Use of communication tools such as eye tracking ... ...

    Abstract Background: Communication is essential to establish patient-caregivers relationship in the intensive care unit. Intubated patients are not able to speak because the tracheal tube prevents vocalization. Use of communication tools such as eye tracking device could improve communication with intubated patients. The objective of this feasibility pilot study was to demonstrate that an eye tracking device specifically developed for the intensive care could be used easily by awake intubated patient with a very short training time.
    Methods: This prospective multicenter study was conducted in four intensive care units. We included awake adult intubated patients. The device used included an eye-tracking infrared detection and a communication interface specifically developed.
    Results: A total of 151 patients were included: the median age of patients was 66 years (56-72) and 97 (64%) were male, 97 patients (64%) succeed totally (installation; calibration, succeed to select all three icons), 124 (82%) succeed to select at least one icon, and 111 (74%) succeed to point to at least two icons. The main reasons for failure to use the device were: difficulties to open or to keep the eyes open, difficulties to installing the device occurred, and patient fatigue.
    Conclusions: This study shows that the use of an eye tracking technology device specifically designed for the intensive care setting, with a short training is easy to use for intubated patient. Patients, relatives and caregivers showed high satisfaction.
    MeSH term(s) Adult ; Aged ; Communication ; Critical Illness/therapy ; Eye-Tracking Technology ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies
    Language English
    Publishing date 2022-05-13
    Publishing country Italy
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.22.16275-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: L'eye tracking pour renforcer la communication en réanimation.

    Bodet-Contentin, Laëtitia / Barougier, Anouck / Chartier, Delphine / Havard, Élodie / Brondeau, Murielle / Lorrier, Marie-Annis / Tregaro, Anne-Sophie

    Revue de l'infirmiere

    2016  , Issue 220, Page(s) 33–35

    Abstract: In a bid to improve communication and the quality of care of patients in intensive care, a nursing team studied the eye tracking system. An innovative tablet, tested for several months, helps to reinforce exchanges between patients, their families and ... ...

    Title translation Eye tracking to improve communication in intensive care.
    Abstract In a bid to improve communication and the quality of care of patients in intensive care, a nursing team studied the eye tracking system. An innovative tablet, tested for several months, helps to reinforce exchanges between patients, their families and the caregivers.
    MeSH term(s) Communication ; Critical Care/methods ; Eye Movements ; Humans
    Language French
    Publishing date 2016-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2016.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

    Angus, Derek C / Derde, Lennie / Al-Beidh, Farah / Annane, Djillali / Arabi, Yaseen / Beane, Abigail / van Bentum-Puijk, Wilma / Berry, Lindsay / Bhimani, Zahra / Bonten, Marc / Bradbury, Charlotte / Brunkhorst, Frank / Buxton, Meredith / Buzgau, Adrian / Cheng, Allen C / de Jong, Menno / Detry, Michelle / Estcourt, Lise / Fitzgerald, Mark /
    Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer / Schweikert, Sacha / Wibrow, Bradley / Rauniyar, Rashmi / Myers, Erina / Fysh, Ed / Dawda, Ashlish / Mevavala, Bhaumik / Litton, Ed / Ferrier, Janet / Nair, Priya / Buscher, Hergen / Reynolds, Claire / Santamaria, John / Barbazza, Leanne / Homes, Jennifer / Smith, Roger / Murray, Lauren / Brailsford, Jane / Forbes, Loretta / Maguire, Teena / Mariappa, Vasanth / Smith, Judith / Simpson, Scott / Maiden, Matthew / Bone, Allsion / Horton, Michelle / Salerno, Tania / Sterba, Martin / Geng, Wenli / Depuydt, Pieter / De Waele, Jan / De Bus, Liesbet / Fierens, Jan / Bracke, Stephanie / Reeve, Brenda / Dechert, William / Chassé, Michaël / Carrier, François Martin / Boumahni, Dounia / Benettaib, Fatna / Ghamraoui, Ali / Bellemare, David / Cloutier, Ève / Francoeur, Charles / Lamontagne, François / D’Aragon, Frédérick / Carbonneau, Elaine / Leblond, Julie / Vazquez-Grande, Gloria / Marten, Nicole / Wilson, Maggie / Albert, Martin / Serri, Karim / Cavayas, Alexandros / Duplaix, Mathilde / Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / Carmona Flores, Rosario / León López, Rafael / de la Fuente Martos, Carmen / Allan, Angela / Polgarova, Petra / Farahi, Neda / McWilliam, Stephen / Hawcutt, Daniel / Rad, Laura / O’Malley, Laura / Whitbread, Jennifer / Kelsall, Olivia / Wild, Laura / Thrush, Jessica / Wood, Hannah / Austin, Karen / Donnelly, Adrian / Kelly, Martin / O’Kane, Sinéad / McClintock, Declan / Warnock, Majella / Johnston, Paul / Gallagher, Linda Jude / Mc Goldrick, Clare / Mc Master, Moyra / Strzelecka, Anna / Jha, Rajeev / Kalogirou, Michael / Ellis, Christine / Krishnamurthy, Vinodh / Deelchand, Vashish / Silversides, Jon / McGuigan, Peter / Ward, Kathryn / O’Neill, Aisling / Finn, Stephanie / Phillips, Barbara / Mullan, Dee / Oritz-Ruiz de Gordoa, Laura / Thomas, Matthew / Sweet, Katie / Grimmer, Lisa / Johnson, Rebekah / Pinnell, Jez / Robinson, Matt / Gledhill, Lisa / Wood, Tracy / Morgan, Matt / Cole, Jade / Hill, Helen / Davies, Michelle / Antcliffe, David / Templeton, Maie / Rojo, Roceld / Coghlan, Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, Graziella / Brightling, Chris / Bourne, Michelle / Craner, Michelle / Watters, Malcolm / Prout, Rachel / Davies, Louisa / Pegler, Suzannah / Kyeremeh, Lynsey / Arbane, Gill / Wilson, Karen / Gomm, Linda / Francia, Federica / Brett, Stephen / Sousa Arias, Sonia / Elin Hall, Rebecca / Budd, Joanna / Small, Charlotte / Birch, Janine / Collins, Emma / Henning, Jeremy / Bonner, Stephen / Hugill, Keith / Cirstea, Emanuel / Wilkinson, Dean / Karlikowski, Michal / Sutherland, Helen / Wilhelmsen, Elva / Woods, Jane / North, Julie / Sundaran, Dhinesh / Hollos, Laszlo / Coburn, Susan / Walsh, Joanne / Turns, Margaret / Hopkins, Phil / Smith, John / Noble, Harriet / Depante, Maria Theresa / Clarey, Emma / Laha, Shondipon / Verlander, Mark / Williams, Alexandra / Huckle, Abby / Hall, Andrew / Cooke, Jill / Gardiner-Hill, Caroline / Maloney, Carolyn / Qureshi, Hafiz / Flint, Neil / Nicholson, Sarah / Southin, Sara / Nicholson, Andrew / Borgatta, Barbara / Turner-Bone, Ian / Reddy, Amie / Wilding, Laura / Chamara Warnapura, Loku / Agno Sathianathan, Ronan / Golden, David / Hart, Ciaran / Jones, Jo / Bannard-Smith, Jonathan / Henry, Joanne / Birchall, Katie / Pomeroy, Fiona / Quayle, Rachael / Makowski, Arystarch / Misztal, Beata / Ahmed, Iram / KyereDiabour, Thyra / Naiker, Kevin / Stewart, Richard / Mwaura, Esther / Mew, Louise / Wren, Lynn / Willams, Felicity / Innes, Richard / Doble, Patricia / Hutter, Joanne / Shovelton, Charmaine / Plumb, Benjamin / Szakmany, Tamas / Hamlyn, Vincent / Hawkins, Nancy / Lewis, Sarah / Dell, Amanda / Gopal, Shameer / Ganguly, Saibal / Smallwood, Andrew / Harris, Nichola / Metherell, Stella / Lazaro, Juan Martin / Newman, Tabitha / Fletcher, Simon / Nortje, Jurgens / Fottrell-Gould, Deirdre / Randell, Georgina / Zaman, Mohsin / Elmahi, Einas / Jones, Andrea / Hall, Kathryn / Mills, Gary / Ryalls, Kim / Bowler, Helen / Sall, Jas / Bourne, Richard / Borrill, Zoe / Duncan, Tracey / Lamb, Thomas / Shaw, Joanne / Fox, Claire / Moreno Cuesta, Jeronimo / Xavier, Kugan / Purohit, Dharam / Elhassan, Munzir / Bakthavatsalam, Dhanalakshmi / Rowland, Matthew / Hutton, Paula / Bashyal, Archana / Davidson, Neil / Hird, Clare / Chhablani, Manish / Phalod, Gunjan / Kirkby, Amy / Archer, Simon / Netherton, Kimberley / Reschreiter, Henrik / Camsooksai, Julie / Patch, Sarah / Jenkins, Sarah / Pogson, David / Rose, Steve / Daly, Zoe / Brimfield, Lutece / Claridge, Helen / Parekh, Dhruv / Bergin, Colin / Bates, Michelle / Dasgin, Joanne / McGhee, Christopher / Sim, Malcolm / Hay, Sophie Kennedy / Henderson, Steven / Phull, Mandeep-Kaur / Zaidi, Abbas / Pogreban, Tatiana / Rosaroso, Lace Paulyn / Harvey, Daniel / Lowe, Benjamin / Meredith, Megan / Ryan, Lucy / Hormis, Anil / Walker, Rachel / Collier, Dawn / Kimpton, Sarah / Oakley, Susan / Rooney, Kevin / Rodden, Natalie / Hughes, Emma / Thomson, Nicola / McGlynn, Deborah / Walden, Andrew / Jacques, Nicola / Coles, Holly / Tilney, Emma / Vowell, Emma / Schuster-Bruce, Martin / Pitts, Sally / Miln, Rebecca / Purandare, Laura / Vamplew, Luke / Spivey, Michael / Bean, Sarah / Burt, Karen / Moore, Lorraine / Day, Christopher / Gibson, Charly / Gordon, Elizabeth / Zitter, Letizia / Keenan, Samantha / Baker, Evelyn / Cherian, Shiney / Cutler, Sean / Roynon-Reed, Anna / Harrington, Kate / Raithatha, Ajay / Bauchmuller, Kris / Ahmad, Norfaizan / Grecu, Irina / Trodd, Dawn / Martin, Jane / Wrey Brown, Caroline / Arias, Ana-Marie / Craven, Thomas / Hope, David / Singleton, Jo / Clark, Sarah / Rae, Nicola / Welters, Ingeborg / Hamilton, David Oliver / Williams, Karen / Waugh, Victoria / Shaw, David / Puthucheary, Zudin / Martin, Timothy / Santos, Filipa / Uddin, Ruzena / Somerville, Alastair / Tatham, Kate Colette / Jhanji, Shaman / Black, Ethel / Dela Rosa, Arnold / Howle, Ryan / Tully, Redmond / Drummond, Andrew / Dearden, Joy / Philbin, Jennifer / Munt, Sheila / Vuylsteke, Alain / Chan, Charles / Victor, Saji / Matsa, Ramprasad / Gellamucho, Minerva / Creagh-Brown, Ben / Tooley, Joe / Montague, Laura / De Beaux, Fiona / Bullman, Laetitia / Kersiake, Ian / Demetriou, Carrie / Mitchard, Sarah / Ramos, Lidia / White, Katie / Donnison, Phil / Johns, Maggie / Casey, Ruth / Mattocks, Lehentha / Salisbury, Sarah / Dark, Paul / Claxton, Andrew / McLachlan, Danielle / Slevin, Kathryn / Lee, Stephanie / Hulme, Jonathan / Joseph, Sibet / Kinney, Fiona / Senya, Ho Jan / Oborska, Aneta / Kayani, Abdul / Hadebe, Bernard / Orath Prabakaran, Rajalakshmi / Nichols, Lesley / Thomas, Matt / Worner, Ruth / Faulkner, Beverley / Gendall, Emma / Hayes, Kati / Hamilton-Davies, Colin / Chan, Carmen / Mfuko, Celina / Abbass, Hakam / Mandadapu, Vineela / Leaver, Susannah / Forton, Daniel / Patel, Kamal / Paramasivam, Elankumaran / Powell, Matthew / Gould, Richard / Wilby, Elizabeth / Howcroft, Clare / Banach, Dorota / Fernández de Pinedo Artaraz, Ziortza / Cabreros, Leilani / White, Ian / Croft, Maria / Holland, Nicky / Pereira, Rita / Zaki, Ahmed / Johnson, David / Jackson, Matthew / Garrard, Hywel / Juhaz, Vera / Roy, Alistair / Rostron, Anthony / Woods, Lindsey / Cornell, Sarah / Pillai, Suresh / Harford, Rachel / Rees, Tabitha / Ivatt, Helen / Sundara Raman, Ajay / Davey, Miriam / Lee, Kelvin / Barber, Russell / Chablani, Manish / Brohi, Farooq / Jagannathan, Vijay / Clark, Michele / Purvis, Sarah / Wetherill, Bill / Dushianthan, Ahilanandan / Cusack, Rebecca / de Courcy-Golder, Kim / Smith, Simon / Jackson, Susan / Attwood, Ben / Parsons, Penny / Page, Valerie / Zhao, Xiao Bei / Oza, Deepali / Rhodes, Jonathan / Anderson, Tom / Morris, Sheila / Xia Le Tai, Charlotte / Thomas, Amy / Keen, Alexandra / Digby, Stephen / Cowley, Nicholas / Southern, David / Reddy, Harsha / Campbell, Andy / Watkins, Claire / Smuts, Sara / Touma, Omar / Barnes, Nicky / Alexander, Peter / Felton, Tim / Ferguson, Susan / Sellers, Katharine / Bradley-Potts, Joanne / Yates, David / Birkinshaw, Isobel / Kell, Kay / Marshall, Nicola / Carr-Knott, Lisa / Summers, Charlotte

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1317–1329

    Abstract: Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.: Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.: Design, setting, and participants: An ...

    Abstract Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.
    Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.
    Design, setting, and participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020.
    Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108).
    Main outcomes and measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%).
    Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively.
    Conclusions and relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions.
    Trial registration: ClinicalTrials.gov Identifier: NCT02735707.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Early Termination of Clinical Trials ; Female ; Humans ; Hydrocortisone/administration & dosage ; Hydrocortisone/adverse effects ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiration, Artificial/statistics & numerical data ; SARS-CoV-2 ; Shock/drug therapy ; Shock/etiology ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Hydrocortisone (WI4X0X7BPJ)
    Keywords covid19
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.17022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

    Angus, Derek C / Derde, Lennie / Al-Beidh, Farah / Annane, Djillali / Arabi, Yaseen / Beane, Abigail / van Bentum-Puijk, Wilma / Berry, Lindsay / Bhimani, Zahra / Bonten, Marc / Bradbury, Charlotte / Brunkhorst, Frank / Buxton, Meredith / Buzgau, Adrian / Cheng, Allen C / de Jong, Menno / Detry, Michelle / Estcourt, Lise / Fitzgerald, Mark /
    Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Writing Committee for the REMAP-CAP Investigators, / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer / Schweikert, Sacha / Wibrow, Bradley / Rauniyar, Rashmi / Myers, Erina / Fysh, Ed / Dawda, Ashlish / Mevavala, Bhaumik / Litton, Ed / Ferrier, Janet / Nair, Priya / Buscher, Hergen / Reynolds, Claire / Santamaria, John / Barbazza, Leanne / Homes, Jennifer / Smith, Roger / Murray, Lauren / Brailsford, Jane / Forbes, Loretta / Maguire, Teena / Mariappa, Vasanth / Smith, Judith / Simpson, Scott / Maiden, Matthew / Bone, Allsion / Horton, Michelle / Salerno, Tania / Sterba, Martin / Geng, Wenli / Depuydt, Pieter / De Waele, Jan / De Bus, Liesbet / Fierens, Jan / Bracke, Stephanie / Reeve, Brenda / Dechert, William / Chassé, Michaël / Carrier, François Martin / Boumahni, Dounia / Benettaib, Fatna / Ghamraoui, Ali / Bellemare, David / Cloutier, Ève / Francoeur, Charles / Lamontagne, François / D’Aragon, Frédérick / Carbonneau, Elaine / Leblond, Julie / Vazquez-Grande, Gloria / Marten, Nicole / Wilson, Maggie / Albert, Martin / Serri, Karim / Cavayas, Alexandros / Duplaix, Mathilde / Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / Carmona Flores, Rosario / León López, Rafael / de la Fuente Martos, Carmen / Allan, Angela / Polgarova, Petra / Farahi, Neda / McWilliam, Stephen / Hawcutt, Daniel / Rad, Laura / O’Malley, Laura / Whitbread, Jennifer / Kelsall, Olivia / Wild, Laura / Thrush, Jessica / Wood, Hannah / Austin, Karen / Donnelly, Adrian / Kelly, Martin / O’Kane, Sinéad / McClintock, Declan / Warnock, Majella / Johnston, Paul / Gallagher, Linda Jude / Mc Goldrick, Clare / Mc Master, Moyra / Strzelecka, Anna / Jha, Rajeev / Kalogirou, Michael / Ellis, Christine / Krishnamurthy, Vinodh / Deelchand, Vashish / Silversides, Jon / McGuigan, Peter / Ward, Kathryn / O’Neill, Aisling / Finn, Stephanie / Phillips, Barbara / Mullan, Dee / Oritz-Ruiz de Gordoa, Laura / Thomas, Matthew / Sweet, Katie / Grimmer, Lisa / Johnson, Rebekah / Pinnell, Jez / Robinson, Matt / Gledhill, Lisa / Wood, Tracy / Morgan, Matt / Cole, Jade / Hill, Helen / Davies, Michelle / Antcliffe, David / Templeton, Maie / Rojo, Roceld / Coghlan, Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, Graziella / Brightling, Chris / Bourne, Michelle / Craner, Michelle / Watters, Malcolm / Prout, Rachel / Davies, Louisa / Pegler, Suzannah / Kyeremeh, Lynsey / Arbane, Gill / Wilson, Karen / Gomm, Linda / Francia, Federica / Brett, Stephen / Sousa Arias, Sonia / Elin Hall, Rebecca / Budd, Joanna / Small, Charlotte / Birch, Janine / Collins, Emma / Henning, Jeremy / Bonner, Stephen / Hugill, Keith / Cirstea, Emanuel / Wilkinson, Dean / Karlikowski, Michal / Sutherland, Helen / Wilhelmsen, Elva / Woods, Jane / North, Julie / Sundaran, Dhinesh / Hollos, Laszlo / Coburn, Susan / Walsh, Joanne / Turns, Margaret / Hopkins, Phil / Smith, John / Noble, Harriet / Depante, Maria Theresa / Clarey, Emma / Laha, Shondipon / Verlander, Mark / Williams, Alexandra / Huckle, Abby / Hall, Andrew / Cooke, Jill / Gardiner-Hill, Caroline / Maloney, Carolyn / Qureshi, Hafiz / Flint, Neil / Nicholson, Sarah / Southin, Sara / Nicholson, Andrew / Borgatta, Barbara / Turner-Bone, Ian / Reddy, Amie / Wilding, Laura / Chamara Warnapura, Loku / Agno Sathianathan, Ronan / Golden, David / Hart, Ciaran / Jones, Jo / Bannard-Smith, Jonathan / Henry, Joanne / Birchall, Katie / Pomeroy, Fiona / Quayle, Rachael / Makowski, Arystarch / Misztal, Beata / Ahmed, Iram / KyereDiabour, Thyra / Naiker, Kevin / Stewart, Richard / Mwaura, Esther / Mew, Louise / Wren, Lynn / Willams, Felicity / Innes, Richard / Doble, Patricia / Hutter, Joanne / Shovelton, Charmaine / Plumb, Benjamin / Szakmany, Tamas / Hamlyn, Vincent / Hawkins, Nancy / Lewis, Sarah / Dell, Amanda / Gopal, Shameer / Ganguly, Saibal / Smallwood, Andrew / Harris, Nichola / Metherell, Stella / Lazaro, Juan Martin / Newman, Tabitha / Fletcher, Simon / Nortje, Jurgens / Fottrell-Gould, Deirdre / Randell, Georgina / Zaman, Mohsin / Elmahi, Einas / Jones, Andrea / Hall, Kathryn / Mills, Gary / Ryalls, Kim / Bowler, Helen / Sall, Jas / Bourne, Richard / Borrill, Zoe / Duncan, Tracey / Lamb, Thomas / Shaw, Joanne / Fox, Claire / Moreno Cuesta, Jeronimo / Xavier, Kugan / Purohit, Dharam / Elhassan, Munzir / Bakthavatsalam, Dhanalakshmi / Rowland, Matthew / Hutton, Paula / Bashyal, Archana / Davidson, Neil / Hird, Clare / Chhablani, Manish / Phalod, Gunjan / Kirkby, Amy / Archer, Simon / Netherton, Kimberley / Reschreiter, Henrik / Camsooksai, Julie / Patch, Sarah / Jenkins, Sarah / Pogson, David / Rose, Steve / Daly, Zoe / Brimfield, Lutece / Claridge, Helen / Parekh, Dhruv / Bergin, Colin / Bates, Michelle / Dasgin, Joanne / McGhee, Christopher / Sim, Malcolm / Hay, Sophie Kennedy / Henderson, Steven / Phull, Mandeep-Kaur / Zaidi, Abbas / Pogreban, Tatiana / Rosaroso, Lace Paulyn / Harvey, Daniel / Lowe, Benjamin / Meredith, Megan / Ryan, Lucy / Hormis, Anil / Walker, Rachel / Collier, Dawn / Kimpton, Sarah / Oakley, Susan / Rooney, Kevin / Rodden, Natalie / Hughes, Emma / Thomson, Nicola / McGlynn, Deborah / Walden, Andrew / Jacques, Nicola / Coles, Holly / Tilney, Emma / Vowell, Emma / Schuster-Bruce, Martin / Pitts, Sally / Miln, Rebecca / Purandare, Laura / Vamplew, Luke / Spivey, Michael / Bean, Sarah / Burt, Karen / Moore, Lorraine / Day, Christopher / Gibson, Charly / Gordon, Elizabeth / Zitter, Letizia / Keenan, Samantha / Baker, Evelyn / Cherian, Shiney / Cutler, Sean / Roynon-Reed, Anna / Harrington, Kate / Raithatha, Ajay / Bauchmuller, Kris / Ahmad, Norfaizan / Grecu, Irina / Trodd, Dawn / Martin, Jane / Wrey Brown, Caroline / Arias, Ana-Marie / Craven, Thomas / Hope, David / Singleton, Jo / Clark, Sarah / Rae, Nicola / Welters, Ingeborg / Hamilton, David Oliver / Williams, Karen / Waugh, Victoria / Shaw, David / Puthucheary, Zudin / Martin, Timothy / Santos, Filipa / Uddin, Ruzena / Somerville, Alastair / Tatham, Kate Colette / Jhanji, Shaman / Black, Ethel / Dela Rosa, Arnold / Howle, Ryan / Tully, Redmond / Drummond, Andrew / Dearden, Joy / Philbin, Jennifer / Munt, Sheila / Vuylsteke, Alain / Chan, Charles / Victor, Saji / Matsa, Ramprasad / Gellamucho, Minerva / Creagh-Brown, Ben / Tooley, Joe / Montague, Laura / De Beaux, Fiona / Bullman, Laetitia / Kersiake, Ian / Demetriou, Carrie / Mitchard, Sarah / Ramos, Lidia / White, Katie / Donnison, Phil / Johns, Maggie / Casey, Ruth / Mattocks, Lehentha / Salisbury, Sarah / Dark, Paul / Claxton, Andrew / McLachlan, Danielle / Slevin, Kathryn / Lee, Stephanie / Hulme, Jonathan / Joseph, Sibet / Kinney, Fiona / Senya, Ho Jan / Oborska, Aneta / Kayani, Abdul / Hadebe, Bernard / Orath Prabakaran, Rajalakshmi / Nichols, Lesley / Thomas, Matt / Worner, Ruth / Faulkner, Beverley / Gendall, Emma / Hayes, Kati / Hamilton-Davies, Colin / Chan, Carmen / Mfuko, Celina / Abbass, Hakam / Mandadapu, Vineela / Leaver, Susannah / Forton, Daniel / Patel, Kamal / Paramasivam, Elankumaran / Powell, Matthew / Gould, Richard / Wilby, Elizabeth / Howcroft, Clare / Banach, Dorota / Fernández de Pinedo Artaraz, Ziortza / Cabreros, Leilani / White, Ian / Croft, Maria / Holland, Nicky / Pereira, Rita / Zaki, Ahmed / Johnson, David / Jackson, Matthew / Garrard, Hywel / Juhaz, Vera / Roy, Alistair / Rostron, Anthony / Woods, Lindsey / Cornell, Sarah / Pillai, Suresh / Harford, Rachel / Rees, Tabitha / Ivatt, Helen / Sundara Raman, Ajay / Davey, Miriam / Lee, Kelvin / Barber, Russell / Chablani, Manish / Brohi, Farooq / Jagannathan, Vijay / Clark, Michele / Purvis, Sarah / Wetherill, Bill / Dushianthan, Ahilanandan / Cusack, Rebecca / de Courcy-Golder, Kim / Smith, Simon / Jackson, Susan / Attwood, Ben / Parsons, Penny / Page, Valerie / Zhao, Xiao Bei / Oza, Deepali / Rhodes, Jonathan / Anderson, Tom / Morris, Sheila / Xia Le Tai, Charlotte / Thomas, Amy / Keen, Alexandra / Digby, Stephen / Cowley, Nicholas / Southern, David / Reddy, Harsha / Campbell, Andy / Watkins, Claire / Smuts, Sara / Touma, Omar / Barnes, Nicky / Alexander, Peter / Felton, Tim / Ferguson, Susan / Sellers, Katharine / Bradley-Potts, Joanne / Yates, David / Birkinshaw, Isobel / Kell, Kay / Marshall, Nicola / Carr-Knott, Lisa

    The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

    2020  

    Keywords Writing Committee for the REMAP-CAP Investigators ; Humans ; Pneumonia ; Viral ; Coronavirus Infections ; Shock ; Hydrocortisone ; Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Treatment Outcome ; Respiration ; Artificial ; Adult ; Middle Aged ; Intensive Care Units ; Female ; Male ; Early Termination of Clinical Trials ; Pandemics ; Betacoronavirus ; covid19
    Language English
    Publisher JAMA
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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