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  1. Article ; Online: Performance of the 47-kilodalton membrane protein versus DNA polymerase I genes for detection of Treponema pallidum by PCR in ulcers.

    Gayet-Ageron, Angèle / Laurent, Frédéric / Schrenzel, Jacques / Charton, Béatrice / Jimenez-Getaz, Gisela / Tangomo, Manuela / Ferry, Tristan / Sednaoui, Patrice / Lautenschlager, Stephan / Toutous-Trellu, Laurence / Martinez de Tejada, Begoña / Cavassini, Matthias / Emonet, Stéphane / Perneger, Thomas / Salord, Hélène

    Journal of clinical microbiology

    2015  Volume 53, Issue 3, Page(s) 976–980

    Abstract: Treponema pallidum PCR (Tp-PCR) is a direct diagnostic method for primary and secondary syphilis, but there is no recommendation regarding the best choice of target gene. In this study, we sequentially tested 272 specimens from patients with sexually ... ...

    Abstract Treponema pallidum PCR (Tp-PCR) is a direct diagnostic method for primary and secondary syphilis, but there is no recommendation regarding the best choice of target gene. In this study, we sequentially tested 272 specimens from patients with sexually transmitted ulcers using Tp-PCR targeting the tpp47 and then polA genes. The two methods showed similar accuracies and an almost-perfect agreement.
    MeSH term(s) Adult ; Carrier Proteins/analysis ; Carrier Proteins/genetics ; DNA Polymerase I/analysis ; DNA Polymerase I/genetics ; Female ; Humans ; Lipoproteins/analysis ; Lipoproteins/genetics ; Male ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Polymerase Chain Reaction/methods ; Prospective Studies ; Syphilis/diagnosis ; Syphilis/microbiology ; Treponema pallidum/genetics ; Treponema pallidum/isolation & purification ; Ulcer/microbiology
    Chemical Substances 47-kDa immunogen, Treponema pallidum ; Carrier Proteins ; Lipoproteins ; DNA Polymerase I (EC 2.7.7.-)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.03444-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A community effort in SARS-CoV-2 drug discovery.

    Schimunek, Johannes / Seidl, Philipp / Elez, Katarina / Hempel, Tim / Le, Tuan / Noé, Frank / Olsson, Simon / Raich, Lluís / Winter, Robin / Gokcan, Hatice / Gusev, Filipp / Gutkin, Evgeny M / Isayev, Olexandr / Kurnikova, Maria G / Narangoda, Chamali H / Zubatyuk, Roman / Bosko, Ivan P / Furs, Konstantin V / Karpenko, Anna D /
    Kornoushenko, Yury V / Shuldau, Mikita / Yushkevich, Artsemi / Benabderrahmane, Mohammed B / Bousquet-Melou, Patrick / Bureau, Ronan / Charton, Beatrice / Cirou, Bertrand C / Gil, Gérard / Allen, William J / Sirimulla, Suman / Watowich, Stanley / Antonopoulos, Nick / Epitropakis, Nikolaos / Krasoulis, Agamemnon / Itsikalis, Vassilis / Theodorakis, Stavros / Kozlovskii, Igor / Maliutin, Anton / Medvedev, Alexander / Popov, Petr / Zaretckii, Mark / Eghbal-Zadeh, Hamid / Halmich, Christina / Hochreiter, Sepp / Mayr, Andreas / Ruch, Peter / Widrich, Michael / Berenger, Francois / Kumar, Ashutosh / Yamanishi, Yoshihiro / Zhang, Kam Y J / Bengio, Emmanuel / Bengio, Yoshua / Jain, Moksh J / Korablyov, Maksym / Liu, Cheng-Hao / Marcou, Gilles / Glaab, Enrico / Barnsley, Kelly / Iyengar, Suhasini M / Ondrechen, Mary Jo / Haupt, V Joachim / Kaiser, Florian / Schroeder, Michael / Pugliese, Luisa / Albani, Simone / Athanasiou, Christina / Beccari, Andrea / Carloni, Paolo / D'Arrigo, Giulia / Gianquinto, Eleonora / Goßen, Jonas / Hanke, Anton / Joseph, Benjamin P / Kokh, Daria B / Kovachka, Sandra / Manelfi, Candida / Mukherjee, Goutam / Muñiz-Chicharro, Abraham / Musiani, Francesco / Nunes-Alves, Ariane / Paiardi, Giulia / Rossetti, Giulia / Sadiq, S Kashif / Spyrakis, Francesca / Talarico, Carmine / Tsengenes, Alexandros / Wade, Rebecca C / Copeland, Conner / Gaiser, Jeremiah / Olson, Daniel R / Roy, Amitava / Venkatraman, Vishwesh / Wheeler, Travis J / Arthanari, Haribabu / Blaschitz, Klara / Cespugli, Marco / Durmaz, Vedat / Fackeldey, Konstantin / Fischer, Patrick D / Gorgulla, Christoph / Gruber, Christian / Gruber, Karl / Hetmann, Michael / Kinney, Jamie E / Padmanabha Das, Krishna M / Pandita, Shreya / Singh, Amit / Steinkellner, Georg / Tesseyre, Guilhem / Wagner, Gerhard / Wang, Zi-Fu / Yust, Ryan J / Druzhilovskiy, Dmitry S / Filimonov, Dmitry A / Pogodin, Pavel V / Poroikov, Vladimir / Rudik, Anastassia V / Stolbov, Leonid A / Veselovsky, Alexander V / De Rosa, Maria / De Simone, Giada / Gulotta, Maria R / Lombino, Jessica / Mekni, Nedra / Perricone, Ugo / Casini, Arturo / Embree, Amanda / Gordon, D Benjamin / Lei, David / Pratt, Katelin / Voigt, Christopher A / Chen, Kuang-Yu / Jacob, Yves / Krischuns, Tim / Lafaye, Pierre / Zettor, Agnès / Rodríguez, M Luis / White, Kris M / Fearon, Daren / Von Delft, Frank / Walsh, Martin A / Horvath, Dragos / Brooks, Charles L / Falsafi, Babak / Ford, Bryan / García-Sastre, Adolfo / Yup Lee, Sang / Naffakh, Nadia / Varnek, Alexandre / Klambauer, Günter / Hermans, Thomas M

    Molecular informatics

    2023  Volume 43, Issue 1, Page(s) e202300262

    Abstract: The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and ... ...

    Abstract The COVID-19 pandemic continues to pose a substantial threat to human lives and is likely to do so for years to come. Despite the availability of vaccines, searching for efficient small-molecule drugs that are widely available, including in low- and middle-income countries, is an ongoing challenge. In this work, we report the results of an open science community effort, the "Billion molecules against COVID-19 challenge", to identify small-molecule inhibitors against SARS-CoV-2 or relevant human receptors. Participating teams used a wide variety of computational methods to screen a minimum of 1 billion virtual molecules against 6 protein targets. Overall, 31 teams participated, and they suggested a total of 639,024 molecules, which were subsequently ranked to find 'consensus compounds'. The organizing team coordinated with various contract research organizations (CROs) and collaborating institutions to synthesize and test 878 compounds for biological activity against proteases (Nsp5, Nsp3, TMPRSS2), nucleocapsid N, RdRP (only the Nsp12 domain), and (alpha) spike protein S. Overall, 27 compounds with weak inhibition/binding were experimentally identified by binding-, cleavage-, and/or viral suppression assays and are presented here. Open science approaches such as the one presented here contribute to the knowledge base of future drug discovery efforts in finding better SARS-CoV-2 treatments.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Pandemics ; Biological Assay ; Drug Discovery
    Language English
    Publishing date 2023-11-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2537668-8
    ISSN 1868-1751 ; 1868-1743
    ISSN (online) 1868-1751
    ISSN 1868-1743
    DOI 10.1002/minf.202300262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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