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  1. AU="Chatelier, Josh"
  2. AU="Passarelli, L."
  3. AU="Marques, R"
  4. AU="Restaino, Valeria"
  5. AU="Wang, Haochen"
  6. AU=Shoib Sheikh
  7. AU=Patel Ishan
  8. AU="Mongioì, Laura M"
  9. AU="Fernández-Pacheco, Borja Camacho"
  10. AU=Waghmare Alpana AU=Waghmare Alpana
  11. AU="Peyre, Marion"
  12. AU=Mulazimoglu L
  13. AU=Roy Satyaki
  14. AU="Li Yuanyuan"
  15. AU=Khan Shehryar
  16. AU=Cole Sarah L
  17. AU="Júnior, Raimundo Nonato Colares Camargo"
  18. AU="Feeney, Judith A"

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  1. Artikel ; Online: Transient acquired donor peanut allergy presenting as life-threatening anaphylaxis following lung transplantation.

    Stojanovic, Stephanie / Chatelier, Josh / Bosco, Julian / O'Hehir, Robyn E / Snell, Greg

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Band 129, Heft 4, Seite(n) 517–519

    Mesh-Begriff(e) Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Arachis ; Humans ; Lung Transplantation/adverse effects ; Peanut Hypersensitivity/diagnosis ; Tissue Donors
    Sprache Englisch
    Erscheinungsdatum 2022-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.06.029
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  2. Artikel ; Online: A single-center experience of COVID-19 infection in patients with primary immunodeficiency.

    Zhou, Jessie J / Jin, Celina / Leang, Zhi Xiang / Chatelier, Josh / Godsell, Jack / Tsang, Sylvia / Douglass, Jo A / Yong, Michelle K / Slavin, Monica / Bryant, Vanessa L / Slade, Charlotte A / Chan, Samantha

    The journal of allergy and clinical immunology. Global

    2024  Band 3, Heft 2, Seite(n) 100241

    Abstract: Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, ...

    Abstract Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, and local availability of vaccination and specific COVID-19 therapies. There are few reports on the experience of Australian patients with PID during the pandemic.
    Objectives: In this retrospective study, we describe the baseline characteristics and short-term outcomes of patients with PID who were infected by COVID-19 and known to the Royal Melbourne Hospital, a major tertiary center in Victoria, Australia.
    Methods: Between April 2021 and April 2022, a total of 31 of 138 patients with PID were affected by COVID-19. More than half of them had 3 vaccine doses at the time of infection (which at the time was considered being fully vaccinated) and received COVID-19-targeted treatment.
    Results: All of the infected patients had ambulatory disease, with no cases of morbidity or mortality. In line with the current literature, the PID subtypes described did not appear to independently predict worse outcomes.
    Conclusions: Some protective factors include this cohort's relatively younger average age and its high uptake of vaccination and COVID-19 therapies.
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2024.100241
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  3. Artikel: Managing Exacerbations in Thunderstorm Asthma: Current Insights.

    Chatelier, Josh / Chan, Samantha / Tan, Ju Ann / Stewart, Alastair G / Douglass, Jo Anne

    Journal of inflammation research

    2021  Band 14, Seite(n) 4537–4550

    Abstract: Epidemic thunderstorm asthma (ETSA) occurs following a thunderstorm due to the interaction of environmental and immunologic factors. Whilst first reported in the 1980s, the world's largest event in Melbourne, Australia, on November 21, 2016 has led to a ... ...

    Abstract Epidemic thunderstorm asthma (ETSA) occurs following a thunderstorm due to the interaction of environmental and immunologic factors. Whilst first reported in the 1980s, the world's largest event in Melbourne, Australia, on November 21, 2016 has led to a wealth of clinical literature seeking to identify its mechanisms, susceptibility risk factors, and management approaches. Thunderstorm asthma (TA) typically presents during an aeroallergen season in individuals sensitized to perennial rye grass pollen (RGP) in Australia, or fungus in the United Kingdom, in combination with meteorological factors such as thunderstorms and lightning activity. It is now well recognized that large pollen grains, which usually lodge in the upper airway causing seasonal allergic rhinitis (SAR), are ruptured during these events, leading to sub-pollen particles respirable to the lower respiratory tract causing acute asthma. The identified risk factors of aeroallergen sensitization, specifically to RGP in Australians with a history of SAR, and individuals born in Australia of South-East Asian descent as a risk factor for TA has been key in selecting appropriate patients for preventative management. Moreover, severity-determining risk factors for ETSA-related asthma admission or mortality, including pre-existing asthma or prior hospitalization, poor inhaled corticosteroid adherence, and outdoor location at the time of the storm are important in identifying those who may require more aggressive treatment approaches. Basic treatments include optimizing asthma control and adherence to inhaled corticosteroid therapy, treatment of SAR, and education regarding TA to increase recognition of at-risk days. Precision treatment approaches may be more beneficial in select individuals, including the use of allergen immunotherapy and even biologic treatment to mitigate asthma severity. Finally, we discuss the importance of environmental health literacy in the context of concerns surrounding the increased frequency of ETSA due to climate change and its implications for the frequency and severity of future events.
    Sprache Englisch
    Erscheinungsdatum 2021-09-08
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S324282
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  4. Artikel ; Online: Repeated adrenaline requirements for anaphylaxis.

    Chatelier, Josh / Stojanovic, Stephanie / Lin, Tiffany / Denton, Eve / Dabscheck, Eli / Hew, Mark / Bosco, Julian J

    Internal medicine journal

    2022  Band 51, Heft 12, Seite(n) 2133–2139

    Abstract: We examined the pattern of adrenaline administration in patients presenting with anaphylaxis. Forty-four percent required repeated adrenaline administration, among whom there had been greater cardiorespiratory compromise. Repeated administration was more ...

    Abstract We examined the pattern of adrenaline administration in patients presenting with anaphylaxis. Forty-four percent required repeated adrenaline administration, among whom there had been greater cardiorespiratory compromise. Repeated administration was more frequent in males and older patients, and those triggered by insect sting or unknown cause; no other patient factors were identified. This study supports the provision of two adrenaline auto-injectors to all anaphylaxis patients.
    Mesh-Begriff(e) Anaphylaxis/drug therapy ; Epinephrine ; Humans ; Male
    Chemische Substanzen Epinephrine (YKH834O4BH)
    Sprache Englisch
    Erscheinungsdatum 2022-01-10
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15614
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  5. Artikel ; Online: Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency.

    Chan, Samantha / Godsell, Jack / Horton, Miles / Farchione, Anthony / Howson, Lauren J / Margetts, Mai / Jin, Celina / Chatelier, Josh / Yong, Michelle / Sasadeusz, Joseph / Douglass, Jo A / Slade, Charlotte A / Bryant, Vanessa L

    Frontiers in immunology

    2022  Band 13, Seite(n) 815193

    Abstract: Background: Common Variable Immunodeficiency (CVID) is classified as a 'Predominantly Antibody Deficiency' (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients. This evidence includes CVID patients diagnosed with ... ...

    Abstract Background: Common Variable Immunodeficiency (CVID) is classified as a 'Predominantly Antibody Deficiency' (PAD), but there is emerging evidence of cellular immunodeficiency in a subset of patients. This evidence includes CVID patients diagnosed with cytomegalovirus (CMV) infection, a hallmark of 'combined immunodeficiency'. CMV infection also has the potential to drive immune dysregulation contributing to significant morbidity and mortality in CVID. We aim to determine the extent of cellular immune dysfunction in CVID patients, and whether this correlates with CMV infection status.
    Methods: We conducted a single-center retrospective cohort study of individuals with CVID at the Royal Melbourne Hospital, and identified patients with and without CMV disease or viraemia. We then isolated T-cells from patient and healthy donor blood samples and examined T-cell proliferation and function.
    Results: Six patients (7.6%, 6/79) had either CMV disease (pneumonitis or gastrointestinal disease), or symptomatic CMV viraemia. A high mortality rate in the cohort of patients with CVID and CMV disease was observed, with 4 deaths in the period of analysis (66.6%, 4/6). Individuals with CMV infection showed reduced T-cell division in response to T-cell receptor (TCR) stimulation when compared with CMV-negative patients.
    Discussion: This study demonstrates the morbidity and mortality associated with CMV in CVID, and highlights the need for focused interventions for patients with CVID at risk of CMV disease.
    Mesh-Begriff(e) Common Variable Immunodeficiency ; Cytomegalovirus ; Cytomegalovirus Infections ; Humans ; Morbidity ; Primary Immunodeficiency Diseases ; Retrospective Studies ; Viremia/complications
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.815193
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  6. Artikel ; Online: Goat milk skin products may cause the development of goat milk allergy.

    De Luca, Joseph Francis / Mackay, Graham Angus / Chatelier, Josh William / Chan, Samantha Sing-Yi / Zhang, Stephanie Sihan / Godsell, Jack / Spriggs, Kymble / Slade, Charlotte / Douglass, Jo Anne

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2022  Band 52, Heft 5, Seite(n) 706–710

    Mesh-Begriff(e) Animals ; Goats ; Humans ; Milk/adverse effects ; Milk Hypersensitivity ; Milk Proteins
    Chemische Substanzen Milk Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-04-06
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14133
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  7. Artikel ; Online: Perceptions on Home-Administration of Biologics in the Context of Severe Asthma: An International Qualitative Study.

    Flokstra-de Blok, Bertine / Kocks, Janwillem / Wouters, Hans / Arling, Chantal / Chatelier, Josh / Douglass, Jo / Heaney, Liam G / Holmes, Joshua / Humbert, Marc / Kolanowski, Mary / Landsman, Jeanet J A / Lugogo, Njira / Malpass, Alice / Meijer, Jiska / Metz, Boyd / de Mul, Bibicha / Postma, Frank / Leving, Marika

    The journal of allergy and clinical immunology. In practice

    2022  Band 10, Heft 9, Seite(n) 2312–2323.e2

    Abstract: Background: Biologics are an effective therapy for severe asthma. Home administration of biologics by patients is likely to facilitate their accessibility. Yet little is known about patients' and health care providers' (HCPs) perceptions regarding home ... ...

    Abstract Background: Biologics are an effective therapy for severe asthma. Home administration of biologics by patients is likely to facilitate their accessibility. Yet little is known about patients' and health care providers' (HCPs) perceptions regarding home administration of biologics.
    Objective: The aim of this study is to create more insight into the perceptions and experiences of patients and HCPs regarding home administration of biologics in the context of the treatment of severe asthma.
    Methods: A qualitative international study was performed in the Netherlands, United States, Australia, and United Kingdom. In each country, 2 focus groups were held with potential/recent and long-term users of biologics at home. Prior to the focus groups, patients were prompted with themes on online forums. For triangulation purposes, interviews were held with HCPs to discuss salient findings from forums and focus groups. Data were analyzed with qualitative content analysis.
    Results: In total, 75 patients participated in the forums, of which 40 participated in the focus groups. Furthermore, 12 HCPs were interviewed. The following overarching themes were identified: living with severe asthma; practical aspects of using biologics; the role of HCPs regarding biologics; social support from family, friends, and others; effectiveness of biologics and other treatments; side effects of biologics.
    Conclusions: This study showed that, for those using biologics for severe asthma, the benefits of home administration of biologics usually outweigh inconvenience and side effects. Guided practice, accessible support contact, and monitoring including social support should be central in the transition from hospital to home administration of asthma biologics.
    Mesh-Begriff(e) Asthma/drug therapy ; Biological Products/therapeutic use ; Health Personnel ; Humans ; Qualitative Research ; Social Support
    Chemische Substanzen Biological Products
    Sprache Englisch
    Erscheinungsdatum 2022-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.04.015
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  8. Artikel ; Online: Randomized controlled trial of omalizumab in treatment-resistant systemic and cutaneous mastocytosis (ROAM).

    McComish, Jeremy S / Slade, Charlotte A / Buizen, Luke / Paul, Sanjoy K / Chatelier, Josh W / Unglik, Gary / Nicholls, Katherine A / Spriggs, Kymble / Chan, Samantha S / Godsell, Jack / Auyeung, Priscilla / Tan, Zi Hao / DeLuca, Joseph / Patel, Mittal / Kuek, Lin Eon / Tran, Yang / Kern, Johannes S / Scardamaglia, Laura / Varigos, George A /
    Juneja, Surender / Grabek, Julian A / Christie, Michael / Mackay, Graham A / Douglass, Jo A

    The journal of allergy and clinical immunology. In practice

    2023  Band 11, Heft 7, Seite(n) 2248–2250.e3

    Mesh-Begriff(e) Humans ; Omalizumab/therapeutic use ; Mastocytosis, Cutaneous/drug therapy ; Anti-Allergic Agents/therapeutic use ; Mastocytosis, Systemic/drug therapy ; Mastocytosis/drug therapy
    Chemische Substanzen Omalizumab (2P471X1Z11) ; Anti-Allergic Agents
    Sprache Englisch
    Erscheinungsdatum 2023-04-23
    Erscheinungsland United States
    Dokumenttyp Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.04.008
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  9. Artikel ; Online: Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells.

    Edwards, Emily S J / Bosco, Julian J / Aui, Pei M / Stirling, Robert G / Cameron, Paul U / Chatelier, Josh / Hore-Lacy, Fiona / O'Hehir, Robyn E / van Zelm, Menno C

    Frontiers in immunology

    2019  Band 10, Seite(n) 2593

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) Adolescent ; Adult ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/etiology ; Agammaglobulinemia/metabolism ; Aged ; Aged, 80 and over ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; Biomarkers ; Female ; Humans ; Immunoglobulin M/blood ; Immunoglobulin M/immunology ; Immunologic Memory ; Immunophenotyping ; Lymphocyte Count ; Male ; Middle Aged ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Young Adult
    Chemische Substanzen Biomarkers ; Immunoglobulin M
    Sprache Englisch
    Erscheinungsdatum 2019-11-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02593
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  10. Artikel ; Online: Modulation of soluble and particulate antigen transport in afferent lymph by monophosphoryl lipid A.

    de Veer, Michael / Kemp, Joanna / Chatelier, Josh / Elhay, Martin J / Meeusen, Els N T

    Immunology and cell biology

    2011  Band 90, Heft 4, Seite(n) 404–410

    Abstract: Vaccine adjuvants stimulate the innate immune system and determine the outcome of the immune response induced. A better understanding of their action is therefore crucial to the development of new and safer vaccines. Monophosphoryl lipid A (MPL), a ' ... ...

    Abstract Vaccine adjuvants stimulate the innate immune system and determine the outcome of the immune response induced. A better understanding of their action is therefore crucial to the development of new and safer vaccines. Monophosphoryl lipid A (MPL), a 'detoxified' version of lipolysaccharide, is a promising new adjuvant component in human vaccines. The present study uses an ovine lymphatic cannulation model to study cell recruitment and antigen transport from the injection site into the afferent lymph, and how this is modulated by co-injection with MPL. Compared with saline, MPL injections caused only minor variations in lymph flow and no difference in cell number migrating into the lymph. MPL did, however, cause a significantly increased recruitment of neutrophils and monocytes, but not dendritic cells (DC) into the lymph for the first 12 h. Soluble ovalbumin (OVA) antigen flowed freely into the lymph over a 24-h period and was slightly reduced at 6-9 h in the MPL-injected sites. OVA-coated fluorescent 1-μ beads were initially transported predominantly by neutrophils and, from 24 to 72 h, by DC. MPL induced an increased and more sustained transport of beads by neutrophils and monocytes although it did not increase the phagocytic capacity of these cells. In contrast to aluminium adjuvant, MPL did not increase bead transport by DC at the later time point. These studies provide important new insights in the in vivo action of different adjuvants and the initial events that set up an immune response after vaccination.
    Mesh-Begriff(e) Adjuvants, Immunologic ; Animals ; Antigens/metabolism ; Immunity/drug effects ; Lipid A/administration & dosage ; Lipid A/analogs & derivatives ; Lipid A/pharmacology ; Lipid A/therapeutic use ; Lymph/metabolism ; Protein Transport/drug effects ; Protein Transport/immunology ; Sheep ; Solubility ; Treatment Outcome ; Vaccines
    Chemische Substanzen Adjuvants, Immunologic ; Antigens ; Lipid A ; Vaccines ; monophosphoryl lipid A (MWC0ET1L2P)
    Sprache Englisch
    Erscheinungsdatum 2011-06-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2011.53
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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