Artikel: Terpenes and cannabidiol against human corona and influenza viruses-Anti-inflammatory and antiviral in vitro evaluation.
Biotechnology reports (Amsterdam, Netherlands)
2024 Band 41, Seite(n) e00829
Abstract: The activity of the terpenes and Cannabidiol (CBD) against human coronavirus (HCoV) strain OC43 and influenza A (H1N1) was evaluated in human lung fibroblasts (MRC-5 cells). Also, we examined whether these ingredients inhibit pro-inflammatory cytokines ... ...
Abstract | The activity of the terpenes and Cannabidiol (CBD) against human coronavirus (HCoV) strain OC43 and influenza A (H1N1) was evaluated in human lung fibroblasts (MRC-5 cells). Also, we examined whether these ingredients inhibit pro-inflammatory cytokines in peripheral blood mononuclear cells (PBMC). The tested preparations exhibited both anti-inflammatory and antiviral effects. The combination of terpenes was effective against both HCoV-OC43 and influenza A (H1N1) virus. The addition of CBD improved the antiviral activity in some, but not all cases. This variation in activity may suggest an antiviral mechanism. In addition, there was a strong correlation between the quantitative results from a cell-viability assay and the cytopathic effect after 72 h, as observed under a microscope. The anti-inflammatory properties of terpenes were demonstrated using a pro-inflammatory cytokine-inhibition assay, which revealed significant cytokine inhibition and enhanced by the addition of CBD. |
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Sprache | Englisch |
Erscheinungsdatum | 2024-01-17 |
Erscheinungsland | Netherlands |
Dokumenttyp | Journal Article |
ZDB-ID | 2801018-8 |
ISSN | 2215-017X |
ISSN | 2215-017X |
DOI | 10.1016/j.btre.2024.e00829 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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