Article ; Online: Point-of-Care Test for Assessing Tenofovir Adherence: Feasibility and Recommendations from Women in an Oral PrEP Program in Kenya and Their Healthcare Providers.
2021 Volume 25, Issue 11, Page(s) 3617–3629
Abstract: Oral pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality when taken as recommended. Women in sub-Saharan Africa may have adherence challenges that remain undisclosed to providers. Real-time measures that identify non-adherence ... ...
| Abstract | Oral pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention modality when taken as recommended. Women in sub-Saharan Africa may have adherence challenges that remain undisclosed to providers. Real-time measures that identify non-adherence can allow for immediate exploration of adherence challenges, counseling and interventions. We conducted a formative qualitative study in Kenya to explore oral PrEP experiences and reactions to a point-of-care urine test (UT) identifying recent (past 4 days) non-adherence to tenofovir-based PrEP among female PrEP users (25 in-depth interviews; 4 focus groups) and health care provider (10 key informant interviews). Findings indicate that use of the UT would be highly feasible in the context of regular PrEP care, largely acceptable to clients and providers, and could improve adherence. Clients emphasized the need for transparent client-centered strategies in delivering results. This formative study informs the development of tools to implement this point-of-care UT in future interventional studies and clinical settings. |
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| MeSH term(s) | Anti-HIV Agents/therapeutic use ; Feasibility Studies ; Female ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Health Personnel ; Humans ; Kenya ; Medication Adherence ; Point-of-Care Testing ; Pre-Exposure Prophylaxis ; Tenofovir | |||||
| Chemical Substances | Anti-HIV Agents ; Tenofovir (99YXE507IL) | |||||
| Language | English | |||||
| Publishing date | 2021-04-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1339885-4 | |||||
| ISSN | 1573-3254 ; 1090-7165 | |||||
| ISSN (online) | 1573-3254 | |||||
| ISSN | 1090-7165 | |||||
| DOI | 10.1007/s10461-021-03255-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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