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  1. Article ; Online: A Review on Microencapsulation as Method of Drug Delivery

    Chaturvedi Priyanka / Sharma Praveen

    BIO Web of Conferences, Vol 86, p

    2024  Volume 01033

    Abstract: Microencapsulation can be described as heavy, fluid or gaseous substance packaging engineering with thin polymeric coatings, creating small particles called microcapsules. Microencapsulation is very helpful to increase the solubility of drugs. For the ... ...

    Abstract Microencapsulation can be described as heavy, fluid or gaseous substance packaging engineering with thin polymeric coatings, creating small particles called microcapsules. Microencapsulation is very helpful to increase the solubility of drugs. For the drugs of BCS Class-II we use this technique which enables us to get more solubility and increase dissolution profile. This is a novel method of drug delivery. In future aspect we can use this technique in the foodindustry, beverages. A microencapsulation approach for the preparation of an intrauterine contraceptionsystem was alsosuggested. This technique is helpful to overcome poor solubility, low Bioavaibility and less stability.This method also gives more control over the drawback of conventional dosages form.
    Keywords microencapsulation ; bioavailability ; solubility ; novel drug delivery ; Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Effectiveness of polyhexamethylene biguanide, chlorhexidine, and calcium hydroxide intracanal medicament against intraradicular mature polymicrobial biofilm: A microbiological study.

    Khan, Aleena / Nikhil, Vineeta / Pandey, Anita / Chaturvedi, Priyanka

    Journal of conservative dentistry : JCD

    2022  Volume 25, Issue 5, Page(s) 536–540

    Abstract: Aim: To compare the effectiveness of different intracanal medicaments against polymicrobial biofilm formed by : Materials and methods: Eighty mature human roots with intraradicular polymicrobial biofilm were randomly assigned into four groups (: ... ...

    Abstract Aim: To compare the effectiveness of different intracanal medicaments against polymicrobial biofilm formed by
    Materials and methods: Eighty mature human roots with intraradicular polymicrobial biofilm were randomly assigned into four groups (
    Results: The CFU/ml data were analyzed using unpaired
    Conclusions: All the three tested intracanal medicaments such as CH, CHX, and PHMB Gel were effective in reducing the microbial count. CH has a limited antimicrobial effect against the polymicrobial biofilm found inside the root canal. 2% CHX gel has a time-dependent antimicrobial effect. PHMB has a superior antimicrobial effect in comparison with CHX and CH.
    Language English
    Publishing date 2022-09-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2064481-4
    ISSN 0972-0707
    ISSN 0972-0707
    DOI 10.4103/jcd.jcd_288_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: an approach by enhanced bioavailability.

    Dwivedi, Pankaj / Khatik, Renuka / Chaturvedi, Priyanka / Khandelwal, Kiran / Taneja, Isha / Raju, Kanumuri Siva Rama / Dwivedi, Hemlata / Singh, Sunil Kumar / Gupta, Pramod Kumar / Shukla, Prashant / Tripathi, Priyanka / Singh, Sarika / Tripathi, Renu / Wahajuddin / Paliwal, Sarvesh Kumar / Dwivedi, Anil Kumar / Mishra, Prabhat Ranjan

    Colloids and surfaces. B, Biointerfaces

    2015  Volume 126, Page(s) 467–475

    Abstract: The present work is focused on the preparation of nanoemulsions (NEs) loaded with arteether (ART) for its enhanced efficacy against malaria parasites. ART-NEs have been prepared using high pressure homogenization (HPH) technique with the aim of improving ...

    Abstract The present work is focused on the preparation of nanoemulsions (NEs) loaded with arteether (ART) for its enhanced efficacy against malaria parasites. ART-NEs have been prepared using high pressure homogenization (HPH) technique with the aim of improving its solubility and thus its bioavailability. ART-NEs were optimized in terms of pressure and number of cycles. Globule size and size distributions were chosen as quality parameters. The maximum drug loading was achieved up to 93 ± 7.4% with globule size 156 ± 10.2 nm and zeta potential of -23.3 ± 3.4 mV. The developed ART-NEs were found to be stable in terms of globule size and size distribution at different pH. The in vitro release profile of the ART-NEs showed 62% drug release within 12h. The percentage cell viability of blank NEs were within acceptable limits. A sensitive assay method for the determination of ART in rat plasma by liquid chromatography-mass spectrometry (LC-MS) was employed after oral administration of ART-NEs. The pharmacokinetic study showed significantly enhanced bioavailability of ART in ART-NE-V. The area under curve (AUC) of ART-NE-V was AUC0-t 1988.411 ± 119.66 h ng/ml which was significantly higher (p<0.05) than ART in ground nut oil (GNO) AUC0-t 671.852 ± 187.05 h ng/ml. The Cmax of ART-NE-V (1506 ± 161.22 ng/ml) was also significantly higher (p<0.05) than ART in GNO (175.2 ± 16.54 ng/ml) and ART given intramuscularly (IM) (278.05 ± 38.59 ng/ml). The ART-NE-V was having significantly high antimalarial efficacy and survival rate of mice giving 80% cure rate at 12.5 mg/kg for 5 days in comparison to 30% cure rate of ART in GNO at the same daily dose and it was also comparable to the 100% cure rate at 12.5 mg/kg for 5 days for ART given intramuscularly. In conclusion ART-NE can be a promising oral delivery system for ART.
    MeSH term(s) Administration, Oral ; Animals ; Antimalarials/administration & dosage ; Antimalarials/blood ; Antimalarials/pharmacokinetics ; Antimalarials/pharmacology ; Artemisinins/administration & dosage ; Artemisinins/blood ; Artemisinins/pharmacokinetics ; Artemisinins/pharmacology ; Biological Availability ; Caco-2 Cells ; Cell Line ; Cell Survival/drug effects ; Emulsions/chemistry ; Humans ; Malaria/drug therapy ; Malaria/parasitology ; Mice ; Nanostructures/chemistry ; Parasitic Sensitivity Tests ; Particle Size ; Plasmodium yoelii/drug effects ; Rats ; Surface Properties
    Chemical Substances Antimalarials ; Artemisinins ; Emulsions ; artemotil (XGL7GFB9YI)
    Language English
    Publishing date 2015-02-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2014.12.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: GJ 367b: A dense, ultrashort-period sub-Earth planet transiting a nearby red dwarf star.

    Lam, Kristine W F / Csizmadia, Szilárd / Astudillo-Defru, Nicola / Bonfils, Xavier / Gandolfi, Davide / Padovan, Sebastiano / Esposito, Massimiliano / Hellier, Coel / Hirano, Teruyuki / Livingston, John / Murgas, Felipe / Smith, Alexis M S / Collins, Karen A / Mathur, Savita / Garcia, Rafael A / Howell, Steve B / Santos, Nuno C / Dai, Fei / Ricker, George R /
    Vanderspek, Roland / Latham, David W / Seager, Sara / Winn, Joshua N / Jenkins, Jon M / Albrecht, Simon / Almenara, Jose M / Artigau, Etienne / Barragán, Oscar / Bouchy, François / Cabrera, Juan / Charbonneau, David / Chaturvedi, Priyanka / Chaushev, Alexander / Christiansen, Jessie L / Cochran, William D / De Meideiros, José R / Delfosse, Xavier / Díaz, Rodrigo F / Doyon, René / Eigmüller, Philipp / Figueira, Pedro / Forveille, Thierry / Fridlund, Malcolm / Gaisné, Guillaume / Goffo, Elisa / Georgieva, Iskra / Grziwa, Sascha / Guenther, Eike / Hatzes, Artie P / Johnson, Marshall C / Kabáth, Petr / Knudstrup, Emil / Korth, Judith / Lewin, Pablo / Lissauer, Jack J / Lovis, Christophe / Luque, Rafael / Melo, Claudio / Morgan, Edward H / Morris, Robert / Mayor, Michel / Narita, Norio / Osborne, Hannah L M / Palle, Enric / Pepe, Francesco / Persson, Carina M / Quinn, Samuel N / Rauer, Heike / Redfield, Seth / Schlieder, Joshua E / Ségransan, Damien / Serrano, Luisa M / Smith, Jeffrey C / Šubjak, Ján / Twicken, Joseph D / Udry, Stéphane / Van Eylen, Vincent / Vezie, Michael

    Science (New York, N.Y.)

    2021  Volume 374, Issue 6572, Page(s) 1271–1275

    Abstract: Ultrashort-period (USP) exoplanets have orbital periods shorter than 1 day. Precise masses and radii of USP exoplanets could provide constraints on their unknown formation and evolution processes. We report the detection and characterization of the USP ... ...

    Abstract Ultrashort-period (USP) exoplanets have orbital periods shorter than 1 day. Precise masses and radii of USP exoplanets could provide constraints on their unknown formation and evolution processes. We report the detection and characterization of the USP planet GJ 367b using high-precision photometry and radial velocity observations. GJ 367b orbits a bright (
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aay3253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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