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  1. Article ; Online: Complex Cardiovascular Interventions: Visualization, Planning, Outcomes.

    Chatzizisis, Yiannis S

    JACC. Case reports

    2019  Volume 1, Issue 2, Page(s) 124–126

    Language English
    Publishing date 2019-08-21
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2019.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coronary plaque phenotyping with cardiac CTA: Separating the signal from the noise.

    Kumar, Arnav / Stillman, Arthur E / Chatzizisis, Yiannis S

    Atherosclerosis

    2023  Volume 373, Page(s) 66–68

    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Plaque, Atherosclerotic ; Heart ; Coronary Angiography ; Fractional Flow Reserve, Myocardial ; Coronary Stenosis ; Computed Tomography Angiography ; Predictive Value of Tests
    Language English
    Publishing date 2023-04-20
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.04.001
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    Zs.A 226: Show issues Location:
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  3. Article: Case Report: Invasive and Non-invasive Hemodynamic Assessment of Coronary Artery Disease: Strengths and Weaknesses.

    Gajanan, Ganesh / Samant, Saurabhi / Hovseth, Chad / Chatzizisis, Yiannis S

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 885249

    Abstract: Coronary angiography has been the gold standard for assessment of coronary artery disease (CAD) and guidance for percutaneous coronary interventions (PCI). Physiology-guided PCI has shown increased safety and efficacy, improved resource utilization, and ... ...

    Abstract Coronary angiography has been the gold standard for assessment of coronary artery disease (CAD) and guidance for percutaneous coronary interventions (PCI). Physiology-guided PCI has shown increased safety and efficacy, improved resource utilization, and better clinical outcomes in patients with stable angina and acute coronary syndromes. The three cases presented and discussed in this report illustrate the strengths and weaknesses of the available invasive and non-invasive methods for the physiological assessment of CAD. As technology evolves, invasive non-wire-based (angiography-derived FFR) and non-invasive (FFR
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.885249
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  4. Article: Case Report: ST-Elevation Myocardial Infarction Secondary to Acute Atherothrombotic Occlusion Treated With No Stent Strategy.

    Dhawan, Rahul / Samant, Saurabhi / Gajanan, Ganesh / Chatzizisis, Yiannis S

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 834676

    Abstract: Background: Intravascular imaging plays a vital role in the pathophysiology-based diagnosis and treatment of patients with ST-elevation myocardial infarction (STEMI). We present a case of STEMI due to plaque erosion, which was managed with a no stent ... ...

    Abstract Background: Intravascular imaging plays a vital role in the pathophysiology-based diagnosis and treatment of patients with ST-elevation myocardial infarction (STEMI). We present a case of STEMI due to plaque erosion, which was managed with a no stent approach.
    Case summary: A 43-year-old female with a history of tobacco abuse presented with an anterior STEMI. Coronary angiography revealed acute thrombotic occlusion of the left anterior descending artery with spontaneous recanalization. Intravascular imaging with optical coherence tomography (OCT) demonstrated plaque erosion as the underlying etiology for the acute thrombotic occlusion. A no stent strategy with aspiration thrombectomy and dual antiplatelet therapy was used to manage the patient given that there was no evidence of plaque rupture. Repeat coronary imaging was done at 2 months to assess the status of the lesion.
    Conclusion: A 43-year-old female with STEMI due to plaque erosion was successfully managed only by thrombus aspiration and not by angioplasty and stent placement. Individualized treatment approaches in patients with acute coronary syndromes, can not only achieve optimal management goals but also avoid unnecessary complications associated with interventions. This case illustrates how intracoronary imaging and pathophysiology-guided treatment can dramatically change management. In this young patient, STEMI was managed purely by thrombus aspiration. Intravascular imaging obviated the need for stent placement possibly preventing stent-related complications including restenosis and thrombosis.
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.834676
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  5. Article ; Online: Real time reduced order model for angiography fractional flow reserve.

    Hashemi, Javad / Patel, Bhavesh / Chatzizisis, Yiannis S / Kassab, Ghassan S

    Computer methods and programs in biomedicine

    2022  Volume 216, Page(s) 106674

    Abstract: Background and objectives: Fractional flow reserve (FFR) is the gold standard for quantification of coronary stenosis and pressure wire is the gold standard for measuring FFR. Recently, computational fluid dynamics (CFD) methods have been used to ... ...

    Abstract Background and objectives: Fractional flow reserve (FFR) is the gold standard for quantification of coronary stenosis and pressure wire is the gold standard for measuring FFR. Recently, computational fluid dynamics (CFD) methods have been used to compute FFR less invasively using images obtained from coronary angiography. This approach is, however, computationally intensive and solutions to reduce computation time are clearly required.
    Methods: We hypothesized that FFR can be calculated instantly using a reduced order model (ROM) derived using response surface method (RSM) for simulation modeling in lieu of the computationally intensive CFD. Specifically, eleven physiological and anatomical factors known to affect FFR were selected as input variables, and Plackett-Burman analysis was performed in conjunction with CFD on model arteries to identify set of variables affecting FFR the most. Based on the Box-Behnken design, a mathematical model was developed to compute FFR using the retained set of variables.
    Results: The model fidelity was tested on a cohort of 90 patients (100 coronary arteries) with known pressure-wire FFR. FFR derived from this ROM had a strong correlation with pressure-wire FFR with sensitivity of 89.4%, specificity of 100% and area under curve of 0.947 (p < 0.05).
    Conclusions: The ROM method can be used to reliably calculate FFR in patients with coronary stenosis and able to replace time-consuming CFD-based FFR estimation and provide instead a real-time calculation method.
    MeSH term(s) Coronary Angiography/methods ; Coronary Stenosis/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Humans ; Predictive Value of Tests ; Severity of Illness Index
    Language English
    Publishing date 2022-02-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.106674
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  6. Article ; Online: The stenotic vulnerable plaque: Identifying the substrate of acute coronary syndromes.

    Kumar, Arnav / Giannopoulos, Andreas A / Chatzizisis, Yiannis S

    Atherosclerosis

    2021  Volume 320, Page(s) 95–97

    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Coronary Artery Disease ; Coronary Vessels/diagnostic imaging ; Hemodynamics ; Humans ; Plaque, Atherosclerotic
    Language English
    Publishing date 2021-01-31
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2021.01.024
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    Zs.A 226: Show issues Location:
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  7. Article ; Online: Building Coronary Lesion-Specific Predictive Models Using the Proper Prognostic Parameters: A Look Into the Computational Hemodynamics of the Matter.

    Giannopoulos, Andreas A / Chatzizisis, Yiannis S

    JACC. Cardiovascular imaging

    2018  Volume 11, Issue 9, Page(s) 1371–1372

    MeSH term(s) Acute Coronary Syndrome ; Angiography ; Hemodynamics ; Humans ; Hydrodynamics ; Prognosis
    Language English
    Publishing date 2018-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2018.06.018
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  8. Article ; Online: Clash of Oral P2Y

    Chatzizisis, Yiannis S / Stefanadis, Christodoulos

    Journal of the American College of Cardiology

    2018  Volume 71, Issue 4, Page(s) 382–385

    MeSH term(s) Acute Coronary Syndrome ; Angioplasty ; Humans ; Myocardial Infarction ; Prasugrel Hydrochloride ; Purinergic P2Y Receptor Antagonists ; Ticagrelor
    Chemical Substances Purinergic P2Y Receptor Antagonists ; Prasugrel Hydrochloride (G89JQ59I13) ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.12.004
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    Zs.MO 196: Show issues

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  9. Article ; Online: Coronary computed tomography angiography in asymptomatic patients: Still a taboo or precision medicine?

    Korosoglou, Grigorios / Chatzizisis, Yiannis S / Raggi, Paolo

    Atherosclerosis

    2020  Volume 317, Page(s) 47–49

    MeSH term(s) Computed Tomography Angiography ; Coronary Angiography ; Humans ; Hyperlipoproteinemia Type II ; Plaque, Atherosclerotic ; Precision Medicine ; Prognosis ; Taboo
    Language English
    Publishing date 2020-12-04
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2020.12.001
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  10. Article ; Online: Computational optimization of a novel atraumatic catheter for local drug delivery in coronary atherosclerotic plaques.

    Sarker, Sunandita / Chatzizisis, Yiannis S / Terry, Benjamin S

    Medical engineering & physics

    2020  Volume 79, Page(s) 26–32

    Abstract: Early identification and treatment of high-risk plaques before they rupture, and precipitate adverse events constitute a major challenge in cardiology today. Computational simulations are a time- and cost-effective way to study the performance, and to ... ...

    Abstract Early identification and treatment of high-risk plaques before they rupture, and precipitate adverse events constitute a major challenge in cardiology today. Computational simulations are a time- and cost-effective way to study the performance, and to optimize a system. The main objective of this work is to optimize the flow of a novel atraumatic local drug delivery catheter for the treatment of coronary atherosclerosis. The mixing and spreading effectiveness of a drug fluid was analyzed utilizing computational fluid dynamics (CFD) in a coronary artery model. The optimum infusion flow of the nanoparticle-carrying drug fluid was found by maximizing the drug volume fraction and minimizing drug velocity at the artery wall, while maintaining acceptable wall shear stress (WSS). Drug velocities between 15 m/s and 20 m/s are optimum for local drug delivery. The resulting parameters from this study will be used to fabricate customized prototypes for future in-vivo experiments.
    MeSH term(s) Catheters ; Coronary Artery Disease/drug therapy ; Drug Delivery Systems/instrumentation ; Equipment Design ; Humans ; Plaque, Atherosclerotic/drug therapy ; Shear Strength
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1181080-4
    ISSN 1873-4030 ; 1350-4533
    ISSN (online) 1873-4030
    ISSN 1350-4533
    DOI 10.1016/j.medengphy.2020.03.003
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