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  1. AU="Chaudhari, Amol"
  2. AU="Planagumà, Jesús"
  3. AU="de Rezende, Grazielli Rocha"
  4. AU="Mohadeseh NEZAM"
  5. AU="Daniel Pecos-Martín"
  6. AU="Gentle, Popular"
  7. AU=Wang Jirui
  8. AU="Bielik, Martin"
  9. AU="Simon A.F. Darroch"
  10. AU="Suzuki, Kenichi G N"
  11. AU="Hu, Yizhong"
  12. AU=Sasaki Kotaro
  13. AU=Abd-Elsayed Alaa
  14. AU="Jung, Hee-Jun"
  15. AU="Struckmann, Stephan"
  16. AU=Coward Richard
  17. AU="Ghazizadeh, Shabnam"
  18. AU="Rebecca A Butcher"
  19. AU="Kimberlyn Roosa"
  20. AU=Chian Ri-Cheng
  21. AU="Alzalzalah, Sayed"
  22. AU=Kaufman Jonathan J
  23. AU="Kim, Jin K"
  24. AU="Zevakov, S A"
  25. AU="Sui Phang"
  26. AU="Kolomeichuk, Lilia V"
  27. AU="Sabuj Kanti Mistry"
  28. AU="Basurto-Lozada, Daniela"
  29. AU="Takashima, Shin-Ichiro"
  30. AU="Teresinha Leal"
  31. AU="Angélique B van 't Wout"
  32. AU="Roberts, Nicholas J"
  33. AU="Chauhan, Gaurav B"
  34. AU=Hanjaya-Putra Donny
  35. AU=Powell James
  36. AU="Russell, Todd"
  37. AU=Forth Scott
  38. AU="Kreutzer, Susanne" AU="Kreutzer, Susanne"
  39. AU="St John, Maie"
  40. AU=Gerhardy A
  41. AU="Qi, Huixin"
  42. AU="Dobosiewicz, May"
  43. AU="Srivastava, Rakesh"
  44. AU="Grevtsov K.I."

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  1. Artikel ; Online: Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft.

    Chauhan, Niketa / Lakhkar, Nilay / Chaudhari, Amol

    Journal of materials science. Materials in medicine

    2021  Band 32, Heft 6, Seite(n) 60

    Abstract: The process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties ... ...

    Abstract The process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.
    Mesh-Begriff(e) Biocompatible Materials/chemistry ; Bone Regeneration ; Bone Substitutes ; Bone Transplantation/instrumentation ; Bone Transplantation/methods ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cell Survival ; Dental Pulp/cytology ; Glass/chemistry ; Humans ; In Vitro Techniques ; Microscopy, Confocal ; Microscopy, Electron, Scanning ; Osteogenesis ; Particle Size ; Phosphates/chemistry ; Porosity ; Spectroscopy, Fourier Transform Infrared ; Stem Cells/cytology ; Temperature ; Tissue Scaffolds/chemistry ; X-Ray Diffraction
    Chemische Substanzen Biocompatible Materials ; Bone Substitutes ; Phosphates
    Sprache Englisch
    Erscheinungsdatum 2021-05-17
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 1031752-1
    ISSN 1573-4838 ; 0957-4530
    ISSN (online) 1573-4838
    ISSN 0957-4530
    DOI 10.1007/s10856-021-06532-8
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  2. Artikel ; Online: Strategic considerations on developing a CHIKV vaccine and ensuring equitable access for countries in need.

    Cherian, Neil / Bettis, Alison / Deol, Arminder / Kumar, Arun / Di Fabio, Jose Luis / Chaudhari, Amol / Yimer, Solomon / Fahim, Raafat / Endy, Timothy

    NPJ vaccines

    2023  Band 8, Heft 1, Seite(n) 123

    Abstract: Chikungunya is an arboviral disease caused by the chikungunya virus (CHIKV) afflicting tropical and sub-tropical countries worldwide. It has been identified as a priority pathogen by the Coalition for Epidemics Preparedness Innovations (CEPI) and as an ... ...

    Abstract Chikungunya is an arboviral disease caused by the chikungunya virus (CHIKV) afflicting tropical and sub-tropical countries worldwide. It has been identified as a priority pathogen by the Coalition for Epidemics Preparedness Innovations (CEPI) and as an emerging infectious disease (EID) necessitating further action as soon as possible by the World Health Organization (WHO). Recent studies suggest that disability-adjusted life years (DALYs) due to CHIKV infection are as high as 106,089 DALYs lost globally. Significant progress has been made in the development of several vaccines, aimed at preventing CHIKV infections. This perspective article summarizes CEPI's efforts and strategic considerations for developing a CHIKV vaccine and ensuring equitable access for CHIKV endemic countries.
    Sprache Englisch
    Erscheinungsdatum 2023-08-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00722-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Role of oxygen scavengers in limiting oxygen permeation into emulsions and improving stability of encapsulated retinol

    Chaudhari, Amol / Nitin Nitin

    Journal of food engineering. 2015 July, v. 157

    2015  

    Abstract: The oxidation reactions significantly limit quality and shelf life of food products. The overall goal of this study was to evaluate the relative efficiency of selected oxygen scavengers in limiting oxygen permeation into the oil phase of the emulsion and ...

    Abstract The oxidation reactions significantly limit quality and shelf life of food products. The overall goal of this study was to evaluate the relative efficiency of selected oxygen scavengers in limiting oxygen permeation into the oil phase of the emulsion and its impact on stability of encapsulated model bioactive compound. Sodium sulfite (Na2SO3), glucose oxidase+catalase (GOx+catalase) and ascorbic acid (AA) were evaluated as water-soluble oxygen scavengers. The results show that GOx+catalase was approximately 6 times more effective in improving stability of retinol encapsulated in the oil phase of the emulsion than Na2SO3. Na2SO3 reduced the rate of permeation of oxygen into the oil phase of the emulsion by approximately 2.5 times as compared to the control emulsion but was not effective in limiting degradation of retinol encapsulated in the emulsion. AA was not effective in limiting oxygen permeation into the emulsion. This study demonstrates the potential of oxygen scavengers in limiting oxygen permeation in emulsion and their impact on improving oxidative stability of encapsulated bioactives.
    Schlagwörter ascorbic acid ; bioactive compounds ; emulsions ; encapsulation ; foods ; free radical scavengers ; glucose ; oils ; oxidation ; oxidative stability ; oxygen ; shelf life ; sodium sulfite ; vitamin A
    Sprache Englisch
    Erscheinungsverlauf 2015-07
    Umfang p. 7-13.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 622518-4
    ISSN 0260-8774
    ISSN 0260-8774
    DOI 10.1016/j.jfoodeng.2015.01.021
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  4. Artikel: Circadian clocks, diets and aging.

    Chaudhari, Amol / Gupta, Richa / Makwana, Kuldeep / Kondratov, Roman

    Nutrition and healthy aging

    2017  Band 4, Heft 2, Seite(n) 101–112

    Abstract: Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as ... ...

    Abstract Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as calorie restriction, have many well-documented positive metabolic effects as well as the potential to extend longevity in different organisms. Recently, the circadian clocks were put forward as integral components of the calorie restriction mechanisms. The circadian clocks generate the circadian rhythms in behavior, physiology, and metabolism; circadian disruption is associated with reduced fitness and decreased longevity. Here we focus on recent advances in the interplay between the circadian clocks and dietary paradigms. We discuss how the regulation of the circadian clocks by feeding/nutrients and regulation of nutrient signaling pathways by the clocks may contribute to the beneficial effects of calorie restriction on metabolism and longevity, and whether the circadian system can be engaged for future medical applications.
    Sprache Englisch
    Erscheinungsdatum 2017-03-31
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2879828-4
    ISSN 2451-9502 ; 2451-9480
    ISSN (online) 2451-9502
    ISSN 2451-9480
    DOI 10.3233/NHA-160006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Silica nanoparticle based techniques for extraction, detection, and degradation of pesticides.

    Bapat, Gandhali / Labade, Chaitali / Chaudhari, Amol / Zinjarde, Smita

    Advances in colloid and interface science

    2016  Band 237, Seite(n) 1–14

    Abstract: Silica nanoparticles (SiNPs) find applications in the fields of drug delivery, catalysis, immobilization and sensing. Their synthesis can be mediated in a facile manner and they display broad range compatibility and stability. Their existence in the form ...

    Abstract Silica nanoparticles (SiNPs) find applications in the fields of drug delivery, catalysis, immobilization and sensing. Their synthesis can be mediated in a facile manner and they display broad range compatibility and stability. Their existence in the form of spheres, wires and sheets renders them suitable for varied purposes. This review summarizes the use of silica nanostructures in developing techniques for extraction, detection and degradation of pesticides. Silica nanostructures on account of their sorbent properties, porous nature and increased surface area allow effective extraction of pesticides. They can be modified (with ionic liquids, silanes or amines), coated with molecularly imprinted polymers or magnetized to improve the extraction of pesticides. Moreover, they can be altered to increase their sensitivity and stability. In addition to the analysis of pesticides by sophisticated techniques such as High Performance Liquid Chromatography or Gas chromatography, silica nanoparticles related simple detection methods are also proving to be effective. Electrochemical and optical detection based on enzymes (acetylcholinesterase and organophosphate hydrolase) or antibodies have been developed. Pesticide sensors dependent on fluorescence, chemiluminescence or Surface Enhanced Raman Spectroscopic responses are also SiNP based. Moreover, degradative enzymes (organophosphate hydrolases, carboxyesterases and laccases) and bacterial cells that produce recombinant enzymes have been immobilized on SiNPs for mediating pesticide degradation. After immobilization, these systems show increased stability and improved degradation. SiNP are significant in developing systems for effective extraction, detection and degradation of pesticides. SiNPs on account of their chemically inert nature and amenability to surface modifications makes them popular tools for fabricating devices for 'on-site' applications.
    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland Netherlands
    Dokumenttyp Review ; Journal Article
    ZDB-ID 210507-x
    ISSN 1873-3727 ; 0001-8686
    ISSN (online) 1873-3727
    ISSN 0001-8686
    DOI 10.1016/j.cis.2016.06.001
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  6. Artikel: Beverage emulsions: Comparison among nanoparticle stabilized emulsion with starch and surfactant stabilized emulsions

    Chaudhari, Amol / Yuanjie Pan / Nitin Nitin

    Food research international. 2015 Mar., v. 69

    2015  

    Abstract: Emulsions are widely used in beverages to impart desired appearance and flavor to the products. Ring formation in beverages with emulsions during thermal processing and storage is one of the key challenges. This study was aimed at comparing the relative ... ...

    Abstract Emulsions are widely used in beverages to impart desired appearance and flavor to the products. Ring formation in beverages with emulsions during thermal processing and storage is one of the key challenges. This study was aimed at comparing the relative effectiveness of silica nanoparticle based emulsifiers with surfactant and biopolymer based emulsifier (modified starch) in influencing physical stability of emulsions in a model juice. The stability of emulsions was measured by characterizing changes in emulsion droplet size, zeta potential, UV–vis absorbance and visual evaluation of phase separation or ring formation in both primary emulsions and beverage emulsions as a function of storage time. The influence of thermal processing on stability of emulsions both immediately after processing and upon storage was evaluated. The thermal processing conditions simulated both high temperature short time and low temperature long time pasteurization conditions. The results demonstrate that the mean droplet diameter of primary emulsions stabilized by selected emulsifiers was stable during storage for 21days with and without pasteurization. Based on measurements of mean droplet diameter and visible ring formation, polyoxyethylene sorbitan monolaurate (tween-20) stabilized emulsion was not stable in a model juice and the stability of this emulsion was further reduced with thermal processing. In contrast, starch and silica stabilized emulsions in a model juice did not show significant changes in particle diameter or visible ring formation during storage with and without prior thermal processing, although starch stabilized emulsion did show a decrease in absorbance during storage. Zeta potential measurements in a model juice indicate that the surface properties of emulsions were significantly distinct from those of primary emulsion, indicating interaction of juice components with the emulsion interface influencing the surface charge at the interface. These changes in zeta potential of emulsion droplets did not correlate with reduced stability of the emulsions. Overall, the results demonstrate that nanoparticle stabilized emulsions can improve stability of emulsion in beverages as compared to surfactant and biopolymer stabilized emulsions and provides a comprehensive matrix to evaluate stability of emulsions in beverages.
    Schlagwörter absorbance ; beverages ; biopolymers ; droplet size ; droplets ; emulsifiers ; emulsions ; flavor ; juices ; modified starch ; nanoparticles ; pasteurization ; polysorbates ; separation ; silica ; storage time ; surfactants ; temperature ; zeta potential
    Sprache Englisch
    Erscheinungsverlauf 2015-03
    Umfang p. 156-163.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2014.12.030
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    Z 2972: Hefte anzeigen

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  7. Artikel ; Online: Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation.

    Chaudhari, Amol / Gupta, Richa / Patel, Sonal / Velingkaar, Nikkhil / Kondratov, Roman

    Molecular biology of the cell

    2017  Band 28, Heft 6, Seite(n) 834–842

    Abstract: Insulin-like growth factor (IGF) signaling plays an important role in cell growth and proliferation and is implicated in regulation of cancer, metabolism, and aging. Here we report that IGF-1 level in blood and IGF-1 signaling demonstrates circadian ... ...

    Abstract Insulin-like growth factor (IGF) signaling plays an important role in cell growth and proliferation and is implicated in regulation of cancer, metabolism, and aging. Here we report that IGF-1 level in blood and IGF-1 signaling demonstrates circadian rhythms. Circadian control occurs through cryptochromes (CRYs)-transcriptional repressors and components of the circadian clock. IGF-1 rhythms are disrupted in
    Mesh-Begriff(e) Animals ; Circadian Clocks/physiology ; Circadian Rhythm/physiology ; Cryptochromes/genetics ; Cryptochromes/metabolism ; DNA-Binding Proteins/metabolism ; Down-Regulation ; Dwarfism/metabolism ; Growth Hormone ; Insulin-Like Growth Factor I/biosynthesis ; Insulin-Like Growth Factor I/metabolism ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism ; Signal Transduction ; Trans-Activators/metabolism
    Chemische Substanzen Cryptochromes ; DNA-Binding Proteins ; STAT5 Transcription Factor ; Trans-Activators ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6) ; Jak2 protein, mouse (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Sprache Englisch
    Erscheinungsdatum 2017-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E16-08-0624
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  8. Artikel ; Online: Antifungal activity against Candida albicans of starch Pickering emulsion with thymol or amphotericin B in suspension and calcium alginate films.

    Cossu, Andrea / Wang, Min S / Chaudhari, Amol / Nitin, Nitin

    International journal of pharmaceutics

    2015  Band 493, Heft 1-2, Seite(n) 233–242

    Abstract: Conventional antifungal treatments against Candida albicans in the oral cavity often result in increased cytotoxicity. The goal of this study was to determine the potential of starch Pickering emulsion as a delivery vehicle for an antifungal natural ... ...

    Abstract Conventional antifungal treatments against Candida albicans in the oral cavity often result in increased cytotoxicity. The goal of this study was to determine the potential of starch Pickering emulsion as a delivery vehicle for an antifungal natural phenolic compound such as thymol in simulated saliva fluid (SSF) compared to amphotericin B. An oil-in-water (o/w) emulsion was stabilized using starch particles. Physical stability of the emulsion and disruption induced by α-amylase activity in SSF was evaluated. Encapsulated thymol in o/w emulsion was compared to encapsulated amphotericin B for antifungal activity against C. albicans in suspension using emulsions or zone inhibition assay on agar plates using emulsions dispersed in alginate films. Results showed that the emulsions were stable for at least three weeks. Digestion of the emulsion by α-amylase led to coalescence of emulsion droplets. The antifungal activity of thymol and amphotericin B in emulsion formulation was enhanced upon incubation with α-amylase. Results from the zone inhibition assay demonstrated efficacy of the emulsions dispersed in alginate films. Interestingly, addition of α-amylase to the alginate films resulted in a decreased inhibitory effect. Overall, this study showed that starch Pickering emulsions have a potential to deliver hydrophobic antifungal compounds to treat oral candidiasis.
    Mesh-Begriff(e) Alginates/chemistry ; Amphotericin B/chemistry ; Amphotericin B/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Candida albicans/drug effects ; Candida albicans/growth & development ; Drug Delivery Systems ; Emulsions ; Glucuronic Acid/chemistry ; Hexuronic Acids/chemistry ; Starch/chemistry ; Suspensions ; Thymol/chemistry ; Thymol/pharmacology ; alpha-Amylases/chemistry
    Chemische Substanzen Alginates ; Antifungal Agents ; Emulsions ; Hexuronic Acids ; Suspensions ; Thymol (3J50XA376E) ; Amphotericin B (7XU7A7DROE) ; Glucuronic Acid (8A5D83Q4RW) ; alginic acid (8C3Z4148WZ) ; Starch (9005-25-8) ; alpha-Amylases (EC 3.2.1.1)
    Sprache Englisch
    Erscheinungsdatum 2015-09-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2015.07.065
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  9. Artikel ; Online: Safety of Russian-Backbone Trivalent, Live Attenuated Seasonal Influenza Vaccine in Healthy Subjects: Open-Label, Non-randomized Phase 4 Study.

    Nigwekar, Prashant V / Kumar, Anuj / Padbidri, Vikram V / Choudhury, Amlan / Chaudhari, Amol B / Kulkarni, Prasad S

    Drug safety

    2017  Band 41, Heft 2, Seite(n) 171–177

    Abstract: Introduction and aim: A trivalent live attenuated influenza vaccine (Nasovac-S: Methodology: This non-randomized, open-label, single-arm study among individuals ≥ 2 years of age involved administration of 0.5 mL of Nasovac-S intranasally, with a 1- ... ...

    Abstract Introduction and aim: A trivalent live attenuated influenza vaccine (Nasovac-S
    Methodology: This non-randomized, open-label, single-arm study among individuals ≥ 2 years of age involved administration of 0.5 mL of Nasovac-S intranasally, with a 1-month follow-up after vaccination. Adverse events (AEs) were collected via structured diaries.
    Results: Among 500 vaccinated subjects, 160 were between 2 and 17 years of age, 240 were 18-49 years old and 100 were 50 years and older. A total of 533 solicited reactions were reported. The majority of these reactions were mild, and almost all of them resolved without any sequelae. A total of 20% of subjects reported at least one local solicited reaction, and 23% reported at least one systemic solicited reaction. None of the 45 unsolicited AEs reported by 37 subjects (7.4%) were causally related to the study vaccine.
    Conclusions: The data from the study adds to the existing safety database of Nasovac-S.
    Registry: Clinical Trials Registry of India (CTRI/2015/08/006074).
    Mesh-Begriff(e) Administration, Intranasal/methods ; Adolescent ; Adult ; Child ; Child, Preschool ; Drug-Related Side Effects and Adverse Reactions/immunology ; Female ; Healthy Volunteers ; Humans ; India ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Russia ; Seasons ; Vaccination/methods ; Vaccines, Attenuated/adverse effects ; Vaccines, Inactivated/adverse effects ; Young Adult
    Chemische Substanzen Influenza Vaccines ; Vaccines, Attenuated ; Vaccines, Inactivated
    Sprache Englisch
    Erscheinungsdatum 2017-10-11
    Erscheinungsland New Zealand
    Dokumenttyp Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-017-0605-3
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  10. Artikel: Status Report on COVID-19 Vaccines Development.

    Kumar, Arun / Dowling, William E / Román, Raúl Gómez / Chaudhari, Amol / Gurry, Celine / Le, Tung Thanh / Tollefson, Stig / Clark, Carolyn E / Bernasconi, Valentina / Kristiansen, Paul A

    Current infectious disease reports

    2021  Band 23, Heft 6, Seite(n) 9

    Abstract: Purpose of review: The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected lives of billions of individuals, globally. There is an urgent need to develop interventions including vaccines to control the ongoing ... ...

    Abstract Purpose of review: The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected lives of billions of individuals, globally. There is an urgent need to develop interventions including vaccines to control the ongoing pandemic.
    Recent findings: Development of tools for fast-tracked testing including small and large animal models for vaccine efficacy analysis, assays for immunogenicity assessment, critical reagents, international biological standards, and data sharing allowed accelerated development of vaccines. More than 300 vaccines are under development and 9 of them are approved for emergency use in various countries, with impressive efficacy ranging from 50 to 95%. Recently, several new SARS-CoV-2 variants have emerged and are circulating globally, and preliminary findings imply that some of them may escape immune responses against previous variants and diminish efficacy of current vaccines. Most of these variants acquired new mutations in their surface protein (Spike) which is the antigen in most of the approved/under development vaccines.
    Summary: In this review, we summarize novel and traditional approaches for COVID-19 vaccine development including inactivated, attenuated, nucleic acid, vector and protein based. Critical assessment of humoral and cell-mediated immune responses induced by vaccines has shown comparative immunogenicity profiles of various vaccines in clinical phases. Recent reports confirmed that some currently available vaccines provide partial to complete protection against emerging SARS-CoV-2 variants. If more mutated variants emerge, current vaccines might need to be updated accordingly either by developing vaccines matching the circulating strain or designing multivalent vaccines to extend the breadth.
    Sprache Englisch
    Erscheinungsdatum 2021-04-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019948-X
    ISSN 1534-3146 ; 1523-3847
    ISSN (online) 1534-3146
    ISSN 1523-3847
    DOI 10.1007/s11908-021-00752-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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