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  1. Article ; Online: Carbazole-based semicarbazones and hydrazones as multifunctional anti-Alzheimer agents.

    Patel, Kishan B / Patel, Dushyant V / Patel, Nirav R / Kanhed, Ashish M / Teli, Divya M / Gandhi, Bhumi / Shah, Bhavik S / Chaudhary, Bharat N / Prajapati, Navnit K / Patel, Kirti V / Yadav, Mange Ram

    Journal of biomolecular structure & dynamics

    2021  Volume 40, Issue 20, Page(s) 10278–10299

    Abstract: With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and ... ...

    Abstract With the aim to combat a multi-faceted neurodegenerative Alzheimer's disease (AD), a series of carbazole-based semicarbazide and hydrazide derivatives were designed, synthesized and assessed for their cholinesterase (ChE) inhibitory, antioxidant and biometal chelating activity. Among them, (
    MeSH term(s) Humans ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Acetylcholinesterase/chemistry ; Semicarbazones/pharmacology ; Hydrazones ; Molecular Docking Simulation ; Carbazoles/pharmacology ; Carbazoles/chemistry ; Chelating Agents/pharmacology ; Chelating Agents/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Alzheimer Disease/drug therapy ; Structure-Activity Relationship
    Chemical Substances Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7) ; hydrazinecarbothioamide ; Semicarbazones ; Hydrazones ; Carbazoles ; Chelating Agents ; Antioxidants
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2021.1942212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Further Studies on Triazinoindoles as Potential Novel Multitarget-Directed Anti-Alzheimer's Agents.

    Patel, Dushyant V / Patel, Nirav R / Kanhed, Ashish M / Teli, Divya M / Patel, Kishan B / Gandhi, Pallav M / Patel, Sagar P / Chaudhary, Bharat N / Shah, Dharti B / Prajapati, Navnit K / Patel, Kirti V / Yadav, Mange Ram

    ACS chemical neuroscience

    2020  Volume 11, Issue 21, Page(s) 3557–3574

    Abstract: The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on the progression of Alzheimer's disease in patients have revised the research focus from single targets to multitarget-directed ligands. A novel ... ...

    Abstract The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their low impact on the progression of Alzheimer's disease in patients have revised the research focus from single targets to multitarget-directed ligands. A novel series of substituted triazinoindole derivatives were obtained by introducing various substituents on the indole ring for the development of multitarget-directed ligands as anti-AD agents. The experimental data indicated that some of these compounds exhibited significant anti-AD properties. Among them, 8-(piperidin-1-yl)-
    MeSH term(s) Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Cholinesterase Inhibitors/pharmacology ; Drug Design ; Humans ; Ligands ; Mice ; Pharmaceutical Preparations ; Rats ; Structure-Activity Relationship
    Chemical Substances Amyloid beta-Peptides ; Cholinesterase Inhibitors ; Ligands ; Pharmaceutical Preparations ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.0c00448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents.

    Patel, Dushyant V / Patel, Nirav R / Kanhed, Ashish M / Teli, Divya M / Patel, Kishan B / Joshi, Prashant D / Patel, Sagar P / Gandhi, Pallav M / Chaudhary, Bharat N / Prajapati, Navnit K / Patel, Kirti V / Yadav, Mange Ram

    Bioorganic chemistry

    2020  Volume 101, Page(s) 103977

    Abstract: Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer's ... ...

    Abstract Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer's disease, a novel series of carbazole-based stilbene derivatives were designed by the fusion of carbazole ring with stilbene scaffold. The designed compounds were synthesized and evaluated for their anti-AD activities including cholinesterase inhibition, Aβ aggregation inhibition, antioxidant and metal chelation properties. Amongst them, (E)-1-(4-(2-(9-ethyl-9H-carbazol-3-yl)vinyl)phenyl)-3-(2-(pyrrolidin-1-yl)ethyl)thiourea (50) appeared to be the best candidate with good inhibitory activities against AChE (IC
    MeSH term(s) Alzheimer Disease/drug therapy ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Stilbenes/therapeutic use ; Structure-Activity Relationship
    Chemical Substances Stilbenes
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.103977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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