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Article ; Online: Impact of porous nanomaterials on inhibiting protein aggregation behaviour.

Bardhan, Munmun / Dolui, Sandip / Chaudhuri, Siddhi / Paul, Uttam / Bhattacharjee, Gaurav / Ghosal, Manorama / Maiti, Nakul C / Mukhopadhyay, Debashis / Senapati, Dulal

RSC advances

2021 Volume 11, Issue 6, Page(s) 3354–3362

Abstract: Aggregation of intrinsically disordered as well as the ordered proteins under certain premises or physiological conditions leads to pathological disorder. Here we have presented a detailed investigation on the effect of a porous metallic (Au) and a non- ... ...

Abstract	Aggregation of intrinsically disordered as well as the ordered proteins under certain premises or physiological conditions leads to pathological disorder. Here we have presented a detailed investigation on the effect of a porous metallic (Au) and a non-metallic (Si) nanomaterial on the formation of ordered (fiber-like/amyloid) and disordered (amorphous) aggregates of proteins. Porous nanogold (PNG) was found to reduce the amyloid aggregation of insulin but does not have much impact on the lag phase in the aggregation kinetics, whereas porous nano-silica (PNS) was found both to decrease the amount of aggregation as well as prolong the lag phase of amyloid fiber formation from insulin. On the other hand, both the porous nanoparticles are found to decrease the extent of amorphous aggregation (with slight improvement for PNS) of pathogenic huntingtin (Htt) protein in Huntington's disease cell model. This is a noted direct observation in controlling and understanding protein aggregation diseases which may help us to formulate nanotherapeutic drugs for future clinical applications.
Language	English
Publishing date	2021-01-15
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra10927d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Essential Dynamics of an Effective Phototherapeutic Drug in a Nanoscopic Delivery Vehicle: Psoralen in Ethosomes for Biofilm Treatment.

Bagchi, Damayanti / Dutta, Shreyasi / Singh, Priya / Chaudhuri, Siddhi / Pal, Samir Kumar

ACS omega

2017 Volume 2, Issue 5, Page(s) 1850–1857

Abstract: Appropriate localization of a drug and its structure/functional integrity in a delivery agent essentially dictates the efficacy of the vehicle and the medicinal activity of the drug. In the case of a phototherapeutic drug, its photoinduced dynamics ... ...

Abstract	Appropriate localization of a drug and its structure/functional integrity in a delivery agent essentially dictates the efficacy of the vehicle and the medicinal activity of the drug. In the case of a phototherapeutic drug, its photoinduced dynamics becomes an added parameter. Here, we have explored the photoinduced dynamical events of a model phototherapeutic drug psoralen (PSO) in a potential delivery vehicle called an ethosome. Dynamic light scattering confirms the structural integrity of the ethosome vehicle after the encapsulation of PSO. Steady state and picosecond resolved polarization gated spectroscopy, including the well-known strategy of solvation and Förster resonance energy transfer, reveal the localization of the drug in the vehicle and the environment in the proximity of PSO. We have also investigated the efficacy of drug delivery to various individual bacteria (Gram-negative:
Language	English
Publishing date	2017-05-05
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN	2470-1343
DOI	10.1021/acsomega.7b00187
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vitamin B2 in nanoscopic environments under visible light: photosensitized antioxidant or phototoxic drug?

Chaudhuri, Siddhi / Batabyal, Subrata / Polley, Nabarun / Pal, Samir Kumar

The journal of physical chemistry. A

2014 Volume 118, Issue 22, Page(s) 3934–3943

Abstract: Vitamin B2 has been studied as a conventional antioxidant (in the dark) since its discovery in 1926. The effect of visible light on vitamin B2-containing food has a long history of scientific investigation. Although photodegradation of the vitamin ... ...

Abstract	Vitamin B2 has been studied as a conventional antioxidant (in the dark) since its discovery in 1926. The effect of visible light on vitamin B2-containing food has a long history of scientific investigation. Although photodegradation of the vitamin producing several photoproducts is evident in certain experimental conditions, phototoxicity revealing an additional oxidative stress in the medium is also clear from some reports. Here we report the photosensitized antioxidant effect of the vitamin, which is found to be greater than 2 orders of magnitude more efficient than that in the dark condition. The photoinduced antioxidant property is apparently paradoxical compared to the reported phototoxic effect of the vitamin. Our present study unravels a unified picture underlying the difference in character of vitamin B2 under visible light irradiation. UV-vis absorption and fluorescence studies in a number of physiologically relevant nanoscopic environments (micelles and reverse micelles) reveal the antioxidant activity to a well-known oxidative stress marker 2,2-diphenyl-1-picrylhydrazyl (DPPH) as well as a phototoxicity effect resulting in self-degradation of the vitamin. Picosecond-resolved Förster resonance energy transfer (FRET) from the vitamin to the marker DPPH in the biomimetic environments clearly reveals the role of proximity of an oxidizing agent in the photoinduced effect of the vitamin. Our systematic and detailed studies unravel a simple picture of the mechanistic pathway of the photosensitized vitamin in the physiologically important environments leading to the antioxidant/phototoxicity effect of the vitamin. The excited vitamin transfers its electron to the oxidizing agent in proximity for the antioxidant effect, but otherwise it employs oxygen to generate reactive oxygen species (ROS), resulting in phototoxicity/self-degradation.
MeSH term(s)	Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Biomimetic Materials/chemistry ; Biphenyl Compounds/chemistry ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Kinetics ; Light ; Micelles ; Molecular Structure ; Oxygen/chemistry ; Photochemical Processes ; Photosensitizing Agents/chemistry ; Picrates/chemistry ; Reactive Oxygen Species/chemistry ; Riboflavin/chemistry ; Sodium Azide/chemistry
Chemical Substances	Antioxidants ; Biphenyl Compounds ; Micelles ; Photosensitizing Agents ; Picrates ; Reactive Oxygen Species ; Sodium Azide (968JJ8C9DV) ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH) ; Oxygen (S88TT14065) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2014-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp502904r
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Article ; Online: Direct observation of key photoinduced dynamics in a potential nano-delivery vehicle of cancer drugs.

Sardar, Samim / Chaudhuri, Siddhi / Kar, Prasenjit / Sarkar, Soumik / Lemmens, Peter / Pal, Samir Kumar

Physical chemistry chemical physics : PCCP

2015 Volume 17, Issue 1, Page(s) 166–177

Abstract: In recent times, significant achievements in the use of zinc oxide (ZnO) nanoparticles (NPs) as delivery vehicles of cancer drugs have been made. The present study is an attempt to explore the key photoinduced dynamics in ZnO NPs upon complexation with a ...

Abstract	In recent times, significant achievements in the use of zinc oxide (ZnO) nanoparticles (NPs) as delivery vehicles of cancer drugs have been made. The present study is an attempt to explore the key photoinduced dynamics in ZnO NPs upon complexation with a model cancer drug protoporphyrin IX (PP). The nanohybrid has been characterized by FTIR, Raman scattering and UV-Vis absorption spectroscopy. Picosecond-resolved Förster resonance energy transfer (FRET) from the defect mediated emission of ZnO NPs to PP has been used to study the formation of the nanohybrid at the molecular level. Picosecond-resolved fluorescence studies of PP-ZnO nanohybrids reveal efficient electron migration from photoexcited PP to ZnO, eventually enhancing the ROS activity. The dichlorofluorescin (DCFH) oxidation and no oxidation of luminol in PP/PP-ZnO nanohybrids upon green light illumination unravel that the nature of ROS is essentially singlet oxygen rather than superoxide anions. Surface mediated photocatalysis of methylene blue (MB) in an aqueous solution of the nanohybrid has also been investigated. Direct evidence of the role of electron transfer as a key player in enhanced ROS generation from the nanohybrid is also clear from the photocurrent measurement studies. We have also used the nanohybrid in a model photodynamic therapy application in a light sensitized bacteriological culture experiment.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Drug Delivery Systems ; Escherichia coli/drug effects ; Escherichia coli Infections/drug therapy ; Fluorescence Resonance Energy Transfer ; Humans ; Light ; Models, Molecular ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Neoplasms/drug therapy ; Protoporphyrins/administration & dosage ; Protoporphyrins/chemistry ; Protoporphyrins/pharmacology ; Reactive Oxygen Species/chemistry ; Zinc Oxide/chemistry
Chemical Substances	Anti-Bacterial Agents ; Antineoplastic Agents ; Protoporphyrins ; Reactive Oxygen Species ; zinc protoporphyrin (15442-64-5) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2015-01-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c4cp03749a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sensitization of an endogenous photosensitizer: electronic spectroscopy of riboflavin in the proximity of semiconductor, insulator, and metal nanoparticles.

Chaudhuri, Siddhi / Sardar, Samim / Bagchi, Damayanti / Singha, Shib Shankar / Lemmens, Peter / Pal, Samir Kumar

The journal of physical chemistry. A

2015 Volume 119, Issue 18, Page(s) 4162–4169

Abstract: Riboflavin (Rf) is a class of important vitamins (Vitamin B2) and a well-known antioxidant. Here we have synthesized nanohybrids of Rf with a number of inorganic nanoparticles (NPs); namely zinc oxide (ZnO), titanium oxide (TiO2), aluminum oxide (Al2O3) ... ...

Abstract	Riboflavin (Rf) is a class of important vitamins (Vitamin B2) and a well-known antioxidant. Here we have synthesized nanohybrids of Rf with a number of inorganic nanoparticles (NPs); namely zinc oxide (ZnO), titanium oxide (TiO2), aluminum oxide (Al2O3) and gold NPs of similar sizes. While high resolution transmission electron microscopy (HRTEM) confirms integrity and sizes of the NPs, intactness of the molecular structure of the drug Rf is revealed from absorption and steady-state emission spectra of the drug in the nanohybrid. Raman spectroscopy on the nanohybrids shows the nature of molecular complexation of the drug with the inorganic NPs. For the semiconductor and insulator NPs, the complexation is found to be noncovalent, however, a covalent attachment of the drug with the dangling bonds of metal atoms at the surface is observed. In order to investigate antioxidant activity of the nanohybrids, we have performed 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay of the nanohybrids in dark as well as under blue light irradiation. Whereas change of the antioxidant activity of the nanohybrids with respect to free riboflavin in the absence of light is observed to be insignificant, a drastic change in the activity in the case of TiO2 and ZnO in the presence of light is evident. No change in the case of Al2O3 and a significant decrease in the antioxidant activity for gold nanohybrids are also remarkable. Picosecond-resolved fluorescence studies on the nanohybrids reveal a molecular picture of the differential antioxidant activities. An ultrafast photoinduced electron transfer from Rf to ZnO and TiO2 are clearly evident from the corresponding fluorescence transients. We have compared the picosecond-resolved transients with that of Rf in the presence of a well-known electron acceptor benzoquinone (BQ) and found similar time scales. No temporal change in the fluorescence transient of riboflavin in Al2O3 nanohybrids compared to that of free Rf is observed indicating uneventful excited state relaxation of the nanohybrids. Nanosurface energy transfer (NSET) over Förster resonance energy transfer (FRET) is found to be the prevailing de-excitation mechanism in the case of gold nanohybrids, because of the strong spectral overlap between Rf emission and surface plasmon absorption of the gold NPs. Different excited state mechanisms as revealed from our studies are expected to be useful for the design of NP-sensitized drugs, which are reported sparsely in the literature.
MeSH term(s)	Aluminum Oxide/chemistry ; Gold/chemistry ; Microscopy, Electron, Transmission ; Nanoparticles/chemistry ; Particle Size ; Photosensitizing Agents/chemistry ; Riboflavin/chemistry ; Semiconductors ; Surface Properties ; Titanium/chemistry ; Zinc Oxide/chemistry
Chemical Substances	Photosensitizing Agents ; titanium dioxide (15FIX9V2JP) ; Gold (7440-57-5) ; Titanium (D1JT611TNE) ; Aluminum Oxide (LMI26O6933) ; Zinc Oxide (SOI2LOH54Z) ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2015-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.5b03021
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Article: Modulation of stability and functionality of a phyto-antioxidant by weakly interacting metal ions: curcumin in aqueous solution

Bagchi, Damayanti / Chaudhuri, Siddhi / Sardar, Samim / Choudhury, Susobhan / Polley, Nabarun / Lemmens, Peter / Pal, Samir Kumar

RSC advances. 2015 Nov. 30, v. 5, no. 124

2015

Abstract: The natural polyphenol curcumin and its metal coordinated complexes show obvious benefits in the medical therapies of cancer and several neurodegenerative diseases. On the other side their stability and bioavailability are critical issues. The present ... ...

Abstract	The natural polyphenol curcumin and its metal coordinated complexes show obvious benefits in the medical therapies of cancer and several neurodegenerative diseases. On the other side their stability and bioavailability are critical issues. The present study is an attempt to address the stability and functionality of curcumin upon complexation with transition metal ions. We have synthesized and optically characterized metallo–curcumin complexes with Cu(ii) and Zn(ii). From femtosecond resolved upconversion studies an interaction at the molecular level is revealed based on an observed photoinduced electron transfer from curcumin to the metal ions. In order to investigate the antioxidant activity of the complexes, we have performed a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay in dark. The Cu(ii)–curcumin complex exhibits an enhanced and recyclable activity, more pronounced compared to that of the Zn(ii)–curcumin complex, which can be attributed to the weaker O–H bond present in the former case. In contrast, the Zn(ii) complex has a higher solubility and stability in aqueous media than the Cu(ii) complex. To address stability vs. functionality issues, we have suggested a facile method that enhances the solubility and stability of curcumin in aqueous media by metalation with Zn(ii) and a successional replacement of Zn(ii) in the complex by Cu(ii) through a simple route to enhance the activity prior to its use. We have also used the complex in a model anti-bacteriological assay experiment where it shows significantly higher activity compared to pure curcumin. The dichlorofluorescin (DCFH) oxidation indicates an enhancement in ROS generation, which in turn is responsible for the enhanced antioxidative property of the Cu(ii)–curcumin complex. Our results provide a promising method to use metallo–curcumin complexes in diverse biological applications.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; antioxidant activity ; aqueous solutions ; bioavailability ; chemical bonding ; copper ; curcumin ; electron transfer ; metal ions ; models ; neoplasms ; neurodegenerative diseases ; oxidation ; polyphenols ; solubility ; zinc
Language	English
Dates of publication	2015-1130
Size	p. 102516-102524.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c5ra21593e
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of caffeine in DNA recognition of a potential food-carcinogen benzo[a]pyrene and UVA induced DNA damage.

Banerjee, Soma / Chaudhuri, Siddhi / Maity, Anup Kumar / Saha, Partha / Pal, Samir Kumar

Journal of molecular recognition : JMR

2014 Volume 27, Issue 8, Page(s) 510–520

Abstract: Electron transfer (ET) reactions are important for their implications in both oxidative and reductive DNA damages. The current contribution investigates the efficacy of caffeine, a xanthine alkaloid in preventing UVA radiation induced ET from a ... ...

Abstract	Electron transfer (ET) reactions are important for their implications in both oxidative and reductive DNA damages. The current contribution investigates the efficacy of caffeine, a xanthine alkaloid in preventing UVA radiation induced ET from a carcinogen, benzo[a]pyrene (BP) to DNA by forming stable caffeine-BP complexes. While steady-state emission and absorption results emphasize the role of caffeine in hosting BP in aqueous medium, the molecular modeling studies propose the energetically favorable structure of caffeine-BP complex. The picosecond-resolved emission spectroscopic studies precisely explore the caffeine-mediated inhibition of ET from BP to DNA under UVA radiation. The potential therapeutic activity of caffeine in preventing DNA damage has been ensured by agarose gel electrophoresis. Furthermore, time-gated fluorescence microscopy has been used to monitor caffeine-mediated exclusion of BP from various cell lines including squamous epithelial cells, WI-38 (fibroblast), MCF-7 (breast cancer) and HeLa (cervical cancer) cells. Our in vitro and ex vivo experimental results provide imperative evidences about the role of caffeine in modified biomolecular recognition of a model carcinogen BP by DNA resulting dissociation of the carcinogen from various cell lines, implicating its potential medicinal applications in the prevention of other toxic organic molecule induced cellular damages.
MeSH term(s)	Benzo(a)pyrene/chemistry ; Caffeine/chemistry ; Cell Line, Tumor ; DNA Damage ; HeLa Cells ; Humans ; MCF-7 Cells ; Models, Molecular ; Oxidation-Reduction ; Spectrum Analysis ; Ultraviolet Rays
Chemical Substances	Benzo(a)pyrene (3417WMA06D) ; Caffeine (3G6A5W338E)
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1015084-5
ISSN	1099-1352 ; 0952-3499
ISSN (online)	1099-1352
ISSN	0952-3499
DOI	10.1002/jmr.2379
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Article ; Online: Photoinduced Dynamics and Toxicity of a Cancer Drug in Proximity of Inorganic Nanoparticles under Visible Light.

Chaudhuri, Siddhi / Sardar, Samim / Bagchi, Damayanti / Dutta, Shreyasi / Debnath, Sushanta / Saha, Partha / Lemmens, Peter / Pal, Samir Kumar

Chemphyschem : a European journal of chemical physics and physical chemistry

2016 Volume 17, Issue 2, Page(s) 270–277

Abstract: Drug sensitization with various inorganic nanoparticles (NPs) has proved to be a promising and an emergent concept in the field of nanomedicine. Rose bengal (RB), a notable photosensitizer, triggers the formation of reactive oxygen species under green- ... ...

Abstract	Drug sensitization with various inorganic nanoparticles (NPs) has proved to be a promising and an emergent concept in the field of nanomedicine. Rose bengal (RB), a notable photosensitizer, triggers the formation of reactive oxygen species under green-light irradiation, and consequently, it induces cytotoxicity and cell death. In the present study, the effect of photoinduced dynamics of RB upon complexation with semiconductor zinc oxide NPs is explored. To accomplish this, we successfully synthesized nanohybrids of RB with ZnO NPs with a particle size of 24 nm and optically characterized them. The uniform size and integrity of the particles were confirmed by high-resolution transmission electron microscopy. UV/Vis absorption and steady-state fluorescence studies reveal the formation of the nanohybrids. ultrafast picosecond-resolved fluorescence studies of RB-ZnO nanohybrids demonstrate an efficient electron transfer from the photoexcited drug to the semiconductor NPs. Picosecond-resolved Förster resonance energy transfer from ZnO NPs to RB unravel the proximity of the drug to the semiconductor at the molecular level. The photoinduced ROS formation was monitored using a dichlorofluorescin oxidation assay, which is a conventional oxidative stress indicator. It is observed that the ROS generation under green light illumination is greater at low concentrations of RB-ZnO nanohybrids compared with free RB. Substantial photodynamic activity of the nanohybrids in bacterial and fungal cell lines validated the in vitro toxicity results. Furthermore, the cytotoxic effect of the nanohybrids in HeLa cells, which was monitored by MTT assay, is also noteworthy.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Candida albicans/cytology ; Candida albicans/drug effects ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Escherichia coli/cytology ; Escherichia coli/drug effects ; HeLa Cells ; Humans ; Light ; Microbial Sensitivity Tests ; Nanoparticles/chemistry ; Particle Size ; Photochemical Processes ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Reactive Oxygen Species/metabolism ; Rose Bengal/chemistry ; Rose Bengal/pharmacology ; Semiconductors ; Surface Properties ; Zinc Oxide/chemistry ; Zinc Oxide/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Antifungal Agents ; Antineoplastic Agents ; Photosensitizing Agents ; Reactive Oxygen Species ; Rose Bengal (1ZPG1ELY14) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2016-01-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1439-7641
ISSN (online)	1439-7641
DOI	10.1002/cphc.201500905
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