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  1. Article ; Online: Morphology of Tissue Disruption at Sites of High-Grade Tumors.

    Chaudhury, Mousumi

    World journal of oncology

    2020  Volume 11, Issue 4, Page(s) 127–138

    Abstract: Background: Invasive solid cancers originating from diverse organs like breast, ovary and lung metastasize to distant sites. The structural changes at the primary sites of these high-grade tumors have not been well characterized. The main aim of the ... ...

    Abstract Background: Invasive solid cancers originating from diverse organs like breast, ovary and lung metastasize to distant sites. The structural changes at the primary sites of these high-grade tumors have not been well characterized. The main aim of the current study was to examine if there is any morphological overlap of metastasizing tissues of different invasive tumors.
    Methods: Whole slide hematoxylin and eosin (H&E) stained images from web repository of multiple tumor specimens were used for this study. ImageJ was used for image processing and analysis.
    Results: The metastatic tissue(s) at the primary sites of different examined high-grade tumors appeared similar, irrespective of the organ of origin of the primary tumor. Numerous cellular excrescences with the repetitive appearance of a bulb-like projection with a narrowed-off trailing end were seen emanating from the tumor cell membrane. Many of them contained nuclei, while others were empty vesicles. Although these structures were not exactly equal in their dimensions, the rubrics of architectural distortion in different high-grade tumors were conserved.
    Conclusions: The preliminary observations suggest for the first time that there is structural similarity of the epithelial dysmorphia in many high-grade invasive tumors irrespective of their parental tissue of origin. This commonality of morphological prints of metastases suggests that common pathways of cytosolic force generation are activated during temporal progression of cancer, resulting in the conserved mushroom-shaped appearance of the dismantling individual cell or cell clusters from the parental epithelium. The conserved genomic mechanisms underlying these fascinating observations merit testing and validation in future studies.
    Language English
    Publishing date 2020-08-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2548989-6
    ISSN 1920-454X ; 1920-454X
    ISSN (online) 1920-454X
    ISSN 1920-454X
    DOI 10.14740/wjon1262
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  2. Article ; Online: In vitro activity of the newly approved antimicrobial agent Cefiderocol against Carbapenem resistant Gram negative clinical isolates.

    Khanchandani, Himanshi / Chaudhury, Madhulika / Rao, M Srihari / Ramakrishna, N / Venkataramana, B / Chaudhury, Abhijit

    Indian journal of medical microbiology

    2024  Volume 48, Page(s) 100556

    Abstract: Introduction: Carbapenem resistant Gram negative bacteria have emerged as priority pathogens in recent years. Cefiderocol is a siderophore cephalosporin licensed in 2019 with claimed activity against ESBL producing and carbapenem resistant bacteria with ...

    Abstract Introduction: Carbapenem resistant Gram negative bacteria have emerged as priority pathogens in recent years. Cefiderocol is a siderophore cephalosporin licensed in 2019 with claimed activity against ESBL producing and carbapenem resistant bacteria with much better safety margin compared to colistin. The present study was undertaken to assess the in vitro activity of cefiderocol against carbapenem resistant clinical isolates, compared to some select antimicrobial agents including colistin.
    Materials and methods: Seventy-seven isolates of Gram negative bacteria belonging to the three commonly encountered groups of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp were included. Susceptibility testing for Cefiderocol was determined by Kirby-Bauer's disk diffusion technique as per CLSI guidelines using Cefiderocol disc (30 μg). Sensitivity for the other agents were determined using automated system.
    Results: Of the 77 isolates, 58.4% belonged to Enterobacterales, followed by P.aeruginosa (27.3%) and Acinetobacter spp (14.3%). Three out of 45 Enterobacterales isolates, one out of 21 P.aeruginosa and none in the Acinetobacter group were found resistant to cefiderocol. All the isolates were intermediate sensitive (I) for colistin since the "susceptible" interpretive category has been eliminated. Tigecycline showed good activity (80.0% sensitive) against Enterobacterales followed by aztreonam (71.1% sensitive).
    Conclusion: Cefiderocol is not yet available in India and our study is possibly the second one from this country demonstrating in vitro resistance to this important antimicrobial agent. However, with a relatively better safety profile compared to colistin, cefiderocol can be an important agent to combat these highly resistant pathogens.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2024.100556
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  3. Article: Could "Low Quality of Life" Rather Than "Significant Symptoms" Be Better Criteria for the Selection of Patients for the Repair of a Giant Hiatus Hernia?

    Elniel, Mohammed / Chaudhury, Madhu / Desai, Nasreen / Lo, Christina / Daté, Ravindra S

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55740

    Abstract: Purpose Giant hiatus hernia (GHH) repair is undertaken electively in symptomatic patients, to prevent complications such as gastric volvulus and subsequent mortality. Advances in laparoscopy and perioperative care have reduced the risk of GHH repair, and ...

    Abstract Purpose Giant hiatus hernia (GHH) repair is undertaken electively in symptomatic patients, to prevent complications such as gastric volvulus and subsequent mortality. Advances in laparoscopy and perioperative care have reduced the risk of GHH repair, and improvement in quality of life (QoL) has become an important outcome measure. In our unit, we have been assessing QoL in all the operated as well as non-operated patients with GHH, using the "Quality of Life in Reflux and Dyspepsia" (QOLRAD) questionnaire. We sought to evaluate differences in QoL between patients who were managed conservatively for GHH and those who underwent GHH repair over a two-year period. Methods All patients seen in the Upper Gastrointestinal Tertiary Unit in Lancashire Teaching Hospitals NHS Trust with GHH between January 2015 and December 2022 were identified from a prospectively kept database. QOLRAD scores were analyzed and compared between conservatively and operatively managed patients using the Mann-Whitney U test. Demographic and operative outcome data were also collected. Results Eighty-seven patients with GHH were included. QoL of 51 patients improved significantly after elective surgery. Five out of 36 patients, who were initially treated conservatively, elected to have repair during their follow-up period. These 5 Patients had a lower initial QOLRAD score in comparison to those whose management remained conservative (2.72 vs 5.05, Mann Whitney U test p=0.034), and their QOLRAD scores also improved significantly after the operation. QOLRAD scores in conservatively managed patients remained stable over a two-year follow-up period. Conclusion Objectively calculated low QoL may be a more useful tool than subjective symptoms in selecting patients for elective repair of GHH.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55740
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  4. Article ; Online: Spectrum of high-resolution computed tomography pattern in lungs in patients with connective tissue disorders.

    Chaudhury, Maheswar / Kishore, E Hari / Lingam, Likhitha / Panda, Adya Kinkar

    Annals of African medicine

    2023  Volume 22, Issue 3, Page(s) 246–251

    Abstract: Background: Connective tissue disease associated with interstitial lung disease, or CT-ILD, is a lung condition that affects a large number of patients with a connective tissue disease.: Objective: Our aim in this study is to correlation between ... ...

    Abstract Background: Connective tissue disease associated with interstitial lung disease, or CT-ILD, is a lung condition that affects a large number of patients with a connective tissue disease.
    Objective: Our aim in this study is to correlation between images of high-resolution computed tomography (HRCT) of different connective tissue diseases associated interstitial lung diseases (CTD-ILDs).
    Methods: We shall be aiming to investigate the feasibility of HRCT imaging and thereby avoid lung biopsy in such patients.
    Results: Rheumatoid arthritis predominantly presented with usual interstitial pneumonia (UIP) (47.8%), followed by nonspecific interstitial pneumonia (NSIP) (30.4%). Mixed connective tissue disorder predominantly presented with NSIP and UIP (42.8%), followed by organizing pneumonia (OP) (14.2%). Systemic lupus erythematosus predominantly presented with UIP (38.8%), followed by NSIP (27.7%). Sjogren's syndrome predominantly presented with lymphocytic interstitial pneumonia (40%), followed by UIP (26.6%). Scleroderma predominantly presented with UIP (45.4%), followed by NSIP (36.4%). Sarcoidosis predominantly presented with UIP (75%), followed by NSIP (25%). Dermatomyositis predominantly presented with NSIP (50%), followed by UIP and OP each (25%).
    Conclusion: Both clinicians and radiologists should be aware of the expected evolution of HRCT changes in a variety of CT-ILDs.
    MeSH term(s) Humans ; Retrospective Studies ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/pathology ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/diagnostic imaging ; Connective Tissue Diseases/pathology ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/complications ; Idiopathic Pulmonary Fibrosis/pathology ; Tomography, X-Ray Computed/methods ; Connective Tissue/pathology
    Language English
    Publishing date 2023-07-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2165792-0
    ISSN 0975-5764 ; 0975-5764
    ISSN (online) 0975-5764
    ISSN 0975-5764
    DOI 10.4103/aam.aam_157_21
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  5. Article: Volatility and expected option returns: A note

    Chaudhury, Mo

    Economics letters. 2017 Mar., v. 152

    2017  

    Abstract: We show analytically that the relationship between asset volatility and expected option return is ambiguous. Numerical results elaborate how the direction and magnitude of the relationship depend on asset beta and volatility levels, and option moneyness ... ...

    Abstract We show analytically that the relationship between asset volatility and expected option return is ambiguous. Numerical results elaborate how the direction and magnitude of the relationship depend on asset beta and volatility levels, and option moneyness and maturity.
    Keywords assets
    Language English
    Dates of publication 2017-03
    Size p. 1-4.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0165-1765
    DOI 10.1016/j.econlet.2016.12.014
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Efficacy of Incisional Ropivacaine Infiltration by Presternal Multi-Orifice Catheter for Post-sternotomy Pain Relief in Pediatric Patients Undergoing Cardiac Surgery: A Prospective, Randomized, Controlled Study.

    Das, Devishree / Chauhan, Sandeep / Gayatri, Sushama / Chaudhury, Minati / Makhija, Neeti / Bisoi, Akshay K

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 11, Page(s) 2282–2288

    Abstract: Objective: To evaluate the efficacy of incisional ropivacaine infiltration by presternal multi-orifice catheter to manage poststernotomy pain in pediatric cardiac surgery.: Design: A prospective, randomized, and double-blind comparative study.: ... ...

    Abstract Objective: To evaluate the efficacy of incisional ropivacaine infiltration by presternal multi-orifice catheter to manage poststernotomy pain in pediatric cardiac surgery.
    Design: A prospective, randomized, and double-blind comparative study.
    Setting: At a single-institution tertiary referral cardiac center.
    Participants: The study comprised 200 children undergoing cardiac surgeries through a midline sternotomy.
    Interventions: Children were allocated randomly to 1 of 3 groups. Group A (n = 65) and group B (n = 64) received 0.375% ropivacaine infusion and intermittent bolus, respectively, by presternal multi-orifice catheter, whereas Group C (n = 64) did not receive any local anesthetic (LA) drug. Postoperatively, intravenous paracetamol was used for multimodal analgesia, and fentanyl was given as rescue analgesia, respectively.
    Measurements and main results: Pain was assessed by a Modified Objective Pain Score (MOPS) for 48 hours postextubation. Group B had significantly lower early MOPS at the first hour, but in the later period, the mean MOPS was lower in group A. The requirement of the first rescue analgesia was 3 ± 1.51, 6.1 ± 2.26, and 2.6 ± 0.87 hours for groups A (n = 60), B (n = 60), and C (n = 60), respectively. The 48-hour fentanyl consumption was significantly lower (p < 0.001) in group A (0.5 ± 0.68 µg/kg) and group B (0.7 ± 0.86 µg/kg) than the control group (3.4 ± 0.68 µg/kg). The length of intensive care unit stay was lower (p < 0.001) in groups A and B than in group C; however, the length of hospital stay was comparable (p = 0.07).
    Conclusion: LA bolus and infusion through presternal multi-orifice catheter provided effective analgesia postoperatively. However, the bolus was more efficacious in the early phase but equivalent in later periods. Therefore, bolus and LA infusion can be used for steady poststernotomy pain relief in children undergoing cardiac surgeries.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.07.007
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  7. Article: How did the financial crisis affect daily stock returns?

    Chaudhury, Mo

    The journal of investing Vol. 23, No. 3 , p. 65-84

    2014  Volume 23, Issue 3, Page(s) 65–84

    Author's details Mo Chaudhury
    Language English
    Size graph. Darst.
    Publisher Institutional Investor
    Publishing place New York, NY
    Document type Article
    ZDB-ID 1359366-3
    ISSN 1068-0896
    Database ECONomics Information System

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  8. Article ; Online: Temporal trends in adults' sports participation patterns in England between 1997 and 2006: the Health Survey for England.

    Stamatakis, E / Chaudhury, M

    British journal of sports medicine

    2008  Volume 42, Issue 11, Page(s) 901–908

    Abstract: Objective: To examine temporal trends in participation in sport and exercise activities in England between 1997 and 2006 while taking into account wider societal changes.: Design: A series of annual cross-sectional surveys.: Setting and ... ...

    Abstract Objective: To examine temporal trends in participation in sport and exercise activities in England between 1997 and 2006 while taking into account wider societal changes.
    Design: A series of annual cross-sectional surveys.
    Setting and participants: Nationally representative samples of men (n = 27 217) and women (n = 33 721) aged >or=16 years.
    Main outcome measures: Any (more than once every 4 weeks) and regular (more than once a week) participation in overall sport and exercise and a number of sport and exercise groupings (eg cycling, swimming, gym and fitness club-based activities (G/FC), racquet sports). Time point (1997/98, 2003/04, 2006) was the main dependent variable.
    Results: Age-standardised overall regular participation changed from 40.8% in 1997/98 to 41.2% in 2006 for men (multivariable-adjusted participation OR = 1.11 in 2006, 95% CI 1.03 to 1.19, p<0.001) and from 31.2% to 33.9% for women (1.21, 1.13 to 1.29, p<0.001). Regular G/FC increased from 17.0% to 19.2% for men (1.19, 1.09 to 1.30) and from 15.9% to 18.7% for women (1.23, 1.14 to 1.33) and regular running increased from 2.4% to 4.0% for women only (1.84, 1.56 to 2.18). Overall increases were apparent only in older adults (>or=45 years) (1.25, 1.16 to 1.35, p<0.001). Young men (16-29 years) had reduced ORs for cycling (0.72, 0.58 to 0.88, p = 0.008), dancing (0.60, 0.45 to 0.82, p = 0.001), running (0.78, 0.64 to 0.94, p<0.001) and racquet sports (0.60, 0.42 to 0.86, p = 0.003). In men, increases were pronounced only among men from non-manual social classes, higher income households and white ethnic backgrounds.
    Conclusions: Sports and exercise participation in England has changed between 1997 and 2006 as the result of increases among middle-aged and older adults and decreases among young men. There are no signs that the participation gap between less and more advantaged population groups is narrowing.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Cross-Sectional Studies ; England/epidemiology ; Exercise ; Female ; Health Behavior ; Health Surveys ; Humans ; Male ; Middle Aged ; Regression Analysis ; Sex Factors ; Socioeconomic Factors ; Sports/statistics & numerical data ; Sports/trends ; Young Adult
    Language English
    Publishing date 2008-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 600592-5
    ISSN 1473-0480 ; 0306-3674
    ISSN (online) 1473-0480
    ISSN 0306-3674
    DOI 10.1136/bjsm.2008.048082
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  9. Article ; Online: Longest delayed hemothorax reported after blunt chest injury.

    Yap, Darren / Ng, Miane / Chaudhury, Madhu / Mbakada, Nik

    The American journal of emergency medicine

    2017  

    Abstract: Introduction: Blunt chest injury is a common presentation to the emergency department. However, a delayed hemothorax after blunt trauma is rare; current literature reports a delay of up to 30days. We present a case of 44-day delay in hemothorax which ... ...

    Abstract Introduction: Blunt chest injury is a common presentation to the emergency department. However, a delayed hemothorax after blunt trauma is rare; current literature reports a delay of up to 30days. We present a case of 44-day delay in hemothorax which has not been previously reported in current literature.
    Case report: A 52-year-old Caucasian male first presented to the emergency department complaining of persistent right sided chest pain 2weeks after having slipped on a wet surface at home. His initial chest X-ray showed fractures of the right 7th and 8th ribs without a hemothorax or pneumothorax. He returned 30days after the initial consultation (44days post-trauma) having increasing shortness of breath. A chest X-ray this time revealed a large right hemothorax and 1850ml of blood drained from his chest. There was a complete resolution of the hemothorax within 48h and the patient was discharged after a 6-week follow-up with the chest physicians.
    Discussion: Delayed hemothorax after blunt trauma is a rare clinical occurrence but associated with significant morbidity and mortality. The management of delayed hemothorax includes draining the hemothorax and controlling the bleeding. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Emergency physicians should be vigilant and weary that hemothorax could be a possibility after a chest injury despite a delay in presentation. A knowledge of delayed hemothorax will prompt physicians in providing important advice, warning signs and information to patients after a chest injury to avoid a delay in seeking medical attention.
    Language English
    Publishing date 2017-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2017.10.025
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  10. Article ; Online: Physical and Physiological Factors Influence Behavioral Responses of Cochliomyia macellaria (Diptera: Calliphoridae) to Synthetic Attractants.

    Chaudhury, M F / Zhu, J J / Skoda, S R

    Journal of economic entomology

    2017  Volume 110, Issue 4, Page(s) 1929–1934

    Abstract: Volatile chemicals from waste artificial larval media as well as from bovine blood inoculated with bacteria isolated from screwworm-infested wounds attract gravid females of Cochliomyia hominivorax Coquerel and Cochliomyia macellaria (F.). Chemicals ... ...

    Abstract Volatile chemicals from waste artificial larval media as well as from bovine blood inoculated with bacteria isolated from screwworm-infested wounds attract gravid females of Cochliomyia hominivorax Coquerel and Cochliomyia macellaria (F.). Chemicals identified from volatiles are dimethyl disulfide, dimethyl trisulfide, phenol, p-cresol, and indole; a blend of these attracted females to oviposit. Present studies investigated the effectiveness of these compounds, either in a blend or individually as potential oviposition attractants. Tests were conducted to determine the effects of gender, ovarian age, and the color and type of substrates on attraction response and oviposition of C. macellaria adults. Results showed that substrates treated with dimethyl trisulfide (DMTS) alone or the five-compound blend alone attracted significantly more gravid females than other chemicals. Black substrates treated with DMTS attracted more gravid flies than did the yellow substrates. Yellow substrates treated with indole attracted more males and nongravid females. In oviposition tests, females deposited significantly more eggs on meat-based substrates than those without meat. These findings suggest that several factors have to be considered for developing an effective oviposition attractant that should include effectiveness of individual chemicals used, the ratio of the chemicals in a blend, and their concentrations. Also, an effective trap design will need to consider using suitable color which will selectively attract gravid females.
    MeSH term(s) Age Factors ; Animals ; Chemotaxis ; Diptera/physiology ; Female ; Male ; Oviposition/drug effects ; Pheromones/pharmacology ; Sex Factors
    Chemical Substances Pheromones ; insect attractants
    Language English
    Publishing date 2017-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3031-4
    ISSN 1938-291X ; 0022-0493
    ISSN (online) 1938-291X
    ISSN 0022-0493
    DOI 10.1093/jee/tox145
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