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  1. Article: Role of CDK4/6 inhibitors in targeting Rb proficient small cell lung cancer.

    Corbett, Virginia / Sen, Triparna / Chauhan, Aman

    Translational lung cancer research

    2024  Volume 13, Issue 1, Page(s) 190–194

    Language English
    Publishing date 2024-01-18
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Review of practice informing data and current state of NCCN consensus guidelines in hepatobiliary cancers.

    Corbett, Virginia / Li, Daneng / Chauhan, Aman

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 5, Page(s) 798–803

    Language English
    Publishing date 2023-09-18
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Leveraging Programmatic Collaboration for a Radiopharmaceutical Clinic.

    Kunos, Charles A / Martin, Molly E / Georgiou, Michalis F / Kuker, Russ A / Chauhan, Aman

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the ... ...

    Abstract Radiation oncologists, radiopharmacists, nuclear medicine physicians, and medical oncologists have seen a renewed clinical interest in radiopharmaceuticals for the curative or the palliative treatment of cancer. To allow for the discovery and the clinical advancement of targeted radiopharmaceuticals, these stakeholders have reformed their trial efforts and remodeled their facilities to accommodate the obligations of a program centered upon radioactive investigational drug products. Now considered informally as drugs and not beam radiotherapy, radiopharmaceuticals can be more easily studied in the traditional clinical trial enterprise ranging from phase 0-I to phase III studies. Resources and physical facilities allocated to radiopharmaceuticals have brought forth new logistics and patient experience for safe and satisfactory drug delivery. The clinical use of theranostic agents-that is, diagnostic and therapeutic radionuclide pairs-has accelerated radiopharmaceutical development.
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071396
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  4. Article ; Online: TEM8 in Oncogenesis: Protein Biology, Pre-Clinical Agents, and Clinical Rationale.

    Kareff, Samuel A / Corbett, Virginia / Hallenbeck, Paul / Chauhan, Aman

    Cells

    2023  Volume 12, Issue 22

    Abstract: The TEM8 protein represents an emerging biomarker in many solid tumor histologies. Given the various roles it plays in oncogenesis, including but not limited to angiogenesis, epithelial-to-mesenchymal transition, and cell migration, TEM8 has recently ... ...

    Abstract The TEM8 protein represents an emerging biomarker in many solid tumor histologies. Given the various roles it plays in oncogenesis, including but not limited to angiogenesis, epithelial-to-mesenchymal transition, and cell migration, TEM8 has recently served and will continue to serve as the target of novel oncologic therapies. We review herein the role of TEM8 in oncogenesis. We review its normal function, highlight the additional roles it plays in the tumor microenvironment, and synthesize pre-clinical and clinical data currently available. We underline the protein's prognostic and predictive abilities in various solid tumors by (1) highlighting its association with more aggressive disease biology and poor clinical outcomes and (2) assessing its associated clinical trial landscape. Finally, we offer future directions for clinical studies involving TEM8, including incorporating pre-clinical agents into clinical trials and combining previously tested oncologic therapies with currently available treatments, such as immunotherapy.
    MeSH term(s) Humans ; Receptors, Cell Surface/metabolism ; Neoplasm Proteins/metabolism ; Microfilament Proteins ; Neoplasms/therapy ; Cell Transformation, Neoplastic ; Carcinogenesis ; Biology ; Tumor Microenvironment
    Chemical Substances Receptors, Cell Surface ; Neoplasm Proteins ; Microfilament Proteins
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12222623
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  5. Article ; Online: Comments on: Comparison of the effectiveness of amblyopia treatment with eye-patch and binocular Occlu-tab for the same treatment duration.

    Sapra, Himanshu / Chauhan, Aman / Sutar, Samir / Chaurasiya, Ritesh Kumar

    Indian journal of ophthalmology

    2023  Volume 71, Issue 5, Page(s) 2321–2322

    MeSH term(s) Humans ; Amblyopia/therapy ; Duration of Therapy ; Visual Acuity ; Treatment Outcome ; Vision, Binocular
    Language English
    Publishing date 2023-05-18
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_3297_22
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 329: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 598: Show issues

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  6. Article: Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics.

    Corbett, Virginia / Hallenbeck, Paul / Rychahou, Piotr / Chauhan, Aman

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 930207

    Abstract: Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators. Oncolytic viruses (OV) are an ... ...

    Abstract Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators. Oncolytic viruses (OV) are an integral pillar of immuno-oncology and hold potential for not only delivering durable anti-tumor responses but also converting "cold" tumors to "hot" tumors. In this review we will discuss one such promising oncolytic virus called Seneca Valley Virus (SVV-001) and its therapeutic implications. SVV development has seen seismic evolution over the past decade and now boasts of being the only OV with a practically applicable biomarker for viral tropism. We discuss relevant preclinical and clinical data involving SVV and how bio-selecting for TEM8/ANTXR1, a negative tumor prognosticator can lead to first of its kind biomarker driven oncolytic viral cancer therapy.
    Language English
    Publishing date 2022-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.930207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pediatric Neuroendocrine Neoplasms: Rare Malignancies with Incredible Variability.

    Castle, Jennifer T / Levy, Brittany E / Chauhan, Aman

    Cancers

    2022  Volume 14, Issue 20

    Abstract: Neuroendocrine neoplasms (NENs) encompass a variety of neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) which can arise anywhere in the body. While relatively rare in the pediatric population, the incidence of NENs has increased in the ... ...

    Abstract Neuroendocrine neoplasms (NENs) encompass a variety of neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) which can arise anywhere in the body. While relatively rare in the pediatric population, the incidence of NENs has increased in the past few decades. These neoplasms can be devastating if not diagnosed and treated early, however, symptoms are variable and can be indolent for many years. There is a reported median of 10 years from the appearance of the first symptoms to time of diagnosis. Considering some of these neoplasms have a mortality rate as high as 90%, it is crucial healthcare providers are aware of NENs and remain vigilant. With better provider education and easily accessible resources for information about these neoplasms, awareness can be improved leading to earlier disease recognition and diagnosis. This manuscript aims to provide an overview of both the most common NENs as well as the rarer NENs with high lethality in the pediatric population. This review provides up to date evidence and recommendations, encompassing recent changes in classification and advances in treatment modalities, including recently completed and ongoing clinical trials.
    Language English
    Publishing date 2022-10-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14205049
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  8. Article: Comprehensive Assessment of Somatostatin Receptors in Various Neoplasms: A Systematic Review.

    Priyadarshini, Shista / Allison, Derek B / Chauhan, Aman

    Pharmaceutics

    2022  Volume 14, Issue 7

    Abstract: Somatostatin receptors (SSTR) are expressed in various neoplasms and can be targeted for both diagnostics as well as therapeutics. This systematic review aims to compile and discuss the prevalence of somatostatin receptor expression in various neoplasms. ...

    Abstract Somatostatin receptors (SSTR) are expressed in various neoplasms and can be targeted for both diagnostics as well as therapeutics. This systematic review aims to compile and discuss the prevalence of somatostatin receptor expression in various neoplasms. We performed a literature search from Google Scholar and PubMed using relevant keywords to look for all publicly available data regarding SSTR expression in various cancers. Both histopathological and radiographical studies were included for SSTR assessment. We found that many cancers express SSTR with varying prevalence. SSTR is now a well-established theranostics biomarker. We now have highly sensitive and specific diagnostic modalities like gallium 68 DOTATATE and copper 64 DOTATATE scans to screen for SSTR-2 and then target it therapeutically with lutetium 177 DOTATATE. A thorough understanding of SSTR expression in other tumors will open the channels for exploring potential SSTR targeting.
    Language English
    Publishing date 2022-07-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14071394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical Application of Oncolytic Viruses: A Systematic Review.

    Cook, Mary / Chauhan, Aman

    International journal of molecular sciences

    2020  Volume 21, Issue 20

    Abstract: Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons. However, it was not until the introduction of immune checkpoint inhibitors that we realized the ... ...

    Abstract Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons. However, it was not until the introduction of immune checkpoint inhibitors that we realized the true potential of immunotherapy in combating cancer. Oncolytic viruses are one such immunotherapeutic tool that is currently being explored in cancer therapeutics. We present the most comprehensive systematic review of all oncolytic viruses in Phase 1, 2, and 3 clinical trials published to date. We performed a systematic review of all published clinical trials indexed in PubMed that utilized oncolytic viruses. Trials were reviewed for type of oncolytic virus used, method of administration, study design, disease type, primary outcome, and relevant adverse effects. A total of 120 trials were found; 86 trials were available for our review. Included were 60 phase I trials, five phase I/II combination trials, 19 phase II trials, and two phase III clinical trials. Oncolytic viruses are feverously being evaluated in oncology with over 30 different types of oncolytic viruses being explored either as a single agent or in combination with other antitumor agents. To date, only one oncolytic virus therapy has received an FDA approval but advances in bioengineering techniques and our understanding of immunomodulation to heighten oncolytic virus replication and improve tumor kill raises optimism for its future drug development.
    MeSH term(s) Clinical Trials as Topic ; Combined Modality Therapy/methods ; Disease Management ; Gene Transfer Techniques ; Genetic Vectors/genetics ; Humans ; Neoplasms/etiology ; Neoplasms/therapy ; Oncolytic Virotherapy/adverse effects ; Oncolytic Virotherapy/methods ; Oncolytic Viruses/classification ; Oncolytic Viruses/genetics ; Treatment Outcome
    Language English
    Publishing date 2020-10-12
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21207505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cellulose/chitosan/g-C3N4 nano-architectured films for visible light induced photocatalytic removal of methylene blue and Cr (VI) from water

    Chauhan, Aman / Negi, Archana / Kashyap, Rajiv / Sharma, Bunty / Sharma, Ramesh K. / Chaudhary, Ganga Ram

    Industrial Crops & Products. 2023 Oct., v. 202 p.117113-

    2023  

    Abstract: The adverse impact of aggravating water pollution levels has exponentially trickled down to each and every component of the biosphere. The engineering of naturally occurring materials such as biopolymers has become an attractive solution for wastewater ... ...

    Abstract The adverse impact of aggravating water pollution levels has exponentially trickled down to each and every component of the biosphere. The engineering of naturally occurring materials such as biopolymers has become an attractive solution for wastewater treatment. In this work, we have fabricated cellulose-based films hybridized with chitosan and g-C₃N₄ for visible light-induced removal of methylene blue and Cr (VI) ions from water. FE-SEM and X-ray diffraction data revealed a strong association of g-C₃N₄ in the cellulose chitosan network. The high porosity and specific surface area of cellulose and chitosan in the g-C₃N₄ network led to an increase in both its adsorption and degradation efficiency. The maximum efficiency of 98% and 96% for both methylene blue photooxidation and Cr (VI) photoreduction process, respectively was observed with the formulation containing 50 wt% g-C₃N₄. In addition to that, films retained their activity for 5 consecutive cycles showing their high reusability potential. Besides, the proposed films also showed excellent antibacterial properties towards S. aureus bacteria. Therefore, looking at the magnificent green, cost-effective, and simple operational nature of the films, it is anticipated that these films will play a key role in various wastewater treatment technologies.
    Keywords X-ray diffraction ; adsorption ; biopolymers ; biosphere ; cellulose ; chitosan ; cost effectiveness ; light ; methylene blue ; photocatalysis ; photooxidation ; photoreduction ; porosity ; surface area ; wastewater treatment ; water pollution ; Nanomaterials ; Catalytic film ; Environmental applications
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2023.117113
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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