Article ; Online: Preclinical pharmacokinetic exploration of a novel osteoporotic quinazolinone-benzopyran-indole hybrid (S019-0385) using LC-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems
2023 Volume 53, Issue 6-7, Page(s) 484–497
Abstract: 1. The current investigation was to develop and validate the LC-MS/MS method in order to analyse the various pharmacokinetic parameters of S019-0385. A sensitive, selective, and robust LC-MS/MS approach was established and validated for measuring S019- ... ...
| Abstract | 1. The current investigation was to develop and validate the LC-MS/MS method in order to analyse the various pharmacokinetic parameters of S019-0385. A sensitive, selective, and robust LC-MS/MS approach was established and validated for measuring S019-0385 in female mice plasma and tissue, using optimal multiple reaction monitoring (MRM) transition |
|---|---|
| MeSH term(s) | Humans ; Mice ; Female ; Animals ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Tissue Distribution ; Biological Availability ; Feces ; Reproducibility of Results |
| Language | English |
| Publishing date | 2023-11-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 120287-x |
| ISSN | 1366-5928 ; 0049-8254 |
| ISSN (online) | 1366-5928 |
| ISSN | 0049-8254 |
| DOI | 10.1080/00498254.2023.2265475 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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