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  1. Article: Severe acute respiratory distress syndrome: Does ECMO have a role?

    Chauhan, Sandeep

    The National medical journal of India

    2019  Volume 31, Issue 5, Page(s) 287–288

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Respiratory Distress Syndrome, Adult
    Language English
    Publishing date 2019-08-21
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.4103/0970-258X.261184
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2493: Show issues Location:
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  2. Article ; Online: Atrioventricular septal defects.

    Chauhan, Sandeep

    Annals of cardiac anaesthesia

    2018  Volume 21, Issue 1, Page(s) 1–3

    MeSH term(s) Cardiac Surgical Procedures/methods ; Cardiac Surgical Procedures/mortality ; Heart Septal Defects/mortality ; Heart Septal Defects/surgery ; Humans
    Language English
    Publishing date 2018-01-16
    Publishing country India
    Document type Editorial
    ZDB-ID 2106866-5
    ISSN 0974-5181 ; 0971-9784
    ISSN (online) 0974-5181
    ISSN 0971-9784
    DOI 10.4103/aca.ACA_219_17
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  3. Article ; Online: Cellulose nanocrystals based delivery vehicles for anticancer agent curcumin.

    Kumar, Rajesh / Chauhan, Sandeep

    International journal of biological macromolecules

    2022  Volume 221, Page(s) 842–864

    Abstract: Cancer is a complex disease that starts with genetic alterations and mutations in healthy cells. The past decade has witnessed a huge demand for new biocompatibility and high-performance intelligent drug delivery systems. Curcumin (CUR) is a bioactive ... ...

    Abstract Cancer is a complex disease that starts with genetic alterations and mutations in healthy cells. The past decade has witnessed a huge demand for new biocompatibility and high-performance intelligent drug delivery systems. Curcumin (CUR) is a bioactive stimulant with numerous medical benefits. However, because of its hydrophobic nature, it has low bioavailability. The utilization of many biobased materials has been found to improve the loading of hydrophobic drugs. Cellulose nanocrystals (CNCs) with exceptional qualities and a wide range of applications, feature strong hydrophilicity and lipophilicity, great emulsification stability, high crystallinity and outstanding mechanical attributes. In this review, numerous CNCs-based composites have been evaluated for involvement in the controlled release of CUR. The first part of the review deals with recent advancements in the extraction of CNCs from lignocellulose biomass. The second elaborates some recent developments in the post-processing of CNCs in conjunction with other materials like natural polymers, synthetic polymers, β-CD, and surfactants for CUR loading/encapsulation and controlled release. Furthermore, numerous CUR drug delivery systems, challenges, and techniques for effective loading/encapsulation of CUR on CNCs-based composites have been presented. Finally, conclusions and future outlooks are also explored.
    MeSH term(s) Cellulose/chemistry ; Curcumin ; Delayed-Action Preparations ; Nanoparticles/chemistry ; Polymers/chemistry ; Antineoplastic Agents ; Excipients
    Chemical Substances Cellulose (9004-34-6) ; Curcumin (IT942ZTH98) ; Delayed-Action Preparations ; Polymers ; Antineoplastic Agents ; Excipients
    Language English
    Publishing date 2022-09-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.09.077
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  4. Article: Cellulose nanocrystals based delivery vehicles for anticancer agent curcumin

    Kumar, Rajesh / Chauhan, Sandeep

    International journal of biological macromolecules. 2022 Nov. 30, v. 221

    2022  

    Abstract: Cancer is a complex disease that starts with genetic alterations and mutations in healthy cells. The past decade has witnessed a huge demand for new biocompatibility and high-performance intelligent drug delivery systems. Curcumin (CUR) is a bioactive ... ...

    Abstract Cancer is a complex disease that starts with genetic alterations and mutations in healthy cells. The past decade has witnessed a huge demand for new biocompatibility and high-performance intelligent drug delivery systems. Curcumin (CUR) is a bioactive stimulant with numerous medical benefits. However, because of its hydrophobic nature, it has low bioavailability. The utilization of many biobased materials has been found to improve the loading of hydrophobic drugs. Cellulose nanocrystals (CNCs) with exceptional qualities and a wide range of applications, feature strong hydrophilicity and lipophilicity, great emulsification stability, high crystallinity and outstanding mechanical attributes. In this review, numerous CNCs-based composites have been evaluated for involvement in the controlled release of CUR. The first part of the review deals with recent advancements in the extraction of CNCs from lignocellulose biomass. The second elaborates some recent developments in the post-processing of CNCs in conjunction with other materials like natural polymers, synthetic polymers, β-CD, and surfactants for CUR loading/encapsulation and controlled release. Furthermore, numerous CUR drug delivery systems, challenges, and techniques for effective loading/encapsulation of CUR on CNCs-based composites have been presented. Finally, conclusions and future outlooks are also explored.
    Keywords antineoplastic agents ; bioavailability ; biocompatibility ; biomass ; cellulose ; crystal structure ; curcumin ; emulsifying ; encapsulation ; hydrophilicity ; hydrophobicity ; lignocellulose ; lipophilicity ; nanocrystals
    Language English
    Dates of publication 2022-1130
    Size p. 842-864.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2022.09.077
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  5. Article ; Online: A two-in-one thiosemicarbazide and whole pine needle-based adsorbent for rapid and efficient adsorption of methylene blue dye and mercuric ions.

    Kumari, Babita / Chauhan, Sandeep / Chauhan, Ghanshyam S / Kumar, Kiran / Jamwal, Pooja / Ranote, Sunita

    Environmental science and pollution research international

    2024  Volume 31, Issue 14, Page(s) 21591–21609

    Abstract: Herein, we report the synthesis of an oxidized pine needle-thiosemicarbazone Schiff base (OPN-TSC) from whole pine needles (WPN) as a dual-purpose adsorbent to remove a cationic dye, methylene blue (MB), and ... ...

    Abstract Herein, we report the synthesis of an oxidized pine needle-thiosemicarbazone Schiff base (OPN-TSC) from whole pine needles (WPN) as a dual-purpose adsorbent to remove a cationic dye, methylene blue (MB), and Hg
    MeSH term(s) Coloring Agents ; Methylene Blue ; Adsorption ; Mercury ; Water Pollutants, Chemical ; Ions ; Semicarbazides
    Chemical Substances Coloring Agents ; Methylene Blue (T42P99266K) ; thiosemicarbazide (6056O8W6ET) ; Mercury (FXS1BY2PGL) ; Water Pollutants, Chemical ; Ions ; Semicarbazides
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32446-3
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    Z 5915: Show issues

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  6. Article ; Online: KMnO₄-oxidized whole pine needle based adsorbent for selective and efficient removal of cationic dyes

    Babitā Kumārī / Chauhan, Ghanshyam S. / Ranote, Sunita / Jamwal, Pooja / Kumar, Rajesh / Kumar, Kiran / Chauhan, Sandeep

    International Journal of Phytoremediation. 2024 Jan. 28, v. 26, no. 2, p. 178-192

    2024  , Page(s) 178–192

    Abstract: In the present study, we report the chemical modification of the dried and fallen pine needles (PNs) via a simple protocol using KMnO₄ oxidation. The oxidized PNs (OPNs) were evaluated as adsorbents using some cationic and anionic dyes. The successful ... ...

    Abstract In the present study, we report the chemical modification of the dried and fallen pine needles (PNs) via a simple protocol using KMnO₄ oxidation. The oxidized PNs (OPNs) were evaluated as adsorbents using some cationic and anionic dyes. The successful synthesis of OPNs adsorbent was characterized by various techniques to ascertain its structural attributes. The adsorbent showed selectivity for the cationic dyes with 96.11% removal (P ᵣ) for malachite green (MG) and 89.68% P ᵣ for methylene blue (MB) in 120 min. Kinetic models namely, pseudo-first order, pseudo-second order, and Elovich were applied to have insight into adsorption. Additionally, three adsorption isotherms, i.e., Langmuir, Freundlich, and Temkin were also applied. The dye adsorption followed a pseudo-second-order kinetic model with R ² > 0.99912 for MG and R ² > 0.9998 for MB. The adsorbent followed the Langmuir model with a maximum adsorption capacity (q ₘ) of 223.2 mg/g and 156.9 mg/g for MG and MB, respectively. Furthermore, the OPNs showed remarkable regeneration and recyclability up to nine adsorption-desorption cycles with appreciable adsorption for both the dyes. The use of OPNs as an adsorbent for the removal of dyes from wastewater, therefore, provides an ecologically benign, low-cost, and sustainable solution.
    Keywords adsorbents ; adsorption ; conifer needles ; kinetics ; malachite green ; methylene blue ; oxidation ; phytoremediation ; sorption isotherms ; wastewater ; Dye ; KMnO4 ; Lignocellulosic biomass ; reusability ; wastewater treatment
    Language English
    Dates of publication 2024-0128
    Size p. 178-192
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2055357-2
    ISSN 1549-7879 ; 1522-6514
    ISSN (online) 1549-7879
    ISSN 1522-6514
    DOI 10.1080/15226514.2023.2231555
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    In stock of ZB MED Bonn / Germany

    Z 7638: Show issues

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  7. Article ; Online: Comparison of tranexamic acid with aprotinin in pediatric cardiac surgery.

    Chauhan, Sandeep

    Annals of cardiac anaesthesia

    2015  Volume 18, Issue 1, Page(s) 27–28

    MeSH term(s) Antifibrinolytic Agents/adverse effects ; Antifibrinolytic Agents/therapeutic use ; Aprotinin/adverse effects ; Aprotinin/therapeutic use ; Blood Coagulation Disorders/prevention & control ; Cardiac Surgical Procedures/methods ; Female ; Humans ; Male ; Postoperative Hemorrhage/prevention & control ; Tranexamic Acid/adverse effects ; Tranexamic Acid/therapeutic use
    Chemical Substances Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1) ; Aprotinin (9087-70-1)
    Language English
    Publishing date 2015-01
    Publishing country India
    Document type Comment ; Journal Article
    ZDB-ID 2106866-5
    ISSN 0974-5181 ; 0971-9784
    ISSN (online) 0974-5181
    ISSN 0971-9784
    DOI 10.4103/0971-9784.148317
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  8. Article ; Online: Comparison of Left Ventricular Global Longitudinal Strain with Ejection Fraction as a Predictor for Peri-operative IABP Insertion in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A Pilot Study.

    Kumar, Sanjeev / Malik, Vishwas / Chauhan, Sandeep / Das, Devishree / Hote, Milind P / Devagourou, V

    Annals of cardiac anaesthesia

    2023  Volume 26, Issue 3, Page(s) 295–302

    Abstract: Background: Prophylactic use of intra-aortic balloon pump (IABP) mainly depends on left ventricular (LV) systolic function. Global longitudinal strain (GLS) is a robust prognostic parameter for LV strain. It has proved to be more sensitive than LV ... ...

    Abstract Background: Prophylactic use of intra-aortic balloon pump (IABP) mainly depends on left ventricular (LV) systolic function. Global longitudinal strain (GLS) is a robust prognostic parameter for LV strain. It has proved to be more sensitive than LV ejection fraction (EF) as a measure of LV systolic function and is a strong predictor of outcome.
    Aim: To determine whether GLS can be used as a reliable marker and its cut-off value for IABP insertion in patients undergoing elective off-pump coronary artery bypass grafting (OPCABG).
    Settings and design: A prospective observational clinical study which included 100 adult patients scheduled for elective OPCABG.
    Materials and methods: Two-dimensional (2D) speckle tracking echocardiography (STE)-estimated GLS was computed and compared with LV EF measured by three dimensional (3D) echocardiography for the insertion of IABP. The intensive care unit (ICU) parameters were correlated with echocardiographic parameters to predict early post-operative outcome.
    Results: IABP insertion correlates better with GLS (post-revascularization > pre-revascularization) than with 3D LV EF. Receiver operating characteristic (ROC) curve analysis revealed the highest area under the curve (AUC, 0.972) with a cut-off value of > -9.8% for GLS compared to 3D LV EF (AUC, 0.938) with a cut-off value of ≤ 44%. ICU parameters show better correlation with E/e'> GLS > WMSI than 3D LV EF.
    Conclusion: GLS is a better predictor of IABP insertion compared to 3D LV EF in patients undergoing OPCABG.
    MeSH term(s) Adult ; Humans ; Coronary Artery Bypass, Off-Pump ; Global Longitudinal Strain ; Pilot Projects ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Function, Left ; Prospective Studies
    Language English
    Publishing date 2023-07-20
    Publishing country India
    Document type Observational Study ; Journal Article
    ZDB-ID 2106866-5
    ISSN 0974-5181 ; 0971-9784
    ISSN (online) 0974-5181
    ISSN 0971-9784
    DOI 10.4103/aca.aca_144_22
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  9. Article ; Online: Ventricular assist devices.

    Chauhan, Sandeep

    Annals of cardiac anaesthesia

    2013  Volume 16, Issue 4, Page(s) 257–258

    MeSH term(s) Anesthesia ; Endoscopy, Gastrointestinal ; Female ; Heart-Assist Devices ; Humans ; Male
    Language English
    Publishing date 2013-10
    Publishing country India
    Document type Comment ; Journal Article
    ZDB-ID 2106866-5
    ISSN 0974-5181 ; 0971-9784
    ISSN (online) 0974-5181
    ISSN 0971-9784
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  10. Article ; Online: Efficacy of Incisional Ropivacaine Infiltration by Presternal Multi-Orifice Catheter for Post-sternotomy Pain Relief in Pediatric Patients Undergoing Cardiac Surgery: A Prospective, Randomized, Controlled Study.

    Das, Devishree / Chauhan, Sandeep / Gayatri, Sushama / Chaudhury, Minati / Makhija, Neeti / Bisoi, Akshay K

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 11, Page(s) 2282–2288

    Abstract: Objective: To evaluate the efficacy of incisional ropivacaine infiltration by presternal multi-orifice catheter to manage poststernotomy pain in pediatric cardiac surgery.: Design: A prospective, randomized, and double-blind comparative study.: ... ...

    Abstract Objective: To evaluate the efficacy of incisional ropivacaine infiltration by presternal multi-orifice catheter to manage poststernotomy pain in pediatric cardiac surgery.
    Design: A prospective, randomized, and double-blind comparative study.
    Setting: At a single-institution tertiary referral cardiac center.
    Participants: The study comprised 200 children undergoing cardiac surgeries through a midline sternotomy.
    Interventions: Children were allocated randomly to 1 of 3 groups. Group A (n = 65) and group B (n = 64) received 0.375% ropivacaine infusion and intermittent bolus, respectively, by presternal multi-orifice catheter, whereas Group C (n = 64) did not receive any local anesthetic (LA) drug. Postoperatively, intravenous paracetamol was used for multimodal analgesia, and fentanyl was given as rescue analgesia, respectively.
    Measurements and main results: Pain was assessed by a Modified Objective Pain Score (MOPS) for 48 hours postextubation. Group B had significantly lower early MOPS at the first hour, but in the later period, the mean MOPS was lower in group A. The requirement of the first rescue analgesia was 3 ± 1.51, 6.1 ± 2.26, and 2.6 ± 0.87 hours for groups A (n = 60), B (n = 60), and C (n = 60), respectively. The 48-hour fentanyl consumption was significantly lower (p < 0.001) in group A (0.5 ± 0.68 µg/kg) and group B (0.7 ± 0.86 µg/kg) than the control group (3.4 ± 0.68 µg/kg). The length of intensive care unit stay was lower (p < 0.001) in groups A and B than in group C; however, the length of hospital stay was comparable (p = 0.07).
    Conclusion: LA bolus and infusion through presternal multi-orifice catheter provided effective analgesia postoperatively. However, the bolus was more efficacious in the early phase but equivalent in later periods. Therefore, bolus and LA infusion can be used for steady poststernotomy pain relief in children undergoing cardiac surgeries.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.07.007
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    Zs.MO 31: Show issues

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