LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 27

Search options

  1. Article ; Online: Daratumumab combinations for patients with newly diagnosed and relapsed multiple myeloma.

    Popat, Rakesh / Chavda, Selina J

    The Lancet. Haematology

    2023  Volume 10, Issue 10, Page(s) e788–e789

    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Dexamethasone/therapeutic use ; Patients ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances daratumumab (4Z63YK6E0E) ; Antibodies, Monoclonal ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(23)00244-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Co-operation of MCL-1 and BCL-X

    Galas-Filipowicz, Daria / Chavda, Selina J / Gong, Jia-Nan / Huang, David C S / Khwaja, Asim / Yong, Kwee

    Frontiers in oncology

    2024  Volume 14, Page(s) 1394393

    Abstract: Introduction: BCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We ... ...

    Abstract Introduction: BCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We examined the function of BCL-2 family proteins in stromal-mediated resistance to carfilzomib-induced cytotoxicity in MM cells.
    Methods: Co-cultures employing HS5 stromal cells were used to model the interaction with stroma. MM cells were exposed to CFZ in a 1-hour pulse method. The expression of BCL-2 family proteins was assessed by flow cytometry and WB. Pro-survival proteins: MCL-1, BCL-2 and BCL-X
    Results: CFZ induced dose-dependent cell death of MM cells, primarily mediated by apoptosis. Culture of MM cells on HS-5 stromal cells resulted in reduced cytotoxicity to CFZ in a cell contact-dependent manner, upregulated expression of MCL-1 and increased dependency on BCL-X
    Conclusion: Stromal interactions alter the dependence on BCL-2 family members, providing a rationale for dual inhibition to abrogate the protective effect of stroma and restore sensitivity to CFZ.
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1394393
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Interesting case of lymphocytosis and splenomegaly.

    Chavda, Selina J / Dearden, Claire

    BMJ (Clinical research ed.)

    2016  Volume 352, Page(s) i1227

    MeSH term(s) Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cladribine/administration & dosage ; Diagnosis, Differential ; Female ; Humans ; Leukemia, Hairy Cell/blood ; Leukemia, Hairy Cell/complications ; Leukemia, Hairy Cell/diagnosis ; Leukemia, Hairy Cell/drug therapy ; Leukemia, Hairy Cell/immunology ; Lymphocytosis/blood ; Lymphocytosis/complications ; Lymphocytosis/diagnosis ; Lymphocytosis/drug therapy ; Lymphocytosis/etiology ; Lymphocytosis/immunology ; Rituximab/administration & dosage ; Splenomegaly/diagnosis ; Splenomegaly/drug therapy ; Splenomegaly/etiology ; Splenomegaly/immunology ; Treatment Outcome
    Chemical Substances Cladribine (47M74X9YT5) ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2016-03-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.i1227
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Ascites.

    Chavda, Selina J / Bloom, Stuart L

    British journal of hospital medicine (London, England : 2005)

    2015  Volume 76, Issue 2, Page(s) C23–7

    MeSH term(s) Ascites/diagnosis ; Ascites/etiology ; Ascites/therapy ; Drainage ; Heart Failure/complications ; Humans ; Liver Cirrhosis/complications ; Neoplasms/complications ; Physical Examination/methods ; Portasystemic Shunt, Transjugular Intrahepatic ; Sodium Potassium Chloride Symporter Inhibitors/therapeutic use
    Chemical Substances Sodium Potassium Chloride Symporter Inhibitors
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2015.76.2.C23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: A young woman with fever and loss of consciousness.

    Chavda, Selina J / Pickard, Lucy / Thomas, Alison / Uprichard, James

    BMJ (Clinical research ed.)

    2018  Volume 363, Page(s) k4363

    MeSH term(s) Diagnosis, Differential ; Female ; Fever/diagnosis ; Humans ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Unconsciousness/diagnosis ; Young Adult
    Language English
    Publishing date 2018-12-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k4363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Applying current smouldering myeloma risk models to a UK single-centre cohort and clinical features at progression.

    Ainley, Louise / Camilleri, Marquita / Chavda, Selina J / McMillan, Annabel / Lee, Lydia / Popat, Rakesh / Sillito, Francesca / Yong, Kwee

    British journal of haematology

    2021  Volume 196, Issue 6, Page(s) e63–e66

    MeSH term(s) Cohort Studies ; Disease Progression ; Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/therapy ; Smoldering Multiple Myeloma ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17969
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Bruising and abnormal leucocytes on a blood film--a haematological emergency.

    Chavda, Selina J / Lindsay, Sophie / Willis, Fenella / Koh, Mickey

    BMJ (Clinical research ed.)

    2017  Volume 356, Page(s) j1164

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Arsenicals/administration & dosage ; Contusions/etiology ; Contusions/pathology ; Gingival Hemorrhage/etiology ; Gingival Hemorrhage/pathology ; Humans ; Lethargy/etiology ; Lethargy/pathology ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/pathology ; Leukocytes/pathology ; Male ; Oxides/administration & dosage ; Tretinoin/administration & dosage ; Young Adult
    Chemical Substances Arsenicals ; Oxides ; Tretinoin (5688UTC01R) ; arsenic trioxide (S7V92P67HO)
    Language English
    Publishing date 2017--23
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.j1164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Salvage second autologous stem cell transplant for relapsed multiple myeloma in the novel agent era benefits a subset of patients: single-center UK experience.

    Richards, Huw / Chavda, Selina J / Wilson, William / Camilleri, Marquita / Cohen, Oliver / Horder, Jackie / Newrick, Fiona / Papanikolaou, Xenofon / Sive, Jonathan / Lee, Lydia / Popat, Rakesh / Wechalekar, Ashutosh / Kyriakou, Charalampia / Yong, Kwee / Rabin, Neil

    Leukemia & lymphoma

    2021  Volume 62, Issue 14, Page(s) 3544–3547

    MeSH term(s) Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Multiple Myeloma/therapy ; Neoplasm Recurrence, Local/therapy ; Retrospective Studies ; Salvage Therapy ; Transplantation, Autologous ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1961240
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: The hands-on guide to the Foundation Programme

    Donald, Anna / Stein, Michael / Hill, Ciaran / Chavda, Selina J

    2015  

    Institution Foundation Programme (Great Britain. National Health Service)
    Author's details Anna Donald, Michael Stein, Ciaran Scott Hill, Selina J. Chavda
    MeSH term(s) Medical Staff, Hospital/organization & administration ; Clinical Competence ; Internship and Residency/organization & administration ; Medicine
    Keywords Great Britain
    Language English
    Size xviii, 257 pages :, illustrations
    Edition Fifth edition.
    Document type Book
    Note Preceded by The hands-on guide for junior doctors / Anna Donald, Michael Stein, Ciaran Scott Hill. 4th ed. 2011.
    ISBN 9781118767467 ; 1118767462
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Association of hypertension and cardiac events in patients with multiple myeloma receiving carfilzomib: practical management recommendations.

    Chavda, Selina J / Pocock, Rachael / Cheesman, Simon / Lee, Kyung-Min / Dowling, Emma / Marks, Daniel J B / Kyriakou, Charalampia / Lee, Lydia / Sive, Jonathan / Wechalekar, Ashutosh / Rabin, Neil / Yong, Kwee / Popat, Rakesh

    British journal of haematology

    2020  Volume 190, Issue 5, Page(s) e312–e316

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Databases, Factual ; Female ; Heart Diseases/chemically induced ; Heart Diseases/mortality ; Heart Diseases/prevention & control ; Humans ; Hypertension/chemically induced ; Hypertension/mortality ; Hypertension/prevention & control ; Male ; Middle Aged ; Models, Cardiovascular ; Multiple Myeloma/drug therapy ; Multiple Myeloma/mortality ; Multiple Myeloma/pathology ; Oligopeptides/administration & dosage ; Oligopeptides/adverse effects ; Practice Guidelines as Topic ; Retrospective Studies
    Chemical Substances Oligopeptides ; carfilzomib (72X6E3J5AR)
    Language English
    Publishing date 2020-06-14
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16889
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top