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Article: Description and Clinical Management of Patients With Glanzmann's Thrombasthenia in a University Hospital, a Referral Center Specialized in Hemostasis, in Bogotá, Colombia.

Solano, Maria H / Chaves, Karen / Casas, Claudia P

2022 Volume 14, Issue 6, Page(s) e25657

Abstract: Introduction Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelets caused by a deficiency in the glycoprotein IIb-IIIa. Bleeding from the skin, mucous membranes, and ecchymosis are symptoms manifested starting in early childhood. ...

Abstract	Introduction Glanzmann's thrombasthenia (GT) is an autosomal recessive disorder of platelets caused by a deficiency in the glycoprotein IIb-IIIa. Bleeding from the skin, mucous membranes, and ecchymosis are symptoms manifested starting in early childhood. There may also be major bleeding conditions as a result of surgical procedures or trauma. The treatment is based on platelet transfusions, antifibrinolytic agents, and recombinant activated factor VII (rFVIIa). Objective To describe the demographic and clinical characteristics as well as the main treatment strategies used during bleeding events or procedures for patients diagnosed with GT that required inpatient attention at a university hospital, a referral center specialized in hemostasis, in the city of Bogota. Materials and methods A descriptive retrospective cohort study was done over a period of 10 years that included nine patients over 18 years of age diagnosed with GT. Results A total of 34 admissions were reported, 23 due to bleeding and 11 for scheduled surgery. Some of the admissions for bleeding (38%) (n=13) required surgical procedures. Overall, 23 surgical procedures were done, six of which were classified as major. Seventy-seven percent of the patients were women with a median age of 37. Their most common symptoms were mucosal and genitourinary bleeding. The use of antifibrinolytics was registered in 28 events, followed by the use of platelet transfusion in 19, and the use of rFVIIa in 17. The average hospital stay was eight days. Conclusion The characteristics registered and the treatments established for this cohort of Colombian patients with GT are similar to those reported in other hospitals around the world. GT presents diagnostic and therapeutic challenges and, therefore, acquiring more knowledge about this pathology is needed within this context.
Language	English
Publishing date	2022-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25657
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Book ; Online: Bruxismo e COVID-19

Chaves, Karen Dantur Batista

2020

Abstract: O vídeo tem por objetivo apresentar a relação do Bruxismo com o COVID-19, tanto para o público acadêmico de diversas áreas da saúde, quanto para o público leigo. É apresentada a relação de sinais e sintomas no sistema mastigatório decorrente do Bruxismo, ...

Abstract	O vídeo tem por objetivo apresentar a relação do Bruxismo com o COVID-19, tanto para o público acadêmico de diversas áreas da saúde, quanto para o público leigo. É apresentada a relação de sinais e sintomas no sistema mastigatório decorrente do Bruxismo, bem como sua exacerbação em função do stress apresentado pelos indivíduos em situação de isolamento social. Também, alternativas caseiras para diminuir os sintomas. Não é possível instalar um arquivo de vídeo. Apenas transfira-o para seu computador e abra como um arquivo comum. Arquivos de vídeo não podem ser editados, mas podem ser visualizados em players como o VLC Media Player (que é gratuito), o Windows Media Player ou o QuickTime. Os formatos mais comuns de vídeo serão executados normalmente por estes players (avi, mpeg e mp4). Vídeo
Keywords	Bruxismo ; Covid -19 ; Ciências da saúde ; covid19
Language	Portuguese
Publishing date	2020-05-01
Publishing country	br
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A critical review of the applicability of serological screening for Leishmaniasis in blood banks in Brazil

Rodrigues, Wellington Francisco / Mendes, Niege Silva / de Carvalho Ribeiro, Patrícia / Mendes Filho, Daniel / Parreira, Ricardo Cambraia / Chaves, Karen Cristina Barbosa / de Abreu, Melissa Carvalho Martins / Miguel, Camila Botelho

Journal of parasitic diseases. 2021 Mar., v. 45, no. 1

2021

Abstract: Leishmaniasis is a group of diseases caused by several species of protozoa. It is a major public health concern in its visceral form, accounting annually for 59,000 deaths, and an estimated 12 million infected patients per year. The importance of VL ... ...

Abstract	Leishmaniasis is a group of diseases caused by several species of protozoa. It is a major public health concern in its visceral form, accounting annually for 59,000 deaths, and an estimated 12 million infected patients per year. The importance of VL resides not only in its high incidence and wide distribution but also in the possibility of the disease progressing to the severe and lethal forms, especially in children and immunosuppressed individuals, when associated with malnutrition and concomitant infections. This study is a bibliographical review, aiming to understand the sensitivity and specificity parameters of the tests used to detect Leishmaniasis, as well as to understand if there is any relevance in proposing a serological screening for Leishmaniasis in blood banks. In general, we observed that there are currently several types of tests for detecting Leishmaniasis: parasitological, serological and molecular. In such tests, many serological methods and kits are available for the detection of asymptomatic visceral leishmaniasis, but there is variability in sensitivity and specificity among the methods. The gold standard for the diagnosis of visceral leishmaniasis is the parasitological method, through the aspiration of bone marrow, with higher sensitivity by splenic puncture. Due to the relevance of the disease and the available data from research centers, there is evidence to propose a transfusion serological screening for visceral Leishmaniasis, pointing to the need for further studies.
Keywords	Protozoa ; blood ; bone marrow ; malnutrition ; public health ; visceral leishmaniasis ; Brazil
Language	English
Dates of publication	2021-03
Size	p. 109-117.
Publishing place	Springer India
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-020-01283-9
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Article ; Online: Comparative effectiveness of photobiomodulation and manual therapy alone or combined in TMD patients: a randomized clinical trial.

Brochado, Fernanda Thomé / Jesus, Luciano Henrique de / Carrard, Vinicius Coelho / Freddo, Angelo Luiz / Chaves, Karen Dantur / Martins, Manoela Domingues

Brazilian oral research

2018 Volume 32, Page(s) e50

Abstract: The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. Fifty-one TMD ... ...

Abstract	The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. Fifty-one TMD patients were randomly assigned to three groups: the PBM group (n = 18), which received PBM with 808 nm, 100 mW, 13.3 J/cm2, and 4 J per point; the MT group (n=16) for 21 minutes each session on masticatory muscles and temporomandibular joint TMJ; and the CT group (n = 17), applied during twelve sessions. Seven evaluations were performed in different moments using visual analogue scale (VAS), Research Diagnosis Criteria for Temporomandibular Disorders (RDC/TMD) Axis I and II, and Beck anxiety inventory (BAI). All groups demonstrated reductions in pain and improvement in jaw movements during treatment and at follow-up (< 0.001). The assessment of psychosocial aspects of TMD, comparing baseline and follow-up in all treatment groups, revealed that treatment did not promote modification in the intensity of chronic pain (p > 0.05). However, depression symptoms showed a reduction in PBM and CT groups (p≤0.05). All treatments promoted reduction in physical symptoms with and without pain and enhancement of jaw disabilities (p ≤ 0.05). MT promotes improvement in 5 functions, PBM in 2, and CT in 1 (p < 0.001). BAI analysis revealed that all treatments lead to a reduction in anxiety symptoms (p≤0.05). All protocols tested were able to promote pain relief, improve mandibular function, and reduce the negative psychosocial aspects and levels of anxiety in TMD patients. However, the combination of PBM and MT did not promote an increase in the effectiveness of both therapies alone.
MeSH term(s)	Adult ; Aged ; Anxiety/physiopathology ; Anxiety/prevention & control ; Chronic Pain/physiopathology ; Chronic Pain/psychology ; Chronic Pain/therapy ; Combined Modality Therapy/methods ; Depression/physiopathology ; Depression/prevention & control ; Female ; Follow-Up Studies ; Humans ; Jaw/physiopathology ; Low-Level Light Therapy/methods ; Male ; Masticatory Muscles/physiopathology ; Middle Aged ; Musculoskeletal Manipulations/methods ; Pain Management/methods ; Pain Measurement ; Reference Values ; Reproducibility of Results ; Surveys and Questionnaires ; Temporomandibular Joint Disorders/physiopathology ; Temporomandibular Joint Disorders/psychology ; Temporomandibular Joint Disorders/therapy ; Time Factors ; Treatment Outcome ; Visual Analog Scale ; Young Adult
Language	English
Publishing date	2018-07-10
Publishing country	Brazil
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2179332-3
ISSN	1807-3107 ; 1806-8324 ; 1517-7491
ISSN (online)	1807-3107
ISSN	1806-8324 ; 1517-7491
DOI	10.1590/1807-3107bor-2018.vol32.0050
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Article: A critical review of the applicability of serological screening for Leishmaniasis in blood banks in Brazil.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

2020 Volume 45, Issue 1, Page(s) 109–117

Abstract	Leishmaniasis is a group of diseases caused by several species of protozoa. It is a major public health concern in its visceral form, accounting annually for 59,000 deaths, and an estimated 12 million infected patients per year. The importance of VL resides not only in its high incidence and wide distribution but also in the possibility of the disease progressing to the severe and lethal forms, especially in children and immunosuppressed individuals, when associated with malnutrition and concomitant infections. This study is a bibliographical review, aiming to understand the sensitivity and specificity parameters of the tests used to detect Leishmaniasis, as well as to understand if there is any relevance in proposing a serological screening for Leishmaniasis in blood banks. In general, we observed that there are currently several types of tests for detecting Leishmaniasis: parasitological, serological and molecular. In such tests, many serological methods and kits are available for the detection of asymptomatic visceral leishmaniasis, but there is variability in sensitivity and specificity among the methods. The gold standard for the diagnosis of visceral leishmaniasis is the parasitological method, through the aspiration of bone marrow, with higher sensitivity by splenic puncture. Due to the relevance of the disease and the available data from research centers, there is evidence to propose a transfusion serological screening for visceral Leishmaniasis, pointing to the need for further studies.
Language	English
Publishing date	2020-10-08
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-020-01283-9
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Article: Influence of the patient's clinical information on the diagnostic reproducibility and accuracy of MRI scans of temporomandibular joint pathologies.

Bisi, Mauricio / Teixeira, Eduardo Rolim / Chaves, Karen Dantur Batista / Silveira, Heloisa Emilia Dias / Grossi, Marcio Lima

The International journal of prosthodontics

2014 Volume 27, Issue 3, Page(s) 245–249

Abstract: Purpose: To evaluate the influence of the patient's clinical information on the accuracy as well as interexaminer and intraexaminer reproducibilities of temporomandibular joint (TMJ) magnetic resonance imaging (MRI) scans.: Materials and methods: ... ...

Abstract	Purpose: To evaluate the influence of the patient's clinical information on the accuracy as well as interexaminer and intraexaminer reproducibilities of temporomandibular joint (TMJ) magnetic resonance imaging (MRI) scans. Materials and methods: Forty MRI scans from 20 TMJs corresponding to 7 TMJ pathologies (ie, degenerative alterations of the condyle, degenerative alterations of the mandibular fossa, alterations in the morphology of the TMJ disc, disc displacement with reduction, disc displacement without reduction, TMJ effusion, and TMJ hypermobility) were assessed by seven uncalibrated specialists in temporomandibular disorders (TMD) at baseline, 30 day-, and 60-day follow-ups for accuracy and reproducibility. No clinical information was provided before the 60-day follow up. Results: Examiners had a poor to regular accuracy (0.10 to 0.36), kappa index and 5% to 60% correct positive diagnosis) when compared with the radiologist's diagnoses (gold standard). The interexaminer reproducibility ranged from moderate to substantial (kappa = 0.32 to 0.71), and the intraexaminer reproducibility ranged from moderate to perfect (kappa = 0.38 to 1.00). Provision of clinical information improved neither the accuracy nor the reproducibility of the results (P < .05), with the exception of the intraexaminer reproducibility of one examiner. Conclusions: Calibration is needed in assessing TMJ MRI scans, even when trained specialists are provided with clinical information from the patient.
MeSH term(s)	Adolescent ; Adult ; Calibration ; Facial Pain/diagnosis ; Female ; Follow-Up Studies ; Humans ; Joint Dislocations/diagnosis ; Joint Instability/diagnosis ; Magnetic Resonance Imaging/statistics & numerical data ; Male ; Mandibular Condyle/pathology ; Medical History Taking ; Middle Aged ; Observer Variation ; Osteoarthritis/diagnosis ; Range of Motion, Articular/physiology ; Reproducibility of Results ; Sound ; Synovial Fluid ; Temporal Bone/pathology ; Temporomandibular Joint Disc/pathology ; Temporomandibular Joint Disorders/diagnosis ; Young Adult
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645046-5
ISSN	1942-4426 ; 0893-2174
ISSN (online)	1942-4426
ISSN	0893-2174
DOI	10.11607/ijp.3583
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Article ; Online: Endostatin neoadjuvant gene therapy extends survival in an orthotopic metastatic mouse model of renal cell carcinoma.

de Souza Braga, Marina / Chaves, Karen Barbosa / Chammas, Roger / Schor, Nestor / Bellini, Maria Helena

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2012 Volume 66, Issue 4, Page(s) 237–241

Abstract: Despite recent advances in targeted therapy, renal cell carcinoma (RCC) remains one of the most lethal urologic malignancies. Approximately 30% of patients with localised RCC will develop metastases after curative surgery. Presurgical therapy has been ... ...

Abstract	Despite recent advances in targeted therapy, renal cell carcinoma (RCC) remains one of the most lethal urologic malignancies. Approximately 30% of patients with localised RCC will develop metastases after curative surgery. Presurgical therapy has been explored for treatment of localised RCC. Endostatin (ES) is a fragment of collagen XVIII that possesses antiangiogenic activity. In this study, we examined the potential use of an antiangiogenic agent as a neoadjuvant therapy in an orthotopic metastatic mouse model of RCC. BALB/c mice bearing Renca cells were treated before nephrectomy with NIH/3T3-LendSN cells. At the end of the experiment, ES serum levels were measured. Primary and metastatic tumour area and microvascular area were determined. In the survival studies, mice were monitored daily until they died. ES serum levels in treated mice were higher in the control group (P<0.05). The median primary tumour area and the mean microvascular area were significantly lower in the ES-treated group compared to control group (P<0.05). The proliferation of Renca cells in the ES-treated group was significantly reduced compared with the control group (P<0.01). ES therapy led to a significant reduction in the number of pulmonary metastatic nodules compared with the control group (P<0.01). Kaplan-Meier survival curves showed that the probability of survival was significantly higher in mice receiving ES therapy (P=0.0243, Log-Rank test). Our results indicated that neoadjuvant ES gene therapy has the potential to decrease tumour burden, extend survival, and may have clinical benefit in the management of RCC.
MeSH term(s)	Animals ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/therapy ; Cell Proliferation ; Combined Modality Therapy ; Endostatins/administration & dosage ; Endostatins/blood ; Endostatins/genetics ; Genetic Therapy/methods ; Kaplan-Meier Estimate ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Male ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Neoadjuvant Therapy/methods ; Neoplasm Metastasis ; Nephrectomy/methods ; Survival Rate
Chemical Substances	Endostatins
Language	English
Publishing date	2012-06
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2011.11.002
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Article: Ethnic differences in potentially preventable hospitalizations among Asian Americans, Native Hawaiians, and other Pacific Islanders: implications for reducing health care disparities.

Moy, Ernest / Mau, Marjorie K / Raetzman, Susan / Barrett, Marguerite / Miyamura, Jill B / Chaves, Karen H / Andrews, Roxanne

Ethnicity & disease

2013 Volume 23, Issue 1, Page(s) 6–11

Abstract: Objectives: A serious challenge to eliminating US health disparities stems from the inability to reliably measure outcomes, particularly for numerically small populations. Our study aimed to produce reliable estimates of health care quality among Native ...

Abstract	Objectives: A serious challenge to eliminating US health disparities stems from the inability to reliably measure outcomes, particularly for numerically small populations. Our study aimed to produce reliable estimates of health care quality among Native Hawaiian (NH), Other Pacific Islander (PI), and Asian American (AA) subgroups. Design: Prevention Quality Indicators (PQIs) from the Agency for Healthcare Research and Quality were used to calculate 3 PQI composites and 8 individual chronic condition indicators. Data sources were the Healthcare Cost and Utilization Project State Inpatient Databases and the Hawaii Health Survey. Main outcome measures: Risk-adjusted PQI rates for adults were computed for 2005 through 2007. Relative rates for 2007 were calculated for each racial/ethnic group and compared to Whites. Statistical significance was based on P < .05 from a two-sided t test. Results: The combined AANHPI group had higher overall and chronic PQI composite rates than Whites in 2007. When disaggregated into discrete racial/ethnic subgroups, Chinese and Japanese had lower rates than Whites for all 3 composites, whereas NH and Other PI subgroups typically had the worst health outcomes. Trends in PQI rates from 2005 through 2007 showed persistent gaps between groups, especially across chronic PQIs. Conclusions: Despite recent efforts to reduce racial/ethnic health care disparities, significant gaps remain in potentially preventable hospitalization rates. Practical tools that measure inequities across diverse, numerically small populations may suggest ways to optimally funnel limited resources toward improving racial/ethnic differences in health outcomes.
MeSH term(s)	Asian Americans ; Hawaii ; Healthcare Disparities/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Minority Health ; Native Hawaiian or Other Pacific Islander ; Outcome Assessment, Health Care ; Quality Indicators, Health Care ; Young Adult
Language	English
Publishing date	2013-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1274267-3
ISSN	1945-0826 ; 1049-510X
ISSN (online)	1945-0826
ISSN	1049-510X
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Article ; Online: Vascular endothelial growth factor as a biomarker for endostatin gene therapy.

Braga, Marina Souza / Turaça, Thiago Lauro / Foguer, Karen / Chaves, Karen Cristina Barbosa / Pesquero, João Bosco / Chammas, Roger / Schor, Nestor / Bellini, Maria Helena

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2013 Volume 67, Issue 6, Page(s) 511–515

Abstract: Renal cell carcinoma (RCC) is characterized by high vascular endothelial growth factor (VEGF) production and, consequently, excessive angiogenesis. Several strategies have been developed to target angiogenesis as a method for treating metastatic RCC ( ... ...

Abstract	Renal cell carcinoma (RCC) is characterized by high vascular endothelial growth factor (VEGF) production and, consequently, excessive angiogenesis. Several strategies have been developed to target angiogenesis as a method for treating metastatic RCC (mRCC). Endostatin (ES) is a C-terminal fragment of collagen XVIII that has antiangiogenic activity. The aim of this study was to investigate the predictive value of circulating VEGF-A in a murine model of mRCC after ES gene therapy. ES therapy did not affect the levels of collagen XVIII/ES or ES in the tissue. The circulating level of ES was increased in the control and ES-treated groups (normal vs. control, P<0.05 and ES-treated vs. control, P<0.001), and the intratumoral vessels were significantly decreased (ES-treated vs. control, P<0.05). ES therapy decreased the VEGF mRNA levels. The tissue and circulating levels of VEGF in the control group were significantly higher than normal (P<0.01 and P<0.05, respectively). Treatment with ES significantly reduced the VEGF concentrations in both compartments (P<0.001 for tissue and P<0.05 for plasma). Our findings indicate that in addition to the directly targeted tumor vessels, ES exerts its antitumor effect by down-regulating VEGF gene expression in renal tumor cells. Additionally, our findings point to the predictive value of VEGF for ES therapy.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/therapy ; Collagen Type XVIII/genetics ; Endostatins/genetics ; Genetic Therapy/methods ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Mice ; Mice, Inbred BALB C ; RNA, Messenger/genetics ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Angiogenesis Inhibitors ; Biomarkers, Tumor ; Collagen Type XVIII ; Endostatins ; RNA, Messenger ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, mouse
Language	English
Publishing date	2013-07
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2013.04.008
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Article ; Online: Fibronectin expression is decreased in metastatic renal cell carcinoma following endostatin gene therapy.

Chaves, Karen Cristina Barbosa / Turaça, Lauro Thiago / Pesquero, João Bosco / Mennecier, Gregory / Dagli, Maria Lucia Zaidan / Chammas, Roger / Schor, Nestor / Bellini, Maria Helena

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2012 Volume 66, Issue 6, Page(s) 464–468

Abstract: Tumor cells induce the disruption of homeostasis between cellular and extracellular compartments to favor tumor progression. The expression of fibronectin (FN), a matrix glycoprotein, is increased in several carcinoma cell types, including renal cell ... ...

Abstract	Tumor cells induce the disruption of homeostasis between cellular and extracellular compartments to favor tumor progression. The expression of fibronectin (FN), a matrix glycoprotein, is increased in several carcinoma cell types, including renal cell carcinoma (RCC). RCC are highly vascularized tumors and are often amenable to antiangiogenic therapy. Endostatin (ES) is a fragment of collagen XVIII that possesses antiangiogenic activity. In this study, we examined the modulation of FN gene expression by ES gene therapy in a murine metastatic renal cell carcinoma (mRCC) model. Balb/C mice bearing Renca cells were treated with NIH/3T3-LXSN cells or NIH/3T3-LendSN cells. At the end of the experiment, the ES serum levels were measured, and the FN gene expression was assessed using real-time PCR. The tissue FN was evaluated by western blotting and by immunofluorescence analysis. The ES serum levels in treated mice were higher than those in the control group (P<0.05). ES treatment led to significant decreases at the FN mRNA (P<0.001) and protein levels (P<0.01). Here, we demonstrate the ES antitumor effect that is mediated by down-regulation of FN expression in mRCC.
MeSH term(s)	Animals ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/secondary ; Carcinoma, Renal Cell/therapy ; Clone Cells ; Down-Regulation ; Endostatins/blood ; Endostatins/genetics ; Endostatins/therapeutic use ; Fibronectins/metabolism ; Genetic Therapy ; Kidney Neoplasms/blood ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Male ; Mice ; Mice, Inbred BALB C ; NIH 3T3 Cells ; Neoplasm Transplantation ; RNA, Messenger/metabolism ; Recombinant Proteins/blood ; Recombinant Proteins/metabolism
Chemical Substances	Endostatins ; Fibronectins ; RNA, Messenger ; Recombinant Proteins
Language	English
Publishing date	2012-09
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2012.04.003
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